Clinical trials: Claudication
Peripheral Arterial Disease
Ramipril Treatment of Claudication: Oxidative Damage and Muscle Fibrosis
Peripheral artery disease (PAD) is a manifestation of atherosclerosis that produces progressive narrowing and occlusion of the arteries supplying the lower extremities.
- Trial name
- NCT02842424
- Testing
- Ramipril
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Nebraska
Intermittent Claudication
The Effects of Claudication Severity on Functional Outcomes
Peripheral artery disease (PAD) affects over 236 million people globally. A classic symptom of PAD is intermittent claudication (IC) which is associated with reductions in physical function.
- Trial name
- NCT04370327
- Testing
- Pain Free Exercise (PF), Moderate Claudication Pain Exercise (MOD-P), Maximal Claudication Pain Exercise (MAX-P)
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- University of Central Lancashire
Peripheral Vascular Disease, Peripheral Arterial Disease
EVERO Drug-coated Balloon (DCB) Randomized Trial
The primary objective of the study is to evaluate the long-term safety and effectiveness of the Advance Evero™ 18 Everolimus-coated Percutaneous Transluminal Angioplasty Balloon Catheter (hereafter referred to as the Evero…
- Trial name
- NCT07144150
- Testing
- Evero DCB, Paclitaxel DCB
- Where
- 12 sites in United States
- Volunteers
- 410 people
- Sponsor
- Cook Research Incorporated
Peripheral Artery Disease, Intermittent Claudication
Improving Mobility After Revascularization in Peripheral Artery Disease
Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ischemia.
- Conditions
- Peripheral Artery Disease, Intermittent Claudication, Peripheral Vascular Disease, Mobility Limitation
- Trial name
- IMPACT PAD (NCT06686121)
- Testing
- Home Based Exercise, Nitrate Rich Beetroot Juice, Attention Control
- Where
- 8 sites in United States
- Volunteers
- 386 people
- Sponsor
- Northwestern University
Peripheral Artery Disease, Claudication, Intermittent
Passive Calf Stretching Therapy in Peripheral Artery Disease
The goal of this clinical trial is to assess the effects of passive calf muscle stretching in patients diagnosed with peripheral artery disease (PAD). The main question it aims to answer are: 1.
- Trial name
- NCT06041880
- Testing
- Passive calf muscle stretching device
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Penn State University
Peripheral Artery Disease
Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease
The INTERCEDE randomized trial will establish whether six-months of intermittent pneumatic compression combined with walking exercise improves walking endurance at six-month follow-up, compared to walking exercise + sham…
- Trial name
- INTERCEDE (NCT03871075)
- Testing
- intermittent pneumatic compression, exercise, Health Education
- Where
- 4 sites in United States
- Volunteers
- 211 people
- Sponsor
- Northwestern University
Peripheral Artery Disease
Community-based Exercise Following Revascularization for PAD
The primary goal of this clinical trial is to evaluate whether a community-based structured exercise therapy (CB-SET) intervention, which could be accessible and easily disseminated, adds benefit to peripheral artery disease…
- Trial name
- NCT04252950
- Testing
- CB-SET, Revascularization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Peripheral Artery Disease (PAD)
The NICE-PAD II Trial
Among people with peripheral artery disease (PAD) age 50 and older, the investigators will test the hypothesis that PAD participants randomized to nicotinamide riboside (NR) will have greater improvement or less decline in…
- Trial name
- NICE (NCT07782671)
- Testing
- Nicotinamide Riboside (NR)
- Volunteers
- 250 people
- Sponsor
- Northwestern University
Peripheral Arterial Disease, Stenosis
FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease
FGF-1 for the treatment of patients with peripheral arterial disease with intermittent claudication.
- Conditions
- Peripheral Arterial Disease, Stenosis, Intermittent Claudication
- Trial name
- NCT00424866
- Testing
- FGF-1
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Venturis Therapeutics, Inc.
Femoral Arterial Calcification, Peripheral Arterial Disease
CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions
The primary goal of the study is to obtain effect size data on the use of Shockwave Intravascular Lithotripsy (IVL) technology in calcified common femoral lesions in patients with peripheral artery disease for a series of…
- Conditions
- Femoral Arterial Calcification, Peripheral Arterial Disease, Claudication, Critical Limb Ischemia
- Trial name
- NCT05145478
- Testing
- Shockwave Intravascular Lithotripsy (IVL)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Peripheral Artery Disease, Exercise
Response to Exercise and Nitric Oxide in PAD
RESIST PAD is a randomized trial of 200 PAD patients to establish: 1) whether a 12-week exercise intervention significantly increases Δ nitrite at 12-week follow-up, compared to control; 2) whether exercise "responders" have…
- Conditions
- Peripheral Artery Disease, Exercise, Intermittent Claudication, Nitric Oxide
- Trial name
- RESIST (NCT06657976)
- Testing
- Supervised Treadmill Exercise, Attention Control, Nitrate-Rich Beetroot Juice + supervised exercise therapy
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Peripheral Arterial Disease, Aortoiliac Occlusive Disease
Predictors of Major Adverse Limb Events After Endovascular Iliac Stenting: a Real-world Cohort Study
Peripheral arterial disease involving the iliac arteries is a common manifestation of systemic atherosclerosis and a major cause of lifestyle-limiting claudication and chronic limb-threatening ischemia.
- Conditions
- Peripheral Arterial Disease, Aortoiliac Occlusive Disease, Chronic Limb-Threatening Ischemia, Intermittent Claudication
- Trial name
- PREMISE-ILIAC (NCT07672249)
- Testing
- Iliac stenting
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Peripheral Arterial Disease, Intermittent Claudication
Heat Therapy for Peripheral Arterial Disease (HEATPAD)
Peripheral arterial disease (PAD) is a disabling condition, with symptoms of muscle cramping or pain on exertion, which can substantially reduce quality of life.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Critical Limb Ischemia
- Trial name
- HEATPAD (NCT06186505)
- Testing
- AirGlove
- Volunteers
- healthy volunteers welcome
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Claudication, Peripheral Artery Disease
The Effects of a Novel, Non-ischemic and Pain-free Exercise Intervention in Peripheral Artery Disease
This study is a 3-month, prospective, randomized controlled clinical trial designed to address the efficacy of the Non-Ischemic Exercise (NICE) program to improve exercise and vascular outcome measures in patients with peripheral…
- Trial name
- NICE (NCT05712395)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease
Post-Market Registry of AURYON Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease
The PATHFINDER Registry is a prospective, non-randomized, single arm, multicenter observational study. This pilot registry is aimed to evaluate the performance (peri-procedural) and clinical outcomes (intermediate and long-term)…
- Conditions
- Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease, PAD
- Trial name
- PATHFINDER (NCT04229563)
- Testing
- AURYON Atherectomy System
- Where
- 10 sites in United States
- Volunteers
- 102 people
- Sponsor
- Angiodynamics, Inc.
Stable Coronary Artery Disease, Acute Coronary Syndromes
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages.
- Conditions
- Stable Coronary Artery Disease, Acute Coronary Syndromes, Critical Limb Ischemia, Intermittent Claudication
- Trial name
- NCT07588295
- Testing
- Optical Coherence Tomography assessment
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Maria Cecilia Hospital
Peripheral Arterial Disease (PAD)
Recreational Team Handball Programme for Patients With Peripheral Arterial Disease
This randomized controlled trial (RCT) aims to evaluate the physical and physiological demands, the feasibility and the health, physical fitness and disease-specific outcomes of a progressive recreational team handball-based…
- Trial name
- NCT07582588
- Testing
- Recreational team handball programme
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- University Institute of Maia
Peripheral Artery Disease, Claudication, Intermittent
Red Light Treatment in Peripheral Artery Disease
Subjects with a known diagnosis of peripheral artery disease as measured by an abnormal ankle brachial index (<.9 or >1.1) will undergo a single 5 min exposure of 670 nm light, 1 cm above the gastrocnemius muscle.
- Conditions
- Peripheral Artery Disease, Claudication, Intermittent, Vasodilation
- Trial name
- NCT03203239
- Testing
- Red Light (670 nm energy), Octafluoropropane
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Peripheral Arterial Disease
Evaluation of the Effectiveness of Hybrid Cardiac Rehabilitation in Peripheral Artery Disease
Peripheral artery disease (PAD) is a common atherosclerotic condition characterized by reduced blood flow to the lower extremities, leading to intermittent claudication, decreased walking capacity, and impaired quality of life.
- Trial name
- NCT07550959
- Testing
- Hybrid Cardiac Rehabilitation, Supervised Exercise Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Biruni University
Intermittent Claudication
MetfOrmin BenefIts Lower Extremities With Intermittent Claudication
Peripheral arterial disease (PAD) affects over 20% of aged adults and is very common among Veterans due significant tobacco use.
- Trial name
- MOBILE IC (NCT05132439)
- Testing
- Metformin ER
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development