Clinical trials: Chronic Spine Pain
Intervertebral Disc Degeneration, Chronic Low-back Pain
Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD
DREAM is a phase II B efficacy monocentric, prospective, randomized, controlled double blinded trial, comparing intra-discal autologous adult bone marrow mesenchymal stem cells (BM-MSC) therapy and sham treated controls in…
- Trial name
- DREAM (NCT05066334)
- Testing
- Autologous BM-MSC
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Chronic Pain
The Benefits of Massage for Back Pain
This study evaluates the effectiveness of a oriented massage by comparing it with that of a classic symmetrical massage.
- Trial name
- NCT07664969
- Testing
- Massage
- Where
- New Caledonia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cabinet d'ostéopathie Michel Boeuf
Chronic Postoperative Pain
Placebo Effect In Spinal Cord Electrical Stimulation for Pain
Objective: To evaluate if spinal cord stimulation (SCS) performs better than placebo (no stimulation) in the long term to reduce persistent neuropathic leg pain refractory to medication and other conservative treatments in…
- Trial name
- PISCES (NCT06585033)
- Testing
- Spinal cord stimulation
- Where
- 4 sites in Netherlands, Norway and 1 more
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Chronic Low-back Pain
Effects of Different Treatment Methods Applied to Spine in Chronic Non-Spesific Low Back Pain
We aimed to investigate the effects of instrument assisted manipulation (IAM) and Mulligan mobilization with movement (MWM) on joint range of motion (ROM), pain, proprioception, endurance, back awareness and disability in…
- Trial name
- NCT05638997
- Testing
- Instrument assisted manipulation + Core exercises, Mulligan mobilization with movement + Core exercises, Core exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Tokat Gaziosmanpasa University
Chronic Pain, Spine Disease
An Observational Study of Integrated Chronic Pain Management in a Community Health Center
This was a prospective observational study with the primary objective of quantifying a change in pain scores after 6-12 months of two separate interventions within the study site (pain team and chiropractic team).
- Trial name
- NCT04490291
- Testing
- chronic pain team, chiropractic team
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Low Back Pain
Do Lower Spine Injections Improve Outcomes for Lower Back Pain Patients
The purpose of this project is to determine the effect of lower back injections on select biomechanical outcomes, walking patterns, lower back flexibility and balance.
- Trial name
- NCT01381224
- Testing
- Observation of biomechanical effects post injection
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain
SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients
SPINE-RISK VE is a prospective multicenter cohort study designed to develop and internally validate a multimodal preoperative predictive model for Failed Back Surgery Syndrome (FBSS), now classified as Persistent Spinal Pain…
- Conditions
- Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain, Postoperative Pain, Lumbar Spine Surgery
- Trial name
- SPINE-RISK VE (NCT07693517)
- Testing
- SPINE-RISK VE multimodal preoperative assessment
- Where
- Venezuela
- Volunteers
- 150 people
- Sponsor
- juan jose valero quintero,MD
Chronic Pain, Neuropathic Pain
Neuronal Activation Accuracy in Closed-loop Spinal Cord Stimulation
Observational, prospective, single-center to assess neuronal activation accuracy and stimulation sensation in patients with closed-loop spinal cord stimulation therapy.
- Conditions
- Chronic Pain, Neuropathic Pain, Persistent Spinal Pain Syndrome Type 2
- Trial name
- NAA (NCT06775535)
- Testing
- ECAP-controlled, closed-loop SCS
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Karel Hanssens
Low Back Pain, Musculoskeletal Pain
Regional Manual Therapy and Motor Control Exercise for Chronic Low Back Pain
Purpose: The primary purpose of this study is to determine whether or not the addition of thoracic, pelvic, and hip manual therapy to a standard physical therapy (PT) approach consisting of motor control exercises and lumbar…
- Trial name
- NCT02170753
- Testing
- Regional manual therapy, Standard physical therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Low-back Pain
The BEST Trial: Biomarkers for Evaluating Spine Treatments
The BEST Trial (Biomarkers for Evaluating Spine Treatments) is a National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)-sponsored clinical trial being conducted through the NIH Helping to End Addiction…
- Trial name
- BEST (NCT05396014)
- Testing
- Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM)
- Where
- 12 sites in United States
- Volunteers
- 1,014 people
- Sponsor
- University of North Carolina, Chapel Hill
Pain
Perioperative Pain Management In Spine Surgery Patients: Part I
The purpose of this study is a comparison of pain management in opioid-tolerant spine surgery patients using a perioperative dosing goal of 150% of patient's baseline oral morphine equivalent (OME), as compared to standard…
- Trial name
- NCT01447888
- Testing
- 150% Oral Morphine Equivalent (OME), Clinical Judgment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Allina Health System
Chronic Non-specific Low-Back Pain, Chronic Non-specific Neck Pain
Diaphragmatic Breathing Training in Chronic Spinal Pain
The goal of this clinical trial is to learn whether adding breathing training to an exercise program can improve pain, mood, and thinking skills in adults with chronic spinal pain.
- Trial name
- NCT07539116
- Testing
- Structured Exercise program, Diaphragmatic Breathing Training
- Where
- 2 sites in Greece
- Volunteers
- 183 people
- Sponsor
- Democritus University of Thrace
Anxiety, Depression
Optimizing Mental Health in Orthopedic Care
This study will utilize qualitative cross-sectional and quantitative longitudinal methods. In semi-structured interviews, orthopedic providers and patients with spine conditions will discuss their overall perspectives, specific…
- Conditions
- Anxiety, Depression, Back Pain, Neck Pain
- Trial name
- NCT05194722
- Testing
- Wysa mobile app
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Back Pain, Back Disorder
Clinical Trial of Dvectis Pads in Comparison to no Pad Use in Patients With Chronic Lumbar Spine Pain
1. Introduction 1.1 Description of the Trial The trial was a monocentric, open, randomized, 3-arm clinical trial that took place at the Department of Orthopaedics of the Karviná Miners' Hospital (Karvinská hornická nemocnice…
- Conditions
- Back Pain, Back Disorder, Disease Lumbar Spine
- Trial name
- NCT03947580
- Testing
- Use of the Dvectis Single pad, Use of the Dvectis Double pad, Use of no pad
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- DD-Hippero s.r.o.
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Cervical Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of lidocaine and ketamine in the same syringe versus remifentanyl analgesia in cervical spine…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05717361
- Testing
- ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
Chronic Spine Pain, Fibromyalgia
Resilience Skills Self-Management for Chronic Pain.
The investigators will conduct a randomized controlled trial of an 8-week resilience-enhanced CBT online self-management program for chronic pain plus usual care (PRISM), standard e-CBT self-management plus usual care (e-CBT)…
- Trial name
- NCT03304613
- Testing
- Web-based Cognitive Behavioral Therapy (e-CBT) Self-Management, Promoting Resilience through Innovative Self-Management
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Chronic Non-specific Low Back Pain
Motor Learning for the Lumbar Spine Using Sensor-based Postural Feedback: a Randomized Controlled Trial
A large subgroup of patients with chronic non-specific low back pain have motor control impairments. During motor control exercises, different forms of external feedback can be used to support training.
- Trial name
- NCT02773160
- Testing
- Sensor-based postural feedback, Mirror feedback, Control group
- Where
- 2 sites in Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Neck Pain
Specific Manual Approach to the Suboccipital Area on Patients With Chronic Mechanical Neck Pain
There are different inhibition suboccipital techniques, usually adjuvant of physiotherapy, for treatment of patients with chronic neck pain.
- Trial name
- NCT02832232
- Testing
- translational dorsal glide mobilization technique grade III, pressure maintained suboccipital Inhibition technique, Control Group
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Spine Injuries and Disorders, Pain, Chronic
Real-Time Accurate Pathology Inspection and Decompression Study
The primary objective is changes in spine and lower limb pain following a laser-assisted neural decompression (LAND) procedure for the treatment of lumbar, thoracic, or cervical spine and/or extremity pain.
- Conditions
- Spine Injuries and Disorders, Pain, Chronic, Pain, Back, Pain, Neck
- Trial name
- RAPID (NCT05347108)
- Testing
- laser-assisted neural decompression (LAND) procedure
- Where
- United States
- Sponsor
- KM Clinical Research Group
Low Back Pain, Low Back Ache
Measuring Reliability of Spine Mobilization in Low Back Pain
This observational study aims to learn how to measure joint motion and tissue response when pressure is applied to the back and examine how the nervous system responds to the applied pressure.
- Conditions
- Low Back Pain, Low Back Ache, Low Back Pain, Mechanical, Low Back Pain, Posterior Compartment
- Trial name
- NCT07582705
- Testing
- Spinal mobilization
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center