Clinical trials: Circadian Clocks
Cushing Syndrome, Adrenal Insufficiency
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous…
- Conditions
- Cushing Syndrome, Adrenal Insufficiency, Cushing Disease, Addison Disease
- Trial name
- CHROnOS (NCT04374721)
- Testing
- circadian gene expression evaluation
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Circadian Rhythm, Diabetes
Study of Circadian Clock Properties in Healthy Subjects, Obese and Type 2 Diabetic Patients.
The investigators aimed to characterize human circadian clockwork in healthy individuals in comparison to obese and type 2 diabetic subjects, employing the noninvasive experimental approach allowing the study of circadian profile…
- Conditions
- Circadian Rhythm, Diabetes, Obesity
- Trial name
- NCT02384148
- Testing
- Circadian rhythm measurement, Skin biopsy
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Pneumonia, Necrotizing Soft Tissue Infection
The Role of Circadian Clock Proteins in Innate and Adaptive Immunity
Our data suggest that modulating the characteristics of light carries the potential to modify the host response to injury and critical illness and thus, improve outcome.
- Conditions
- Pneumonia, Necrotizing Soft Tissue Infection, Intraabdominal Infections, Infection Joint
- Trial name
- NCT03482245
- Testing
- Blue Light
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Washington University School of Medicine
Type2 Diabetes Mellitus, Cardiovascular Diseases
Behavioral Chronotype: Impact on Sleep and Metabolism
The purpose of this study is to examine how the timing of eating changes how the body makes and uses energy (metabolism). This study will also examine if metabolism changes with age.
- Trial name
- NCT03647306
- Testing
- Early Total Caloric Intake, Late Total Caloric Intake, Extended Overnight Fast
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Circadian Rhythm
Pistacho and Sleep Quality
The goal of this study is to evaluate the effect of pistachio (Pistacia vera L.) consumption on plasma melatonin, antioxidant capacity, and circadian rhythms in overweight young adults.
- Trial name
- PistaSleep (NCT07651605)
- Testing
- Pistacho supplementation
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Queretaro
Ovulation, Female Fertility
FemiClock: Non-invasive Tools Development (Salivary and Hair Progesterone) for Ovulation Detection in Heathy Women With Regular Menstrual Cycles Without Contraception.
Currently, the gold standard to confirm ovulation is measuring LH and/or progesterone in blood. However, because confirmation requires a blood sample, this approach is not suitable for epidemiological studies evaluating the…
- Conditions
- Ovulation, Female Fertility, Menstrual Cycle
- Trial name
- FemiClock (NCT07687823)
- Testing
- Diagnostic Test: Non-invasive ovulation biomarker assessment - Smartwatch, Diagnostic Test: Non-invasive ovulation biomarker assessment - Questionnaires, Hormonal blood assessment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Bipolar Disorder, Mania
Clocks in Sync - Circadian Rhythm and Bipolar Mania
The sleep-wake cycle is severely disrupted during an episode of mania. Often mania is treated with medications that can come with significant side effects.
- Trial name
- CIS (NCT06504342)
- Testing
- Blue-blocking glasses, Time-restricted eating, Lightly tinted glasses
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Ottawa Hospital Research Institute
Chronodisruption, Shift Work Disorder
Impact of Shift Work on Glucose and Lipid Metabolism of Hospital Workers
The aim of the study is to evaluate circadian glucose, activity and dietary rhythms, as well as metabolic and cardiovascular risk associated with night shift work, sleep quality and well-being in a cohort of hospital staff…
- Conditions
- Chronodisruption, Shift Work Disorder, Glucose and Lipid Metabolism
- Trial name
- METASHIFT (NCT07426211)
- Where
- 2 sites in Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Olga Ramich (formerly Pivovarova)
Parkinson Disease, Sleep Disorders
Clock and Narcolepsy Genetic Variants and the Effects of Stalevo® (Levodopa/Carbidopa/Entacapone) on Sleep Disorders in Parkinson's Disease
The purpose of this study is to investigate the genetic variants of clock and narcolepsy genes that determine the therapeutic effects of Stalevo® on the quality of sleep in patients with Parkinson's Disease.
- Trial name
- NCT02452606
- Testing
- Stalevo®
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Postpartum Women, Diabetes, Gestational
Circadian Clocks and Eating Patterns (Cohort)
For women of reproductive age, the overall postpartum weight retention (weight gain between pregnancies) plays a significant role in long-term obesity.
- Trial name
- NCT04642534
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Health Behavior, Healthy
Effects of Fasting in the Bahá'í Faith
The aim of the study is to find out the effects a specific religious fast (i.e. Bahá'í fast) has on certain metabolic parameters, hydration, psyche and circadian clock.
- Trial name
- BF (NCT03443739)
- Testing
- Intermittent Fasting
- Where
- Germany
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Poor Sleep Quality, Gut Microbiome
The Impact of Overnight Active Temperature Regulation on the Gut Microbiome, Inflammation, and Circadian Rhythm.
This study examines whether two continuous weeks of overnight active temperature regulation (via the Eight Sleep Pod) use affects gut microbiome composition, inflammation, and the body's daily temperature and blood pressure…
- Conditions
- Poor Sleep Quality, Gut Microbiome, Gut Health, Inflammation
- Trial name
- NCT07848594
- Testing
- Overnight Active Temperature Regulation: Eight Sleep Pod System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eight Sleep Inc.
Postoperative Delirium, General Anesthesia
The Disorder of Circadian Clock Gene and Early Cognitive Dysfunction After General Anesthesia
Postoperative cognitive dysfunction (POCD) is a common postoperative complication in patients aged 65 and over, which refers to cognitive function changes such as memory decline and attention deficit after anesthesia and surgery.
- Conditions
- Postoperative Delirium, General Anesthesia, Exosomes, Clock Gene
- Trial name
- NCT04421872
- Testing
- receiving general anesthesia
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Cryopyrin Associated Periodic Syndrome, Familial Cold Urticaria
Circadian Rhythm Deregulation in Patients With CAPS
Circadian rhythms are characterized by the physiology's adaptation to the alternation of day and night, enabling to adapt to the environment. These rhythms are generated by a molecular clock within each cell.
- Conditions
- Cryopyrin Associated Periodic Syndrome, Familial Cold Urticaria, Muckle-Wells Syndrome, CINCA Syndrome
- Trial name
- ICARUS (NCT06544018)
- Testing
- Genetic analysis of NLRP3, Circadian rhythm measurement, Saliva sampling
- Where
- 6 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Circadian Rhythm Sleep Disorder, Circadian Rhythm Disorder Caused by Drug
Changes in Circadian Rhythm After Anaesthesia in Children
In this study the investigators will examine the effect of general anesthesia and surgery on sleep duration and sleep quality in children, using questionnaires and a sleep diary.
- Conditions
- Circadian Rhythm Sleep Disorder, Circadian Rhythm Disorder Caused by Drug, Circadian Rhythm Sleep Disorder, Jet Lag Type, Jet Lag
- Trial name
- CLOCKSkids (NCT05618405)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Asthma, Healthy
Air Pollution, Asthma and Circadian Clocks
Societies become increasingly urban - more than half the world's population now lives in cities. Urbanization elevates anthropogenic (man-made) exposure to air pollutants.
- Trial name
- APACC (NCT03406351)
- Testing
- Observational
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Circadian Dysregulation
Body Clocks - Coordination of Peripheral and Central Oscillators
The investigators are conducting an observational trial examining young women over the course of 28 days in which we are monitoring movement, sleep, heart rate, oxygen saturation, gut physiology, light, and menstrual cycle.
- Trial name
- NCT07459764
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University