Clinical trials: Chronic Tympanic Membrane Perforation
Tympanic Membrane Perforation, Chronic Otitis Media
Platelet-Rich Fibrin in Revision Cartilage Tympanoplasty
The aim of this study is to evaluate the success rate of revision surgery using a conchal cartilage graft supported with autologous platelet-rich fibrin (PRF), performed under local anesthesia, in patients who previously…
- Trial name
- NCT07893418
- Testing
- PRF-supported conchal cartilage tympanoplasty under local anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Tympanic Membrane Perforation, Conductive Hearing Loss
Outcomes of Cartilage Tympanoplasty in Children
This study evaluates the anatomical and hearing outcomes of cartilage tympanoplasty in pediatric patients with chronic tympanic membrane perforations.
- Conditions
- Tympanic Membrane Perforation, Conductive Hearing Loss, Chronic Otitis Media
- Trial name
- NCT07866222
- Testing
- Cartilage Tympanoplasty
- Volunteers
- 35 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation, Otitis Media
Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results?
Large tympanic membrane (eardrum) perforations present a surgical challenge and are historically associated with lower graft take rates compared to smaller perforations.
- Conditions
- Tympanic Membrane Perforation, Otitis Media, Suppurative Otitis Media, Chronic Suppurative Otitis Media
- Trial name
- NCT07834892
- Testing
- Conchal Cartilage and Perichondrium Tympanoplasty, Conchal Cartilage, Perichondrium, and Temporalis Fascia Tympanoplasty
- Volunteers
- 50 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation, Chronic Otitis Media
Boomerang-Shaped Cartilage Graft in Endoscopic Tympanoplasty
This study evaluates the anatomical and functional outcomes of using a boomerang-shaped chondroperichondrial graft in endoscopic Type I tympanoplasty for repairing anterior or subtotal tympanic membrane perforations.
- Trial name
- NCT07823894
- Testing
- Endoscopic Type I Tympanoplasty with Boomerang-Shaped Chondroperichondrial Graft
- Volunteers
- 50 people
- Sponsor
- Assiut University
Chronic Tympanic Membrane Perforation
In-office Repair of Chronic Tympanic Membrane Perforations
The goal of this clinical trial is to compare the application of fibroblast growth factor 2 (FGF2) with normal saline for the healing of chronic tympanic membrane (TM) perforations. This is an extension of a prior study.
- Trial name
- NCT06448039
- Testing
- Fibroblast Growth Factor 2, Saline control
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- D. Bradley Welling, MD, PhD
Chronic Otitis Media Tympanic Membrane Perforation
Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in Adults
This single-center controlled trial evaluated whether intraoperative application of autologous platelet-rich plasma (PRP)-impregnated absorbable gelatin sponge improves graft take rates and audiological outcomes in adults…
- Trial name
- NCT07664319
- Testing
- Autologous platelet-rich plasma (PRP)-impregnated Spongostan, Dry Spongostan (absorbable gelatin sponge)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ebubekir Toprak
Chronic Otitis Media, Tympanic Membrane Perforation
A Prospective Comparative Study of Dry vs Wet Temporalis Fascia Graft in Tympanoplasty
This study was conducted to compare two methods of using temporalis fascia graft in tympanoplasty, namely wet temporalis fascia graft and dry temporalis fascia graft.
- Trial name
- NCT07595484
- Testing
- Wet Temporalis Fascia Graft Tympanoplasty, Dry Temporalis Fascia Graft Tympanoplasty
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Chronic Otitis Media, Tympanic Membrane Perforation
Comparison of Postoperative Outcomes of Interlay vs Underlay Graft in Tympanoplasty
Chronic otitis media is a long-term ear infection that may cause a hole in the eardrum, leading to repeated ear discharge and hearing loss.
- Conditions
- Chronic Otitis Media, Tympanic Membrane Perforation, Conductive Hearing Loss
- Trial name
- NCT07149480
- Testing
- Underlay Tympanoplasty, Interlay Tympanoplasty
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Chronic Tympanic Membrane Perforation
A Study to Assess ASP0598 Otic Solution Following Topical Application in the Ear in Subjects With Chronic Tympanic Membrane Perforation (CTMP)
The primary purpose of this study was to evaluate the safety and tolerability of ASP0598 Otic Solution. This study also evaluated the efficacy of ASP0598 otic solution.
- Trial name
- NCT04305184
- Testing
- ASP0598
- Where
- 10 sites in United States
- Volunteers
- 36 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Chronic Suppurative Otitis Media
Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical Study
This study aimed to compare the effect of adding HA versus PRP to endoscopic FGM in cases of small or medium-sized central TM perforation in the form of: 1. Evaluation of the graft uptake rate. 2.
- Trial name
- NCT06505252
- Testing
- enoscopic Myringoplasty
- Volunteers
- 60 people
- Sponsor
- Assiut University
Otitis Media Chronic, Tympanic Membrane Perforation
Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections
This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma as a supplement to the surgical treatment of chronic tympanic membrane perforations.
- Trial name
- NCT04761562
- Testing
- Platelet- and extracellular vesicle-rich plasma, Control group
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana