Clinical trials: Chronobiology Disorders
Sleep, Circadian Dysregulation
reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit
The goal of this pilot clinical trial is to learn whether a program to support sleep and the body's daily rhythms can be delivered safely and consistently to critically ill adults in intensive care units (ICUs).
- Conditions
- Sleep, Circadian Dysregulation, ICU, Delirium in Intensive Care Unit
- Trial name
- ALIGN ICU (NCT07886567)
- Testing
- Sleep chronobundle, Control
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm
Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
This is a multicenter, double-blind, randomized study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon and matching placebo in male and female participants with DSWPD.
- Conditions
- Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
- Trial name
- NCT04652882
- Testing
- Tasimelteon
- Where
- 17 sites in United States, Austria and 1 more
- Volunteers
- 43 people
- Sponsor
- Vanda Pharmaceuticals
Suicidal Ideation, Circadian Rhythm Disorders
Mind After Midnight
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts.
- Conditions
- Suicidal Ideation, Circadian Rhythm Disorders, Sleep Deprivation, Sleep Wake Disorders
- Trial name
- MaM (NCT07438912)
- Testing
- Sleep Pressure Manipulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Aging, Aging, Biological
Evaluation of the Effect of Seasonality on Biological Age in Adults
This research aims to provide insights on how seasonal variations influence biological age and enhance the design and analysis of long-term lifestyle interventions targeting biological clocks.
- Conditions
- Aging, Aging, Biological, Aging, Healthy, BIOLOGICAL CLOCKS
- Trial name
- SeasonAGE (NCT07242833)
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Sleep, Circadian Rhythm Disorders
Sleep Timing, Eating and Activity Measurement Study
There is strong reason to believe that sleep promotion during adolescence could yield long-term health rewards; the investigators' data show that, when they get more sleep, Morning Larks have impressively reduced intake of…
- Conditions
- Sleep, Circadian Rhythm Disorders, Dietary Habits
- Trial name
- STEAM (NCT04992611)
- Testing
- Sleep Extension (Early), Sleep Extension (Late)
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Insomnia Disorder, Circadian Rhythm Disorders
Translation and Validation of the French Version of the Sleep Regularity Questionnaire: a New Tool to Address the the Challenge of Sleep Health
Sleep is an essential function for physical and mental health. The mismatch between biological rhythms and the social rhythms of individuals is increasingly common in modern societies.
- Trial name
- PRIMO (NCT06727448)
- Testing
- SRQ questionnaire
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Binge-Eating Disorder, Circadian Rhythm Disorders
The Role of the Circadian System in Binge Eating Disorder
Binge eating disorder (BED) shows prominent circadian features that suggest a delay in circadian phase, and preliminary evidence shows binge eating may be responsive to chronobiological interventions, implicating a circadian…
- Trial name
- CHRONO-BE (NCT04724668)
- Testing
- Melatonin (3hrs before DLMO), Morning light version 1, Morning light version 2
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Obesity, Hypertension
Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans
Experimental data have shown that timing of sodium intake impacts diurnal patterns of sodium excretion. The purpose of this study is to test the hypothesis that the time of day for salt intake impacts (1) blood pressure rhythms…
- Conditions
- Obesity, Hypertension, Circadian Dysregulation, Salt; Excess
- Trial name
- NCT04021355
- Testing
- Oral sodium supplementation
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Circadian Dysregulation
Body Clocks - Coordination of Peripheral and Central Oscillators
The investigators are conducting an observational trial examining young women over the course of 28 days in which we are monitoring movement, sleep, heart rate, oxygen saturation, gut physiology, light, and menstrual cycle.
- Trial name
- NCT07459764
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Circadian Dysregulation
OCEAN Registry: Obesity and Clock for Elegant Aging Registry
This study aims to study the relationships between obesity, circadian rhythm, and aging. The investigators set up a prospective cohort registry for morbid obesity, obesity, and normal subjects with annual follow-up.
- Conditions
- Obesity, Circadian Dysregulation, Aging, Cardiovascular Disease
- Trial name
- OCEAN (NCT02674230)
- Where
- Taiwan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Sleep Deprivation, Circadian Dysregulation
The Microbiome and Resilience to Sleep and Circadian Disruption
This study is about how sleep loss and being awake at night impacts the ability to think, changes molecules in the blood, and alters the bacteria that live in the gut that typically help keep people healthy.
- Conditions
- Sleep Deprivation, Circadian Dysregulation, Stress
- Trial name
- NCT03747367
- Testing
- Insufficient Sleep, Prebiotic
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Circadian Dysregulation, Light Exposure
Feasibility of Light Therapy in the Pediatric Intensive Care Unit (ICU)
The goal of this clinical trial is to understand how easy or difficult it is for critically ill children (4-17 years old) to have light therapy while in the pediatric ICU.
- Conditions
- Circadian Dysregulation, Light Exposure, Pediatric Critical Illness
- Trial name
- NCT07384585
- Testing
- Light Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Laura Beth Kalvas
Cardiovascular Risk Factor, Circadian Dysregulation
Body Weight, Sleep, and Heart Health
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity.
- Conditions
- Cardiovascular Risk Factor, Circadian Dysregulation, Obesity
- Trial name
- NCT03388788
- Testing
- Positron Emission Tomography (PET) scanning of cardiac function at 3 time points across the 24 hour circadian cycle
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pregnancy Complications, Mental Health Issue
Psychobiological Interventions in Pregnancy
This randomized control trial will evaluate whether a physical activity intervention can improve mental health and biologic markers of stress in pregnant people with depressive or anxiety symptoms.
- Conditions
- Pregnancy Complications, Mental Health Issue, Depression, Anxiety, Pregnancy, High Risk
- Trial name
- PIP (NCT06430853)
- Testing
- Step count goal, Actigraph watch
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Stanford University
Sleep Deprivation, Circadian Rhythm Disorders
PBM Effects on Health and Well-being in Humans
The goal of this clinical study is to assess the effects of different photobiomodulation (PBM) conditions in men and women between 25 and 65 years old with daytime sleepiness/drowsiness and /or mild mood complaints but be…
- Trial name
- NCT05619133
- Testing
- PBM
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seaborough Life Science B.V.
Circadian Rhythm Disorders
Effects of Blocking Blue Light at Night Post CABG, AVR, MVR, CABG AVR, CABG MVR, or SAH
Purpose The purpose of this study is to determine whether filtering out blue light at nighttime reduces post-surgical inflammation and/or moderates cognitive decline and mood and sleep alterations in patients undergoing elective…
- Trial name
- NCT04578249
- Testing
- Blue light-blocking goggles, Clear goggles
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- West Virginia University
Dementia, Alzheimer Disease
Multidisciplinary Expert System for the Assessment & Management of Complex Brain Disorders
The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through…
- Conditions
- Dementia, Alzheimer Disease, Epilepsy, Sleep Disorder
- Trial name
- MES-CoBraD (NCT05171725)
- Testing
- EEG,PSG, biosample collection (blood and CSF), neuropsychological testing
- Where
- 4 sites in Greece, Israel and 2 more
- Volunteers
- 635 people, healthy volunteers welcome
- Sponsor
- Neurological Institute of Athens
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Circadian Rhythm Disorders
Melatonin Agonist for Shift-time Workers.
The study of the relationship between sleep pattern, attention performance, and heart rate variability among night workers.
- Trial name
- NCT07382843
- Testing
- Ramelteon
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Aging, Mental Disorder
Self-Care for Dementia Caregivers
The Self-care for Dementia Caregivers Study is a behavioral health intervention that uses digital monitoring tools and motivational health coaching to help caregivers of persons with dementia engage in a regular routine of sleep…
- Conditions
- Aging, Mental Disorder, Eating, Healthy, Physical Inactivity
- Trial name
- Care2 (NCT05309577)
- Testing
- Behavioral Self-Monitoring + Motivational Interviewing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh