Clinical trials: Chronic Traumatic Encephalopathy
Chronic Traumatic Brain Injury
Association of Amino Acid Prevalence and Chronic Brain Injury
Years after a suffering a brain injury, individuals remain in a physically and cognitively impaired state. The investigators believe that the concentrations of amino acids in the blood are chronically altered and yield negative…
- Trial name
- NCT02113124
- Where
- 3 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Brent Masel
Traumatic Brain Injury, Cerebral Palsy
Walking Dynamic Among Children With Brain Damge
The goal of the present study was to look at the effect of changing walking parameters on the dynamic walking characteristics among children post severe traumatic brain injury, children with cerebral palsy and typically developed…
- Trial name
- NCT02839369
- Testing
- walking under varies conditions
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Spinal Cord Injury, Hyperalgesia, Secondary
MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI
The goal of this study is to compare the changes that occur in sensation and chemical properties of the brain following SCI between individuals that experience chronic pain and those that do not, and between those with SCI and…
- Conditions
- Spinal Cord Injury, Hyperalgesia, Secondary, Hyperalgesic Sensations
- Trial name
- MRS (NCT00561782)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Concussion, Mild
The Combined Effect of Chronic Cannabis Use and Subconcussive Head Impacts on Brain Health
The purpose of this pilot study is to better understand the effects of chronic cannabis (THC) use on the neural responses to subconcussive head impacts, as a form of repetitive soccer headings.
- Trial name
- NCT04641832
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Epilepsy, Migraine
Clinical Applications of High-Frequency Oscillations
The objective of this study is to utilize high-frequency brain signals (HFBS) to localize functional brain areas and characterize HFBS in epilepsy, migraine, and other brain disorders.
- Conditions
- Epilepsy, Migraine, Headache, Pain
- Trial name
- HFOs (NCT00600717)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Complex Regional Pain Syndromes, Fibromyalgia
Virtual Environment Rehabilitation for Patients With Motor Neglect Trial
Motor neglect describes a loss of function without a loss of strength, reflexes or sensation. Motor neglect has been described in patients with traumatic brain injury, stroke and chronic pain conditions, e.g.
- Conditions
- Complex Regional Pain Syndromes, Fibromyalgia, Stroke, Traumatic Brain Injury
- Trial name
- VERMONT (NCT03887962)
- Testing
- Virtual Environment Biofeedback, Treadmill walking with no Virtual Environment Biofeedback
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Pressure Injuries, Spinal Cord Injuries (SCI)
Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries
Pressure injuries are chronic wounds that frequently occur in immobilized patients and are associated with delayed healing, reduced quality of life, and significant psychological burden.
- Conditions
- Pressure Injuries, Spinal Cord Injuries (SCI), Traumatic Brain Injury
- Trial name
- NCT07493889
- Testing
- High-Voltage Monophasic Pulsed Current Electrical Stimulation, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Dementia, Traumatic Brain Injury (TBI)
Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel
The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI)…
- Conditions
- Dementia, Traumatic Brain Injury (TBI), Mild Cognitive Impairment (MCI), Chronic Traumatic Encephalopathy (CTE)
- Trial name
- NCT01891383
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Traumatic Brain Injury, Cerebral Palsy
Validity and Reliability of Perceived Exertion Rating Scale in Children With Brain Damage
The purpose of this study is to examine the reliability and validity of the rating of perceived exertion scale in children post severe traumatic brain injury during treadmill exercise.
- Trial name
- NCT01840644
- Testing
- Walking on treadmill, different velocities and incline
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Spinal Cord Injuries, Cerebral Palsy
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries
- Trial name
- NCT02592291
- Testing
- MHealth
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cerebral Palsy (CP)
Go For It: to Improve Levels of Daily Physical Activity and to Reduce the Sedentary Life Style of Adolescents With CP
Long hours of daily sitting and lack of Physical Activity (PA) are risk factors for morbidity and mortality. People with movement disabilities, including adolescents with Cerebral Palsy (CP) tend to lead a sedentary life styl and…
- Trial name
- NCT02978469
- Testing
- Life style changing: reducing sedentary behavior
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after…
- Conditions
- Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
- Trial name
- NCT04124029
- Testing
- No Intervention is used for this study but all subjects will be asked to complete electroencephalogram (EEG) testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain Injury
The aim of this research is to determine if the biological fluids (blood/saliva) from chronic brain-injured patients (both blast and non-penetrating TBI) contain reproducible protein markers.
- Trial name
- Chronic TBI (NCT01171131)
- Testing
- Blood/saliva sampling
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Alzheimer's Disease (AD), Parkinson's Disease (PD)
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects
The goal of this study is to assess [18F]MNI-777 PET imaging as a tool to detect tau pathology in the brain of individuals who carry a clinical diagnosis of a tauopathy, including: Alzheimer's Disease (AD),Parkinson's disease…
- Conditions
- Alzheimer's Disease (AD), Parkinson's Disease (PD), Chronic Traumatic Encephalopathy (CTE), Progressive Supranuclear Palsy (PSP)
- Trial name
- NCT02103894
- Testing
- [18F]T807 ([18F]MNI-777)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Brain Injuries, Brain Injuries, Traumatic
A Trial Evaluating Effects of COMT Inhibition in Patients With Acquired Brain Injury
This is a follow-up study for an ongoing open label trial conducted by the Sheppard Pratt-Lieber Research Institute utilizing the catechol-O-methyl-transferase (COMT) inhibitor Tolcapone to evaluate its effects on cognition and…
- Conditions
- Brain Injuries, Brain Injuries, Traumatic, Brain Injury, Chronic
- Trial name
- NCT03273062
- Testing
- Tolcapone 200 MG
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sheppard Pratt Health System