Clinical trials: Cleft Lip and Palate, open to volunteers
Cleft Lip and Cleft Palate, Cleft Lip Palate
Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation.
The goal of this clinical trial is to learn if teaching speech skills to infants with cleft palates, prior to palate repair, will help them to develop speech and language skills.
- Conditions
- Cleft Lip and Cleft Palate, Cleft Lip Palate, Cleft Lip and/or Palate, Cleft Palate
- Trial name
- NCT07219901
- Testing
- Early intervention for language, articulation and palatal function skills
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Old Dominion University
Cleft Lip and Palate, Rhinoplasty
Single Stage Versus Multiple Staged Repair of Nasal & Alveolar Deformities in Patients With Cleft Lip and Palate
Cleft lip and palate patients are commonly seen among maxillofacial patients. Patients with cleft lip and palate have evident cosmetic nasal deformities.
- Trial name
- NCT06510881
- Testing
- Rhinoplasty with or without cleft alveolus repair
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cleft Lip and Palate, Cleft Palate Children
Perceptions of High and Low Intensity Speech Intervention in Children With a Cleft Palate
A cleft (lip and) palate is the most common congenital abnormality of the face and skull with a significant social impact, affecting speech, hearing, feeding, oral behavior, dentition and satisfaction with appearance.
- Conditions
- Cleft Lip and Palate, Cleft Palate Children, Speech Therapy, Speech Disorders in Children
- Trial name
- NCT07781566
- Testing
- High-intensity speech therapy for children with cleft palate, Low-intensity speech therapy for children with cleft palate
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- University Ghent
Cleft Lip and Palate
Phase I-IIa, to Evaluate the Safety, Feasibility, and Efficacy of the Use of BIOCLEFT in the Treatment of Cleft Palate.
Phase I/II, controlled, open-label, randomized, single site clinical trial to assess the safety and feasibility, as well as hint efficacy evidence of a bioengineered palate mucosa substitute on nanostructured fibrin-agarose…
- Trial name
- NCT06408337
- Testing
- implantation with an autologous human palatal mucosa substitute made of nanostructured fibrin-agarose generated by tissue engineering (BIOCLEFT).
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Elisa María Cubiles Montero de Espinosa
Cleft Palate, Orofacial Cleft
Neural Network to Calculate Morphology of the Cleft Palate to Reduce Cleft Lip and Palate Treatment Burden.
This study is to develop a neural network to compute palatal three dimensional (3D) geometry by using routinely taken intraoral/palatal photographs and palatal casts of infants with cleft lip and palate deformity for reducing…
- Trial name
- NCT04342234
- Testing
- data collection of palatal casts and palatal images of cleft patients routinely treated at the institution
- Where
- Switzerland
- Volunteers
- 450 people
- Sponsor
- University Hospital, Basel, Switzerland
Cleft Lip Palate, Orofacial Cleft
Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery
Orofacial clefts are among the most common congenital malformations, affecting approximately 1 in 700-1500 live births worldwide.
- Conditions
- Cleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia Assessment
- Trial name
- NCT07557576
- Testing
- Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Iva Smiljanić
Cleft Lip and Cleft Palate
Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and Palate
The aim of this work is to study the relation between SNP rs2235371 of IRF 6 gene and Non-Syndromic Cleft Lip and Palate in Egyptian Patients in a prospective study
- Trial name
- NCT06730880
- Testing
- PCR
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Maxillary Hypoplasia, Cleft Lip Palate
Time and Type Dependent Evaluation of Different Techniques for Correction of Cleft Maxillary Hypoplasia
Maxillary hypoplasia in CLP deformities results from congenital reduction in midfacial growth and the effects of the surgical scar from CLP repair.Turvey et al.
- Conditions
- Maxillary Hypoplasia, Cleft Lip Palate, Orthognathic Surgery
- Trial name
- NCT06852196
- Testing
- orthognathic surgery ,lefort 1,bsso ,DO, distraction osteogenesis
- Volunteers
- 22 people
- Sponsor
- Assiut University
Cleft Lip Palate
Safety and Efficacy of Bone Bioengineering Kit With Stem Cells for Alveolar Cleft Repair
The objective of this study is to compare the safety and efficacy of a bone tissue engineering kit - composed of 10⁶ autologous mesenchymal stem cells derived from deciduous dental pulp combined with Bio-Oss® Collagen - with…
- Trial name
- NCT07305623
- Testing
- Bioengineering kit composed of stem cells from deciduous teeth and biomaterial., iliac crest bone graft surgery
- Where
- 2 sites in Brazil
- Volunteers
- 205 people
- Sponsor
- Instituto de Tecnologia do Paraná
Cleft Lip, Cleft Palate
Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet)
The Allied Cleft \& Craniofacial Quality-Improvement and Research Network (ACCQUIREnet) is a group of multidisciplinary cleft teams that have implemented a system for prospective collection of outcomes data, based on the ICHOM…
- Conditions
- Cleft Lip, Cleft Palate, Cleft Lip and Palate
- Trial name
- ACCQUIREnet (NCT02702869)
- Testing
- cleft lip repair, cleft palate repair, oronasal fistula repair
- Where
- 11 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Duke University
Cleft Lip and Palate
Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing
Despite significant progress made in identification on numerous genes and gene pathways critical for craniofacial development, several approaches, ie mutation screening of specific candidates, association studies and even…
- Trial name
- GENEPIC (NCT03065686)
- Testing
- identification of genetic factors
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cleft Palate Children, Speech Therapy
Effect and Cost-utility of of High Intensity vs. Low Intensity Speech Intervention in Children With Cleft Palate
Achieving speech that is understandable and acceptable to others is the key outcome in cleft treatment. Therefore, speech therapy provided by a speech-language pathologist is necessary.
- Conditions
- Cleft Palate Children, Speech Therapy, Speech Disorders in Children, Cleft Lip and Palate
- Trial name
- NCT06381713
- Testing
- High intensive combined phonetic-phonological intervention, Low intensive combined phonetic-phonological intervention
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Ghent
Cleft Palate +/- Lip
Speech Intervention Frameworks in Cantonese-speaking Children and Adolescences With Cleft Palate +/- Lip
Cleft Palate ± Lip (CP±L) is one of the most well-known congenital anomalies worldwide. Children and adolescences with CP±L are at high risk of developing speech and communication difficulties due to a range of cleft-related…
- Trial name
- NCT07692061
- Testing
- Non-linear based phonological speech intervention, Linear-based speech intervention
- Where
- Hong Kong
- Volunteers
- 12 people
- Sponsor
- Chinese University of Hong Kong
Cleft Lip and Cleft Palate
Aesthetic and Functional Self-Assessment Following Rhinoseptoplasty in Patients With Unilateral Cleft Lip and Palate
Secondary rhino-septoplasty in unilateral cleft lip and palate is the treatment of choice for the correction of aesthetic deformities and the functional impact on ventilation nasal. It remains a difficult treatment.
- Trial name
- RHINOFENTE (NCT07048418)
- Testing
- Mailing and completing CLEFT-Q and NOSE questionnaires
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Blepharocheilodontic Syndrome
CDH1-associated Blepharocheilodontic Syndrome Registry
The aim of the CDH1-associated Blepharocheilodontic Syndrome (BCDS) registry is to better characterize the clinical features of this condition and exploring whether CDH1 variants linked to BCDS may also increase cancer risk.
- Trial name
- NCT07133464
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Cleft Lip and Palate
Use of Computer Aided Design and 3D Printing for Anesthesiology Management in a Pediatric Patient With Cleft Facial Defect
Congenital malformations of the orofacial area are the most common congenital malformations in children with an incidence of 1.8 children with orofacial cleft per 1000 healthy births in the Czech Republic.
- Trial name
- 3D obturator (NCT04422847)
- Testing
- 3D obturator
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Brno University Hospital