Clinical trials: Citrulline
Healthy
Setria Performance Blend Supplementation
The objective of this trial is to evaluate the effects of setria performance blend supplementation on endurance performance in healthy men.
- Trial name
- NCT04090138
- Testing
- Setria performance blend
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes Mellitus
Effect of L-Citrulline Supplementation on Arginase Activity and Vascular Function in Diabetes
Arginase has recently been implicated in an array of vascular conditions including atherosclerosis , hypertension and vascular complication of diabetes.
- Trial name
- NCT03358264
- Testing
- L-citrulline
- Where
- Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Determine the Effects of Nitrosigine and Citrulline-malate on Flow-mediated Dilation Among Young Adults
Evaluation of Sports Supplements on Blood Flow
Many athletes seek to increase their plasma (blood) nitric oxide content prior to exercise in order to augment vasodilation. Increased vasodilation during exercise, especially high intensity resistance training, allows for more…
- Trial name
- NCT04278053
- Testing
- inositol-stabilized arginine silicate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Blood Pressure
Oral L-Citrulline and ADMA in Pregnancy
The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to obese subjects will decrease the plasma ADMA/L-arginine ratio, lower maternal blood pressure, improve…
- Trial name
- NCT00743210
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Citrulline, Nitrate
Long-Term Effect of Combined Citrulline and Nitrate-Rich Beetroot Extract Supplementation
Citrulline (CIT) and nitrate-rich beetroot extract (BEET) are widely studied ergogenic aids. However, both supplements have been studied in sort-term and isolated.
- Conditions
- Citrulline, Nitrate, Athletes
- Trial name
- NCT05143879
- Testing
- Citrulline, Nitrate, Nitrate plus Citrulline
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Burgos Nutrition
Hypertension
Impact of Citrulline and Arginine Supplementation on the Post-exercise Hypotension (PEH)
Post-exercise hypotension (PEH) is a established phenomenon as one of the non-pharmacological ways of reducing blood pressure, producing important impacts, particularly in hypertensive individuals.
- Trial name
- PEH (NCT03378596)
- Testing
- L-citrulline + L-arginine, L-arginine, L-citrulline
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Juliano Casonatto
Postmenopausal, Overweight and Obesity
Markers of Atherosclerosis in Overweight, Postmenopausal Women Following Daily Watermelon Consumption
The primary purpose of this study is to determine the effectiveness of six weeks of watermelon puree supplementation, compared to control (no treatment), on blood antioxidant capacity, inflammation markers in the blood…
- Trial name
- NCT04015544
- Testing
- Watermelon
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Hypertension
Effect of Polyphenols Combined to L-citrulline on Ambulatory Blood Pressure
The general objective of this project is to investigate the chronic effect of consuming supplements combining polyphenols from cranberry and grape seed extracts and L-citrulline (Nitric Oxide Ultra capsules, Pure Encapsulations…
- Trial name
- NCT03679195
- Testing
- NO Ultra
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Laval University
Hypertension
L-citrulline Supplementation, Cold Exposure, & Post-Exercise Muscle Ischemia
Cardiovascular disease (CVD) continues to be the major cause of morbidity and mortality in western countries. It has been shown that CVD events are known to be higher in the winter than in the summer.
- Trial name
- NCT02104375
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Florida State University
Pregnancy Induced Hypertension, Preeclampsia and Eclampsia
Role of L-citrulline in Prevention of Pregnancy Associated Hypertension
The target population for our study is healthy nulliparous pregnant women (first pregnancy) between the 12-16 week of pregnancy. If a subject is eligible, written consent will be obtained by person to person contact.
- Conditions
- Pregnancy Induced Hypertension, Preeclampsia and Eclampsia, Gestational Hypertension
- Trial name
- NCT04979793
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Aging
L-Citrulline and Endothelial Function
The effect of L-Citrulline is well studied in relation to muscle strength, exhaustion, exercise performance, and endothelial function in health and disease.
- Trial name
- NCT05722860
- Testing
- L-Citrulline, capsule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Mitochondrial Diseases
The Effect of Arginine and Citrulline Supplementation on Endothelial Dysfunction in Mitochondrial Diseases
Mitochondrial diseases occur due to inadequate energy production. In addition, nitric oxide (NO) deficiency occurs in mitochondrial diseases.
- Trial name
- NCT02809170
- Testing
- Arginine, Citrulline
- Where
- United Arab Emirates
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Tawam Hospital
Dietary Exposure
Effects of L-arginine and L-citrulline Supplementation on Muscle Respiration
The objective of this trial is to determine the effects of dietary supplementation with the amino acids, L-arginine and L-citrulline, on endurance performance and mitochondrial respiration in healthy men compared to…
- Trial name
- NCT03998800
- Testing
- Dietary Supplement, Endurance exercise on a cycle ergometer
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Asthma, Obesity
Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes
Patients with obese late onset (after childhood) asthma can have lower FeNO levels, yet be highly symptomatic and poorly responsive to inhaled steroids. This is a common asthma phenotype, particularly among females.
- Trial name
- SANDIA (NCT03885245)
- Testing
- L-ctirulline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Intestinal Diseases
Citrulline Challenge Study for Healthy Subjects in the United Kingdom
There are many forms of small bowel disease but their direct consequences on small bowel function are often very hard, if not impossible, to establish.
- Trial name
- CHS-UK (NCT02772861)
- Testing
- Amino Acid Supplement - One dose, 3-Methylhistidine
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University College, London
Type 2 Diabetes
The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes
The purpose of this study is to examine the effect of 4 weeks of Citrulline supplementation on macro- and microvascular function during acute hyperglycemia in middle-aged and older adults with type 2 diabetes.
- Trial name
- NCT06016478
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Obesity, Pre-hypertension
Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition
Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals.
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT02143817
- Testing
- L-citrulline supplementation, Whole Body Vibration Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Citrulline, Blood Flow
Effect of L-Citrulline on Vascular Function
The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.
- Conditions
- Citrulline, Blood Flow, Aging
- Trial name
- NCT03127917
- Testing
- L-citrulline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Sarcopenia, Obesity
Citrulline Supplementation Combined With Exercise: Effect on Muscle Function in Elderly People (CITEX Study)
The main objective of this study is to determine if oral supplementation of Citrulline, when combined with HIIT, can produce significant changes in body composition, muscle quality, muscle metabolism and functional capacity in…
- Trial name
- CITEX (NCT02417428)
- Testing
- Citrulline, Exercise, without exercise
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Université du Québec a Montréal
Healthy Young, Older People With Cardiovascular Disease Risk
Watermelon and Beetroot Products on Endothelial Function
Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases.
- Trial name
- NCT04781595
- Testing
- Watermelon, Beetroot, Watermelon + beetroot
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro