Clinical trials: Circadian Misalignment
Mood Disorders, Major Depressive Diorder
Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers
This single-site prospective observational study aims to validate wearable-derived circadian and behavioral rhythm biomarkers using continuous core body temperature and raw accelerometry measurements and to explore longitudinal…
- Conditions
- Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder
- Trial name
- Calera (NCT07905378)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Healthy, Circadian Misalignment
Aerobic Exercise as a Countermeasure for Night Shift Associated Circadian Misalignment
This study plans to learn more about whether exercise can help protect the body from health problems that happen when a person's sleep and daily schedule are out of sync with their natural body clock (circadian rhythm).
- Trial name
- SHIFT-EX (NCT07668622)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Shift Work Schedule, Circadian Rhythm
Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance
The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction.
- Conditions
- Shift Work Schedule, Circadian Rhythm, Insulin Resistance, Circadian Misalignment
- Trial name
- NCT07494084
- Testing
- Metyrapone And Hydrocortisone, Dextrose, insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington State University
Ischemic Stroke, Acute, Sleep Disorders, Circadian Rhythm
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)
There is a lack of complex studies which could establish the association between genetic circadian factors with the features and short-term outcomes of ischemic stroke, as well as the effects of various auxiliary therapies for…
- Trial name
- NCT05247125
- Testing
- Blue light exposure + Melatonin treatment, Melatonin treatment, Blue light exposure
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Intestinal Failure, Osteoporosis
Effect of Nocturnal Parenteral Nutrition on Bone Turnover and Energy Metabolism
This clinical trial will study the effect of daytime versus nighttime parenteral nutrition on bone turnover, glucose variability, nitrogen balance, sleep and wake rhythm and peripheral clock gene expression in patients with…
- Conditions
- Intestinal Failure, Osteoporosis, Insulin Sensitivity
- Trial name
- NutriSync (NCT05868785)
- Testing
- Parenteral nutrition
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Circadian Rhythm Sleep Disorder, Jet Lag Type
Factors Associated With Infant Circadian Rhythm, Growth, and Temperament
The goal of this observational study is to learn about the role of modifiable factors affecting infant circadian rhythm so that recommendations can be made for better health outcomes for the mother and infant.
- Trial name
- NCT05700136
- Testing
- MOMENT
- Where
- 10 sites in Malaysia
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- UCSI University
Suicidal Ideation, Circadian Rhythm Disorders
Mind After Midnight
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts.
- Conditions
- Suicidal Ideation, Circadian Rhythm Disorders, Sleep Deprivation, Sleep Wake Disorders
- Trial name
- MaM (NCT07438912)
- Testing
- Sleep Pressure Manipulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Cushing Syndrome, Adrenal Insufficiency
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous…
- Conditions
- Cushing Syndrome, Adrenal Insufficiency, Cushing Disease, Addison Disease
- Trial name
- CHROnOS (NCT04374721)
- Testing
- circadian gene expression evaluation
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Depression; Major Depressive Disorder
Sleep/Wake Cycle and Depression: An Imaging and Treatment Study
16.2 million American adults are affected by depression each year. The investigators are studying the relationship between sleep/wake cycle and depression.
- Trial name
- NCT04350567
- Testing
- Sleep Deprivation
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Obesity
Circadian Misalignment and Energy Balance
Preliminary findings from the investigators' lab suggest that circadian misalignment, occurring when meals and sleep are mistimed from one another, alters resting state neuronal processing in areas relevant to food reward and…
- Trial name
- CM (NCT03663530)
- Testing
- Meal times
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Columbia University
Sleep, Circadian Rhythm
Sleep and Circadian Contributions to Nighttime Blood Pressure
Broadly, this study (SCN-BP) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.
- Conditions
- Sleep, Circadian Rhythm, Blood Pressure, Hypertension
- Trial name
- SCN-BP (NCT05656768)
- Testing
- Constant Routine Protocol
- Where
- United States
- Volunteers
- 1,427 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronobiology, Light
Teen Sleep and Light Study
Circadian clocks shift later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents.
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- NCT04921215
- Testing
- Morning bright light
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Critical Illness, Sleep Deprivation
Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle
More than 5 million patients are admitted to the intensive care unit every year in the United States; most of these patients experience profound sleep and circadian disruption.
- Conditions
- Critical Illness, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Unspecified
- Trial name
- ReAlign-ICU (NCT05551325)
- Testing
- Chronobundle - light, chronobundle - feeding, chronobundle - mobility
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Yale University
Sleep Deprivation
Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period
Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely…
- Trial name
- CRISP (NCT06070194)
- Testing
- Time restricted eating (TRE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Irritable Bowel Syndrome (IBS), Circadian Misalignment
A Randomized Crossover Trial of Bright Light Therapy in Irritable Bowel Syndrome
The purpose of this research study is to assess whether morning bright light therapy (BLT) using a wearable device called a Re-Timer could potentially improve Irritable Bowel Syndrome (IBS) symptoms and decrease intestinal…
- Trial name
- NCT06676488
- Testing
- Re-Timer glasses
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Cystic Fibrosis Related Diabetes, Hyperglycaemia
Investigating the Relationship Between Glycemia and Sleep in Adults With Cystic Fibrosis-Related Diabetes
The goal of this at-home, remote study is to understand the relationship between blood sugars and sleep in adults living with Cystic Fibrosis Related Diabetes (CFRD).
- Conditions
- Cystic Fibrosis Related Diabetes, Hyperglycaemia, Insomnia, Cardiometabolic Diseases
- Trial name
- NCT06700889
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Circadian Rhythm Sleep Disorder, Unspecified
Feasibility Pilot of Bright Light in the Intensive Care Unit
To evaluate the feasibility of providing daytime bright light in the ICU in a pilot randomized controlled trial.
- Trial name
- NCT03568045
- Testing
- standard light, 10,000 lux bright light, 4 hours, 10,000 lux bright light, 8 hours
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Healthy
Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance
The primary objectives of the proposed experimental and modeling efforts are to quantify the influences of acute sleep deprivation (short-term homeostatic), chronic sleep restriction (long-term homeostatic), circadian…
- Trial name
- NCT00438438
- Testing
- forced desynchrony protocol with sleep restriction
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital