Clinical trials: Cigarette Smoker
Electronic Cigarette Use, Tobacco Smoking
Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems
The purpose of this study is to estimate nicotine uptake and assess subjective effects during ad libitum use sessions of 4 flavors of JUUL ENDS (also referred to as nicotine salt pod system; NSPS) products (i.e., Virginia…
- Trial name
- NCT04123041
- Testing
- JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Alcohol Drinking, Cigarette Smoking Toxicity
Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder
The proposed research will investigate whether smokers with vs. without current at-risk alcohol drinking (ARD) respond to reduced nicotine cigarettes by increasing their alcohol consumption or smoke exposure, thereby diminishing…
- Trial name
- RedNic (NCT02990455)
- Testing
- Reduced nicotine cigarettes
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Battelle Memorial Institute
Cigarette Smoker, Current Every Day Smoker
Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs
This trial studies biomarkers obtained by bronchoscopy (bronchoalveolar lavage and lung brushings) to determine the effect of smoking e-cigarettes on the lungs.
- Trial name
- NCT03691350
- Testing
- Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Electronic Cigarettes
Assessment of Two New Electronic Cigarettes in Cigarette Smokers
The purpose of this study is to determine differences in nicotine delivery, user behavior, subjective effects, and physiological effects, when cigarette smokers use an two new electronic cigarette devices (JUUL and IQOS) relative…
- Trial name
- NCT03435562
- Testing
- JUUL electronic cigarette, IQOS electronic cigarette, Own Brand cigarette
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Smoking, Cigarette, Alveolar Bone Grafting
Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers
The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers.
- Conditions
- Smoking, Cigarette, Alveolar Bone Grafting, Wound Healing, Bone Healing
- Trial name
- NCT07372183
- Testing
- observational study
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Marquette University
E-cigarette Use, Cigarette Smoking
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers.
- Conditions
- E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
- Trial name
- NCT06372899
- Testing
- E-cigarettes, Oral nicotine pouches
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Smoking
Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Ambulatory Setting
Evaluate if the ad libitum use of the THS 2.2 Menthol (mTHS), a candidate Modified Risk Tobacco Product, for 5 days in confinement, and after 86 days in an ambulatory setting, by apparently adult healthy smokers results in a…
- Trial name
- NCT01989156
- Testing
- THS 2.2 Menthol (mTHS 2.2), Menthol Conventional Cigarette (mCC), Smoking Abstinence (SA)
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine, Vaping
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
To demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected harmful and potentially harmful constituents (HPHC) in smokers switching from cigarette (CIG) to P4M3, an Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Nicotine, Vaping, Nicotine Vaping
- Trial name
- NCT05487456
- Testing
- P4M3 CA35, P4M3 CM35, CIG
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
Evaluating the Acute Effects of Electronic Nicotine Delivery Devices Marketed to Smokers.
The study's aim is to develop a clinical model that can be used to measure the nicotine delivery and tobacco/nicotine abstinence-suppressing capability of electronic devices that are marketed as a means to deliver nicotine to…
- Trial name
- NCT00932295
- Testing
- OB, CROWN SEVEN, NJOY
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Smoking Cessation, Vaping Cessation
Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers
Safety assessment of long-term 3 mg cytisinicline three times daily (TID) exposure for 52 weeks is the main purpose of this study, conducted in the United States.
- Trial name
- ORCA-OL (NCT06435221)
- Testing
- Cytisinicline
- Where
- 29 sites in United States
- Volunteers
- 479 people
- Sponsor
- Achieve Life Sciences
Healthy Volunteers
A Study to Evaluate Nicotine Uptake and Biomarkers in Smokers Using mybluTM Electronic Cigarettes
This study evaluates the overall performance of the currently-marketed MybluTM e-cigarette device and pods, as assessed by nicotine uptake, exposure to smoke constituents, safety and consumer satisfaction, over 8 days.
- Trial name
- NCT04430634
- Testing
- Myblu variant A, Myblu variant B, Myblu variant C
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fontem US LLC
Nicotine Addiction, E-Cig Use
Sex Differences in E-cig Perception: Study 1
The primary objective is to examine the influence of sex on sensory effects, appeal, and reinforcing value of nicotine containing e-cigs in popular flavor components; sweet and cooling.
- Conditions
- Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
- Trial name
- NCT05432830
- Testing
- E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yale University
Periodontal Diseases, Chronic Periodontitis
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status…
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket, Tooth Mobility
- Trial name
- NCT03364751
- Testing
- IQOS, Cigarette
- Where
- 26 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Philip Morris Products S.A.
Nicotine Pouch Self-Administration, Nicotine Pharmacokinetic Study
Acute Effects of Oral Nicotine Pouches
The present human laboratory study will recruit cigarette smokers (n=60) and adult infrequent nicotine users (n=60) to complete two counterbalanced lab sessions in which the participants use nicotine pouches under controlled…
- Conditions
- Nicotine Pouch Self-Administration, Nicotine Pharmacokinetic Study, Nicotine Pharmacodynamic Study
- Trial name
- NCT07128329
- Testing
- Nicotine Pouches
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cigarette Smoking
Serbian Smoking Reduction/Cessation Trial (2SRT)
The study aims to establish if a low-nitrosamine, smokeless tobacco product (Swedish snus) can help adult smokers to reduce and eventually completely quit smoking.
- Trial name
- 2SRT (NCT00601042)
- Testing
- Swedish snus (smokeless tobacco), Onico
- Where
- 2 sites in Serbia
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Swedish Match AB
Smoking, Nicotine Dependence
A Trial of E-cigarettes in Current Cigarette Smokers
The purpose of this study is to examine cigarette smokers' use of electronic cigarettes (e-cigarettes), and how use of e-cigarettes affects short term smoking behavior.
- Conditions
- Smoking, Nicotine Dependence, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT02357173
- Testing
- electronic cigarette, cigarette group
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Medical University of South Carolina
Cigarette Smoking, Drug Use
Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment
The objective of the proposed project is to develop a novel, behavioral approach to smoking cessation that can be integrated with residential drug use treatment for low income substance using smokers with elevated depressive…
- Trial name
- BA-DAS (NCT01372254)
- Testing
- Standard Treatment, BAD-AS, Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Maryland, College Park
Cigarette Smoking, Current Smoker
Quit4Health Intervention in Supporting Smoking Cessation and Preventing Smoking Initiation in Young Adults
This trial studies how well Quit4Health intervention works in supporting smoking cessation and preventing smoking initiation in young adults.
- Trial name
- NCT04009590
- Testing
- Educational Intervention, Questionnaire Administration, Smoking Cessation Intervention
- Where
- United States
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Tobacco Use Disorder
Interest in Smokeless Tobacco Product as a Substitution for Cigarettes in Current Smokers
This randomized clinical trial studies interest in smokeless tobacco product as a substitution for cigarettes in current smokers. Use of smokeless tobacco products may help people stop smoking.
- Trial name
- NCT01800500
- Testing
- smoking cessation intervention, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Roswell Park Cancer Institute
Tobacco Abuse Smoke
Effect of an Inhaled Glucocorticosteroid (ICS) on Endothelial Dysfunction in Cigarette Smokers
The hypothesis underlying the proposed study is that the blunted endothelium-dependent vasodilation seen in the airway of current smokers is also present in the brachial artery, and that the same inhaled corticosteroid (ICS)…
- Trial name
- NCT01216735
- Testing
- Fluticasone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Miami