Clinical trials: Cicatrix, Hypertrophic
Acne Scars - Mixed Atrophic and Hypertrophic
Topical Timolol 0.5% in Atrophic Acne Scar
The aim of the study is to evaluate the efficacy and safety of microneedling combined with topical timolol 0.5% in the treatment of atrophic acne scars.
- Trial name
- NCT05597813
- Testing
- microneedling, microneedling with topical timolol 0.5%
- Volunteers
- 30 people
- Sponsor
- Zagazig University
Hypertrophic Scars
Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery
The objective of this study is to evaluate the efficacy and safety of using ablative fractional laser- assisted topical corticosteroid delivery for the treatment of hypertrophic scar.
- Trial name
- NCT02487212
- Testing
- 0.05% Clobetasol propionate, Petrolatum gel, Fractional Erbium:Yag (2,940-nm) laser
- Where
- Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hypertrophic Scar
Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars
Hypertrophic scarring is a difficult and debilitating condition where one develops excessive scarring after full thickness injury to the skin. This is very common in full thickness burn injury.
- Trial name
- NCT05259137
- Testing
- Intralesional enalaprilat injection
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Hypertrophic Scar
The Vascularity Changes of Scars With Laser Therapy
The purpose of this study is to explore the effects of pulsed dye laser on managing scar vascularity and thickness.
- Trial name
- NCT03986346
- Testing
- pulsed dye laser, standardized care
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 45 people
- Sponsor
- The Hong Kong Polytechnic University
Burns, Hypertrophic Scar
Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar
Laser treatment of hypertrophic burn scars has become increasingly popular for improving scarring in burn survivors. Despite its common use, there a gap in knowledge regrading randomized control trials that demonstrate whether…
- Trial name
- NCT03692273
- Testing
- Luminis ultrapulse fractional ablative carbon dioxide laser, 0.5mm punch biopsy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Wound Healing
Plasma Therapy for Scar Management
This study is a prospective, multicenter, real-world observational study. It aims to evaluate whether adding plasma device therapy to standard scar care is effective and safe for treating various types of scars, including…
- Trial name
- NCT07548593
- Testing
- Plasma Device
- Volunteers
- 800 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hypertrophic Scars
Fractional Microneedling RF vs Intralesional Steroid With & Without Microneedling in Hypertrophic Scars
Comparing between the effect of Fractional Microneedling Radiofrequency Versus Intralesional Steroid Injection with and without Microneedling on Tissue levels of PDGF \& CTGF in Hypertrophic Scars
- Trial name
- NCT04389619
- Testing
- Fractional Microneedling Radiofrequency, Intralesional Steroid Injection with and without Microneedling
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Skin Diseases, Hypertrophic Scar
Piezoelectric Drived Microneedling in Treating Refractory Skin Diseases
Piezoelectric drived microneedling treats refractory skin disorders using hollow microneedles assisted by ultrasound. Mechanically, the injection of medicine by hollow microneedling could makes the distribution of medicine more…
- Conditions
- Skin Diseases, Hypertrophic Scar, Keloid, Plantar Wart
- Trial name
- NCT05488860
- Testing
- Triamcinolone acetonide(scar)/5-ALA(others), Piezoelectric drived microneedling, 5-ALA (a photosensitizer for photodynamic therapy).
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Stem Cell Media, Hypertrophic Scar
Regenerative Effects of Human Stem Cell Media After Laser Therapy in Hypertrophic Scar
The purpose of this study was to determine the effect of combined treatment using nonablative laser and human stem cell media (HSCM) on the regeneration of hypertrophic scars that occurred after burns.
- Conditions
- Stem Cell Media, Hypertrophic Scar, Regeneration
- Trial name
- NCT05004779
- Testing
- human stem cell conditioned media was applied after non-ablative laser therapy, normal saline was applied after non ablative laser therapy
- Volunteers
- 30 people
- Sponsor
- Hangang Sacred Heart Hospital
Hypertrophic
Investigation of a Novel Silicone Dressing to Maximize the Outcomes of Scar Revision Procedures (IMPROVE)
Neodyne has developed an investigational dressing for post-operative incision care. Neodyne is conducting this research to study whether the investigational dressing, called the Neodyne Dressing, can minimize scar formation in a…
- Trial name
- IMPROVE (NCT01430130)
- Testing
- embrace device
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Neodyne Biosciences, Inc.
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hypertrophic Scar
Study to Evaluate Efficacy of OLX10010 in Reducing Recurrence of Hypertrophic Scarring After Scar Revision Surgery
Phase 2a, prospective, randomized, double-blind, intra-subject, placebo-controlled, proof of concept study. Approximately twenty subjects will be randomized 1:1 to one of two treatment arms: Arm A: 2.0 mg/cm OLX10010 biweekly…
- Trial name
- NCT04877756
- Testing
- OLX10010
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Olix Pharmaceuticals, Inc.
Keloid Scars, Hypertrophic Scars
Topical Cryotherapy and Keloid/Hypertrophic Scars
The goal of this clinical trial is to determine whether the application of brief topical cryotherapy immediately before intralesional corticosteroid injections can reduce pain and injection resistance during routine treatment of…
- Trial name
- NCT07336368
- Testing
- Cryotherapy with liquid nitrogen, Intralesional Triamcinolone 10 mg/ml
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sonal Choudhary
Scar, Hypertrophic
Intralesional Treatment of Keloids
Intralesional injection in treatment of keloid
- Trial name
- NCT06729840
- Testing
- Injection
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sohag University
Keloids Scars
Observational Study of Keloids Scars Treated by Shaving and Cryosurgery
Treatment of keloids scars is difficult and controversial. These keloids have a functional and aesthetic impact. A lot of treatment are described with a lot of relapses and aggravation.
- Trial name
- KELOIDS SCARS (NCT02886091)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Brest
Scars, Hypopigmented Scar
Treatment of Hypopigmented Scars With Bimatoprost
Patients who have hypo-pigmented burn scar will have two scars chosen and randomized to treated scar and control scar. The subject will then have both scars treated with fractional ablative CO2 laser (FLSR).
- Conditions
- Scars, Hypopigmented Scar, Hypopigmented Skin, Burn Scar
- Trial name
- NCT06122090
- Testing
- Bimatoprost, Saline
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medstar Health Research Institute
Hypertrophic Scars, Burn Scar Patients
Effect of PRF & Fractional CO2 Laser in Postburn Hypertrophic Scars
Recent advancements in scar management include the use of Plasma Rich Fibrin (PRF) injections and fractional CO2 laser treatments.
- Trial name
- NCT06664268
- Testing
- Plasma rich in growth factors (PRGF-Endoret), Fractional CO2 laser assisted PDT
- Volunteers
- 30 people
- Sponsor
- Assiut University
Acne Scars - Mixed Atrophic and Hypertrophic
Clinical Evaluation of the Safety and Performance of FRF for the Treatment and Reduction of Acne Scarring
Prospective, single centre, evaluator-blind study of the safety and performance of fractional radiofrequency (RF) for the treatment and reduction of acne scarring.
- Trial name
- NCT04827680
- Testing
- Venus Viva MD
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Venus Concept
Scars, Delayed Wound Healing
Nanofat on Wound Healing and Scar Formation
This study will evaluate the effectiveness and safety of intradermal injection of Nanofat on wound healing and scar formation.
- Conditions
- Scars, Delayed Wound Healing, Hypertrophic Scar, Post Inflammatory Hyperpigmentation
- Trial name
- NFWHSF (NCT03850119)
- Testing
- Nanofat injection
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Hypertrophic Scars
Effect of Cryotherpy on Hypertrophic Scar
Purpose of the study: The purpose of the study is to evaluate the therapeutic effect of cryotherpy in treating hypertrophic scar. It will be hypothesized that: Cryotherapy may not have an effect on hypertrophic scar.
- Trial name
- NCT04532840
- Testing
- cryotherapy (Gymna Cryoflow ICE-CT), Exercising, Positioning and splinting, Pressure Therapy and Massage
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zakria Mowafy