Clinical trials: Chronic Venous Insufficiency, CVI
Varicose Veins, Chronic Venous Disorder
First- or Second- Class Compression Hosiery After Endovenous Laser With Sclerotherapy and Ambulatory Phlebectomy
Investigators hypothesize that first class compression therapy during the postoperative period will improve patient adherence due to easier application and reduced discomfort.
- Conditions
- Varicose Veins, Chronic Venous Disorder, Chronic Venous Insufficiency (CVI), Venous Reflux
- Trial name
- FISCHER (NCT06913764)
- Testing
- class I compression stockings of the RAL-GZ 387 standard: 1 month using, class II compression stockings of the RAL-GZ 387 standard: 1 month using
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Moscow City Hospital named after A.K. Eramishantsev
Venous Insufficiency
Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI)
To determine efficacy and tolerability of Antistax 360 mg tablets in chronic venous insufficiency linked to edema (swelling) and subjective symptoms
- Trial name
- NCT00292435
- Testing
- Read vine leaf extract (AS 195)
- Where
- 16 sites in Austria, Czechia and 1 more
- Volunteers
- 202 people
- Sponsor
- Boehringer Ingelheim
Chronic Venous Insufficiency
Study to Evaluate Impact SANKOM Patent Socks in Patients With CVI
Clinical study to evaluate impact on quality of life in patients with Chronic Venous Insufficiency during 4 weeks period of using SANKOM® Patent Socks
- Trial name
- NCT03445091
- Testing
- SANKOM Patent Socks
- Where
- 2 sites in Ukraine
- Volunteers
- 30 people
- Sponsor
- Sankom SA
Lower Extremity Edema, Lower Extremity Edema Chronic
Pedal Pump Clinical Trial on Edema V2
Previous research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal…
- Conditions
- Lower Extremity Edema, Lower Extremity Edema Chronic, CHF - Congestive Heart Failure, CHF Exacerbation
- Trial name
- NCT07809516
- Testing
- Pedal Pump
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hillcrest
Venous Insufficiency
Antistax® in Patients With Chronic Venous Insufficiency
Study to determine the efficacy and tolerability of two dose levels of Antistax relative to placebo in patients suffering from CVI grade I or incipient grade II
- Trial name
- NCT02191280
- Testing
- Antistax®, low dose, Antistax®, high dose
- Volunteers
- 260 people
- Sponsor
- Boehringer Ingelheim
Chronic Venous Insufficiency
The Effect of Structured Exercise on Chronic Venous Insufficiency
Individuals with Chronic Venous Insufficiency (CVI) face a number of complications, such as, muscular dysfunction, limited ankle range of motion(ROM) and diminished calf muscle pump function.
- Trial name
- CVI (NCT03562546)
- Testing
- Strength From Within
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- Shannon Hernon
Chronic Venous Insufficiency, CVI
The Use of Immersive Virtual Reality as a Method of Treating Anxiety and Procedural Pain During Endovenous Laser Ablation (EVLA) of Lower Varicose Veins Under Tumescent Anesthesia
This is a prospective, single-arm, pre-post interventional study designed to evaluate the feasibility, safety, and impact of immersive virtual reality (VR) as an adjunct to tumescent local anesthesia during endovenous laser…
- Trial name
- EVLA+VR (NCT07624929)
- Testing
- VR (VR-Control)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Bydgoszcz University of Science and Technology
Varicose Veins, Varicose Veins of Lower Limb
The Evaluation of the Pathophysiology of Varicose Veins in Pregnancy
Varicose veins (VV) are the early sign of Chronic venous insufficiency (CVI) which are characterised by abnormal tortuosity and dilatation of superficial veins of lower limb extremities.
- Conditions
- Varicose Veins, Varicose Veins of Lower Limb, Chronic Venous Insufficiency, Varicose; Vessel
- Trial name
- NCT05058989
- Testing
- Advanced ultrasound measurements (Duplex ultrasound (DUS) and Vector flow imaging (VFI), Clinical interventions and procedures
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Venous Insufficiency, CVI
Respiratory Functions, Aerobic Capacity and Quality of Life in Chronic Venous Insufficiency
This study aims to retrospectively examine the dataset obtained from a previously conducted study titled 'Inspiratory muscle training in individuals with chronic venous insufficiency: randomized controlled trial'.
- Trial name
- NCT06785805
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Izmir Democracy University
Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher
Reducing Skin Tone Inequities in Chronic Venous Insufficiency
The aim of this project is to define assessment criteria for chronic venous insufficiency (CVI) in people with dark skin tones. It will inform future interventions and modifications to practice for the assessment of CVI in people…
- Conditions
- Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher, Chronic Venous Disease of Lower Limbs, Venous Leg Ulcer (VLU)
- Trial name
- NCT06798766
- Where
- 2 sites in United Kingdom
- Volunteers
- 51 people
- Sponsor
- King's College London
Chronic Venous Insufficiency, CVI
Clinical Investigation of Safety and Effectiveness for the enVVe® System
A staged prospective, randomized, non-blinded, multicenter study.
- Trial name
- TAVVE (NCT07609927)
- Testing
- envve system
- Volunteers
- 220 people
- Sponsor
- Hancock Jaffe Laboratiores, Inc
Venous Insufficiency
Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI)
Main objective: Safety and tolerability of Antistax® film coated tablets Secondary objective: Effect of Antistax® film coated tablets on subjective symptoms of chronic venous insufficiency
- Trial name
- NCT02184234
- Testing
- Antistax film coated tablets
- Volunteers
- 65 people
- Sponsor
- Boehringer Ingelheim
Chronic Venous Insufficiency (CVI)
Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema
Elastic MCT is a widely recognized and the consensus-approved treatment for chronic venous insufficiency (CVI).Efficacy evidence level is often insufficient (grade B or C), or based on studies carried prior to CEAP classification…
- Trial name
- NCT01402921
- Testing
- V0322 BC
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Pierre Fabre Medicament
Chronic Venous Insufficiency (CVI), Deep Vein Reflux
Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System (INFINITE-US)
Prospective, non-randomized, multicenter pre-market early feasibility study (EFS) to evaluate subjects treated with the BlueLeaf System for the treatment of symptomatic chronic venous insufficiency (CVI) of the lower extremity
- Trial name
- INFINITE-US (NCT04225806)
- Testing
- BlueLeaf® Endovenous Valve Formation System (BlueLeaf System)
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Intervene, Inc.
Chronic Venous Disease, Chronic Venous Insufficiency, CVI
The ReCAna for Lower ExtremIty Venous OBstructions and In-StEnt Restenosis Registry
The goal of this observational study is to gather additional safety and performance (effectiveness) data on the device for the treatment of symptomatic lower extremity venous obstructions and occlusions.
- Conditions
- Chronic Venous Disease, Chronic Venous Insufficiency, CVI, Venous Thrombosis, Thrombosis (Stent Thrombosis)
- Trial name
- CALIBER (NCT07529756)
- Testing
- Recanalization and debulking
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Intervene, Inc.
Chronic Venous Insufficiency, CVI, Venous Malformations
Safety of the Sonablate HIFU System for the Ablation of Incompetent Veins of the Periphery
The goal of this clinical trial is to learn if the Sonablate High Intensity Focused Ultrasound device can be safely used to treat patients with Chronic Venous Incompetence (CVI) including those with venous malformations of the…
- Conditions
- Chronic Venous Insufficiency, CVI, Venous Malformations, Venous Leg Ulcers, Klippel-Trenaunay Syndrome
- Trial name
- HIFIVE (NCT06642051)
- Testing
- High Intensity focused ultrasound
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sonablate
Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI
Knee Pain Relief After Endovenous Treatment for Lower Limb Varicose Veins: A Prospective Observational Study
This study will observe patients with lower limb varicose veins who also have knee pain. Many patients with varicose veins experience swelling, heaviness, or aching in the legs, and some also report pain in or around the knee.
- Conditions
- Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI, Knee Pain Chronic, Knee Osteoarthritis
- Trial name
- VV-KNEE (NCT07163312)
- Testing
- Endovenous Ablation for Varicose Veins
- Volunteers
- 50 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Venous Insufficiency
Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI)
It is hoped that with the use of medication, occurs improvement of the CVI parameters, such as edema, pain, night cramps, functional discomfort, heavy feeling and that the drug test is non-inferior than the comparator.
- Trial name
- NCT01110512
- Testing
- Flavonid, Daflon
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Azidus Brasil
Chronic Venous Insufficiency, CVI
Structured Home-Based Exercise and Education for Chronic Venous Insufficiency
The goal of this clinical trial is to learn whether a structured home-based exercise and education program can improve quality of life and leg symptoms in adults with chronic venous insufficiency.
- Trial name
- NCT07777978
- Testing
- Structured Home-Based Exercise and Education Program, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Abant Izzet Baysal University
Lower Extremity Edema, Congestive Heart Failure(CHF)
Pedal Pump Clinical Trial on Edema V1
Previous research on the osteopathic manual technique entitled "Pedal Pump" has shown health benefits, specifically increasing lymphatic flow, decreasing lower extremity edema, and decreasing serum lactic acid after maximal…
- Conditions
- Lower Extremity Edema, Congestive Heart Failure(CHF), Chronic Venous Insufficiency (CVI), Kidney Disease
- Trial name
- NCT07760363
- Testing
- Pedal Pump
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- David McVay