Clinical trials: Claudication
Intermittent Claudication
MetfOrmin BenefIts Lower Extremities With Intermittent Claudication
Peripheral arterial disease (PAD) affects over 20% of aged adults and is very common among Veterans due significant tobacco use.
- Trial name
- MOBILE IC (NCT05132439)
- Testing
- Metformin ER
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis, Poststroke/CVA Hemiparesis
Efficacy of Split Gait in the Treatment of Dynamic Asymmetries in Subjects With Pathologic Claudication
Walking on a split-belt treadmill (each of the two belts running at a different speed) imposes an asymmetrical gait, mimicking limping that has been observed in various pathologic conditions.
- Conditions
- Multiple Sclerosis, Poststroke/CVA Hemiparesis, Parkinson Disease, Amputation
- Trial name
- ESPLICA (NCT04635436)
- Testing
- Split-belt treadmill walking.
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Lumbar Spinal Stenosis
Condition of Approval Study
This prospective, multicenter longitudinal five-year study of X-STOP PEEK usage in LSS patients is designed to supplement pre-market safety and effectiveness data with information on longer-term device performance in a population…
- Trial name
- COAST (NCT00517751)
- Testing
- X-STOP PEEK
- Where
- 23 sites in United States
- Volunteers
- 176 people
- Sponsor
- Medtronic Spine LLC
Spinal Stenosis, Lumbar Region, With Neurogenic Claudication
Clinical Effectiveness, Security And Radiological Changes In Epiduroscopy For Lumbar Stenosis
It will be done a prospective Study involving 38 patients with lumbar stenosis. A magnetic resonance (MR) imaging study and a electromyographic study will be done previously and 3 months after the epiduroscopy to confirm…
- Trial name
- NCT03863067
- Testing
- Epiduroscopy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Sarcopenia, Body Composition
CT Body Composition as Predictor of Exercise Therapy Outcome in Peripheral Arterial Disease
Supervised exercise therapy (SET) is the recommended first treatment for patients with leg artery disease (peripheral arterial disease, PAD) causing pain when walking.
- Conditions
- Sarcopenia, Body Composition, Sarcopenic Obesity, Peripheral Arterial Disease
- Trial name
- COMPOSE-PAD (NCT07433309)
- Testing
- SET physiotherapy, CT scan
- Volunteers
- 128 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Peripheral Artery Disease, Claudication, Intermittent
Lactate Increase in Peripheral Artery Disease
To our knowledge, the measurement of the transcutaneous oxygen pressure during walking is the only continuous method that estimates the importance of ischemia, bilaterally and segment of limb by segment of limb.
- Trial name
- STELLA (NCT03266861)
- Testing
- Exercise oximetry
- Where
- France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Angers
Peripheral Arterial Disease
A Study of the Gore VIABAHN BX for Treatment of Occlusive Disease in the Iliac Arteries.
Evaluation of the Gore(R) VIABAHN BX for the treatment of arterial occlusive disease in the common and/or external iliac arteries.
- Trial name
- VBXFLEX (NCT02080871)
- Testing
- Stenting of the Common and/or External Iliac Arteries
- Where
- 27 sites in United States, New Zealand
- Volunteers
- 134 people
- Sponsor
- W.L.Gore & Associates
Peripheral Arterial Disease (PAD), Intermittent Claudication
Home-based Exercise Therapy for Patients With PAD
Cardiovascular disease represents a considerable economic burden to society and effective preventive measures are necessary. Patients with peripheral arterial disease (PAD) have a severe impairment of functional ability, namely…
- Trial name
- WalkingPAD (NCT04749732)
- Testing
- WalkingPad plus Psychological Intervention - PsyWPad Group, WalkingPad plus Virtual Assistant - CyberWPad Group, WalkingPad group - Paper WPad Group
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Centro Hospitalar do Porto
Peripheral Arterial Disease, Intermittent Claudication
Zibotentan, an Endothelin Receptor Antagonist, Patients With Intermittent Claudication
Peripheral artery disease (PAD) is a major complication of atherosclerosis when blockages in the arteries to leg reduce blood flow and one of the resulting problems is termed intermittent claudication (IC).
- Trial name
- NCT01890135
- Testing
- Zibotentan (ZD4054)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Virginia
Peripheral Arterial Disease, Intermittent Claudication
Arm-crank Exercise Training on Cardiovascular Function of Patients With Peripheral Artery Disease
The aim of the study is to analyze the effect of 12 weeks of arm crank exercise (ACE) training on cardiovascular function in PAD patients, and compare it with treadmill exercise (TE), the actual recommendation for this patients.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Hypertension
- Trial name
- NCT03837639
- Testing
- Arm ergometer, Treadmill ergometer, Control group
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Hospital Israelita Albert Einstein
Peripheral Arterial Occlusive Disease Fontaine Stage IIa
Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication
The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited.
- Trial name
- NCT05111379
- Where
- Estonia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Intermittent Claudication
Assess the Safety and Effectiveness of Once Daily PMR Compared to Twice Daily Pletaal® in Patients With Intermittent Claudication
The study is designed to compare the efficacy and safety of once daily PMR treatment with twice daily Pletaal® treatment in patients with intermittent claudication caused by peripheral arterial disease and are currently treated…
- Trial name
- NCT06886620
- Testing
- Cilostazol 200 mg, Cilostazol 100 mg
- Where
- 5 sites in Taiwan
- Volunteers
- 14 people
- Sponsor
- Genovate Biotechnology Co., Ltd.,
Spinal Stenosis
Effectiveness of a 6-week Specific Rehabilitation Program on Walking Capacity in Patients With Lumbar Spinal Stenosis
The aim of this study is to determine the effectiveness of a 6-week specific rehabilitation program combining education and exercises on walking capacity in patients with LSS causing NC.
- Trial name
- NCT05513326
- Testing
- Exercises and education, Education alone
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Université du Québec à Trois-Rivières
Peripheral Arterial Disease, Claudication, Intermittent
SFA TReatment and vAscular Functions
Endovascular treatment of the superficial femoral artery has a high initial success rate, but restenosis occurs in up to 60% of cases.
- Trial name
- STRAtiFy (NCT03811925)
- Testing
- Angioplasty and drug coated balloon of the superficial femoral artery (SFA), Angioplasty and stenting of the superficial femoral artery (SFA)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Essen
Lumbar Spinal Stenosis, Spondylolisthesis, Grade 1
Pedicle Osteotomy for Stenosis Trial
This is a pivotal Randomized Clinical trial to compare the safety and effectiveness of the Pedicle Lengthening Osteotomy Procedure with implantation of the Altum® Device to open surgical decompression and Transforaminal Lumbar…
- Conditions
- Lumbar Spinal Stenosis, Spondylolisthesis, Grade 1, Neurogenic Claudication
- Trial name
- POST (NCT03381677)
- Testing
- Pedicle Lengthening Osteotomy with Altum® Device, Control
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Innovative Surgical Designs
Spinal Stenosis
Intermittent Neurogenic Claudication Treatment With APERIUS®
The primary purpose of the study is to measure the change in severity of symptoms and ability to function in every day activities in patients suffering from degenerative lumbar spinal stenosis after treatment with the Aperius®…
- Trial name
- INCA (NCT00887744)
- Testing
- Aperius® Percutaneous Interspinous Spacer
- Where
- 12 sites in Belgium, Germany and 1 more
- Volunteers
- 162 people
- Sponsor
- Medtronic Spinal and Biologics
Claudication, Peripheral Artery Disease
The Effects of Diet and Exercise Interventions in Peripheral Artery Disease
This study is a 3-month, prospective, randomized controlled clinical trial designed to address the efficacy of the DASH dietary program combined with a home-based exercise program, quantified by a step activity monitor, to…
- Trial name
- NCT03845036
- Testing
- DASH Diet plus Home-Based Exercise, Home-Based Exercise
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Oklahoma
Peripheral Vascular Disease
Trial of VLTS-934 in Subjects With Intermittent Claudication Secondary to Peripheral Arterial Disease
This is a phase II, multicenter, randomized, double-blind, placebo-controlled trial in which subjects with intermittent claudication (IC) will be randomized to receive a single treatment of VLTS-934 (84 mL, or a total of 420 mg…
- Trial name
- NCT00113009
- Testing
- VLTS-934
- Where
- 32 sites in United States
- Volunteers
- 148 people
- Sponsor
- Valentis
Peripheral Arterial Disease, Intermittent Claudication
Non-Contrast Enhanced Peripheral Magnetic Resonance Angiography
To systematically develop, test, and refine peripheral vascular electrocardiography-gated fast spin echo magnetic resonance imaging for the accurate diagnosis of peripheral arterial disease without gadolinium contrast.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Peripheral Vascular Disease
- Trial name
- NCT02823444
- Testing
- Magnetic Resonance Angiography
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Utah
Peripheral Artery Disease, Claudication, Intermittent
Red Light Treatment in Peripheral Artery Disease
Subjects with a known diagnosis of peripheral artery disease as measured by an abnormal ankle brachial index (<.9 or >1.1) will undergo a single 5 min exposure of 670 nm light, 1 cm above the gastrocnemius muscle.
- Conditions
- Peripheral Artery Disease, Claudication, Intermittent, Vasodilation
- Trial name
- NCT03203239
- Testing
- Red Light (670 nm energy), Octafluoropropane
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham