Clinical trials: Circadian Rhythms
Depression, Anxiety
Simulated Dawn Med Students
Medical students score higher than the general population on measures of depression, anxiety, fatigue, poor sleep and sleepiness. Data suggest that disparages in circadian phase might contribute to these problems.
- Conditions
- Depression, Anxiety, Fatigue, Sleepiness
- Trial name
- NCT02088593
- Testing
- Simulated Dawn Light Box, Sleep Hygiene instructions
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Hypertension, Cardiovascular Risk Factor
Sleep and Circadian Mechanisms of Non-dipping Blood Pressure
This study will be the first to distinguish the relative contributions of sleep, circadian and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the groundwork for optimizing therapies dependent on…
- Trial name
- NCT03558893
- Testing
- Forced Desynchrony
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis, Intermittent Fasting
Intermittent Fasting and Mediterranean Diet in Patient With Multiple Sclerosis
When the literature was reviewed, there is no study in which the effects of intermittent fasting and Mediterranean diet on quality of life, sleep, circadian rhythm and appetite hormones leptin and ghrelin levels in MS patients…
- Trial name
- NCT06546033
- Testing
- application of different types of diet
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Nigde Omer Halisdemir University
Circadian Rhythm, Blood Pressure
Circadian Mechanisms Underlying Non-Dipping Blood Pressure in Blacks
This study seeks to examine central and peripheral circadian mechanisms in Blacks with appropriately dipping systolic blood pressure (blood pressure that dips by at least 10%) compared with non-dipping systolic blood pressure…
- Trial name
- NCT03934255
- Testing
- Constant Routine Protocol
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Circadian Rhythms, Time Perception
The Effect of a Continuous 1-Hour Time Delay on Circadian Rhythms
The purpose of this study is to investigate whether the experience of a daily time delay can affect our internal circadian rhythm.
- Conditions
- Circadian Rhythms, Time Perception, Sleep
- Trial name
- NCT07317349
- Testing
- Fixed daily routine, Daily time delay
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Critical Illness, Sleep Deprivation
Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients
The goal of this project is to determine whether the sleep and circadian rhythms of critically ill patients undergoing mechanical ventilation can be improved through practical strategies that can be employed at the bedside.
- Conditions
- Critical Illness, Sleep Deprivation, Respiratory Failure, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01284140
- Testing
- Sleep and circadian rhythm promotion, Usual care
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Brian Gehlbach
Postoperative Complications
Effect of Daytime Variation on PPCs in Lung Resection Surgery.
The aim of this retrospective study was to evaluate the association between daytime variation in surgery start time and the occurrence of postoperative pulmonary complications (PPCs) and postoperative adverse events (AEs) in…
- Trial name
- NCT05582291
- Where
- China
- Volunteers
- 1,138 people
- Sponsor
- Qianfoshan Hospital
Sleep, Circadian Rhythm
Sleep and Circadian Contributions to Nighttime Blood Pressure
Broadly, this study (SCN-BP) seeks to examine sleep and circadian factors that contribute to blood pressure levels at night.
- Conditions
- Sleep, Circadian Rhythm, Blood Pressure, Hypertension
- Trial name
- SCN-BP (NCT05656768)
- Testing
- Constant Routine Protocol
- Where
- United States
- Volunteers
- 1,427 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Binge-Eating Disorder
Use of Circadian Reset Technology to Alter REM Sleep and Appetitive Control in Patients With Binge Eating Disorder
This project includes testing circadian reset technology (CRT) on frequency of binge eating in a sample of 40 individuals with binge eating disorder. Participants will be randomized to one of two groups.
- Trial name
- NCT06858774
- Testing
- Circadian Reset Technology, VR Headset
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lightning Strategies on Health, Circadian Rhythms Photoentrainment
Population Based Lighting Study on Older Adults
The ENLIGHTENme project aims at collecting evidence about the impact of outdoor and indoor lighting on human health and wellbeing through the development and testing of innovative solutions and policies that will also counteract…
- Conditions
- Lightning Strategies on Health, Circadian Rhythms Photoentrainment, Photoentrainment and Sleep, DLMO
- Trial name
- ENLIGHTENme (NCT05676086)
- Testing
- indoor light intervention, no indoor light
- Where
- Italy
- Volunteers
- 191 people
- Sponsor
- Azienda Usl di Bologna
Vaccine Response, Sleep
Melatonin and Vaccine Response, Immunity, and Chronobiology Study
This study will evaluate the impact of sleep, circadian health and melatonin on flu vaccine immunogenicity.
- Conditions
- Vaccine Response, Sleep, Circadian Rhythm Disorders
- Trial name
- MAVRICS (NCT04953754)
- Testing
- Melatonin, Phillips Actiwatch Spectrum Plus
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Chemotherapy-Induced Amenorrhea
Metabolism, Circadian Rhythms and Ovarian Function
Chemotherapy for cancer, due to its gonadotoxicity, can lead to impaired female fertility, resulting in the occurrence of transient or prolonged chemo-induced amenorrhea (CIA).
- Trial name
- METAB-OV (NCT05007834)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Sleep Disorders, Circadian Rhythm
Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers
EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular…
- Trial name
- NCT02108353
- Testing
- Melatonin 2mg
- Where
- 3 sites in Germany, Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Type 1 Diabetes, Overweight
Effect of Circadian Rhythm and Physical Exercise in Overweight Type 1 Diabetes Patients
Cardiometabolic risk in patients with abdominal obesity and type 1 diabetes can be moderated by life style modifications. There is an intimate link between gene regulation and circadian rhythm in mediating response to exercise in…
- Trial name
- NCT05277532
- Testing
- High intensity interval training (HIIT)
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Colorectal Neoplasm, Circadian Rhythm Sleep Disorder
Sleep and Survival in Colorectal Cancer
Objective The objective of the current trial is to investigate the effect of perioperative sleep and circadian rhythm on the natural course of survival among patient diagnosed with colorectal cancer.
- Conditions
- Colorectal Neoplasm, Circadian Rhythm Sleep Disorder, Depression, Quality of Life
- Trial name
- NCT03254836
- Testing
- Standard of care
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Zealand University Hospital
Circadian Rhythm Disorders, Sepsis
Functionality of Endogenous Biological Clock in Sepsis
The aim of the current study is to demonstrate dysregulation of immune system΄s circadian rhythms as a consequence of sepsis, as well as marked malfunction of the central circadian clock in comparison with patients without sepsis…
- Trial name
- NCT04063332
- Where
- 2 sites in Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Behavioral Responses to Bright Light Therapy in Elders
Effect of Bright Light Treatment On Elders In a Long Term Care Environment
The investigators hypothesize that significant exposure to artificial morning bright light (approximately 200 lux of primarily blue light at eye level for thirty minutes daily) as compared to sham bright red light (placebo) will…
- Trial name
- BrightLights (NCT01042587)
- Testing
- exposure to bright light, low luminosity red light
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pregnancy, Prolonged
Effects of Sleep, Fatigue, and Timing of Post-dates Inductions Among Nulliparas
This randomized clinical trial will examine if there are any differences between post-dates inductions (inductions after 40 weeks of pregnancy) begun in the morning compared to the evening for first-time mothers.
- Trial name
- NCT01542151
- Testing
- Time of labor induction
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Francisco
PreDiabetes, Circadian Dysregulation
Morning Light Treatment to Improve Glucose Metabolism
The primary purpose of this pilot study is to test a novel head worn light device (Re-Timer®) as an intervention to improve glucose metabolism in people with prediabetes.
- Trial name
- ML (NCT03188263)
- Testing
- Bright Light, Dim Light
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Circadian Rhythm Sleep Disorder
Circadian Rhythms and Sleep in Familial DSPS and ASPS
The purpose of this study is to determine the properties of circadian rhythms and sleep propensity in familial advanced and delayed sleep phase syndrome (DSPS).
- Trial name
- NCT00246454
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Northwestern University