Clinical trials: Cigarette Use
Nicotine Dependence, Tobacco Toxicity
Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine…
- Conditions
- Nicotine Dependence, Tobacco Toxicity, Cardiovascular Risk Factors
- Trial name
- SREC22 (NCT05658471)
- Testing
- Standardized Research E-Cigarette (SREC), Over the Counter E-Cigarette (EC), Biological Samples
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cannabis Use, Tobacco Use
Effect of Cannabis on E-Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT06609109
- Testing
- THC High Dose, THC Low Dose, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Smoking Cessation, Smoking, Cigarette
Pictorial Warning Labels & Memory for Relative & Absolute Cigarette Health-risk Information Over Time in Adult Smokers
Pictorial cigarette warning labels (PWLs) are thought to increase risk knowledge, but experimental research has not examined PWLs' longer term effects on memory for health risks.
- Trial name
- NCT03499340
- Testing
- text-only PWL, low arousal graphic PWL, high arousal graphic PWL
- Where
- United States
- Volunteers
- 3,213 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cigarette Smoking-Related Carcinoma, E-Cig Use
Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)
This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use…
- Trial name
- NCT07167225
- Testing
- Effectiveness of different recruitment approaches, Choice of study completion locations, Cannabis Engagement Assessment
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Cigarette Smoking
Predictors of Teen Smoking-cessation
The primary objective of this research is to explore relations between impulsive behavior and smoking-cessation success among treatment-seeking teens enrolled in a quit-smoking program.
- Trial name
- NOT (NCT01141517)
- Testing
- Not-On-Tobacco smoking cessation program
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Nicotine Use Disorder, Tobacco Use Disorder
Evaluation of the Addictive Potential of E-Cigarettes
This study will examine the subject matter from a neurobiological and a neuropsychological vantage point to ascertain whether the e-cigarette is potentially as addictive as the traditional tobacco cigarette.
- Trial name
- EVAPE (NCT04772014)
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Tobacco Use
Expanding the Click City Tobacco Prevention Program to Include E-cigarettes and Other Novel Tobacco Products
The goal of this study is to modify a smoking prevention program for 5th and 6th grade students to also target vaping e-cigarettes.
- Trial name
- NCT03682900
- Testing
- Click City®: Tobacco, Usual Tobacco Curriculum
- Where
- United States
- Volunteers
- 2,673 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Tobacco Dependence
Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine
In this study, smokers will be randomly assigned to one of three conditions for six weeks: 1) nicotine-free cigarettes (0.05mg); 2) extra low nicotine cigarettes (0.3 mg); or 3) medicinal 4 mg nicotine lozenge.
- Trial name
- NCT00777569
- Testing
- Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Smoking Behavior, Cigarette Smoking Behavior
OCAST Cessation Study
The long-term goal is to improve the quality of life of children and their parents who smoke tobacco by facilitating parental smoking cessation in a way that is easy to administer yet effective.
- Conditions
- Tobacco Smoking Behavior, Cigarette Smoking Behavior, Second Hand Tobacco Smoke, Tobacco Use Cessation
- Trial name
- OCAST (NCT01921439)
- Testing
- Personalized Feedback
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Electronic Cigarette Use
Vaporized Nicotine and Autonomic Control
E-cigarettes are marketed as an alternative to smoking for those who want to decrease the health risks of tobacco. Tobacco cigarettes increase heart rate (HR) and arterial pressure, while reducing muscle sympathetic nerve…
- Trial name
- NCT04613609
- Testing
- Electronic Cigarette containing nicotine, Electronic Cigarette without nicotine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Cigarette Smoking, Schizophrenia
Knowledge and Perception of Smoking Risks/Consequences
This proposed 2-year questionnaire study examines views and attitudes regarding health risks of cigarette smoking, smoking patterns and motivators for cessation in smokers who suffer from schizophrenia compared to a sample of…
- Trial name
- SmokCess (NCT00686101)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cigarette Smoking
"Quit Smoking on Your Own" Brief Online Study
Most individuals who smoke want to quit smoking. Most individuals who want to quit, quit on their own. The purpose of this study is to determine whether very brief suggestions provided online are comparatively more effective than…
- Trial name
- TC-PAU-1 (NCT02103829)
- Testing
- Brief Intervention #1, Brief Intervention #2, Brief Intervention #3
- Where
- United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- i4Health
Hiv, Tobacco Use
Trial of a Harm Reduction Strategy for People With HIV Who Smoke Cigarettes
Cigarette smoking is now the leading killer of people with HIV (PWH) in the US, and most cessation strategies tried to date have failed to increase long-term quit rates.
- Trial name
- NCT05642715
- Testing
- EX+, Varenicline, HR
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Little Cigars and Cigarillos (LCC) Use
Little Cigar and Cigarillo Warnings for Youth
This study explores the effect of the little cigars and cigarillos (LCC) warnings on youth who currently use, have ever used, or are susceptible to using LCCs.
- Trial name
- NCT06413797
- Testing
- FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings
- Where
- United States
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Vaping, Electronic Cigarette Use
Vaping Adverse Lung and Heart Events Cohort
This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up.
- Trial name
- VapALERT (NCT06291597)
- Testing
- Vaping
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Laval University
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cigarette Smoking, Alcohol Drinking
Sports, Education and Consumption of Substances in Adolescents
Adolescent substance abuse (SA), which includes the consumption of alcohol, cigarette smoking, the consumption of drugs and other behaviors, is a significant public-health issue in the world today.
- Trial name
- SESA (NCT02629679)
- Testing
- Regular scholastic system and organized sports, Regular scholastic system
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Split
Smoking Cessation, Cigarette Smoking
Effects of Random Nicotine Delivery on Smoking Cessation
The objective of this study is to determine whether treatment with random nicotine delivery via a nicotine film both before and after the target quit date will facilitate smoking cessation relative to treatment with steady state…
- Conditions
- Smoking Cessation, Cigarette Smoking, Smoking (Tobacco) Addiction
- Trial name
- NCT03674970
- Testing
- Nicotine Film
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Smoking, Cigarette
Staccato Loxapine PK in Smokers and Nonsmokers
The objective of this trial was to assess the pharmacokinetics of a single dose of 10 mg Staccato Loxapine administered to smokers compared to nonsmokers.
- Trial name
- NCT00873769
- Testing
- Inhaled Loxapine 10 mg
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Substance Withdrawal Syndrome
Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?
The purpose of this study is to see whether adults who use e-cigarettes every day experience symptoms of nicotine withdrawal when they stop using e-cigarettes for 6 days.
- Trial name
- NCT02825459
- Testing
- Abstinence from e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Vermont