Clinical trials: Citrate
Healthy
A Bioequivalence Study of Citrate Free Mirikizumab (LY3074828) in Healthy Participants
The purpose of this study is to evaluate the amount of mirikizumab (test) that gets into the blood stream and how long it takes the body to get rid of it, when given via autoinjector, an injection under the skin, compared to…
- Trial name
- NCT06475729
- Testing
- Citrate-Free Mirikizumab
- Where
- 6 sites in United States
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Ovulatory Dysfunction, Anovulation
Traditional Clomiphene Citrate Administration vs. Stair-step Approach
The purpose of this study is to compare the length of time to achieve ovulation and pregnancy with a traditional protocol administration of clomiphene citrate versus a stair step administration.
- Conditions
- Ovulatory Dysfunction, Anovulation, Ovulation Induction
- Trial name
- Clomid (NCT01008319)
- Testing
- clomiphene citrate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Oklahoma
Pulmonary Hypertension
Open Label Study of Sildenafil in Patients With Pulmonary Arterial Hypertension
To assess the safety of sildenafil 20 mg TID orally given to Japanese pulmonary arterial hypertension patients (Part 1 and 2) To assess the efficacy after 12 weeks of treatment of sildenafil 20 mg TID orally given to Japanese…
- Trial name
- NCT00454207
- Testing
- sildenafil citrate (UK-92,480)
- Where
- 8 sites in Japan
- Volunteers
- 44 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hyperphosphatemia, End-Stage Renal Disease
A 4-Week Dose-Ranging and Efficacy Trial of KRX-0502 (Ferric Citrate) in Patients With End-Stage Renal Disease
This is a research study for people with high blood phosphorus levels who are on dialysis. This medical condition can cause weakening of the bones and damage other organs.
- Trial name
- NCT01074125
- Testing
- ferric citrate
- Where
- 16 sites in United States, Puerto Rico
- Volunteers
- 154 people
- Sponsor
- Keryx Biopharmaceuticals
Essential Hypertension
Safety Study of RMJH-111b to Treat Essential Hypertension
The purpose of this study was to evaluate the safety of RMJH-111b, including how well it is tolerated, and the effect of RMJH-111b on blood pressure in subjects with hypertension.
- Trial name
- NCT02822222
- Testing
- Magnesium citrate, tribasic anhydrous soft gelatin capsule
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- RMJ Holdings, LLC
Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
Abatacept, Ixazomib Citrate, and Dexamethasone in Treating Patients With Multiple Myeloma Resistant to Chemotherapy
This phase II trial studies how well abatacept, ixazomib citrate, and dexamethasone work in treating patients with multiple myeloma that is resistant to chemotherapy.
- Trial name
- NCT03457142
- Testing
- Abatacept, Dexamethasone, Ixazomib Citrate
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Roswell Park Cancer Institute
Dysmenorrhea
Viagra in the Treatment of Primary Dysmenorrhea
The primary hypothesis is that a 100mg single dose of sildenafil citrate (Viagra) will have a higher improvement rate when compared to placebo in the treatment of moderate to severe primary dysmenorrhea.
- Trial name
- NCT00123162
- Testing
- Sildenafil Citrate
- Where
- Croatia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
End Stage Renal Disease
Pharmacokinetics of Triferic (Ferric Pyrophosphate Citrate) Administered Intravenously to Healthy Adult Volunteers
This is a Phase 1, open-label, three-period sequential dosing study being conducted to determine the pharmacokinetics of Triferic iron administered intravenously (IV) to healthy adults.
- Trial name
- RMFPC-12 (NCT02636049)
- Testing
- Triferic
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rockwell Medical Technologies, Inc.
End Stage Renal Disease, Kidney Failure
A Long-Term Safety Extension Trial of Ferric Citrate in Patients With End-Stage Renal Disease (ESRD) on Dialysis
A long-term safety study of ferric citrate (KRX-0502) in renal failure patients who have completed study KRX-0502-304. Only patients who participated in the KRX-0502-304 trial may participate in this trial.
- Conditions
- End Stage Renal Disease, Kidney Failure, Renal Failure, Hyperphosphatemia
- Trial name
- NCT01554982
- Testing
- ferric citrate
- Where
- 34 sites in United States, Puerto Rico
- Volunteers
- 168 people
- Sponsor
- Keryx Biopharmaceuticals
Vascular Calcification
Effect of Citrate Dialysate on Vascular Calcification
The goal of this study is to determine whether hemodialysis with citrate slows the progression of vascular calcification. Participants will be dialyzed with one of two standard dialysis solutions, one with and one without…
- Trial name
- NCT04956120
- Testing
- Citrate Dialysate, Standard Dialysate
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- Emory University
Bowel Preparation Solutions
Comparison of Clenpiq vs Golytely Bowel Preparation
This is a prospective randomized study which will be done at main campus Cleveland Clinic. The investigators will be comparing the colon cleansing by the Boston Bowel Preparation Scale in participants undergoing colonoscopy as an…
- Trial name
- NCT03198221
- Testing
- Golytely, Clenpiq
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The Cleveland Clinic
Erectile Dysfunction
A Study in Patients With Erectile Dysfunction
The purpose of this study is to investigate if treatment in erectile dysfunction with a long-acting drug (Tadalafil) taken once a day or taken as needed results in a longer treatment adherence and better long term outcomes (over…
- Trial name
- NCT01122264
- Testing
- Tadalafil, Sildenafil Citrate
- Where
- 45 sites in France, Germany and 6 more
- Volunteers
- 770 people
- Sponsor
- Eli Lilly and Company
Multiple Myeloma, Autologous Stem Cell Transplant
A Study of Oral Ixazomib Citrate (MLN9708) Maintenance Therapy in Participants With Multiple Myeloma Following Autologous Stem Cell Transplant
The purpose of this study is to determine the effect of ixazomib citrate maintenance therapy on progression-free survival (PFS), compared to placebo, in participants with newly diagnosed multiple myeloma (NDMM) who have had a…
- Trial name
- NCT02181413
- Testing
- Ixazomib Citrate
- Where
- 227 sites in United States, Argentina and 31 more
- Volunteers
- 656 people
- Sponsor
- Takeda
Erectile Dysfunction
A Multicenter, Open Label, To Evaluate The Efficacy And Satisfaction Of Patrex® In Men With Erectile Dysfunction.
A multicenter open label study to assess the efficacy of sildenafil rapid dose titration to 100 mg in men with erectile dysfunction, based on the Erectile Function (EF) domain score of the International Index of Erectile Function…
- Trial name
- NCT00468650
- Testing
- sildenafil citrate
- Where
- 9 sites in Mexico
- Volunteers
- 117 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypogonadism, Opioid-Related Disorders
Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
The purpose of this randomized controlled clinical trial is to evaluate the effects of clomiphene citrate compared to placebo (substance without active medication) in men who are taking pain medication (opioids) for chronic pain…
- Conditions
- Hypogonadism, Opioid-Related Disorders, Male Infertility
- Trial name
- NCT01880086
- Testing
- Clomiphene citrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Weill Medical College of Cornell University
Bone Diseases, Metabolic, Osteoporosis, Postmenopausal
The Effects of Potassium Citrate on Bone Metabolism
Skeletal buffering of chronic acid loads may contribute to a significant amount of bone loss over time. Evidence from a few small short-term studies suggests that basic compounds, namely potassium citrate and potassium…
- Trial name
- NCT00357331
- Testing
- potassium citrate
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Invasive Breast Carcinoma, Recurrent Breast Carcinoma
Tamoxifen Citrate or Letrozole With or Without Bevacizumab in Treating Women With Stage IIIB or Stage IV Breast Cancer
This randomized phase III trial studies tamoxifen citrate or letrozole together with bevacizumab to see how well it works compared with tamoxifen citrate or letrozole alone in treating women with stage IIIB or stage IV breast…
- Conditions
- Invasive Breast Carcinoma, Recurrent Breast Carcinoma, Stage III Breast Cancer AJCC v6, Stage IV Breast Cancer AJCC v6 and v7
- Trial name
- NCT00601900
- Testing
- Bevacizumab, Laboratory Biomarker Analysis, Letrozole
- Where
- 522 sites in United States, Puerto Rico
- Volunteers
- 394 people
- Sponsor
- National Cancer Institute (NCI)
Pregnancy, Polycystic Ovary Syndrome
Pregnancy in Polycystic Ovary Syndrome II
The primary research hypothesis is that ovulation induction with an aromatase inhibitor (letrozole) is more likely to result in live birth than ovulation induction with a selective estrogen receptor modulator (clomiphene citrate)…
- Trial name
- PPCOSII (NCT00719186)
- Testing
- Clomiphene citrate, Letrozole
- Where
- 12 sites in United States
- Volunteers
- 750 people
- Sponsor
- Yale University
Plasma Cell Leukemia, Plasma Cell Myeloma
Pomalidomide, Ixazomib Citrate, and Dexamethasone in Treating Patients With Previously Treated Multiple Myeloma or Plasma Cell Leukemia
This phase II trial studies how well pomalidomide, ixazomib citrate, and dexamethasone work in treating patients with previously treated multiple myeloma or plasma cell leukemia.
- Conditions
- Plasma Cell Leukemia, Plasma Cell Myeloma, Plasmacytoma
- Trial name
- NCT02547662
- Testing
- Dexamethasone, Ixazomib Citrate, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Pulmonary Arterial Hypertension, Pulmonary Hypertension
Study Looking at Combination Therapy (Sitaxsentan+Sildenafil) Vs. Monotherapy (Sitaxsentan Alone) SR-PAAS -Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil
As monotherapy for pulmonary arterial hypertension (PAH) begins to fail additional therapies are introduced. Although co-administration of sitaxsentan and sildenafil is well tolerated the controlled safety/efficacy database of…
- Trial name
- NCT00796666
- Testing
- Sitaxsentan, Sitaxsentan and Sildenafil
- Where
- 48 sites in United States, Argentina and 16 more
- Volunteers
- 131 people
- Sponsor
- Pfizer