Clinical trials: Chronic Spinal Pain
Chronic Lower Limb Pain
A Safety and Effectiveness Trial of Spinal Cord Stimulation of the Dorsal Root Ganglion for Chronic Lower Limb Pain
The purpose of this study is to evaluate the safety and effectiveness of the AXIUM Neurostimulator System for the treatment of chronic lower limb pain in persons diagnosed with Complex Regional Pain Syndrome (CRPS) or Peripheral…
- Trial name
- ACCURATE (NCT01923285)
- Testing
- AXIUM Neurostimulator System, Control Spinal Cord Stimulation Device
- Where
- 22 sites in United States
- Volunteers
- 152 people
- Sponsor
- Abbott Medical Devices
Low Back Pain
Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain
To demonstrate clinically significant improvements or lack thereof in the caudal epidural patients with our without steroids. To evaluate differences in outcomes in patients receiving steroids compared to those patients…
- Trial name
- NCT00370799
- Testing
- Caudal epidural injection, Caudal Epidural Injection with generic Celestone, Caudal Epidural Injection with Celestone
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Pain Management Center of Paducah
Painful Diabetic Neuropathy
Comparison of 10 kHz SCS Combined With CMM to CMM Alone in the Treatment of Neuropathic Limb Pain
This post-market study is being conducted to document comparative safety, clinical effectiveness, and cost-effectiveness of the addition of HF10™ therapy to CMM compared with CMM alone in subjects with chronic, intractable…
- Trial name
- SENZA-PDN (NCT03228420)
- Testing
- Senza HF10 Therapy, CMM
- Where
- 4 sites in United States
- Volunteers
- 430 people
- Sponsor
- Nevro Corp
Chronic Pain
Study to Characterize Effects of Programming in SCS Patients Undergoing a Temporary Trial
This is a prospective, multi-center, non-randomized, exploratory, single-arm study characterize the effects of programming spinal cord stimulation (SCS) in patients undergoing a Boston Scientific (BSC) spinal cord stimulation…
- Trial name
- NCT02988713
- Testing
- Programming
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Boston Scientific Corporation
Spinal Cord Injuries, Chronic Pain
Development of a Pain Rehabilitation Program for Chronic Pain After SCI
Pain rehabilitation programs are essential for optimal treatment of chronic pain and are usually based on the biopsychosocial model.
- Conditions
- Spinal Cord Injuries, Chronic Pain, Neuropathic Pain, Interprofessional Team Collaboration
- Trial name
- NCT07634796
- Testing
- multi-modality pain management
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Complex Regional Pain Syndrome, Chronic Pain
Spinal Cord Stimulation Versus Nerve Blocks and Physical Therapy
The primary objective of this study is to compare the efficacy of SCS using the Precision implantable neurostimulation device and conventional medical treatment (nerve blocks + physical therapy) in subjects with…
- Conditions
- Complex Regional Pain Syndrome, Chronic Pain, Pain
- Trial name
- NCT00414804
- Testing
- Precision SCS, Nerve Blocks and PT
- Sponsor
- Boston Scientific Corporation
Spinal Cord Injuries
Efficacy and Safety of hUC-MSCs and hUCB-MSCs in the Treatment of Chronic Spinal Cord Injury
There is evidence that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) can differentiate into oligodendrocytes and neurons, and improve the recovery of nerve function, which strongly suggests the feasibility…
- Trial name
- NCT04213131
- Testing
- Stem cell transplantation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Spinal Cord Injuries (SCI), Paralysis, Lower Limbs
Epidural Electrical Stimulation to Restore Standing and Walking in Patients With Chronic Paralysis Due to Spinal Cord Injury: A Study on Motor Recovery, Spasticity Reduction, and Quality of Life Improvement Through Neuromodulation and Intensive Rehabilitation
Spinal cord injury (SCI) is a major cause of morbidity and disability worldwide, significantly impacting patients' quality of life and functional independence.
- Trial name
- EPISTIM-SCI (NCT06847295)
- Testing
- Epidural Electrical Stimulation (EES) using an implanted paddle lead and pulse generator combined with a 12-month intensive rehabilitation program.
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Low Back Pain, Sciatica
Ultrasound-guided Lumbar Periradicular Injection: a Non Irradiating Infiltration Technique
We propose here to evaluate the precision of lumbar periradicular infiltration performed under a transverse ultrasound approach by performing a fluoroscopic control once the needle in the desired position.
- Conditions
- Low Back Pain, Sciatica, Disc, Herniated, Foraminal Hernia
- Trial name
- NCT03453775
- Testing
- Ultrasound guided periradicular lumbar infiltration, Fluoroscopy guided periradicular lumbar infiltration
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Libre de Bruxelles
Pain, Chronic, Pain, Neuropathic
Caregiver Burden and Correlation With Clinical Outcome in Spinal Cord Stimulation for Chronic Neuropathic Pain
Prospective multicentric observational trial on caregiver burden, caregiver satisfaction and clinical outcome in spinal cord stimulation for chronic neuropathic pain.
- Conditions
- Pain, Chronic, Pain, Neuropathic, Failed Back Surgery Syndrome
- Trial name
- CAREstim (NCT04737746)
- Where
- 2 sites in Belgium
- Volunteers
- 42 people
- Sponsor
- AZ Delta
Extremity Injury
Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty
The purpose of this study is to determine the degree to which spinal cord stimulation added to comprehensive medical management can provide increased relief of chronic pain in patients with injuries sustained while on active…
- Trial name
- War Wounded (NCT01616342)
- Testing
- Spinal cord stimulator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Sceptor Pain Foundation
Chronic Low-back Pain
Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain
As a leading cause of disability worldwide, chronic low back pain (cLBP) represents a significant medical and socioeconomic problem with estimated health care spending of $87 billion/annually.
- Trial name
- NCT05265000
- Testing
- tSpinalStim
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Low Back Pain, Pain, Chronic
What Determines a Positive Outcome of Spinal Manipulation for Persistent Low Back Pain: Stiffness or Pain Sensitivity? A Randomized Trial
Introduction Several treatment methods have been proposed to ease the burden of low back pain (LBP) but none are clearly superior.
- Trial name
- POPS (NCT04086667)
- Testing
- Spinal manipulation
- Where
- Denmark
- Volunteers
- 132 people
- Sponsor
- Spine Centre of Southern Denmark
Chronic Low Back Pain, Degenerative Disc Disease
Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms
Opioids are frequently prescribed for chronic low back pain (CLBP). Psychiatric illness, such as high levels of depression and anxiety symptoms, is a common co-occurrence in chronic pain patients (and is termed comorbid negative…
- Conditions
- Chronic Low Back Pain, Degenerative Disc Disease, Depression, Anxiety
- Trial name
- NCT01502644
- Testing
- Oxycodone, Morphine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Brigham and Women's Hospital
Chronic Low Back Pain
Chiropractic Management of Chronic Lower Back Pain in Older Adults
The purpose of this study is to determine the effectiveness of Chiropractic management for treatment of chronic lower back pain in older adults.
- Trial name
- NCT00475787
- Testing
- Spinal Manipulation, Detuned Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- US Department of Veterans Affairs
Pain, Chronic Pain
Efficacy and Safety of Spinal Cord Stimulation in Patients With Chronic Intractable Pain
The purpose of this study is to evaluate the efficacy and safety of spinal cord stimulation (SCS) using the PINS spinal cord stimulator device for chronic and intractable pain.
- Conditions
- Pain, Chronic Pain, Back Pain, Spinal Cord Stimulation
- Trial name
- NCT03858790
- Testing
- PINS Spinal Cord Stimulator
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Spinal Spondyloarthropathies, Axial Spondyloarthritis
Diagnostic Criteria in the Diagnosis of Spinal Spondyloarthropathies in Patients With Chronic Low Back Pain (Study P05320)(COMPLETED)
This is a multi-national, multi-site, observational study to determine which of two strategies, when used by referring physicians is superior in the diagnosis of axial spondyloarthritis (AS) by rheumatologists.
- Trial name
- NCT00726765
- Volunteers
- 1,090 people
- Sponsor
- Merck Sharp & Dohme LLC
Neck Pain
Effects of Holistic Spinal Fascial Mobilization in Neck Pain
This study aims to determine the effects of holistic spinal fascial mobilization on pain, range of motion and function in patients with chronic neck pain so that we can have the best treatment option for patients with chronic…
- Trial name
- NCT05392465
- Testing
- Fascial mobilization group, Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Neck Pain, Low Back Pain
PNE Effectiveness Cluster Trial
This is a cluster randomized trial that involves training regions of physical therapy clinics to use pain neuroscience education or continue with usual care.
- Conditions
- Neck Pain, Low Back Pain, Chronic Pain
- Trial name
- PNE (NCT03168165)
- Testing
- Pain neuroscience education training
- Where
- 41 sites in United States
- Volunteers
- 316 people
- Sponsor
- University of Utah
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego