Clinical trials: Chronic Stable Heart Failure
COPD, Hyperinflation
Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients
Chronic Obstructive Pulmonary disease (COPD) is one of the major clinical entities that causes thousands of deaths every year all over the world and weights a lot on the health care system of every country in terms of direct and…
- Conditions
- COPD, Hyperinflation, Right Cardiac Failure
- Trial name
- NCT01996124
- Testing
- Indacaterol Fumarate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Heart Failure
Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker
This is a study to investigate the safety and tolerability of the partial A1 agonist BAY1067197 in patients with chronic heart failure.
- Trial name
- NCT01945606
- Testing
- BAY1067197 (treatment 2)
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Bayer
Heart Failure
Investigating the Inotropic Potential of Apelin
The apelin-APJ system is a recently discover hormone system that has several important actions in the cardiovascular system. Apelin causes the heart pump with more force and also causes blood vessels to relax.
- Trial name
- INO-apelin (NCT01179061)
- Testing
- Apelin
- Where
- 3 sites in United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
COPD, Heart Failure, Congestive
Clinical Assessment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and/or Chronic Heart Failure (CHF)
Cigarette smoking, the major risk factor for COPD, causes not only airway and lung inflammation, but also systemic effects. These systemic effects of smoking could substantially contribute to the development of chronic diseases…
- Trial name
- NCT01114386
- Testing
- Lung function testing, echocardiography, blood sampling
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Modena and Reggio Emilia
Chronic Stable Heart Failure
Matrix Metalloproteinase (MMP) in Heart Failure
The purpose of this study is to evaluate the production of MMP in failing hearts.
- Trial name
- NCT00663494
- Volunteers
- 22 people
- Sponsor
- Tottori University Hospital
Heart Failure, Ageing
Leipzig Exercise Intervention in Chronic Heart Failure and Aging
In both ageing and heart failure progressive exercise intolerance is observed. The Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study aims to investigate how aerobic short-term training interventions…
- Trial name
- LEICA (NCT00176319)
- Testing
- Aerobic endurance exercise training (ergometer)
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Chronic Stable Heart Failure
Qishenyiqi for Ventricular Remodeling After Myocardial Infarction
The effects of Qishenyiqi dripping pill on cardiac remodeling in patients with chronic stable heart failure have not been reported.
- Trial name
- NCT06699407
- Testing
- Qishenyiqi dripping pills
- Where
- 3 sites in China
- Volunteers
- 210 people
- Sponsor
- Qilu Hospital of Shandong University
Heart Failure
Safety Study of Cenderitide in Stable Chronic Heart Failure
Planned enrollment is approximately twelve subjects with stable chronic heart failure. Enrolled subjects will receive up to eight sequential days of continuous, stepwise, dose increasing, subcutaneous (SQ) infusions of open-label…
- Trial name
- NCT02359227
- Testing
- Cenderitide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Capricor Inc.
Heart Failure, Inflammation
Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation
The purpose of this research study is to determine the effectiveness of low dose colchicine (LoDoCo) on measures of exercise capacity, physical function, frailty, and quality of life, among patients with heart failure with…
- Trial name
- NCT06130059
- Testing
- Low Dose Colchicine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery
Cardiac Rehabilitation Peer Mentorship
The current study is a randomized controlled trial, being conducted at two hospitals in Toronto, Ontario, Canada, involving the randomization of cardiac inpatients into an intervention group, in which they will receive mentorship…
- Conditions
- Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery, Acute Coronary Syndrome, Chronic Stable Heart Failure
- Trial name
- NCT02204449
- Testing
- Cardiac Rehabilitation Peer Mentorship
- Where
- 2 sites in Canada
- Volunteers
- 94 people
- Sponsor
- University Health Network, Toronto
Myocardial Infarction, Percutaneous Coronary Intervention
Text Message Intervention to Improve Cardiac Rehab Participation
Cardiac rehabilitation (CR) is strongly recommended for patients with coronary heart disease. However, patient enrollment and completion of cardiac rehabilitation is low.
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Bypass Surgery, Heart Valve Repair or Replacement
- Trial name
- NCT03346278
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Washington
Heart Failure
Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure
A Phase 1-2a Study of CXL-1020-01 in Patients with Stable Heart Failure
- Trial name
- NCT01092325
- Testing
- CXL-1020, CXL-1020 Dose for Echo Cohort A, CXL-1020 Doses for Echo Cohort B
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Bristol-Myers Squibb
Chronic Heart Failure
Clinical Outcome of Electrical Transcutaneous Auricular Vagal Stimulation in Patients With Stable Symptomatic Chronic Heart Failure
This study aims to investigate whether electrical vagus nerve stimulation in the auricle has an impact on the clinical presentation of heart failure.
- Trial name
- COETAV (NCT06950320)
- Testing
- P-STIM (Biegler, Mauerbach, Austria) is a battery-operated micro-stimulation appliance
- Where
- Austria
- Volunteers
- 13 people
- Sponsor
- Medical University of Vienna
Heart Failure
Water Immersion in Chronic Stable Heart Failure
This study aims to investigate the effects of water immersion and exercise on heart function and blood flow in patients with chronic stable heart failure.
- Trial name
- IMMERSE-HF (NCT02949544)
- Testing
- water immersion
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Heart Failure (CHF), Iron Deficiency
Evaluation on Performance and Oxydative Stress in Patient With Iron deficIency and Stable Heart Failure Study
ERADAL-HF is a double blinded, multi-centre, prospective, randomized, three arm study, enrolled ambulatory patients with chronic heart failure [New York Heart Association (NYHA) class II/III], with iron deficiency [defined as…
- Trial name
- ERADAL-HF (NCT04225728)
- Testing
- Iron Sucrose IV, Ferric polymaltose hydroxide complex IM, Saline solution
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- CN NGANOU-GNINDJIO, MD, MSc
Heart Failure, Vitamin D Deficiency
Vitamin D Supplementation in Chronic Stable Heart Failure
In cross-sectional and prospective cohort studies, vitamin D deficiency is associated with increased mortality, cardiovascular events including sudden cardiac death and stroke, diabetes, hypertension and impaired function of the…
- Trial name
- VITD-HI (NCT01292720)
- Testing
- Cholecalciferol
- Where
- Austria
- Volunteers
- 29 people
- Sponsor
- Medical University of Graz
Chronic Heart Failure
Supplemental Benefit of Angiotensin Receptor Blocker in Hypertensive Patients With Stable Heart Failure Using Olmesartan
The purpose of this study is to investigate whether an angiotensin II receptor blocker (olmesartan), in addition to conventional treatment, will reduce the mortality and morbidity in hypertensive patients with stable chronic…
- Trial name
- SUPPORT (NCT00417222)
- Testing
- olmesartan medoxomil
- Where
- Japan
- Volunteers
- 1,145 people
- Sponsor
- Tohoku University
Heart Failure
Chronic Sildenafil Treatment in Heart Failure
In heart failure (HF), a defective nitric oxide (NO) signaling may be involved in left ventricular (LV) diastolic abnormalities and LV remodelling progression.
- Trial name
- NCT00975494
- Testing
- Sildenafil
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Essential Hypertension, Chronic Stable Angina
Study to Compare the Pharmacokinetic Characteristics and Safety of Dilatrend SR Capsule 32mg and Dilatrend Tablet 25mg
The purpose of this study is to compare the pharmacokinetic characteristics and safety of dilatrend SR capsule 32mg and Dilatrend tablet 25mg in healthy male subjects.
- Conditions
- Essential Hypertension, Chronic Stable Angina, Congestive Heart Failure
- Trial name
- NCT01819870
- Testing
- Dilatrend SR capsule 32mg, Dilatrend IR tablet 25mg
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Hypertension
Clinical Trial to Evaluate Pharmacokinetic Profiles and Safety Between CKD-385 and D935 in Healthy Volunteers
A randomized, open-label, fed, single dose, crossover study to evaluate the pharmacokinetic profiles and safety of CKD-385 in healthy volunteers
- Trial name
- NCT03748212
- Testing
- D935 Cap. 1T, CKD-385 Tab. 1T
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical