Clinical trials: Chronic Tinnitus, open to volunteers
Chronic Subjective Tinnitus
Efficacy Analysis of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Tailor-Made Notched Music Therapy in the Treatment of Chronic Subjective Tinnitus
The goal of this multicenter, randomized, double-blind clinical trial is to compare two treatments for adults with chronic subjective tinnitus.
- Trial name
- NCT07794462
- Testing
- taVNS Combined With TMNMT
- Where
- 6 sites in China
- Volunteers
- 444 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Tinnitus, Hearing Loss, Bilateral or Unilateral
Evaluating How a Tinnitus Implant Affects Tinnitus Loudness in Adults With Chronic Tinnitus and Varying Levels of Hearing Loss
This study will test an experimental Tinnitus Implant System that consists of a cochlear implant, sound processor and programming software.
- Conditions
- Tinnitus, Hearing Loss, Bilateral or Unilateral, Normal Hearing
- Trial name
- TINIS (NCT06641999)
- Testing
- Tinnitus Implant System
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 16 people
- Sponsor
- Cochlear
Tinnitus, Acupuncture
Efficacy of Acupuncture on Chronic Tinnitus and Its Association With Auditory Brainstem Response Measures
The goal of this clinical trial is to learn if acupuncture works to treat chronic tinnitus in adults. It will also learn about the neurophysiological effects of acupuncture on auditory conduction pathway function.
- Conditions
- Tinnitus, Acupuncture, Auditory Brainstem Response
- Trial name
- NCT07522567
- Testing
- Acupuncture
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Tinnitus
Peripheral-central Correlation Study on the Treatment of Chronic Tinnitus With "Dao qi Tong Luo" Based on the Theory of "Connecting the Two Ears to the Brain"
By comparing the clinical manifestations, ABR parameters and cerebral cortex blood oxygen levels of chronic tinnitus patients and healthy subjects under two different body states, the peripheral-central correlation of chronic…
- Trial name
- NCT06401993
- Testing
- The "dao qi tong luo" group, The acupuncture group
- Where
- China
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Chronic Subjective Tinnitus
Trial of Management of Chronic Tinnitus by Sound Therapy and Cognitive Behavioral Therapy
clinical trial: The main aim of this study is to compare the effectiveness of Cognitive Behavioral Therapy (CBT) and Sound Therapy, both individually and in combination, in the management of patients with chronic subjective…
- Trial name
- NCT07665385
- Testing
- Group A: sound therapy, Group B: Cognitive Behavioral Therapy, Group C: Combined CBT + Sound Therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Tinnitus, Subjective, Tinnitus
Bimodal Electrical-Sound Stimulation and Auditory Training for Chronic Tonal Tinnitus
This study tests whether pairing non-invasive stimulation of the greater occipital nerve (NITESGON) with an attentionally demanding auditory frequency discrimination training task reduces tinnitus loudness and tinnitus-related…
- Conditions
- Tinnitus, Subjective, Tinnitus, Chronic Tinnitus
- Trial name
- NITESGON-ADT (NCT07393880)
- Testing
- Real NITESGON, Active Listening, Passive Listening (Control)
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- University of Dublin, Trinity College
Chronic Tinnitus, Anxiety
Internet-Based Mindfulness-Based Cognitive Therapy (iMBCT) for Chronic Tinnitus Patients
This study tested a 6-week, internet-based Mindfulness-Based Cognitive Therapy (MBCT) program designed to help people experiencing distress related to chronic tinnitus.
- Conditions
- Chronic Tinnitus, Anxiety, Depressive
- Trial name
- NCT07183826
- Testing
- Mindfulness-Based Cognitive Therapy (Internet-delivered), No intervention
- Where
- Poland
- Volunteers
- 78 people
- Sponsor
- University of Warsaw
Idiopathic Intracranial Hypertension (IIH)
Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase
This study is aimed at patients suffering from recently discovered intracranial hypertension, caracterized by visual loss, chronic headache and/or tinnitus.
- Trial name
- DIVE IIN EARLY (NCT06919744)
- Testing
- Best medical care, Intervention (stenting)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Montpellier
Chronic Subjective Tinnitus
Transcutaneous Auricular Vagus Nerve Stimulation Combined With Tailor-Made Notched Music Training Therapy for Chronic Subjective Tinnitus
This study is a prospective, multicenter, randomized, controlled, open-label clinical trial designed to evaluate the superiority of transauricular vagus nerve microcurrent stimulation (taVNS) combined with Tailor-Made Notched…
- Trial name
- NCT07469969
- Testing
- transcutaneous auricular vagus nerve stimulation combined with tailor-made notched music training therapy, tinnitus retraining therapy
- Where
- China
- Volunteers
- 386 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Tinnitus, Subjective
Internet-delivered Group Counseling for Chronic Tinnitus
In the treatment of chronic tinnitus, psycho-education plays an import role to provide more insights into the symptoms of tinnitus. However, the need for e-health is increasing.
- Trial name
- NCT04382807
- Testing
- Counseling
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Idiopathic Intracranial Hypertension (IIH)
Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term Acetazolamide
This study is aimed at patients suffering from long term intracranial hypertension (caracterized by visual loss, chronic headache and/or tinnitus), receiving acetazolamide for more than 1 year, having inadequate response to…
- Trial name
- DIVEIINLATE (NCT06945848)
- Testing
- Acetazolamide, Stent (Tentos 4F or Precise ProRX)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Montpellier
Ear Noise, Tinnitus, Noise Induced
Multimodal Therapy for Somatosensory Tinnitus
Tinnitus (ringing or buzzing in the ears) affects approximately 10-15% of the adult population and significantly reduces quality of life in many patients.
- Conditions
- Ear Noise, Tinnitus, Noise Induced, Tinnitus, Subjective, Headache Other
- Trial name
- SOMATIN (NCT07468318)
- Testing
- Multimodal physiotherapy for TMJ and Cervical spine, Combined Exercise Program (Aerobic + Resistance + Breathing), Tinnitus-Specific Psychological Support
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Chronic Tinnitus
Interventional Treatment of Chronic Tinnitus With Acoustic Stimulation
The《Clinical practice guideline: tinnitus》defines tinnitus as the perception of sound without an external source, with patients lasting six months or longer classified as chronic tinnitus.
- Trial name
- NCT07185061
- Testing
- Acoustic Stimulation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Tinnitus
DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury
The goal of this clinical trial is to test a compounded dimethyl sulfoxide (DMSO)-based dual-route therapy for adults with refractory subjective tinnitus linked to long-COVID (post-acute sequelae of SARS-CoV-2) or post-COVID-19…
- Trial name
- DART-TINN (NCT07567274)
- Testing
- DMSO-based otic solution with betahistine, dexamethasone, and lidocaine, DMSO-based transdermal cream with levocarnitine and N-acetylcysteine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Leading Edge Clinic
Tinnitus, Sleep Disturbances
Low-intensity TUS for Sleep Disturbances in Patients With Chronic Tinnitus
Background: Tinnitus, as a common symptom, can jeopardize the sleep quality and brain function and even lead to hearing loss and cognitive decline in elderly patients.
- Conditions
- Tinnitus, Sleep Disturbances, Cognition
- Trial name
- NCT06776705
- Testing
- Low-intensity transcranial ultrasound stimulation
- Where
- 2 sites in Hong Kong
- Volunteers
- 14 people
- Sponsor
- Chinese University of Hong Kong
Chronic Tinnitus
Efficacy Analysis of Personalized-Target Transcranial Magnetic Stimulation (TMS) in the Treatment of Chronic Tinnitus: A Single-Center, Single-Blind Randomized Clinical Trial
The goal of this clinical trial is to evaluate the efficacy and safety of personalized-target transcranial magnetic stimulation (TMS) in the treatment of chronic subjective tinnitus.
- Trial name
- NCT07267455
- Testing
- continuous theta burst stimulation
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Tinnitus, Chronic Subjective Tinnitus
Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus
This study tests whether a single dose of nicotine gum changes brain responses to sounds and the ability to detect target sounds in non-smoking adults with chronic tinnitus.
- Trial name
- NCT07877701
- Testing
- Nicotine polacrilex gum 4 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- San Diego State University
Tinnitus, Bilateral, Cochlear Synaptopathy
A Study Testing Safety and Efficacy of Transtympanic Paliroden for the Treatment of Cochlear Synaptopathy in Participants With Chronic, Constant Tinnitus
The goal of this clinical trial is to investigate if paliroden (CIL001) is safe and can help treat cochlear synaptopathy in adult participants 18-75 years of age with normal hearing thresholds and normal cognition who exhibit…
- Trial name
- REACT (NCT07826507)
- Testing
- paliroden (CIL001)
- Volunteers
- 60 people
- Sponsor
- Cilcare SAS
Chronic Insomnia, Chronic Pain
Lemborexant vs Clonidine vs Sedatives to Treat Insomnia in Chronic Pain Patients
Prospective observational crossover study of 250 adults undergoing chronic pain management. For insomnia treatment, patients alternate their usual prescribed sedative versus Lemborexant or Clonidine; on alternate nights.
- Conditions
- Chronic Insomnia, Chronic Pain, Restless Leg Syndrome (RLS), Substance Abuse
- Trial name
- NCT05618002
- Testing
- Lemborexant
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Salem Anaesthesia Pain Clinic