Clinical trials: Cirrhosis Portal
Cirrhosis, Liver, Portal Hypertension
Cirrhotic and Non-cirrhotic Patients With Clinically Significant Portal Hypertension
Alterations in conventional coagulation tests in patients with cirrhosis and/or portal hypertension do not reliably predict bleeding risk, as hemostatic balance is complex and often compensated.
- Conditions
- Cirrhosis, Liver, Portal Hypertension, Clinically Significant Portal Hypertension(CSPH), Gastroesophageal Varices
- Trial name
- PREDIBLEED (NCT07405749)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Cirrhosis
Thoracoscopic Mesh Repair of Diaphragmatic Defects for Hepatic Hydrothorax
The management of refractory hepatic hydrothorax is challenging and usually unsuccessful. The study will discuss the perioperative treatment, effectiveness, and morphology of diaphragmatic defects of hepatic hydrothorax in…
- Trial name
- NCT02508688
- Testing
- thoracoscopic diaphragmatic repair
- Volunteers
- 63 people
- Sponsor
- National Taiwan University Hospital
Acute Liver Failure, Liver Cirrhosis
Indocyangreen Elimination in Cirrhosis and Acute Liver Failure
Indocyangreen (ICG)is totally biliary eliminated and corresponds to hepatocyte function and liver perfusion. The ICG-clearance will be evaluated as a prognostic marker in liver disease.
- Trial name
- NCT00245310
- Testing
- Indocyangreen (ICG) clearance
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Heidelberg University
Chronic Hepatitis C, Cirrhosis
Transient Elastography to Assess Liver Fibrosis and Portal Hypertension in HCV Cirrhotic Patients Treated With New Antiviral Drugs (SPLEEN-C)
The purpose of this study is to evaluate the effects of sustained virological response in liver and spleen stiffness in patients with HCV compensated advanced chronic liver disease treated with new all oral antiviral drugs in…
- Conditions
- Chronic Hepatitis C, Cirrhosis, Portal Hypertension
- Trial name
- SPLEEN-C (NCT02439567)
- Testing
- Fibroscan: Liver and Spleen elastography
- Where
- Spain
- Volunteers
- 41 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gastric Varices Bleeding, Liver Decompensation
Balloon-occluded Retrograde Transvenous Obliteration for Gastric Variceal Rebleeding
The goal of this randomized controlled trial is to compare the rebleeding rate in cirhotic patients with gastric variceal bleeding receiving balloon-occluded retrograde transvenous obliteration and endoscopic tissue glue…
- Trial name
- NCT06106971
- Testing
- Sodium tetradecyl sulfate, Cyanoacrylate
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Liver Cirrhosis, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Magnetic Resonance Technics for the Assessment of Liver Function Before and After TIPS
Portal hypertension is the end-stage fatal complications of liver cirrhosis. Decompensated cirrhosis patients can pass through transjugular intrahepatic portosystemic shunt to effectively prevent bleeding and refractory ascites.
- Conditions
- Liver Cirrhosis, Transjugular Intrahepatic Portosystemic Shunt (TIPS), Functional Magnetic Resonance Imaging
- Trial name
- NCT03933891
- Testing
- TIPS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- West China Hospital
Liver Cirrhosis, Esophageal and Gastric Varices
The Diagnostic Value of Subharmonic Imaging Technology Combined With Liver Stiffness and Platelet Count for High-risk Esophageal and Gastric Varices in Patients With Liver Cirrhosis
To evaluate the diagnostic value of the combined model of subharmonic-assisted pressure estimation (SHAPE), liver stiffness (LSM), and platelet count (PLT) for high-risk esophageal and gastric varices (HRV)
- Trial name
- NCT07151885
- Testing
- SHAPE
- Where
- China
- Volunteers
- 380 people
- Sponsor
- The First Hospital of Jilin University
Cirrhosis With Esophageal Varices
To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices.
After successful screening of patients based on inclusion criteria, we will measure the baseline Hepatic Venous Pressure Gradient.
- Trial name
- NCT02465645
- Testing
- Carvedilol, Carvedilol + Simvastatin
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Portal Hypertension, Cirrhosis
Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS
The aim of this study is to investigate the possibilities of early and precise management to decrease portal vein pressure in cirrhotic patients, guided by a non-invasive 3D-virtual-model of hepatic portal system (3D-vHPS).
- Trial name
- NCT02925975
- Testing
- Carvedilol, 3D-vHPS, Routine endoscopic procedures
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Changqing Yang
Hepatic Encephalopathy, Cirrhosis
Early Diagnosis and Timely Treatment of Cirrhotic Patients With Minimal Hepatic Encephalopathy (CHESS-NCRCID 2106)
Hepatic encephalopathy (HE) is a common complication of cirrhosis, which seriously damages the life quality of patients. As the disease progresses, 50-80% of patients with cirrhosis develop HE.
- Trial name
- NCT05140837
- Testing
- Psychometric hepatic encephalopathy score & Stroop test, Drug therapy
- Where
- 31 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Chronic Liver Disease
Relative-dose-response Test (RDR) Adaptation for Chronic Liver Disease
The relative-dose-response test (RDR) is considered to be the most accurate method for evaluating vitamin A nutritional status (VANS) in patients suffering from liver disease, as it infers the reserves of the vitamin in the…
- Trial name
- NCT01634698
- Testing
- retinyl palmitate (UNICEF, Melbourne, Australia)
- Where
- Brazil
- Volunteers
- 178 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Cirrhosis, Hepatic Encephalopathy
Hepatic Encephalopathy and Albumin Lasting Cognitive Improvement
Hypothesis: Improvement in cognitive dysfunction with IV albumin in patients with cirrhosis with prior HE and MHE lasts for several weeks after albumin infusion has ended, and is due to persistent improvement in inflammatory…
- Trial name
- HEAL-LAST (NCT06052176)
- Testing
- Albumin Infusion
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Hepatic Pathology (Fibrosis, Cirrhosis, Porto Systemic Shunts)
Development of a Cognitive Tool for Rapid and Reliable Screening of Minimal Hepatic Encephalopathy: Pilot Study
The aim of this project is to evaluate the sensitivity and specificity of a cognitive test toward the presence of minimal hepatic encephalopathy (MHE).
- Trial name
- BLOCK-HE (NCT06619106)
- Testing
- Cognitive test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cirrhosis, Liver, Portal Hypertension
Non-invasive Diagnosis of Portal Hypertension in Cirrhosis Based on Metabolomics Technology
Portal hypertension (PH) is a group of syndromes characterized by abnormal changes in the portal blood flow system, mostly caused by cirrhosis.
- Trial name
- NCT05551884
- Testing
- Metabolites and HVPG
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Cirrhosis, Ascites Hepatic
PEriToneal Catheter Versus Repeated Paracentesis for Ascites in Cirrhosis
Insertion of a tunnelated peritoneal catheter (PleurX) allows repeated intermittent small volume fluid drainage at home. The treatment may improve the management of ascites and have a beneficial effect on the quality of life.
- Conditions
- Cirrhosis, Ascites Hepatic, Ascites (Non-Malignant)
- Trial name
- PETRA (NCT03027635)
- Testing
- PleurX, peritoneal tunnelated catheter, Large Volume Paracentesis, Ciprofloxacin 500Mg Tablet
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Nina Kimer
Cirrhosis
Effect of Physical Training Program on Health-related Quality of Life in Cirrhosis
Physical training improves quality of life (QOL) in non-hepatic diseases. It is possible that the same effect happens in patients with cirrhosis and portal hypertension.
- Trial name
- NCT00517738
- Testing
- Physical training, Diet intervention
- Where
- 2 sites in Mexico
- Volunteers
- 29 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
End Stage Liver Disease
Quantitative Liver Function Tests Using Cholates
As the treatments for liver disease and the availability of liver transplantation have progressed, the number of patients with end stage liver disease continues to increase.
- Trial name
- NCT01907074
- Testing
- Cholates
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Baylor Research Institute
Chronic Hepatitis B, Hepatic Fibrosis
Prospective Cohort Study of Association of Insulin Resistance/Steatosis With Hepatic Fibrosis in CHB and NAFLD
Hepatic steatosis and insulin resistance are associated with severity of fibrosis in non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C.
- Conditions
- Chronic Hepatitis B, Hepatic Fibrosis, Fatty Liver
- Trial name
- NCT02031913
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Boramae Hospital
Liver Cirrhosis, Arterial Hypertension
Clinical Application of Simcyp-Guided Doses of Antihypertensive Drugs in Cirrhotic Patients
This was a prospective, open-label, randomized, parallel pilot clinical study conducted over 3 months on 50 Egyptian cirrhotic patients with arterial hypertension and portal hypertension, evaluating the real-world applicability…
- Trial name
- NCT07397481
- Testing
- Nebivolol 5 mg, Carvedilol 12.5 mg, Nebivolol 2.5 mg
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Cirrhosis, Hepatic Encephalopathy
VE303 for Treatment of Hepatic Encephalopathy (HE)
This research is studying the use of a new drug to learn about its safety and efficacy as a treatment for hepatic encephalopathy.
- Trial name
- NCT04899115
- Testing
- VE303, oral vancomycin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Patricia Bloom