Clinical trials: Circulating Tumor Cell;
Cancer
AssesSment of Early-deteCtion basEd oN liquiD Biopsy in PANCEATIC Cancer (ASCEND-PANCREATIC)
ASCEND-PANCREATIC is a prospective, multi-omics, observational study aimed at early detecting pancreatic cancer by combined assays for biomarkers of cfDNA methylation, circulating tumor DNA (ctDNA) mutation, serum protein markers…
- Trial name
- NCT05556603
- Where
- 3 sites in China
- Volunteers
- 7,062 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Early Detection of Cancer, Cancer
REFLECTION: A Clinical Practice Learning Program for Galleri®
REFLECTION is a multi-center, prospective, non-interventional, cohort study that will enroll approximately 14,000 individuals who have opted to be screened with Galleri®, a blood-based, multi-cancer early detection (MCED) test in…
- Trial name
- NCT05205967
- Testing
- MCED, SOC
- Where
- 16 sites in United States
- Volunteers
- 14,633 people, healthy volunteers welcome
- Sponsor
- GRAIL, Inc.
Oropharynx Cancer, Oropharynx Cancer, Metastatic
Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?
This study investigates if longitudinal analyses of cell-free HPV-DNA in blood samples can be utilized to detect recurrence in patients diagnosed and treated for HPV-positive oropharyngeal squamous cell carcinoma.
- Conditions
- Oropharynx Cancer, Oropharynx Cancer, Metastatic, Oropharynx Cancer, Recurrent, Oropharyngeal Carcinoma
- Trial name
- NCT06592716
- Testing
- Liquid biopsy
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Cancer
Studying Blood Samples in Women With Breast Cancer or a History of Breast Cancer
RATIONALE: Studying samples of blood in the laboratory from patients with current or previous cancer may help doctors learn more about biomarkers related to cancer.
- Trial name
- NCT00898703
- Testing
- flow cytometry, immunoenzyme technique, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
LungLB in Subjects Presenting With Indeterminate Pulmonary Nodules
Correlate performance of LungLB Test with outcome of a scheduled biopsy.
- Trial name
- NCT05171491
- Where
- 12 sites in United States
- Volunteers
- 425 people
- Sponsor
- LungLife AI
Metastatic Breast Cancer
Characterization of Circulating Tumor Cells (CTC) From Patients With Metastatic Breast Cancer Using the CTC-Endocrine Therapy Index
Utilizing CellSearch® technology, the ability to both enumerate and reliably and reproducibly characterize circulating tumor cells (CTC) for tumor markers that predict endocrine sensitivity (estrogen receptor [ER] and Bcl-2) and…
- Trial name
- COMETI P2 (NCT01701050)
- Testing
- Blood collection
- Where
- 20 sites in United States, Canada
- Volunteers
- 121 people
- Sponsor
- Janssen Diagnostics, LLC
Leiomyosarcoma, Pleomorphic Liposarcoma
Detection of Circulating Tumor Cells in Patients With Sarcomas
The sarcomas represent 1% of all cancers in adults, 8% in adolescents and young people, and 10% in children. Even though it is a rare cancer, it contributes to a significant loss of years of life in comparison with other types of…
- Conditions
- Leiomyosarcoma, Pleomorphic Liposarcoma, Synovial Sarcoma, Liposarcoma
- Trial name
- CTCS (NCT02983539)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- AC Camargo Cancer Center
Refractory Colorectal Carcinoma, Stage III Colorectal Cancer AJCC v8
Circulating Cell-Free Tumor DNA Testing in Guiding Treatment for Patients With Advanced or Metastatic Colorectal Cancer
This phase II trial studies circulating cell-free tumor DNA testing to guide treatment with regorafenib or TAS-102 in patients with colorectal cancer that has spread to other areas of the body.
- Conditions
- Refractory Colorectal Carcinoma, Stage III Colorectal Cancer AJCC v8, Stage IIIA Colorectal Cancer AJCC v8, Stage IIIB Colorectal Cancer AJCC v8
- Trial name
- NCT03844620
- Testing
- Best Practice, Laboratory Procedure, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Renal Cell Carcinoma, Advanced Kidney Cancer
Circulating and Urinary Exosomal miRNA in Advanced Kidney Cancer (EXO-RENAL1)
This prospective cohort study will investigate whether changes in circulating and urinary exosomal biomarkers (target exosomal miRNA) are associated with response to systemic treatment in patients with advanced renal cell…
- Trial name
- EXO-RENAL1 (NCT07406646)
- Testing
- Blood and Urine Sampling for Exosomal miRNA Analysis
- Where
- Slovenia
- Volunteers
- 91 people
- Sponsor
- Institute of Oncology Ljubljana
Circulating Tumor Cell, Hepatocellular Carcinoma
Effects of TIVA Versus Inhalational Anaesthesia on Circulating Tumour Cells in Hepatocellular Carcinoma Patients
More than 80% of patients with cancer will be exposed to anaesthesia at some point in their treatment. There is increasing evidence that perioperative events, including the type of anaesthesia drugs utilised, have an impact on…
- Trial name
- NCT04601961
- Testing
- Propofol, Sevoflurane
- Where
- China
- Volunteers
- 220 people
- Sponsor
- The University of Hong Kong
Hepatocellular Carcinoma
HCC Screening Using DNA Methylation Changes in ctDNA
Hepatocellular Carcinoma (HCC) is the fifth most common cancer world-wide. It is particularly prevalent in Asia, and its occurrence is highest in areas where hepatitis B is prevalent, indicating a possible causal relationship.
- Trial name
- NCT03483922
- Testing
- ctDNA methylation in and it's Correlation wth Development and prediction of HCC
- Where
- Bangladesh
- Volunteers
- 403 people
- Sponsor
- HKGepitherapeutics
Esophageal Cancer, Esophageal Adenocarcinoma
Preoperative Image-guided Identification of Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer
Rationale: For locally advanced esophageal cancer the standard treatment consists of 5 weeks of neoadjuvant chemoradiotherapy (nCRT) followed by surgery.
- Conditions
- Esophageal Cancer, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms
- Trial name
- PRIDE (NCT03474341)
- Testing
- MRI, PET-CT, Endoscopy
- Where
- 4 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Carcinoma, Non-small-cell Lung Cancer
Dynamic Changes of Circulating Tumor DNA in Surgical Lung Cancer Patients
Previous study showed circulating tumor DNA levels reflect the total systemic tumor burden. Circulating tumor DNA levels should decrease after complete surgery and could be increase as tumor recurrence.
- Conditions
- Carcinoma, Non-small-cell Lung Cancer, Lung Neoplasms
- Trial name
- NCT02965391
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University People's Hospital
Circulating Neoplastic Cells, Adverse Effect of Radiation Therapy
Circulating Tumor Cell Genome in Peripheral Blood From Hepatocellular Carcinoma Patients Under Radiotherapy
Hepatocellular carcinoma (HCC) is a common cause of cancer mortality in Asia. Most patients were presented with advanced disease.
- Conditions
- Circulating Neoplastic Cells, Adverse Effect of Radiation Therapy, Fatal Outcome
- Trial name
- NCT02066974
- Testing
- hepatoma requiring radiotherapy
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- China Medical University, China
HPV-positive Oropharyngeal Squamous Cell Carcinoma
The Sinai Robotic Surgery Trial in HPV-related Oropharyngeal Squamous Cell Carcinoma (SIRS 2.0 Trial)
The purpose of this study is to determine whether treatment of HPV-related oropharyngeal squamous cell carcinoma in patients with undetectable postoperative HPV circulating tumor DNA (cfHPVDNA) with transoral robotic surgery…
- Trial name
- NCT05419089
- Testing
- Robotic surgery
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Small Cell Lung Cancer, Large Cell Neuroendocrine (NE) Tumors
Genomic and Methylation Markers in SCLC and LCNEC for Chemo-Immunotherapy Resistance Prediction (STRATUS)
The goal of this observational study is to understand how genomic and epigenetic factors contribute to resistance against chemo-immunotherapy in adults diagnosed with extensive-stage small cell lung cancer (ES-SCLC) or metastatic…
- Conditions
- Small Cell Lung Cancer, Large Cell Neuroendocrine (NE) Tumors, Treatment Failure, Biomarkers / Blood
- Trial name
- STRATUS (NCT06717243)
- Testing
- Carboplatin/Cisplatin -Etoposide - Atezolizumab
- Where
- 2 sites in United States, Greece
- Volunteers
- 111 people
- Sponsor
- Oncology Center of Biochemical Education And Research
Advanced Non Small Cell Lung Cancer, Uterine Cancer
Clinical Study of PD-1 Monoclonal Antibody SHR-1210 and Apatinib in Advanced NSCLC, Soft Tissue Sarcoma, and Uterine Cancer
In this one-arm study, histologically or cytologically confirmed advanced NSCLC, uterine malignancies, and soft tissue sarcoma will be enrolled to investigate the efficacy and safety of PD-1 monoclonal antibody SHR-1210 and…
- Conditions
- Advanced Non Small Cell Lung Cancer, Uterine Cancer, Soft Tissue Sarcoma
- Trial name
- NCT04239443
- Testing
- PD-1 inhibitor, Apatinib
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hunan Cancer Hospital
Lung Cancer
Developing Novel Circulating Epigenetic Biomarkers for Early Detection of Lung Cancer
The investigators aim to identify novel circulating methylated biomarkers for early lung cancer detection as well as to develop new technologies that are clinically applicable with high sensitivity and specificity.
- Trial name
- NCT04814407
- Testing
- Blood-derived DNA methylation detection
- Where
- Taiwan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pancreatic Cancer
Acquisition of Portal Venous CTCs and Exosomes From Patients With Pancreatic Cancer by EUS
The investigators are going to explore the diagnostic and prognostic value of circulating tumor cells and exosomes extracted from the portal venous blood obtained with endoscopic ultrasound in pancreatic cancer patients.
- Trial name
- CTCs (NCT03821909)
- Testing
- Endoscopic ultrasound-guided protal venous blood sampling
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ying Lv
Breast Cancer
Randomized Trial With Trastuzumab Versus Observation in Breast Cancer Patients
Epithelial tumor cells can be detected in the bone marrow and/or the peripheral blood [disseminated and circulating tumor cells, (DTCs) and (CTCs) respectively] of otherwise metastases-free patients with early breast cancer.
- Trial name
- NCT00429247
- Testing
- Trastuzumab
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- University Hospital of Crete