Clinical trials: Cigarette Use
Cigarette Smoking
Analysis of Lipid Biomarkers of Exposure and Host Response
The purpose of this prospective, open-label, clinical trial is to establish the feasibility and validity of exhaled breath condensate (EBC) biomarkers for use in studies designed to evaluate harm reduction strategies of smoking.
- Trial name
- NCT00493831
- Testing
- nicotine polacrilex, transdermal system or inhaler
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Nebraska
Schizophrenia, Cognition
Transcranial Direct Current Stimulation (tDCS) As A Treatment For Cigarette Craving and Cognitive Deficits in Schizophrenic
This is a study of the effects of tDCS on smoking, craving for cigarettes, cognition, and psychiatric symptoms in schizophrenic patients who are current smokers or have a history of regular cigarette smoking.
- Conditions
- Schizophrenia, Cognition, Cigarette Smoking
- Trial name
- TDCSSCHIZ (NCT02128919)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
E-Cig Use
Responses to E-Cigarette Advertising
While conventional cigarette use continues to decline among youth and young adults, e-cigarette (EC) use is on the rise. The use of ECs during young adulthood, particularly 18 years of age, is especially alarming because it is…
- Trial name
- NCT04249219
- Testing
- Viewing e-cigarette ads
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Tobacco Use Disorder
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
This study will examine extended exposure to cigarettes varying in nicotine content among adults with opioid use disorder. Those with opioid use disorder are at increased risk for smoking, nicotine dependence, and using high…
- Trial name
- P2S2 (NCT02250664)
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Use
A Study to Evaluate Changes in Smokers Using An Oral Tobacco-Derived Nicotine Product
The purpose of this study was to estimate changes in biomarkers of exposure (BOE) in adult cigarette smokers using an oral tobacco-derived nicotine (OTDN) product relative to adult smokers who continue smoking exclusively.
- Trial name
- NCT04079933
- Testing
- Oral tobacco-derived nicotine product (OTDN)
- Where
- 3 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC
Smoking, Nicotine Addiction
The END Perioperative Smoking Pilot Study
The purpose of this pilot randomized trial is to determine the feasibility of e-cigarettes and telephone counselling (compared to transdermal nicotine replacement and telephone counselling) as a harm-reduction tool that may lead…
- Conditions
- Smoking, Nicotine Addiction, Surgery
- Trial name
- NCT02482233
- Testing
- ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Cigarette Smoking, Tobacco Use
Gabapentin for Smoking Cessation
Gabapentin is an anti-epileptic agent that has shown preliminary evidence of efficacy for improving symptoms of cocaine and alcohol withdrawal in pilot studies.
- Trial name
- NCT00578552
- Testing
- Gabapentin - 1800 mg/day, Gabapentin - 2700 mg/day
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking, Cigarette, Smoking Cessation
Health Systems Reach Interventions Project
This project seeks to identify ways to enhance the reach of evidence-based smoking cessation treatments among adult primary care patients who smoke daily and are not ready to start treatment at study enrollment.
- Trial name
- NCT04199117
- Testing
- Varenicline, Combination nicotine patch and nicotine mini-lozenge treatment, Monetary incentives for initiating treatment
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Wisconsin, Madison
Tobacco Use
A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes
This study evaluates the impact of switching from usual brand cigarettes to very low nicotine cigarettes on cigarette consumption, smoking behavior, and biomarkers of exposure.
- Trial name
- NCT03571724
- Testing
- Non-Menthol Very Low Nicotine Cigarettes, Menthol Very Low Nicotine Cigarettes, Subject's UB non-mentholated filtered cigarettes
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
E Cig Use
Young Adult EC Use and Respiratory Outcomes
E-cigarette (EC) use continues to increase among youth, and EC may be detrimental to youth respiratory health. Public health officials and the Food and Drug Administration (FDA) can now regulate ECs.
- Trial name
- NCT04395274
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoking
Effects of Smoking Environments on Brain Reactivity
The goal of this study is to evaluate correlations between brain reactivity (as assessed via functional magnetic resonance imaging (fMRI) following 24-h abstinence) and the amount of smoking in a specific location.
- Trial name
- CameraCue3 (NCT03421210)
- Testing
- Nicotine patch
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Duke University
Tobacco Smoking
Tobacco and Socioeconomic Disadvantage
Randomized clinical trial comparing 3 brief interventions designed to increase motivation to quit smoking in socioeconomically disadvantaged smokers.
- Trial name
- NCT03620708
- Testing
- Motivational Interviewing, Nicotine Replacement Therapy Sampling, Referral Only
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence
Effects of Varenicline on Cigarette Self Administration
The investigators hypothesize that varenicline will dose dependently attenuate the subjective effects of cigarettes after a period of abstinence.
- Trial name
- NCT00731055
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cigarette Smoking
A Virtual Arm to Stop Smoking
The investigators reported in a pilot study presented at last year's Cybertherapy Conference (Girard \& Turcotte, 2007) that using an action-cue exposure strategy in virtual reality (ACE-VR; crushing virtual cigarettes) might be…
- Trial name
- NCT00639093
- Testing
- psychoeducational / motivational combined with crushing, psychoeducational / motivational combined with control
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
Smoking Cessation
Meclizine as a Potential Smoking Cessation Treatment
The purpose of this study is to evaluate whether meclizine, an antihistamine used to prevent or treat motion sickness, can help smokers quit smoking.
- Trial name
- NCT01443858
- Testing
- Meclizine, Nicotine Patch
- Where
- 4 sites in United States
- Volunteers
- 146 people
- Sponsor
- Duke University
Nicotine Dependence
Concurrent Bupropion / Varenicline for Smoking Cessation
This study focuses on the first step in developing an algorithm for maximizing quit-smoking success based on an adaptive approach, which changes treatment from the initial nicotine replacement therapy (NRT) when that treatment…
- Trial name
- ConNic4 (NCT01303861)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 4 sites in United States
- Volunteers
- 702 people
- Sponsor
- Duke University
Tobacco Use, Tobacco Smoking
Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI)
Due to the pandemic, this study was modified from a randomized clinical trial to test the feasibility, initial efficacy, and mechanisms of action of our PTSC-S intervention to a feasibility and acceptability test of our…
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Tobacco Use Disorder
- Trial name
- PTSC-S (NCT03873337)
- Testing
- Persistence Targeted Smoking Cessation in SMI (PTSC-S), Nicotine patch
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Rutgers, The State University of New Jersey
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Smoking Behaviors, Smoking, Cigarette
AAT + tDCS to Reduce Cue-induced Craving and Smoking Behavior
Smokers are highly reactive to smoking-related stimuli and report that this cue reactivity (CR) is a major obstacle to quitting.
- Trial name
- NCT05426460
- Testing
- Approach/Avoidance Task, Transcranial Direct Current Stimulation, AC
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Cynthia Conklin
Electronic Cigarette Use
Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)
The purpose of this study is to determine if abuse liability indices will be impacted by varying flavors and e-cigarette (ECIG) nicotine delivery capability (i.e., nicotine flux) among current combustible cigarette users.
- Trial name
- NCT05971823
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University