Clinical trials: Clinical
Patients With Different Manifestations of Lyme Borreliosis, Persons With Nonspecific Symptoms and Positive Borrelia Antibodies in Serum
Anti-phospolipid Antibodies in Lyme Borreliosis
Background Lyme borreliosis, caused by Borrelia burgdorferi sensu lato is transmitted to humans through the bite of an infected Ixodes tick. B.
- Conditions
- Patients With Different Manifestations of Lyme Borreliosis, Persons With Nonspecific Symptoms and Positive Borrelia Antibodies in Serum, Blood Donors
- Trial name
- NCT06929546
- Testing
- Anti-phospholipid antibodies
- Where
- Slovenia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Effect of Platelet Rich FibrinDuring Clear Aligner Therapy
Influence of Injectable Platelet Rich Fibrin on Different Orthodontic Tooth Movements During Clear Aligner Therapy
The aim of this prospective clinical project will be to assess the effect of platelet rich fibrin on the rate of different orthodontic tooth movements during clear aligner therapy.
- Trial name
- NCT06380946
- Testing
- iPRF
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Radiation-Induced Mucositis
Efficacy of Glutamine in Management of Radiation Mucositis
The goal of this [ type of study: Clinical trial] is to test effectiveness of glutamine in management of Radiation Induced Mucositis in head and neck cancer patients.
- Trial name
- NCT05856188
- Testing
- Glutamine
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Carious Teeth, Adaptation
Marginal Evaluation of Zirconia Reinforced Lithium Disilicate Partial Coverage Restoration of Egyptian Posterior Teeth.
Objective: To evaluate the marginal adaptation of the zirconia reinforced lithium disilicate (VITA AMBRIA) glass ceramic Inlay/Onlay compared with lithium disilicate(IPS emax Press) glass ceramic Inlay/Onlay in decayed posterior…
- Trial name
- NCT05281861
- Testing
- Zirconia reinforced Lithium disilicate (Vita Ambria) ceramic onlay restoration, Lithium disilicate (IPS e-max press) ceramic onlay restoration
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Nurse-Patient Relations
A Controlled Study of Improved Javelin Side Recumbent Position and Conventional Postural Placement
The Da Vinci surgical robot Xi system assisted laparoscopic pyeloureteroplasty uses the improved javelin side lying position, which can alleviate the unsafe factors of falling from the bed caused by the conventional posture…
- Trial name
- NCT05551442
- Testing
- To explore the comparative study of different positioning methods in robot assisted laparoscopic pyeloplasty., To discuss the comparative study of different position placement methods of renal pelvis ureteroplasty on the Da Vinci robotic Xi platform
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guiyang Maternal and Child Health Care Hospital
Atrophic Vaginitis
A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis
The purpose of this study is to determine the therapeutic equivalence of Mylan's estradiol vaginal cream to Estrace® cream and superiority of both products to placebo.
- Trial name
- NCT02195986
- Testing
- Estradiol Vaginal Cream, 0.01%, Estrace® 0.01% cream
- Where
- 21 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Transposition of Great Arteries
Cardiovascular Magnetic Resonance in Adults With SysTemic Right Ventricle (STAR)
The main aim of the study is to explore HFs in SRV, comparing their magnitude and direction with that of subpulmonary RV and systemic LV.
- Trial name
- STAR (NCT05690854)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Coronavirus
Phase I Clinical Study of Recombinant Novel Coronavirus Vaccine
In this trial, a total of 50 subjects were recruited; the test vaccines were divided into 3 groups, low-dose vaccine groups, high-dose vaccine groups, and placebo groups.
- Trial name
- NCT04445194
- Testing
- Recombinant new coronavirus vaccine (CHO cell) low-dose group, Recombinant new coronavirus vaccine (CHO cells) high-dose group
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.
Skin Inflammation
Skin IaM: An Exploratory Clinical Trial to Evaluate Changes in Skin Appearance, Colour, and/or Texture Following the Induction of a Local Inflammatory Skin Response
This trial will test the feasibility of various imaging devices to detect local skin inflammation prior to clinical manifestation.
- Trial name
- NCT03192280
- Testing
- Leukotriene B4, FLIR One, SCIO
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Dental Anxiety
Effects of Aromatherapy on Anxiety and Pain During Dental Treatment in Adults
Dental anxiety is a common problem in dental care. The aim of this protocol is to evaluate the effect of orange and tea essential oil for the control of anxiety and pain in adults during dental treatments.
- Trial name
- NCT06347679
- Testing
- Aroma diffuser with single-note sweet orange essential oil, Aroma diffuser with single-note tea tree essential oil, Aroma diffuser with water
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Respiratory Syncytial Virus Infections
Clinical Trial of Recombinant RSV Vaccine (CHO Cell) (Adjuvanted) in Chinese Population Aged 18 Years and Older.
The primary objective of the phase I trial is to evaluate the safety and tolerability of different doses of the recombinant respiratory syncytial virus vaccine (CHO cell) (Adjuvanted) in adults aged 18 years and older, with the…
- Trial name
- NCT07582796
- Testing
- Recombinant Respiratory Syncytial Virus Vaccine(CHO cell)(Adjuvanted), Recombinant Respiratory Syncytial Virus Vaccine(CHO cell) (Single adjuvant), Recombinant Respiratory Syncytial Virus Vaccine(CHO cell) (Blank adjuvant)
- Where
- China
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- Ab&B Bio-tech Co., Ltd.JS
Hyperparathyroidism, Secondary
Impact of Parathyroidectomy on Vascular Calcification and Clinical Outcome in Hemodialysis Patients
The aim of this study is to assess the clinical, laboratory and vascular calcification outcome within 6 months duration in patients undergoing surgical parathyroidectomy (total, subtotal, and total with autotransplantation)
- Trial name
- NCT03724188
- Testing
- surgical parathyroidectomy
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Mansoura General Hospital
Bilateral Edentulous Mandible (Kennedy Class I)
Treatment Outcomes After Receiving Conventional Clasp or Precision Attachment Removable Partial Dentures.
PICOTS: P: Kennedy class І patients I : Mandibular removable partial denture with OT Cap attachment C: Mandibular removable partial denture with gingival approaching clasp assembly O: 1ry outcome: Oral Health Related Quality of…
- Trial name
- OTCap (NCT02924142)
- Testing
- OT Cap attachment
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Selective Caries Removal (SCR) Versus Pulpotomy in Preventing Pulp Necrosis and Apical Periodontitis
The study design is a randomized controlled trial and up to 120 teeth, 50 in each of the 2 groups, will be enrolled from the patients at the National University Centre for Oral Health Singapore (NUCOHS) Endodontic unit.
- Trial name
- NCT04672070
- Testing
- Selective Caries Removal, Pulpotomy
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Non-carious Cervical Lesions
Evaluation of the Solvent Evaporation Time of Universal Adhesives in the Quality of Cervical Lesions Restorations
The aim of this study will be to evaluate the effect of prolonging solvent evaporation time on the 6- and 12-months clinical performance of two universal adhesive systems used as selective enamel etch (SEE).
- Trial name
- NCT05945173
- Testing
- Evaporation time for 5 seconds, Evaporation time for 25 seconds, alcohol/water-based universal adhesive
- Where
- Chile
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Pediatric Flexible Flatfoot
Clinical and Functional Outcomes After Subtalar Arthroereisis in Pediatric Flexible Flatfoot
Flexible flatfoot is common in children and adolescents. In some patients, the condition remains painful or limits activity despite non-surgical treatment.
- Trial name
- STA-PFF (NCT07803341)
- Testing
- Subtalar Arthroereisis
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Obesity
A Phase I Study of Single and Multiple Doses of HS-20136-2 Injection in Healthy or Obese Participants
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of HS-20136-2 injection in healthy/obese participants.
- Trial name
- NCT07716241
- Testing
- HS-20136-2
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Angle Class I Malocclusion, Dental Crowding
Clinical Performance of Direct-Printed Versus Thermoformed Aligners
The goal of this study is to evaluate and compare the clinical effectiveness of in-office directly 3D-printed clear aligners versus conventional multilayered thermoformed aligners.
- Conditions
- Angle Class I Malocclusion, Dental Crowding, Tooth Spacing
- Trial name
- NCT07637227
- Testing
- Direct-Printed Aligner, Thermoformed aligner
- Where
- 3 sites in Iraq
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Athlete, Probiotic
Clinical Trial of Lactiplantibacillus Plantarum Dad-13 on Gut Microbiota Profile and Performance in Adolescent Athletes
The aim of this research is to analyze the effect of a Lactiplantibacillus plantarum Dad-13 supplementation on the gut microbiota profile and performance of adolescent athletes.
- Conditions
- Athlete, Probiotic, Performance, Gut Microbiota
- Trial name
- Dad-13 (NCT07476573)
- Testing
- Probiotic Lactiplantibacillus plantarum Dad-13
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Healthy
Drug-Drug Interaction (DDI) Study for TQB3616
To evaluate the effect of itraconazole/rifampicin on the pharmacokinetics of TQB3616 capsules. To assess the safety of a single dose of oral TQB3616 capsules and in combination with itraconazole/rifampicin.
- Trial name
- NCT06662773
- Testing
- TQB3616 capsule + itraconazole, TQB3616 capsule + rifampicin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
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