Clinical trials: Circadian Rhythm
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Countermeasures to Circadian Misalignment
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
- Trial name
- C2CM (NCT04966351)
- Testing
- Time-restricted feeding, Circadian Misalignment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Gingivitis, Circadian Rhythm Disruption
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption
This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and…
- Conditions
- Gingivitis, Circadian Rhythm Disruption, Periodontal Inflammation, Circadian Rhythm Sleep Disorder, Shift Work Type
- Trial name
- Nursma-CIRC-HG (NCT07592052)
- Testing
- Standard Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Inonu University
Poor Sleep Quality, Gut Microbiome
The Impact of Overnight Active Temperature Regulation on the Gut Microbiome, Inflammation, and Circadian Rhythm.
This study examines whether two continuous weeks of overnight active temperature regulation (via the Eight Sleep Pod) use affects gut microbiome composition, inflammation, and the body's daily temperature and blood pressure…
- Conditions
- Poor Sleep Quality, Gut Microbiome, Gut Health, Inflammation
- Trial name
- NCT07848594
- Testing
- Overnight Active Temperature Regulation: Eight Sleep Pod System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eight Sleep Inc.
Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder
Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts
Emergency Medicine (EM) requires 24/7 staff coverage resulting in healthcare workers' circadian rhythm disruptions that impair clinical and cognitive performance, physical recovery, and contribute to burnout.
- Trial name
- NCT06100809
- Testing
- Personalized coaching, Nutrition handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Circadian Rhythm, Health Adult Subjects
Circadian Rhythm and Cardiovascular Recovery After Submaximal Exercise
This cross-sectional, observational, and analytical study aims to investigate the relationship between morningness-eveningness characteristics and cardiovascular recovery after a submaximal exercise test in healthy individuals…
- Trial name
- NCT07833956
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Sleep, Circadian Rhythm
HEARTBEAT SOUND FOR BREASTFEEDİNG DİFFİCULTİES: A RANDOMİZED CONTROLLED TRİAL
This randomized controlled trial aims to evaluate the effect of listening to a pre-recorded, standardized maternal heartbeat sound on perceived stress levels and breastfeeding self-efficacy in mothers experiencing early…
- Conditions
- Sleep, Circadian Rhythm, Pregnancy, Newborn
- Trial name
- NCT07881484
- Testing
- Standardized Maternal Heartbeat Sound Application
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hakan Avan
Diet, High-Fat, Circadian Rhythm
Food and Circadian Timing
The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to…
- Trial name
- FACT (NCT04743271)
- Testing
- High-Fat Diet, Low-Fat Diet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Circadian Rhythm, Energy Balance
Timing and Resistance Exercise: Impact on Eating and Metabolism
Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field.
- Conditions
- Circadian Rhythm, Energy Balance, Appetitive Behavior, Food Reward
- Trial name
- NCT06549322
- Testing
- The exercise in morning, The exercise in evening
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Opioid Use Disorder, Sleep
The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)
Opioid use disorder (OUD) is a chronic relapsing disorder and is well-known for its high-risk rate of overdoses and death. In OUD, sleep and circadian disruptions are highly prevalent, interfere with opioid maintenance treatment…
- Conditions
- Opioid Use Disorder, Sleep, Circadian Rhythms, fMRI Research
- Trial name
- NCT06832007
- Testing
- AYO light glasses (experimental), AYO light glasses (comparator)
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Circadian Rhythm Disruption, Healthy Volunteers
Cronobióticos Naturales
Brief Summary The goal of this clinical trial is to learn if a drink made from native berries of southern Chile can change the body's natural production of melatonin (a hormone that helps control sleep), sleep quality, and some…
- Trial name
- ChronoNaturals (NCT07848464)
- Testing
- Chronobiotic
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad San Sebastián
Hyperthermia, Chronic Primary Pain
Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain
This study, in a quasi-experimental matched two-group pre-post design, investigates the effect of serial water-filtered whole-body hyperthermia on circadian core body temperature, the somatosensory system (nociception) and the…
- Conditions
- Hyperthermia, Chronic Primary Pain, Widespread Pain, Muscular Disease
- Trial name
- HYPPRI-1 (NCT07101978)
- Testing
- serial whole body hyperthermia
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Sleep, Circadian Rhythm Disorders
Sleep Timing, Eating and Activity Measurement Study
There is strong reason to believe that sleep promotion during adolescence could yield long-term health rewards; the investigators' data show that, when they get more sleep, Morning Larks have impressively reduced intake of…
- Conditions
- Sleep, Circadian Rhythm Disorders, Dietary Habits
- Trial name
- STEAM (NCT04992611)
- Testing
- Sleep Extension (Early), Sleep Extension (Late)
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Shift Work Schedule, Circadian Rhythm
Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance
The purpose of this study is to examine the impact of timed cortisol release or differently timed cortisol rhythms on insulin resistance in both men and women undergoing sleep restriction.
- Conditions
- Shift Work Schedule, Circadian Rhythm, Insulin Resistance, Circadian Misalignment
- Trial name
- NCT07494084
- Testing
- Metyrapone And Hydrocortisone, Dextrose, insulin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington State University
Exercise, Physical Performance
Examination of Certain Blood Parameters Following Performance and Acute Exercise at Specific Times of the Day
This study aims to investigate whether the time of day at which acute exercise is performed influences physical performance and acute hormonal and biochemical responses in healthy young male soccer players.
- Conditions
- Exercise, Physical Performance, Circadian Rhythm
- Trial name
- Acute & Blood (NCT07825740)
- Testing
- Standardized Acute Exercise Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Firat University
Chronobiology, Light
Light Timing Study
Chronic circadian misalignment and sleep restriction peak during late adolescence, and are associated with morning daytime sleepiness, poor academic performance, conduct problems, depressed mood, suicidal ideation, substance use…
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- ALT (NCT04753190)
- Testing
- Baseline Sleep Satiation and Phase Stabilization, Gradually Shifted Sleep
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Continuous Glucose Monitoring, Diabetes, Gestational
Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY
The goal of this clinical trial is to examine how daily behavioral patterns in early pregnancy, including sleep, physical activity, and meal timing, influence continuous glucose dynamics and subsequent risk of gestational…
- Conditions
- Continuous Glucose Monitoring, Diabetes, Gestational, Diet During Pregnancy, Meal Time
- Trial name
- NCT07534670
- Testing
- Continuous glucose monitor (CGM), Wrist actigraphy device, AI-based dietary and meal timing logging mobile application
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Circadian Rhythm, Pupillometry
Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep
The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or illnesses.
- Conditions
- Circadian Rhythm, Pupillometry, Sleep
- Trial name
- SCOPE (NCT07753889)
- Testing
- Ocular light exposure from portable light box
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elizabeth B Klerman MD PhD
Sleep, Circadian Rhythm
Dexmedetomidine Trial for Effects on Rhythms, Sleep Architecture, and Biomarker Dynamics in Older Adults
The DEXTER study is a cross-over, double-blind, placebo-controlled pilot research study led by Dr. Peng Li. The goal of this project is to evaluate the safety, feasibility, and biological effects of a single dose of sublingual…
- Trial name
- DEXTER (NCT07800910)
- Testing
- Dexmedetomidine sublingual film
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Shift Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder
Recovery and Early Sleep Tracking Using the SuperPatch REM Patch
A Phase 1 Feasibility Study of the SuperPatch REM Patch for Post-Night-Shift Sleep Recovery in NHS Doctors
- Conditions
- Shift Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Shift Work Sleep Disorders
- Trial name
- REST (NCT07785960)
- Testing
- SuperPatch REM Patch
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SuperPatch Limited LLC
Social Jet Lag, Sleep Disturbance
Self-Acupressure and Social Jet Lag in Female Health Sciences Students
This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on social jet lag, sleep patterns, and sleep quality in female health sciences students.
- Conditions
- Social Jet Lag, Sleep Disturbance, Sleep Quality, Circadian Rhythm Disruption
- Trial name
- NCT07410936
- Testing
- Self-Acupressure Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University