Clinical trials: Circadian Clocks
Diabetes Mellitus, Type 2
Exercise Timing and the Circadian Clock in Individuals With Type 2 Diabetes and Those at Risk
Many investigations have been done to determine the exercise that can elicit the greatest benefits on glycemic control and metabolic health, with findings suggesting that incorporation of higher intensity and longer duration of…
- Trial name
- EX-TIMING (NCT06136013)
- Testing
- HIIT
- Where
- Portugal
- Volunteers
- 34 people
- Sponsor
- Faculdade de Motricidade Humana
Diet Habit
Time of Day Effect on Pesticides Metabolism and Toxicity
The CIRCA-CHEM study is a non-pharmacological, randomized cross-over health intervention trial studying the effect of the time of day on the metabolism and concomitant toxicity of exposures to pesticides found in a balanced…
- Trial name
- CIRCA-CHEM (NCT04177030)
- Testing
- Isopesticide dietary scheme
- Where
- Cyprus
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cyprus University of Technology
Circadian System
Beneficial Effects of Daytime Light Exposure and Physical Activity on the Human Circadian Clock and Sleep
This study is to examine the circadian phase-shifting effects of daylight and physical activity (primary endpoint: shift in dim-light melatonin onset (DLMO)) as well as their effects on sleep the ensuing night and analyzes how…
- Trial name
- DayCiS (NCT05513547)
- Testing
- LE protocol 1: exposure to artificial light, LE protocol 2: natural daylight, LE protocol 3: natural daylight with reduced short-wavelength proportions
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Gingivitis, Circadian Rhythm Disruption
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption
This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and…
- Conditions
- Gingivitis, Circadian Rhythm Disruption, Periodontal Inflammation, Circadian Rhythm Sleep Disorder, Shift Work Type
- Trial name
- Nursma-CIRC-HG (NCT07592052)
- Testing
- Standard Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Inonu University
T1DM, Sleep Disorders, Circadian Rhythm
Influence of Circadian Clock on Hormonal, Metabolic, Neurocognitive Markers in Adolescents With and Without Diabetes
Type 1 diabetes mellitus (T1DM), makes its appearance during childhood and youth, but management implications last till late adulthood.
- Conditions
- T1DM, Sleep Disorders, Circadian Rhythm, ADHD, Memory Impairment
- Trial name
- NCT04054934
- Testing
- Reversed Circadian Rhythm, Normal Circadian Rhythm
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Insomnia
Melatonin Receptor Agonist and Peripheral Biological Markers
People who have insomnia typically co-occur with mental disorders, especially anxiety and depression. It has been documented that the melatonin phase in the depressed patients was reached with a delay.
- Trial name
- NCT03432091
- Testing
- melatonin
- Volunteers
- 40 people
- Sponsor
- National Science and Technology Council, Taiwan
Obesity, Postpartum Weight Retention
ClockWork Postpartum Weight Management Study
The ClockWork Postpartum Weight Management Pilot Study is an intervention study that will assess the feasibility, acceptability, and initial efficacy of the ClockWork intervention among women with prepregnancy overweight/obesity…
- Conditions
- Obesity, Postpartum Weight Retention, Weight Gain, Maternal
- Trial name
- NCT04992637
- Testing
- ClockWork, Usual Care
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pittsburgh
Gingivitis, Periodontitis
Circadian Clock Gene Expression in Periodontal Disease
This observational study aims to investigate whether periodontal inflammation is associated with alterations in the expression of circadian clock-related genes and proteins in gingival tissues.
- Trial name
- PERIOCLOCK (NCT07452783)
- Testing
- Gingival Tissue Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inonu University
Chronobiology Disorders, Circadian Rhythm Disorders
Light Sensitization Study
Circadian rhythm disorders are a class of sleep disorders characterized by misalignment between the timing of sleep and the timing of rhythms driven by the biological clock.
- Conditions
- Chronobiology Disorders, Circadian Rhythm Disorders, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01327040
- Testing
- light exposure
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Metabolic Response to Dietary Modification
The CLOCK Study - A Human Dietary Intervention Study on Peripheral Circadian Clocks and Energy Metabolism
This human dietary intervention study with a cross-over design aims to investigate the effect of two different diurnal patterns of meal composition on peripheral circadian clocks and energy metabolism in healthy men.
- Trial name
- CLOCK (NCT02487576)
- Testing
- Carbohydrate-rich (HC), Fat-rich (HF)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Hypertension, Breakfast Skipper
Early Time-Restricted Eating for Cardiovascular Health
This study will examine whether eating earlier in the day within a consistent 8-hour eating window can improve heart and blood vessel health in older adults with high blood pressure who often skip breakfast.
- Trial name
- ALIGN (NCT07634926)
- Testing
- Early Time-Restricted Eating (eTRE)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Sleep Disorders, Circadian Rhythm, Depression
Melatonin as a Circadian Clock Regulator, Neuromodulator and Myelo-protector in Adjuvant Breast Cancer Chemotherapy
Breast cancer is the second most common cancer in the world, the most common in women, representing the leading cause of death in Brazil.
- Conditions
- Sleep Disorders, Circadian Rhythm, Depression, Genotoxicity, Pain
- Trial name
- NCT03205033
- Testing
- Melatonin 20 MG Oral Capsule
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obesity, Sarcopenia
Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes
The aim of TIMEDIAB is to demonstrate that early TRE (eTRE) combined to late (afternoon) exercise will outperform eTRE combined to morning exercise on muscle function as primary endpoint, and glucose homeostasis as secondary…
- Conditions
- Obesity, Sarcopenia, Post Menopause, Type 2 Diabetes
- Trial name
- TIMEDIAB (NCT07075133)
- Testing
- Antidiabetic diet (control), eTRE diet, Physical activity in the morning
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Metabolic Health
ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks
The purpose of this study is to determine the impact of real-world shiftwork on metabolic flexibility.
- Trial name
- COMET (NCT05820490)
- Testing
- Whole Room Calorimeter, Mixed-Meal Tolerance Test (MMTT), Core Body Temperature
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Healthy Aging
Vestibular Stimulation, Exercise and Light Optimization for Circadian Clock Enhancement (Velocce)
This study investigates the effects of remote interventions based on the exposure to one or more zeitgebers (i.e. adapted physical activity alone or combined with bright light exposure, or galvanic vestibular stimulation)…
- Trial name
- velocce (NCT05030389)
- Testing
- Adapted Physical Activity (APA), Bright Light Exposure (BLE), Galvanic Vestibular Stimulation (GVS)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université de Caen Normandie
Circadian Clock, Postoperative Cognitive Function
The Effect of Circadian Clock System on Perioperative Cognitive Function of Elderly Patients
Postoperative cognitive dysfunction (POCD) is a common postoperative complication in patients aged 65 and above. It refers to the cognitive function changes such as memory decline and attention loss after anesthesia and surgery.
- Conditions
- Circadian Clock, Postoperative Cognitive Function, General Anesthesia, Elderly Patients
- Trial name
- NCT04194866
- Testing
- receiving operation during the day or at night
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shengjing Hospital
Delayed Sleep Phase Syndrome
The Clinical Utility of Measuring the Circadian Clock in Treatment of Delayed Sleep-Wake Phase Disorder
This study will test whether measuring the circadian clock during treatment of delayed sleep-wake phase disorder results in greater improvements in sleep compared to estimating the circadian clock.
- Trial name
- NCT03715465
- Testing
- Melatonin 0.5 MG, Dim Light Melatonin Onset (salivary)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Diet, High-Fat, Circadian Rhythm
Food and Circadian Timing
The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to…
- Trial name
- FACT (NCT04743271)
- Testing
- High-Fat Diet, Low-Fat Diet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Circadian Rhythms
Biomarkers for Peripheral Circadian Clocks in Humans
The purpose of this project is to improve our understanding of peripheral circadian rhythms in humans. Circadian clocks are present in most tissues of the body with importance for optimal physiological function, health, and…
- Trial name
- NCT06296823
- Testing
- Simulated jetlag protocol
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Healthy, Healthy Aging
The Physiological Chronobiome Modified by Age, Sex and Under Evoked Conditions
The investigators piloted the characterization of the human chronobiome. Now, this line of research is extended to explore physiological chronobiome modulated by sex, age and under evoked conditions.
- Trial name
- NCT04225442
- Testing
- Fatty meal to challenge the physiological chronobiome in healthy young and old
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania