Clinical trials: Cigarette Use
Tobacco Dependence
Low Nicotine Cigarettes Plus Electronic Cigarettes
This study aims to determine the health effects of very low nicotine content in cigarettes, in conjunction with the availability of nicotine-containing electronic cigarettes (e-cigs) among smokers with mental health conditions…
- Trial name
- NCT04058717
- Testing
- Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
E-cigarette Use, Cigarette Smoking
BIDI Stick ENDS Abuse Liability and Puffing Topography Assessment
This study assessed the abuse liability (measured by assessing how much nicotine enters the body when the BIDI Stick is used, and how this makes users feel) and puffing topography (puff characteristics like volume and duration)…
- Trial name
- NCT05072925
- Testing
- Tobacco products
- Where
- Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- BIDI Vapor
Electronic Cigarette Use
Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System
The study will assess product use behaviors, biomarkers of exposure, subjective effects, and safety in smokers who switch to a RELX ENDS over 8-weeks.
- Trial name
- NCT04708106
- Testing
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, RELX ENDS Tobacco and Menthol Flavors
- Where
- 5 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Tobacco Use
Telehealth-Filter Ventilation ( COMET2P1 )
The goals of this project are to determine the effects of varying degrees of cigarette filter ventilation on biomarkers of toxicant exposure and smoking behavior and on subjective responses to the cigarette.
- Trial name
- NCT04969783
- Testing
- Ventilated Cigarette Filter, Unventilated Cigarette Filter
- Where
- 2 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Cannabis Use, Tobacco Use
Effect of Cannabis on E-Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT06609109
- Testing
- THC High Dose, THC Low Dose, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Use Disorder
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
This study will examine extended exposure to cigarettes varying in nicotine content among adults with opioid use disorder. Those with opioid use disorder are at increased risk for smoking, nicotine dependence, and using high…
- Trial name
- P2S2 (NCT02250664)
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
E-Cig Use
Understanding the Impact of Cartridge-Based Electronic Cigarettes and Generated Aerosols on Cardiopulmonary Health
Over the last decade, e-cigarettes have become increasingly popular, due to their promotion as a healthy alternative to traditional tobacco cigarettes.
- Trial name
- NCT05199480
- Testing
- Tobacco flavored liquid type 1, Tobacco flavored liquid type 2
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cigarette Smoking, Tobacco Smoking
Enhancing Smoking Cessation in the Homeless Population
The goal of this research study is to enhance smoking cessation rates for homeless smokers. The original study design proposed to test the effects of 1) an Intensive Smoking Intervention, and 2) integrating alcohol abuse…
- Conditions
- Cigarette Smoking, Tobacco Smoking, Smoking, Tobacco
- Trial name
- NCT01932996
- Testing
- nicotine patch plus nicotine gum/lozenge, Intensive Alcohol Intervention
- Where
- United States
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hazardous Drinking, Cigarette Smoking
Naltrexone for At-Risk and Problem Drinking in Smoking Cessation Treatment
To test whether naltrexone compared to placebo can reduce heavy drinking and improve smoking cessation outcomes in heavy drinkers seeking smoking cessation treatment.
- Trial name
- NCT00938886
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brown University
Electronic Cigarette Use, Cigarette Use, Electronic
Evaluating Selected Constituents in the Exhaled Breath Samples
An Open-Label, Multi-Center Study to Evaluate Selected Constituents in the Exhaled Breath Samples From the Use of JUUL Nicotine Salt Pod System Product (5% and 3% Virginia Tobacco, Mint, Mango, Menthol) Users and Conventional…
- Conditions
- Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04143256
- Testing
- JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Smoking, Smoking Behaviors
CSD210903: A Study to Determine Subject Puffing Patterns of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Ambulatory Setting
This is a multi-center, open-label, parallel-cohort-study to evaluate the puffing patterns of healthy adult consumers of tobacco products switching from a usual brand (UB) combustible cigarette (CC) and/or a UB Heated Tobacco…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT05307822
- Testing
- Non-combusted cigarette variant 42001401, Non-combusted cigarette variant 42001399, Non-combusted cigarette variant 40007386
- Where
- 7 sites in United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Cigarette Smoking, Smoking Behaviors
A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
This is a research study to find out if treatment decision making can be improved for smokers who find it difficult to quit with medications.
- Conditions
- Cigarette Smoking, Smoking Behaviors, Treatment
- Trial name
- ADAPT (NCT06118502)
- Testing
- Switching to a different medication, Continued use of the same medication, Switching to a harm reduction tobacco product
- Where
- United States
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Tobacco Cessation, Electronic Nicotine Delivery Systems
Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial
This clinical trial studies whether different flavored electronic nicotine delivery systems (ENDS) help lower smoking and exposure to tobacco toxicants among cigarette smokers interested in reducing their smoking.
- Trial name
- REFLECT (NCT07896330)
- Testing
- Vaping - Fruit flavored ENDS, Biospecimen Collection, Vaping - tobacco flavored ENDS
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
E Cigarette Use
A Behavioral Circuit Breathing Training Intervention on Smoking Cessation and Respiratory Function Among Youth Who Use E-cigarettes
This study aims to evaluate the effects of a six-week behavioral circuit breathing training intervention on smoking cessation and respiratory function compared with diaphragmatic breathing training and usual daily activities
- Trial name
- NCT07882407
- Testing
- Circuit Breathing Intervention, Diaphragmatic Breathing
- Where
- Thailand
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Electronic Cigarette Use
Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC
The goal of this study is to conduct a pilot randomized waitlist-controlled trial to assess the feasibility, acceptability, and preliminary effects of substituting the NIDA standardized research e-cigarette (SREC) for combusted…
- Trial name
- SWITCHED (NCT05881304)
- Testing
- Standardized research e-cigarette (SREC)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anxiety Disorders, Anxiety
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and anxiety sensitivity (AS).
- Conditions
- Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette
- Trial name
- NCT03382093
- Testing
- Personalized Feedback Intervention, Smoking Information Control
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Houston
Tobacco Use Disorder
Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use
In this pilot study, menthol cigarette smokers will be randomized to one of three experimental marketplaces: 1) a condition simulating a ban on menthol cigarettes but not menthol e-cigarettes (condition A); 2) a condition…
- Trial name
- NCT03402243
- Testing
- Menthol ban on cigarettes, Menthol ban on cigarettes and e-cigarettes, No menthol ban
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cigarette Smoking
Comparison of Low Yield Cigarettes in African Americans vs. Whites
The investigators' general hypothesis is that African-Americans (AAs) smoke more for positive reinforcement from nicotine with a "peak-seeking" pattern of smoking (smoking individual cigarettes more intensively with greater…
- Trial name
- 6162-AAPK2 (NCT01058876)
- Testing
- Deuterated nicotine and cotinine
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use
Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability
The overall aim of the current research is to understand purchasing and product choice behaviors of tobacco/nicotine users if banning the sale of fully nicotinized cigarettes were to go into effect.
- Trial name
- NCT03637452
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
E-Cig Use
The Impact of Chronic E-Cigarette Usage on Microvascular Health
The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds.
- Trial name
- NCT06860698
- Testing
- E-cig use
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University