Clinical trials: Cirrhosis Liver
Primary Biliary Cholangitis (PBC)
Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cholangitis: a Real World Study
An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Fenofibrate in Combination with Ursodeoxycholic Acid in Subjects with Primary Biliary Cholangitis (PBC)
- Trial name
- NCT06755541
- Testing
- Fenofibrate in Combination With Ursodeoxycholic Acid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Cirrhosis, Liver, Frailty
Cirrhosis Registry of Hospitalized Patients
Cirrhosis registry of consecutive adult consenting patients hospitalized with liver cirrhosis in the tertiary liver unit
- Conditions
- Cirrhosis, Liver, Frailty, Ascites, Encephalopathy
- Trial name
- RH7 (NCT04767945)
- Where
- Slovakia
- Volunteers
- 2,000 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Esophageal Varices, Portal Hypertension
Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding
The main objective of this study is to determine the efficacy of early administration of Sanvar® in combination with endoscopic treatment for the control of acute variceal bleeding.
- Conditions
- Esophageal Varices, Portal Hypertension, Gastric Varices, Esophageal Bleeding
- Trial name
- NCT00331188
- Testing
- Sanvar® (vapreotide)
- Where
- 19 sites in United States
- Volunteers
- 70 people
- Sponsor
- Debiovision
Chronic Hepatitis C
Study of Efficacy and Safety of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in Chronic Hepatitis C Participants With Child-Pugh (CP)-B Hepatic Insufficiency (MK-5172-059)
This study is being done to evaluate the efficacy and safety of the drug combination grazoprevir (GZR; MK-5172) + elbasvir (EBR; MK-8742) in participants with chronic hepatitis C virus (HCV) genotype (GT) 1, 4, or 6 infection and…
- Trial name
- NCT02115321
- Testing
- Grazoprevir, Elbasvir, MK-5172A
- Volunteers
- 40 people
- Sponsor
- Merck Sharp & Dohme LLC
Cirrhosis Portal
TIPS for PH Patients: an Observational, Cohort Study
This is a single-center, prospective, observational study intended to include patients receiving TIPS for portal hypertension. Baseline data of enrolled patients were recorded, and samples of ascites, feces and urine were…
- Trial name
- NCT06221982
- Testing
- No intervention, observational study
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Liver Fibrosis
Silybin - Vitamin E- Phospholipids Complex Reduces Liver Fibrosis in Patients With Chronic Hepatitis C Treated With Peg-IFN-a and RBV
Chronic hepatitis C is both a virologic and a fibrotic disease, with mortality resulting mainly from the complications of cirrhosis and HCC.
- Trial name
- NCT01935817
- Testing
- Silybin 94 mg + vitamin E 90 mg + phospholipids 194 mg complex
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- University of Catania
Cholestasis, Intrahepatic
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus
This will be a randomized, double-blind, placebo-controlled study to assess safety and tolerability of GSK2330672 administration in subjects with primary biliary cirrhosis (PBC) and symptoms of pruritus.
- Trial name
- NCT01899703
- Testing
- GSK2330672, Ursodeoxycholic acid
- Where
- 3 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- GlaxoSmithKline
Cirrhosis
Influence of Shunt Occlusion on Organ Functions in Hyperammonemic Patients With Cirrhosis Having Porto-systemic Shunt.
The spontaneous Porto-systemic shunt is occluded by intervention procedures like Balloon Occluded Retrograde Transvenous Obliteration (BRTO), Plug-assisted Retrograde Transvenous Obliteration (PARTO) and shunt occlusion…
- Trial name
- NCT03293459
- Testing
- Shunt Occlusion, Standard Medical Treatment (SMT)
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
Safety and Efficacy Study of Umbilical Mesenchymal Stem Cells for Liver Cirrhosis
Liver cirrhosis and subsequent liver failure are leading causes of morbidity and mortality worldwide. Alcohol abuse and viral hepatitis are the most common causes of cirrhosis.
- Trial name
- LC (NCT01573923)
- Testing
- mesenchymal stem cells, Conventional therapy
- Where
- 6 sites in China
- Volunteers
- 320 people
- Sponsor
- Alliancells Bioscience Corporation Limited
Esophageal Varices in Cirrhosis of the Liver
Magnetic-assisted Capsule Endoscope With 3D Images in EV Detection in Cirrhotic Patient
Newly development of capsule endoscopy provides a comfortable and minimal invasive modality which is an alternative to conventional esophagogastroduodenoscopy(EGD).
- Trial name
- NCT04588974
- Testing
- magnetic-assisted capsule endoscope system (InsightEyes EGD System) with or without 3D images
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cirrhosis, Hypertension
Modified Vagus Nerve-preserving Laparoscopic Splenectomy and Azygoportal Disconnection
This study aimed to evaluate whether vagus nerve-preserving laparoscopic splenectomy and azygoportal disconnection is effective and safe, and to determine whether a reduction in the incidence of postoperative complications of the…
- Conditions
- Cirrhosis, Hypertension, Splenectomy, Laparoscopy
- Trial name
- ESVLSD (NCT03396796)
- Testing
- Vagus nerve-preserving group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yangzhou University
Hepatic Fibrosis
Screening for Advanced Liver Fibrosis Using Non-invasive Tests in Primary Care
Liver fibrosis screening is possible at the asymptomatic stage through a healthcare management strategy currently recommended for patients with risk factors for chronic liver disease.
- Trial name
- ANTICIP-SP (NCT06119997)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Grenoble
Liver Cirrhosis, Sleep Disturbance
Daridorexant for Sleep Disturbance in Adults With Liver Cirrhosis
This study will evaluate the efficacy and safety of daridorexant, a dual orexin receptor antagonist, in adults with liver cirrhosis and sleep disturbance, including participants with or without covert hepatic encephalopathy.
- Conditions
- Liver Cirrhosis, Sleep Disturbance, Hepatic Encephalopathy
- Trial name
- NCT07830303
- Testing
- Daridorexant
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Wang Fengmei
Hepatic Encephalopathy, Liver Cirrhosis
Prediction of Post-TIPS Hepatic Encephalopathy in Patients With Liver Cirrhosis
Prediction of hepatic encephalopathy after insertion of a transjugular intrahepatic portosystemic stent shunt (post-TIPS HE) are critical for patient selection prior to TIPS insertion, and a currently unmet, clinically highly…
- Trial name
- NCT05466669
- Where
- 2 sites in Germany
- Volunteers
- 83 people
- Sponsor
- Johannes Gutenberg University Mainz
Advanced Chronic Liver Disease, Urinary Infection
The INFECIR-2 Albumin Prevention Study
The aim of this study is to evaluate whether albumin administration improves short-term survival in patients with advanced cirrhosis and bacterial infections other than Spontaneous Bacterial Peritonitis (SBP).
- Conditions
- Advanced Chronic Liver Disease, Urinary Infection, Pneumonia, Cholangitis
- Trial name
- INFECIR2 (NCT02034279)
- Testing
- Albumin
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- EASL - CLIF Consortium
Hepatic Impairment, Healthy Subjects
The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics
This is a prospective, open-label, single-dose, Phase 1 study, to assess the effect of moderate hepatic impairment due to liver cirrhosis on the pharmacokinetics of aprocitentan (ACT-132577).
- Trial name
- NCT04252495
- Testing
- Aprocitentan
- Where
- 2 sites in Germany, Poland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Critical Illness, Chronic Obstructive Lung Disease
Advance Care Planning Evaluation in Hospitalized Elderly Patients
The purpose of the study is to inform decision-makers of the best strategies to implement advanced care planning (ACP). An advanced care plan (ACP) is a verbal or written instruction describing what kind of care an individual…
- Conditions
- Critical Illness, Chronic Obstructive Lung Disease, Congestive Heart Failure, Cirrhosis
- Trial name
- ACCEPT (NCT01362855)
- Where
- 9 sites in Canada
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Daren K. Heyland
Primary Biliary Cholangitis (PBC)
Study to Evaluate the Efficacy and Safety of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) and Inadequate Response to Ursodeoxycholic Acid
The primary objective of the study is to compare the effect of daily oral administration of elafibranor 80mg and 120 mg on change in serum alkaline phosphatase (ALP) to that of placebo in patients with PBC and inadequate response…
- Trial name
- NCT03124108
- Testing
- Elafibranor 80 mg, Elafibranor 120 mg
- Where
- 24 sites in United States, France and 3 more
- Volunteers
- 45 people
- Sponsor
- Genfit
Primary Biliary Cholangitis
Clinical Research of Tapering UDCA in PBC Patients With a Complete Response
This study explores the feasibility of the reducing medication regimen for Ursodeoxycholic Acid(UDCA) in the treatment of primary biliary cholangitis.
- Trial name
- UDCA PBC (NCT04650243)
- Testing
- ursodeoxycholic acid
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
Liver Diseases, Hepatocellular Cancer
A2ALL-Patients Safety System Improvements in Living Donor Liver Transplantation
Living donor liver transplantation (LDLT), involves complex systems and processes of care that are particularly vulnerable to medical errors and preventable complications.
- Conditions
- Liver Diseases, Hepatocellular Cancer, Endstage Liver Disease, Liver Cirrhosis
- Trial name
- NCT02073435
- Testing
- Donor pain management
- Where
- 4 sites in United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Northwestern University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.