Clinical trials: Chronic Systolic Heart Failure
Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
Study of JK07 in Patients With Chronic Heart Failure
This is a Phase 2, randomized, double-blind, placebo-controlled, multiple dose study to assess the safety, tolerability, and efficacy of JK07 in participants aged 18-85 with heart failure.
- Trial name
- RENEU-HF (NCT06369298)
- Testing
- JK07
- Where
- 62 sites in United States, Canada and 2 more
- Volunteers
- 282 people
- Sponsor
- Salubris Biotherapeutics Inc
Chronic Heart Failure, Iron-deficiency
Effect of Oral sucRosomIal Iron on exerciSE Capacity and Quality of Life in Patients With Heart Failure
The goal of this study is to investigate the effect of oral sucrosomial iron on exercise capacity and quality of life in patients with heart failure (HF) and iron deficiency (ID).
- Conditions
- Chronic Heart Failure, Iron-deficiency, Left Ventricular Systolic Dysfunction
- Trial name
- RISE-HF (NCT06270498)
- Testing
- Sucrosomial iron
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Raffaele De Caterina
Systolic Heart Failure
Hair Cortisol and Testosterone in Heart Failure
The purpose of this study is to determine whether hair cortisol and testosterone levels correlate with heart failure status in patient with chronic congestive heart failure.
- Trial name
- NCT01139697
- Testing
- Hair sampling
- Where
- Israel
- Volunteers
- 46 people
- Sponsor
- Meir Medical Center
Chronic Systolic Heart Failure
Renal Artery Denervation in Chronic Heart Failure Study
The REACH study, is a prospective, double-blinded, randomised, controlled study of the safety and effectiveness of renal denervation in subjects with chronic systolic heart failure.
- Trial name
- REACH (NCT01639378)
- Testing
- Renal Denervation
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- Imperial College London
Systolic Heart Failure
Pedometer-Based Walking Intervention in Patients With Chronic Heart Failure With Reduced Ejection Fraction
A multicenter randomized controlled trial, with follow-up at 6 and 12 months. Physically inactive participants with chronic heart failure with reduced ejection fraction will be randomly assigned to intervention or control arms.
- Trial name
- NCT03041610
- Testing
- Walking intervention
- Where
- Czechia
- Volunteers
- 202 people
- Sponsor
- Charles University, Czech Republic
Decompensated Heart Failure, Ischemic Heart Disease
Clinical and Morphological Characteristics of Chronic Inflammation in the Myocardium in Patients With Decompensated HF With Ischemic Systolic Dysfunction
The purpose of the study is to investigate the clinical and morphological characteristics of chronic subclinical inflammation in the myocardium in patients with decompensated heart failure with ischemic systolic dysfunction.
- Trial name
- FHID (NCT02649517)
- Testing
- Endomyocardial biopsy
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Russian Academy of Medical Sciences
Heart Failure, Systolic, Heart Failure, Diastolic
Implementation of Telerehabilitation In Support of HOme-based Physical Exercise for Heart Failure
ITISHOPE4HF is a randomized controlled trial of telerehabilitation in a heart failure population. The goal is to evaluate if a home-based telerehabilitation project can increase physical activity in heart failure patients.
- Conditions
- Heart Failure, Systolic, Heart Failure, Diastolic, Chronic Kidney Diseases, Cardiorenal Syndrome
- Trial name
- ITISHOPE4HF (NCT03183323)
- Testing
- Telerehabilitation
- Where
- Norway
- Volunteers
- 61 people
- Sponsor
- Helse Nord-Trøndelag HF
Chronic Heart Failure
Cardiovascular Effects of Preferred Home-based Exercise Training in Systolic Heart Failure
The aim of the study is I. To assess whether an individualized exercise training program is superior as compared to usual care with respect to exercise tolerance, II.
- Trial name
- HOMEX-HF-P (NCT02051712)
- Testing
- exercise training, Adherence measures
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Medicine Greifswald
Heart Failure
Phase IIb Safety and Efficacy Study of Different Oral Doses of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease Alone
To assess a new drug, BAY94-8862, given orally at different doses, to evaluate whether it was safe and can help the well-being of patients with worsening chronic heart failure and either type II diabetes with or without chronic…
- Trial name
- ARTS-HF (NCT01807221)
- Testing
- Finerenone (BAY94-8862), Inspra (eplerenone)
- Where
- 172 sites in United States, Australia and 23 more
- Volunteers
- 1,066 people
- Sponsor
- Bayer
Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction
A Study Evaluating an Implantable Cardiac Microcurrent Device in Patients With Chronic Heart Failure
This study evaluates the safety and performance/effectiveness of the C-MIC System, an active implantable medical device designed to treat patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Chronic Heart Failure, Left Ventricular (LV) Systolic Dysfunction, Ischemic and Non-ischemic Cardiomyopathy
- Trial name
- NCT07795359
- Testing
- Subcutaneous cardiac microcurrent treatment
- Volunteers
- 60 people
- Sponsor
- Berlin Heals GmbH
Chronic Systolic Heart Failure
Clinical Trial of Systolic Heart Failure Treatment of IvabRadine Hemisulfate Sustained-release Tablets （FIRST）
Ivabradine acts by inhibiting the ionic If current that modulates the pacemaker activity of sinoatrial node cells. The aim of present study is to evaluate the efficacy and safety of IvabRadine hemisulfate Sustained-release…
- Trial name
- FIRST (NCT02188082)
- Testing
- IvabRadine hemisulfate Sustained-release Tablets
- Where
- 12 sites in China
- Volunteers
- 336 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Heart Failure, Systolic
Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure
The main purpose of this study is to determine whether dietary nitrate supplementation via concentrated beetroot juice improves central and peripheral cardiovascular control and physical capacity in patients with systolic heart…
- Trial name
- NCT02401126
- Testing
- Nitrate supplementation
- Volunteers
- 13 people
- Sponsor
- Queen's University
Blood Pressure, Depression
Essential Hypotension and Allostasis Registry
The essential arterial hypotension and allostasis registry is a prospective, observational research that has the purpose of demonstrating that essential blood pressure (BP) disorders and the associated comorbidities are a result…
- Conditions
- Blood Pressure, Depression, Panic Attack, Fibromyalgia
- Trial name
- ESSENTIAL (NCT02018497)
- Where
- Colombia
- Volunteers
- 5,000 people
- Sponsor
- CES University
Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l)
Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated High Sensitivity C-reactive Protein (Hs-CRP)
The proposed study is a sub-study of the CANTOS trial (A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous canakinumab in the prevention of recurrent cardiovascular events among stable…
- Conditions
- Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l), Reduced Left Ventricle Ejection Fraction (<50%), Symptoms of Heart Failure (NYHA Class II-III)
- Trial name
- NCT01900600
- Testing
- Cardiopulmonary exercise test, Echocardiogram
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
End-stage Renal Disease, Left Ventricular Hypertrophy
Impact of In-centre Nocturnal Hemodialysis on Ventricular Remodeling and Function in End-stage Renal Disease
Background: Recent data indicate that home nocturnal hemodialysis (8 hours of hemodialysis at home for 5-6 nights per week) may have substantial cardiovascular benefits, including regression of left ventricular (LV) hypertrophy…
- Trial name
- NCT00718848
- Testing
- Incentre nocturnal hemodialysis, Remaining on conventional hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Heart Failure, Iron-deficiency
Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure and Iron Deficiency
The goal of this randomized, controlled, open-label, interventional study is to evaluate whether, in patients with heart failure (HF) and iron deficiency (ID), the administration of vitamin D in combination with sucrosomial iron…
- Conditions
- Heart Failure, Iron-deficiency, Heart Failure, Systolic, Heart Failure NYHA Class II
- Trial name
- VICTORID-HF (NCT05702970)
- Testing
- Sucrosomial iron, Vitamin D, Ferric Carboxymaltose 50 MG/ML
- Volunteers
- 258 people
- Sponsor
- University of Padova
Chronic Heart Failure
Effects of Ivabradine on Cardiovascular Events in Patients With Moderate to Severe Chronic Heart Failure and Left Ventricular Systolic Dysfunction. A Three-year International Multicentre Study
The primary objective of this study is to demonstrate the superiority of ivabradine over placebo in the reduction of cardiovascular mortality or hospitalisation for worsening heart failure in patients with moderate to severe…
- Trial name
- SHIFT (NCT02441218)
- Testing
- Ivabradine
- Where
- 2 sites in France, Sweden
- Volunteers
- 6,505 people
- Sponsor
- Institut de Recherches Internationales Servier
Chronic Heart Failure
Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure
The mortality of chronic heart failure patients remains high. Recombinant human Neuregulin-1 (rhNRG-1, also called Neucardin) is a 61 amino acid peptide that acts directly on damaged heart muscle cells to restore their structure…
- Trial name
- ZS-01-210 (NCT01251406)
- Testing
- rhNRG-1 Dose 1, rhNRG-1 Dose 2
- Where
- 13 sites in United States
- Volunteers
- 67 people
- Sponsor
- Zensun Sci. & Tech. Co., Ltd.
Congestive Heart Failure
Blood Volume and Hemodynamic Analysis in Patients With Chronic Heart Failure
The primary hypothesis is that patients with HFREF (heart failure with reduced ejection fraction) will demonstrate a markedly expanded intravascular volume which will correlate with elevated right heart hemodynamics and increased…
- Trial name
- NCT02120014
- Testing
- blood volume measurement, venous plethysmography
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Heart Failure, Systolic Heart Failure
Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure
Controlled exercise training is a valuable therapeutic addition to pharmacological treatment in most patients with chronic heart failure, reducing long-term mortality, preventing cardiac remodeling and improving functional…
- Trial name
- REINCA (NCT02903225)
- Testing
- Cardiac Rehabilitation
- Volunteers
- 40 people
- Sponsor
- Universidad de la Republica