Clinical trials: Climacteric Symptoms
Postmenopause
Use of the Synthetic Hormone CDB-2914 in Treating Symptoms of Menopause
This study will examine the safety and effectiveness of a synthetic hormone, CDB-2914, for treating symptoms of menopause. It will compare the effects of estrogen and CDB-2914 with those of estrogen and progesterone in…
- Trial name
- NCT00009659
- Testing
- CDB 2914
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Menopause, Hot Flushes
Alternative Treatments for Menopausal Women
To investigate the reported health benefits (lipid profile, inflammatory factors, cardiovascular status and bone density) of a novel, phytoestrogen rich, Red Clover treatment on women suffering from both menopause related primary…
- Conditions
- Menopause, Hot Flushes, Osteoporosis, Dyslipidemia
- Trial name
- NCT02028702
- Testing
- Red Clover extract
- Where
- Denmark
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Increased Risk for Development of Breast Cancer
Pilot Study of Bazedoxifene Plus Conjugated Estrogen on Imaging and Blood Biomarkers
Pilot study to test feasibility of 6 months of bazedoxifene (BZA) plus conjugated estrogens (CE) to modulate breast MRI parameters.
- Trial name
- NCT04821375
- Testing
- bazedoxifene plus conjugated estrogens
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Carol Fabian, MD
Menopause, Hot Flashes
Aromatherapy and Yogatherapy for Hot Flashes
The purpose of this study is to verify and analyse psychological and physiological effects of olfactory aromatherapy and yogatherapy respiratory exercises, together and separately, on the quality of life, levels of stress…
- Conditions
- Menopause, Hot Flashes, Hot Flushes
- Trial name
- NCT01816360
- Testing
- Olfactory aromatherapy, Yogatherapy
- Where
- Brazil
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Major Depressive Disorder, Menopausal Staging and Vasomotor Symptoms (for Females)
Desvenlafaxine Succinate (DVS) for Major Depressive Disorder (MDD) in Midlife Men and Women
The main objective of this study is to characterize a range of brain activation symptoms associated with depression and response to treatment in midlife men and women with MDD, using MRI and functional MRI.
- Trial name
- DVS (NCT00888862)
- Testing
- Desvenlafaxine Succinate
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Postmenopausal Symptoms
Pharmacokinetic Evaluation of Brisdelle™ (Formerly Known as Mesafem) Following Single & Repeat Oral Administration in Healthy Postmenopausal Women
The purpose of this study is to assess the pharmacokinetics (absorption, breakdown and elimination from the body), safety and tolerability of Brisdelle (paroxetine mesylate) Capsules 7.5 mg when given as a single dose and…
- Trial name
- N30-005 (NCT01829919)
- Testing
- Brisdelle (paroxetine mesylate)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Noven Therapeutics
Menopause
A Randomized-Controlled Trial to Examine the Effects of a Daily Probiotic Supplement on Common Symptoms of Menopause
Symptoms of menopause can significantly affect overall quality of life. It is hypothesized that probiotic supplements can reduce the severity of these symptoms.
- Trial name
- NCT06148714
- Testing
- Provitalize Natural Menopause Probiotic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maneuver Marketing
Physical Activity, Blood Pressure
Effect of Mat Pilates Training on Women After Menopause
This project aims to verify the chronic effect of Mat Pilates exercise on climacteric symptoms, ambulatory blood pressure responses, lipid and glucose profile and pro and anti-inflammatory and antioxidant markers in…
- Trial name
- NCT03626792
- Testing
- Hypertensive group, Normotensive group
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Hot Flashes, Night Sweats
Comparison of Hormonal Therapy: Mediating Hot Flashes Tapering Regimens for Mediating Hot Flashes
This study will evaluate whether there is a difference in the proportion of women who report a worsening severity of their hot flashes between three tapering schedules for one accepted HT/ET regimen.
- Trial name
- NCT00547001
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Postmenopausal Symptoms
Photobiomodulation in Post Menopause Genitourinary Syndrome
The goal of this project is to evaluate the clinical response of patients with symptoms of genitourinary menopause syndrome after the application of photobiomodulation in the vagina and its introit.
- Trial name
- NCT05557799
- Testing
- Photobiomodulation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Perimenopause, Menopause
The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.
The aim of this clinical trial is to determine if resistance training and a newly developed plant-based nutritional supplement can improve the symptoms and musculoskeletal health of perimenopausal women.
- Trial name
- NCT07135232
- Testing
- Sarmentosin - L- theanine, Resistance Training
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Menopause
The Effects of Fractal Mindfulness Virtual Reality on Menopause Symptoms
The study aimed to establish the effectiveness of an immersive mindfulness virtual reality intervention using fractal software for women experiencing menopausal symptoms.
- Trial name
- NCT07044284
- Testing
- Fractal mindfulness recombination
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- London Metropolitan University
Menopause, Anxiety Disorders
Treating Climacteric Symptoms With a Complex Homeopathic Remedy
The purpose of this study is to determine whether ovaria comp. is effective in relieving climacteric symptoms.
- Conditions
- Menopause, Anxiety Disorders, Depression
- Trial name
- NCT00152776
- Testing
- ovaria comp 10 globuli 3 times per day 24 weeks
- Where
- Germany
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Menopause
Single-Dose Study of Black Cohosh and Red Clover
This Phase I study will assess the pharmacokinetics of two botanicals, Trifolium pratense (red clover) and Cimicifuga racemosa (black cohosh). Participants will receive a single dose of one botanical preparation.
- Trial name
- NCT00010959
- Testing
- Cimicifuga racemosa, Trifolium pratense
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Menopause, Sleep
Cukurova University Faculty of Medicine Non-interventional Clinical Research Institutional Ethics Committe
This research was carried out to determine the effect of therapeutic touch on sleep quality and fatigue in menopausal women.
- Conditions
- Menopause, Sleep, Fatigue, Therapeutic Touch
- Trial name
- NCT05075694
- Testing
- Therapeutic Touch
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cukurova University
HDL Cholesterol
High-density Lipoprotein (HDL) Cholesterol in Women Taking Tibolone
Tibolone (Livial) has been shown in previous studies to lower HDL cholesterol by up to 40%. This study aims to study the effects of fenofibrate on HDL and subfractions in women taking tibolone.
- Trial name
- TibFen (NCT00809068)
- Testing
- fenofibrate and tibolone, tibolone
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Keogh Institute for Medical Research
Obesity
Celecoxib Inhibition of Aromatase Expression and Inflammation in Adipose Tissue of Obese Postmenopausal Women
The study plans to find out whether Celebrex may be potentially useful to decrease inflammation in fat tissues and thereby lower the production of substances such as estrogens that may increase the risk of developing breast…
- Trial name
- NCT01901679
- Testing
- Celebrex
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Postmenopausal Symptoms
The Effects of Isoflavone and Estrogen in Sex Response in Climacteric Women
Climacterium is marked by hypoestrogenism and it is associated to drastic vasomotors symptoms, genital atrophy and humor alteration. Additionally, these symptoms impair sexual life and life quality.
- Trial name
- NCT00905723
- Testing
- estradiol, isoflavone
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Postmenopausal Symptoms
Insomnia and Mindfulness Stress Reduction Program
Menopause is the longest life stage in a woman's life, in which psychological and social changes are experienced as well as physical changes and some health problems occur.
- Trial name
- NCT05202054
- Testing
- mindfulness stress reduction program
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- NURDİLAN SENER
Menopause, Hot Flashes
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
- Conditions
- Menopause, Hot Flashes, Blood Pressure Regulation
- Trial name
- NCT06743269
- Testing
- High-Resistance Inspiratory Muscle Strength Training, Low-Resistance Inspiratory Muscle Strength Training, POWERbreathe K3 device
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic