Clinical trials: Chronic Spinal Pain
Nociceptive Pain, Axial Back Pain
Ultra Low Frequency Neuromodulation for Nociceptive Chronic Low Back Pain
The goal of this clinical trial is to learn if Ultra Low Frequency (ULF) neuromodulation works to treat nociceptive chronic low back pain in adults. It will also evaluate the safety of ULF therapy.
- Trial name
- NCT06763653
- Testing
- ULF therapy, CMM
- Where
- 3 sites in Australia
- Volunteers
- 303 people
- Sponsor
- Presidio Medical, Inc
Low Back Pain, Mechanical Low Back Pain
Thrust Versus Non-thrust Manipulation in Chronic Low Back Pain
This study aims to verify the effects of Thrust Versus Non-thrust Manipulation on Pain, Trunk Proprioception and Postural Stability in Subjects With Chronic Low Back Pain.
- Conditions
- Low Back Pain, Mechanical Low Back Pain, Backache
- Trial name
- NCT02276794
- Testing
- Thrust Manipulation, Non-thrust manipulation (NTM)
- Where
- Brazil
- Volunteers
- 23 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Acute Low Back Pain, Chronic Low Back Pain (CLBP)
Exploring Multidimensional Trajectories in People With Low Back Pain
Low back pain (LBP) is a major health problem in Switzerland and worldwide. Globally, LBP remains the leading cause of years lived with disability and its incidence and associated socioeconomic consequences are predicted to…
- Trial name
- NCT07176845
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Bern University of Applied Sciences
Chronic Spinal Pain
RTMS and Steroid Joint Steroid Injection in Chronic Spinal Pain
Chronic spinal pain (CSP) is one of the most common chronic pain conditions globally. Steroid joint injections (SJI) are a routine treatment option for patients with CLBP that is recalcitrant to other treatments.
- Trial name
- NCT05840354
- Testing
- Magstim Rapid2
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lumbar Degenerative Disc Disease, Lower Back Pain
Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine
Investigate the potential of tissue grafting that includes human mesenchymal stem cells in the repair and potential stabilization of the degenerative Lumbar disk and facet joint denovo and at the time of surgical reconstruction.
- Conditions
- Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
- Trial name
- NCT02529566
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Low Back Pain
Assessment of All Spine Segments ın Individuals With Low Back Pain
The aim of the study is to evaluate the kinematics of all spine segments in 3 planes and compare them with asymptomatic controls using wearable technology while performing functional tasks that patients with chronic low back pain…
- Trial name
- NCT06276322
- Testing
- Low back pain group, Healthy group
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Parkinson's Disease (PD)
Pilot Study of Robotic Spinal Mobilization in Parkinson's Disease
This interventional pilot study will evaluate the safety and clinical efficacy of robotic spinal mobilization in community-dwelling adults with Parkinson's Disease (PD).
- Trial name
- NCT07376122
- Testing
- BackHug Robotic Spinal Mobilization System
- Volunteers
- 30 people
- Sponsor
- Pacla Medical Limited
Neuralgia, Spinal Cord Injuries
A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury
The purpose of this study is to evaluate if pregabalin relieves nerve pain associated with spinal cord injury compared to placebo (pill that contains no active medicine).
- Trial name
- NCT00407745
- Testing
- pregabalin
- Where
- 67 sites in United States, Chile and 8 more
- Volunteers
- 220 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Chronic Pain, Chronic Low-back Pain
Ultra Low Frequency Spinal Cord Stimulation for Chronic Low Back Pain
The Presidio Medical Ultra Low Frequency (ULF™) Spinal Cord Stimulation (SCS) System is intended to provide pain relief to participants who have been clinically diagnosed with chronic low back pain with or without leg pain.
- Trial name
- NCT05837234
- Testing
- ULF SCS
- Where
- 3 sites in Australia
- Volunteers
- 55 people
- Sponsor
- Presidio Medical, Inc
Spinal Cord Injuries
Brivaracetam to Reduce Neuropathic Pain in Chronic Spinal Cord Injury
Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to all pharmacological intervention.
- Trial name
- NCT04379011
- Testing
- Brivaracetam
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Low Back Pain, Neuromuscular Subluxation of Joint
Effects of Dynamic Stabilizatıon Exercises and HVLA Manipulatıon in Low Back Paın
Our aim is to contribute to the literature by comparatively examining the effects of DNS exercises and chiropractic HVLA manipulation on pain, pain-related functional impairment (disability), physical competence level, dynamic…
- Trial name
- DNSHVLA (NCT06277700)
- Testing
- Chiropractic Manipulation (HVLA - high velocity low amplitude), Dynamic Neuromuscular Stabilization
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Lumbar Disc Herniation
Effectiveness of PEMF in Patients With Chronic Radicular Pain Due to Lomber Disc Herniation
The aim of this study is to investigate the effectiveness of pulse magnetic field therapy on pain, functional status, and quality of life in patients with chronic radicular pain due to lumbar disc herniation.
- Trial name
- NCT04049812
- Testing
- PEMF, Hot pack, TENS
- Volunteers
- 50 people
- Sponsor
- Birkan Sonel Tur
Sacroiliac Joint Pain
Peripheral Nerve Stimulation for Treatment of Sacroiliac Joint Pain
Prospective randomized controlled study, primary objective: Pain reduction in patients with chronic Sacroiliac joint pain after therapy either with Peripheral Nerve Stimulation or with best medical treatment.
- Trial name
- SIlencing (NCT05357300)
- Testing
- Peripheral Nerve Stimulation
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- PD Dr. med. Simon Bayerl
Chronic Low Back Pain
Manual Therapy Plus Capacitive and Resistive Electric Transfer Therapy in Individuals With Chronic Low Back Pain
Chronic low back pain is defined as back pain that lasts longer than 12 weeks. The aim of this clinical study is to investigate the efficacy of combining a program of manual techniques with the application of Capacitive and…
- Trial name
- NCT05680467
- Testing
- Manual Therapy, Manual Therapy plus TECAR, Control
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- International Hellenic University
Spinal Cord Injury, Chronic Pain
Spaulding-Harvard Model System: Effects of Transcranial Direct Current Stimulation (tDCS) on Chronic Pain in Spinal Cord Injury
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain associated with spinal cord injury. This study is part of the Spaulding-Harvard Model System.
- Conditions
- Spinal Cord Injury, Chronic Pain, Neuropathic Pain
- Trial name
- NCT01599767
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Spaulding Rehabilitation Hospital
Upper Limb, Pain
Observational, Post Market Study in Treating Chronic Upper Extremity Limb Pain
This is a post-market, open-label, prospective, multi-center, observational study evaluating upper limb pain relief with the DTM™ SCS programming approach.
- Trial name
- PROC2020PM (NCT04466111)
- Testing
- Intellis neurostimulator system
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- SGX Procura LLC
Chronic Pain, Low Back Pain
High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System
Study designed to compare the conventional stimulation programming versus the high frequency stimulation programming of the spinal cord stimulator for subjects who already have a spinal cord stimulator.
- Conditions
- Chronic Pain, Low Back Pain, Radiculopathy, Complex Regional Pain Syndrome (CRPS)
- Trial name
- HFSCS (NCT02265848)
- Testing
- High frequency stimulation, Low frequency stimulation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Center for Clinical Research, Winston-Salem, NC
Back Pain With Radiation, Pain, Postoperative
Burst Crossover Trial
Spinal cord stimulation (SCS) is a widely applied therapy to treat chronic neuropathic pain, and one of the most common indications is persisting radicular neuropathic pain following lumbar spine surgery.
- Trial name
- NCT05372822
- Testing
- Burst Spinal Cord Stimulation, SCS implant
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- St. Olavs Hospital
Chronic Pain
A Randomised Pilot Study to Assess Differences in Stimulation Induced Paresthesia Between 2 Spinal Cord Stimulation Systems
12-SMI-2014 is a post-market, randomised, pilot study to identify and rate differences in patient experiences with two different types of Spinal Cord Stimulator devices which are routinely used to treat chronic pain.
- Trial name
- CHARACTER SCS (NCT02250469)
- Testing
- Treatment with the Axium SCS system, Treatment with the Medtronic SCS System
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Abbott Medical Devices
Chronic Low Back Pain
Effects of the Spinal Manipulative Therapy and Myofascial Release in Individuals With Non-specific Chronic Low Back Pain
The aim will be to compare a experimental group submitted to a protocol of spinal manipulation and myofascial release; and a control group composed by spinal manipulation only, in individuals with chronic non-specific low back…
- Trial name
- ChiroRCT (NCT03434990)
- Testing
- Spinal manipulation/myofascial release, Spinal manipulation
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Brasilia