Clinical trials: Circulating Tumor Cell
Gastric Adenocarcinoma
Characterisation of the Intratumoral Microbiome in Gastric Adenocarcinoma: to a Personalised Medicine
In this study, gastric tumours and adjacent healthy mucosa will be collected from gastric cancer patients operated on for curative purposes.
- Trial name
- MICROGAS (NCT05800236)
- Testing
- Gastrectomy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Early Diagnosis, Diagnostic Techniques and Procedures
Culture System for Isolating Circulating Tumor cells_2
This culture system utilizes the special affinity difference of biomedical material coating for different cells to achieve the effect of isolating tumor cells from the blood sample.
- Trial name
- NCT04125667
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- National Taiwan University Hospital
Carcinoma, Non-small-cell Lung Cancer
Early Diagnosis of Small Pulmonary Nodules by Multi-omics Sequencing
Analyse immune repertoire and genetic mutations of benign and malignant pulmonary nodule，and evaluate peripheral blood detection for identifying nature of pulmonary nodule.
- Conditions
- Carcinoma, Non-small-cell Lung Cancer, Lung Neoplasm
- Trial name
- NCT03320044
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Metastatic Breast Cancer
Characterization of Circulating Tumor Cells (CTC) From Patients With Metastatic Breast Cancer Using the CTC-Endocrine Therapy Index
Utilizing CellSearch® technology, the ability to both enumerate and reliably and reproducibly characterize circulating tumor cells (CTC) for tumor markers that predict endocrine sensitivity (estrogen receptor [ER] and Bcl-2) and…
- Trial name
- COMETI P2 (NCT01701050)
- Testing
- Blood collection
- Where
- 20 sites in United States, Canada
- Volunteers
- 121 people
- Sponsor
- Janssen Diagnostics, LLC
Metastatic Breast Cancer
Plasma Circulating Tumor DNA Analyses in ER+ Metastatic Breast Cancer
The purpose of this study is to evaluate whether increased mutant ESR1 allele fraction in plasma ctDNA 3-6 weeks after initiating salvage endocrine therapy is predictive of progression free survival in patients with ER+…
- Trial name
- NCT03161834
- Testing
- Observational
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
HER2-negative and Hormone-receptor Positive Metastatic Breast Cancer, HER2-negative Circulating Tumor Cells
DETECT IV - A Study in Patients With HER2-negative Metastatic Breast Cancer and Persisting HER2-negative Circulating Tumor Cells (CTCs).
Several studies have indicated that determining prevalence and number of circulating tumor cells (CTCs) at various time points during treatment may be an effective tool for assessing treatment efficacy in metastatic breast cancer…
- Conditions
- HER2-negative and Hormone-receptor Positive Metastatic Breast Cancer, HER2-negative Circulating Tumor Cells, Postmenopausal Female Patients
- Trial name
- NCT02035813
- Testing
- Ribociclib, Eribulin
- Where
- Germany
- Volunteers
- 116 people
- Sponsor
- Prof. Wolfgang Janni
Diffuse Large B Cell Lymphoma
Molecular Monitoring With Circulating Tumor DNA and Nivolumab Maintenance
Patients suffering from diffuse large B-cell lymphoma (DLBCL) who relapse within 12 months of chemotherapy usually undergo salvage therapies, followed by autologous transplant with a low success rate.
- Trial name
- NCT03311958
- Testing
- Nivolumab, IV, 240 mg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Fox Chase Cancer Center
Breast Cancer, Leptomeningeal Metastasis
Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer
This study will prospectively enroll 36 evaluable subjects with breast cancer who are undergoing workup for clinical suspicion of leptomeningeal metastasis (LM).
- Trial name
- NCT02948751
- Testing
- OncoCEE
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Columbia University
Metastatic Colorectal Cancer
Circulating Tumor Cells and Neutrophils Count for Colorectal Metastatic Cancer
Colorectal cancer represents a major public health problem in France because of its high incidence and severe prognosis. Early stages of the disease are well know and have justified the establishment of a mass screening strategy.
- Trial name
- NCT05793775
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Brain Tumor
Non-invasive Brain Tumor Molecular Diagnostics and Monitoring
This prospective multicenter study aims to enroll GBM patients who will undergo repeated assessments (preoperatively and 3 months post-surgery) to detect circulating tumor cells and analyze the transcriptomic profiles of EVs in…
- Trial name
- NCT06501521
- Testing
- Diagnostic test
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Melanoma
Use of Exome Sequence Analysis and Circulating Tumour in Assessing Tumour Heterogeneity in BRAF Mutant Melanoma
Despite recent advances in cancer treatment, little impact has been made on curing as opposed to controlling cancers over the last several decades.
- Trial name
- NCT02251314
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Hepatocellular Carcinoma
Immune Cells as a New Biomarker of Response in Patients Treated by Immunotherapy for Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Treatment options for advanced HCC remain very limited.
- Trial name
- IMMUNOCELL (NCT05044676)
- Testing
- patients with hepatocellular carcinoma
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer
Circulating Cancer Cells/Macrophage HYbrid Cells in Patients With Breast Cancer.
Pilot, prospective, monocentric study aimed at evaluating the rate of patients with circulating cancer cell/macrophage hybrid cells in the peripheral blood.
- Trial name
- CARMMYC (NCT04818125)
- Testing
- Patients with breast cancer (stage I, II III or IV)
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Institut Claudius Regaud
Urothelial Carcinoma
Liquid Biospy for Urinary Cancers
The project aims to characterize the prognostic role of CTCs in Bladder cancer patients, with the specific aims to better stratify patients with non-muscle invasive bladder cancer at the first transurethral resection of tumor and…
- Trial name
- CIRCE (NCT06116396)
- Testing
- Genetic analysis on isolated cells
- Where
- Italy
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Breast Cancer Female
Analysis of Circulating Epithelial Tumor Cells in Peripheral Blood in Patients With Primary Non-metastatic Breast Cancer Under Adjuvant Radiotherapy
The aim of this study was to investigate the systemic effect of radiotherapy on patients with primary non-metastatic breast cancer using CETC and to analyze possible changes in CETC quantity under adjuvant radiotherapy.
- Trial name
- NCT03935802
- Testing
- radiation
- Where
- Germany
- Volunteers
- 161 people
- Sponsor
- University of Jena
Lung Cancer
Circulating and Imaging Biomarkers to Improve Lung Cancer Management and Early Detection
Validation of biomolecular markers in the circulation and radiomic features are the focus of this project.The aim is to assess the role of molecular and cellular biomarkers (exosomes antigens, Circulating tumor cells - CTCs…
- Trial name
- SMAC-2 (NCT04315753)
- Testing
- LDCT (Low Dose CT)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Metastatic Breast Cancer
ACT-MBC: A Study of Circulating Tumor Cells (CTCs) in Metastatic Breast Cancer (MBC)
ACT-MBC prospectively assesses the impact of CTCs on treatment decisions, response assessment and prognosis in MBC patients.
- Trial name
- ACT-MBC (NCT05662345)
- Testing
- CellSearch Circulating Tumor Cells
- Where
- 4 sites in United States
- Volunteers
- 65 people
- Sponsor
- Menarini Silicon Biosystems, INC
Pancreatic Adenocarcinoma
PDAC Peripheral and Portal Vein Sampling
This is a research study in which bio-specimens (whole blood, plasma and serum from peripheral circulation and portal vein) will be collected from patients with pancreatic adenocarcinoma for translational research.
- Trial name
- NCT04289961
- Testing
- Portal vein sampling
- Where
- 2 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- The Christie NHS Foundation Trust
Breast Neoplasms, Circulating Tumor Cells
Detection of Circulating Tumor Cells in Breast Cancer Patients Using a Novel Microfluidic and Raman Spectrum Device
Circulating tumor cells (CTCs) in peripheral blood originate from breast cancer (primary and metastatic lesions) shedding. Utilization of CTCs as novel and noninvasive tests for diagnosis confirmation, therapy selection, and…
- Trial name
- NCT04239105
- Testing
- Microfluidic and Raman spectrum
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Hepatocellular Carcinoma
Frequency of Circulating Tumor Cells (CTCs) and Amount of Cell-free DNA (cfDNA) in Cirrhotic Patients With Hepatocellular Carcinoma (HCC)
All consecutive patients with liver cirrhosis, with clinical and imaging features suggestive of Hepatocellular Carcinoma (HCC) attending the Department of Hepatology, Institute of Liver and Biliary Sciences (ILBS) from February…
- Trial name
- NCT03162198
- Testing
- Cirrhosis with HCC, Cirrhosis without HCC
- Where
- India
- Volunteers
- 53 people
- Sponsor
- Institute of Liver and Biliary Sciences, India