Clinical trials: Chronic Traumatic Brain Injury
Chronic Post-traumatic Headache, Mild Traumatic Brain Injury
Acupuncture in Traumatic Brain Injury
The purpose of the study is to determine the effect of a low vs. high dose of acupuncture treatment in individuals with chronic post-traumatic headache (CPTH).
- Trial name
- AccuTBI (NCT04369911)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- HealthPartners Institute
Chronic Subdural Hematoma
Middle Meningeal Artery Embolisation in Chronic Subdural Hematoma
This international multicenter study evaluates the efficacy and safety of middle meningeal artery embolization (MMAE) using PVA particles or liquid embolic agents as a perioperative treatment to prevent the recurrence of chronic…
- Trial name
- EMMA-CS (NCT07751887)
- Testing
- Middle Meningeal Artery Embolisation
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Hradec Kralove
Chronic Subdural Hematoma
Bedside Versus Operating Room Burr-Hole Drainage of Chronic Subdural Hematoma (DECIDE)
DECIDE (Bedside versus Operating Room Burr-Hole DrainagE of ChronIc SubDural HEmatoma) CSDH is an abnormal collection of blood between the layers of the brain causing brain tissue compression leading to neurological…
- Trial name
- DECIDE (NCT03053895)
- Testing
- CSDH - Bedside twist drill technique, CSDH - Operating Room Burr-hole technique
- Volunteers
- 486 people
- Sponsor
- Hamilton Health Sciences Corporation
Chronic Subdural Hematoma
Postoperative Balloninflation After Evacuation of cSDH
In this prospective, randomized, multicenter trial shall patients with chronic subdural hematoma (cSDH) recruited, who were surgically treated.
- Trial name
- BANISH (NCT04060186)
- Testing
- Balloninflation
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Chronic Subdural Hematoma
Effect and Safety Study of Atorvastatin to Treat Chronic Subdural Hematoma
To evaluate the clinic effects and security of oral administration of Atorvastatin on chronic subdural hematoma (CSDH).
- Trial name
- NCT02024373
- Testing
- Atorvastatin
- Where
- 31 sites in China
- Volunteers
- 200 people
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team
Brain Injuries, Traumatic, Concussion, Brain
rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head
The objective of this study is to investigate the treatment effect of repetitive transcranial magnetic stimulation in patients with a history of both persistent post-traumatic headache and post-concussion symptoms.
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Headaches Chronic, Headache
- Trial name
- TOPiCS-rTMS (NCT03691272)
- Testing
- rTMS - Real Air Film Coil
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Traumatic Brain Injury, Pain
Characterization & Treatment of Chronic Pain After Moderate to Severe TBI
This is a five year multi-site, cross sectional, observational study designed to examine chronic pain and pain treatment after moderate to severe TBI.
- Trial name
- NCT03739307
- Where
- 13 sites in United States
- Volunteers
- 3,805 people
- Sponsor
- Craig Hospital
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
Endovascular middle meningeal artery (MMA) embolization is an emerging treatment for chronic subdural hematoma (cSDH). There is preliminary data to suggest that this minimally invasive therapy may be more efficacious and equally…
- Trial name
- NCT04065113
- Testing
- Middle Meningeal Artery Embolization with polyvinyl alcohol particles (PVA), Drainage of Subdural Hematoma
- Where
- United States
- Sponsor
- Washington University School of Medicine
Traumatic Brain Injury (TBI)
Allopregnanolone in Chronic Complex Traumatic Brain Injury
This study will determine if allopregnanolone (ALLO) improves depression and pain symptoms in patients who have a history of mild traumatic brain injury (TBI) [primary endpoints].
- Trial name
- ALLO (NCT04003285)
- Testing
- Allopregnanolone
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy
This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury…
- Trial name
- NCT04063215
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences LLC
Traumatic Brain Injury
Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury
Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with…
- Trial name
- NCT06520358
- Testing
- Acute Intermittent Hypoxia (AIH), Task specific Airway Protection Training
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Chronic Subdural Hematoma
High Concentration Oxygen Therapy for Pneumocephalus in Chronic Subdural Haematoma: A Prospective Observational Study
Normobaric oxygen therapy was shown to be effective in reducing post craniotomy pneumocephalus. Theoretical assessment of normobaric oxygen therapy in treating pneumocephalus has shown that a higher level of oxygen concentration…
- Trial name
- NCT05143216
- Testing
- Low concentration oxygen group: Room air (0-2Litre Oxygen via Nasal Canula), High concentration oxygen group: Room air (12-15Litre Oxygen via Non-rebreather Mask)
- Where
- Hong Kong
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Dr. David Yuen Chung CHAN
Chronic Subdural Hematoma
To Scan or Not to Scan: The Role of Follow-up CT Scanning for Management of Chronic Subdural Hematoma After Neurosurgical Evacuation
Chronic subdural hematoma (CSH) is one of the most common bleedings of the head. These hematomas develop after minor head trauma and increase in size over weeks.
- Trial name
- TOSCAN (NCT01624545)
- Testing
- cranial CT scan
- Where
- Switzerland
- Volunteers
- 368 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Subdural Hematoma
Intra-Arterial Bevacizumab as an Adjunct to Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
This is a Phase 1, open-label, single-center, dose-escalation study evaluating the safety and tolerability of intra-arterial bevacizumab (IA-BEV) given as an adjunct to middle meningeal artery embolization (MMAE) in adults with…
- Trial name
- SAFER-MMAE (NCT07729098)
- Testing
- Bevacizumab (intra-arterial)
- Volunteers
- 18 people
- Sponsor
- Dheeraj Gandhi
Spasticity, Cerebrovascular Accident
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension…
- Conditions
- Spasticity, Cerebrovascular Accident, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT04815967
- Testing
- Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 32 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Traumatic Brain Injury
Using the Xbox Kinect for Chronic TBI
This study will evaluate the potential for improving balance for a single individual with a history of traumatic brain injury (TBI). The participant will engage in supervised therapy using commercial games on the Xbox Kinect.
- Trial name
- NCT02889289
- Testing
- Xbox One Kinect Gaming
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Chronic Subdural Hematoma, Atrial Fibrillation (AF)
Restarting Early Versus Later Anticoagulation for Chronic Subdural Hematoma With Atrial Fibrillation
The goal of this randomized clinical trial is to assess the benefit of early resumption versus late resumption of oral anticoagulation medication in adults with atrial fibrillation undergoing surgery for chronic subdural…
- Trial name
- RELACS (NCT06696079)
- Testing
- Early Resumption of Oral Anticoagulation Therapy, Late Resumption of Oral Anticoagulation Therapy
- Where
- 6 sites in Finland, Sweden
- Volunteers
- 332 people
- Sponsor
- Rahul Raj
Amputation, Traumatic, Pain, Phantom
Feasibility of Using an App for Managing Phantom Limb Pain Associated with Combat Injury in Ukraine (PAMELA)
In Ukraine, since the beginning of the full-scale war on February 24, 2022, a large number of individuals have lost a limb(s). Many of these amputees cannot access appropriate care in terms of pain management and rehabilitation.
- Conditions
- Amputation, Traumatic, Pain, Phantom, Pain, Acute, Pain, Chronic
- Trial name
- PAMELA (NCT06604507)
- Testing
- non-pharmacological app
- Where
- 5 sites in Ukraine
- Volunteers
- 200 people
- Sponsor
- Winfried Meißner
Chronic Subdural Hematomas
Prospective MMA Embolization Registry
Chronic subdural hematoma (cSDH) is a common condition, particularly in older adults, that can substantially impair patients' quality of life, functional independence, and neurological well-being.
- Trial name
- PRO-EMMA (NCT07626671)
- Testing
- Middle Meningeal Artery Embolization
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury
This prospective observational study evaluates the safety profile and patient-reported outcomes associated with MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy in individuals aged 6 to 75 with chronic…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter
- Trial name
- MUSE-TBI-OBS (NCT07326059)
- Testing
- MUSE Stem Cell Therapy
- Where
- 2 sites in United States, Mexico
- Volunteers
- 10 people
- Sponsor
- Healing Hope International