Clinical trials: Circulatory; Change
Obesity, Diabetes
Effect of Pomegranate Extract Intake on Body Composition and Blood Pressure.
Pomegranate has gained widespread popularity since the health effects of the whole fruit, as well as its juices and extracts, have been studied in relation to a variety of chronic conditions such as hypertension, diabetes…
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT02017132
- Testing
- Pomegranate extract
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Stroke
The Changes of Masticatory / Swallowing Functions and Oropharyngeal Muscle Mass on Sonography After Comprehensive Swallowing Training and Tongue - Pressure Resistance Training in Stroke Patients With Dysphagia
The aims of this study are: 1. Comparing the ultrasound imaging performance of swallowing and chewing function, tongue pressure and oropharyngeal muscle thickness in stroke patients with different levels of swallowing function 2.
- Trial name
- NCT06269718
- Testing
- swallowing therapy, IOPI therapy
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Congenital Disorder, Heart Diseases
Supported Exercise Programme for Adults With Congenital Heart Disease
This study will evaluate if the introduction of a supported exercise programme can improve physical and psychological well-being for adults with congenital heart disease.
- Trial name
- SEACHange (NCT03262168)
- Testing
- Exercise Programme
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Sickle Cell Anemia
Longitudinal Changes in Exercise Capacity in Children and Young Adults With Sickle Cell Anemia
The purpose of this study is to use comprehensive exercise testing to examine longitudinal changes in exercise capacity over a 2 year period in children and young adults with sickle cell anemia.
- Trial name
- NCT01558076
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Deep Vein Thrombosis, Deep Venous Insufficiency
A Study of Modified Limb Braking and Early Bed Mobility Strategies After Femoral Venipuncture Intervention
The goal of this clinical trial is to compare in describe participant population health conditions. The main questions it aims to answer are: To obtain the limb movement and bed mobility limits after femoral venipuncture, in…
- Trial name
- NCT05900622
- Testing
- Reduced postoperative braking and bed rest time.Lower extremity on the puncture side with a 2-hour brake+Get out of bed after 4 hours, Significantly reduce postoperative braking and bed rest time.No braking of the lower limb on the side of the puncture+Get out of bed after 2 hours
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tong Zhu
Cardiovascular Diseases
HOPE-CVD-Virtual: A Virtual Trial to Evaluate the Primary Prevention of CVD
This 4-arm (1:1:1:1) single-blind randomized controlled trial. Arm 1 will communicate risk and encourage behavioral change that mirrors the standard pathway for health screening in Singapore.
- Trial name
- NCT05827861
- Testing
- HeartAge, HOPE-CVD Mobile App, Genetic Risk Score
- Where
- Singapore
- Volunteers
- 1,121 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cardiovascular Diseases
Effect of a PPAR-Alpha Agonist on the Age Related Changes in Myocardial Metabolism and Mechanical Function
The purpose of this study is to determine if treatment with a drug called fenofibrate, which is a PPAR-alpha agonist and controls how the heart metabolizes fats, will reverse the age-related decline in cardiac fat metabolism and…
- Trial name
- PPAR (NCT00627653)
- Testing
- fenofibrate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Hepatic Flow Changes
Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects.
Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%.
- Trial name
- PORTEAU (NCT03589261)
- Testing
- MRI (magnetic resonance imaging)
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fabry Disease
Pre-Clinical White Matter Changes and Associated Connectivity Effects in Fabry Disease
The purpose of this research project is: to use an advanced quantitative MRI technique (FBFI) to detect and quantify brain lesion in patients with FD to use fMRI to identify altered brain function to use FBFI and fMRI together to…
- Trial name
- NCT03678324
- Testing
- Functional MRI and fast bound-pool fraction imaging
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Utah
Prehypertension
Behaviour Change Wheel Intervention to Promote Healthy Behaviors in Adults With Prehypertension
Prehypertension is an important risk factor for developing hypertension and cardiovascular disease. Promoting healthy lifestyle behaviors among young and middle-aged adults with prehypertension may help reduce the risk of…
- Trial name
- NCT07880990
- Testing
- Behaviour Change Wheel-Based Health-Promoting Behavior Intervention, Routine Health Education
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Diabetes
Changes of Endothelial Function Before and After DSA in Patients With Diabetes
Endothelial dysfunction is the early step of atherosclerosis. Therefore, the investigators hypothesize that digital subtraction angiography (DSA) can damage endothelial function.
- Trial name
- NCT01556984
- Testing
- DSA assay
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Healthy
Local Changes of Skin Characteristics After an Application of a Topical Product With a Warming or Cooling Effect
The use of topical over-the-counter (OTC) products with a warming or cooling effect is widespread in the fields of sport, physiotherapy and in private households.
- Trial name
- SRPT (NCT03016221)
- Testing
- Axanova hot gel, Axanova activ gel, Perskindol Dolo Gel
- Where
- Switzerland
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Heart Failure, Sarcopenia
Mechanism of Sarcopenia in Heart Failure
The aim of the study is to provide information on the interaction between socioeconomic factors, daily physical activity, nutrition and lifestyle on loss of muscle mass and muscle function in patients with heart failure.
- Conditions
- Heart Failure, Sarcopenia, Cachexia
- Trial name
- MUSCLE-CHF (NCT05063955)
- Where
- Denmark
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Ocular Physiology, Retina
Is There a Difference in Flicker Induced Vasodilatation Between Smokers and Non-Smokers?
Habitual smoking is associated with an increased risk of coronary artery disease, cerebral and peripheral vascular disease, including ocular diseases like age-related macular degeneration or diabetic retinopathy.
- Conditions
- Ocular Physiology, Retina, Blood Flow Velocity
- Trial name
- NCT00431730
- Testing
- flicker light stimulation
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity
Effects of Weight Loss on Vascular Function in Obese Subjects
To evaluate the effect of weight loss on vascular function in obese with poor cardiovascular health. The investigators will evaluate the effects of weight loss on total and central body adiposity, blood pressure, central…
- Trial name
- NCT04198519
- Testing
- Weight Loss
- Where
- 2 sites in Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mario Fritsch Neves
Stable Angina, Periodontitis
Non-Surgical Periodontal Therapy and Cardiac Biomarkers in Stable Angina
The goal of this clinical study is to learn whether gum treatment can improve heart health. Researchers will compare blood markers related to heart disease before and after routine gum treatment.
- Trial name
- NCT07412795
- Testing
- Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Healthy
Regulation of Optic Nerve Head Blood Flow During Combined Changes in Intraocular Pressure and Arterial Blood Pressure
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. The existence of an effective autoregulation in the optic nerve head (ONH) circulation has been shown in animals and…
- Trial name
- NCT00914992
- Testing
- Suction cup application, Squatting
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Carotid Stenosis
Optical Coherence Tomography Angiography Evaluation of Ocular Changes in Patients With Carotid Artery Stenosis
This study aims to evaluate ocular changes in patients with carotid artery stenosis by optical coherence tomography angiography before and after carotid artery revascularization procedure.
- Trial name
- NCT04326842
- Testing
- Carotid artery revascularization procedure, Optical coherence tomography angiography
- Where
- China
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Retinal Artery Occlusion, Retinal Vein Occlusion
Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Trial name
- NCT02898480
- Testing
- Remote ischemic conditioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Colorectal Cancer, Inflammatory Bowel Disease
Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal Diseases
Nucleotide-binding oligomerization domain 2 (Nod2) signaling is critical for human health.To figure out the clinical relevance of NOD2 ligands, the investigators plan to evaluate the change of NOD2 ligands in inflammatory bowel…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Disease, Atherosclerotic Cardiovascular Disease, Type2 Diabetes Mellitus
- Trial name
- NCT04924686
- Testing
- Observational studies, no intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital