Clinical trials: Clinical
Dental Caries
Preventing Caries with Silver Diamine Fluoride
Background: Early childhood caries (tooth decay, ECC) affected 55% 5-year-old Hong Kong children, and 70% of these children had gross destruction of the upper anterior teeth with negative long-term impacts on health and quality…
- Trial name
- NCT04399369
- Testing
- SDF, NaF
- Where
- Hong Kong
- Volunteers
- 688 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Preeclampsia
Predictors of Aspirin Failure in Preeclampsia Prevention
Hypertensive disorders of pregnancy (including preeclampsia) are among the leading causes of pregnancy complications and maternal deaths worldwide. They also increase the risks to the babies.
- Trial name
- NCT05709483
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Healthy
Clinical Evaluation of the Care On Line Thermometer
The purpose of this clinical study is to evaluate the performance of the COL thermometer by comparing its measurement to equilibrium measurement and to make a final tuning of the thermometer algorithm.
- Trial name
- NCT00544141
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medisim Ltd
Autoimmune Disease
A Study of Safety, Tolerability, PK, and PD of Subcutaneous GenSci136 in Healthy Adults.
This study is designed to evaluate the safety, tolerability, PK and PD of GenSci136 in a randomized, double-blind, placebo-controlled trial involving healthy adult participants.
- Trial name
- NCT07366866
- Testing
- GenSci136
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Malocclusion, Angle Class III
Dentofacial Effects Of Two Non-Compliance Appliances In The Treatment Of Growing Skeletal Class III Patients
Early orthodontic treatment of Class III malocclusions with skeletal and dentoalveolar imbalances, represents a continuous dilemma.
- Trial name
- NCT04825951
- Testing
- CS 2000
- Where
- Egypt
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Chronic Hepatitis B
GLS4/RTV and TAF Drug-drug Interaction
The purpose of this study is to evaluate the drug-drug-interaction (DDI), pharmacokinetics (PK) and tolerability of GLS4/RTV combined with TAF in healthy subjects.
- Trial name
- NCT04551261
- Testing
- GLS4, RTV, TAF
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Dental Cements, Tooth Abnormalities
Artificial Root-End Barriers
This study retrospectively looks to determine the clinical success of ProRoot MTA used as an artificial apical barrier in teeth with immature apices.
- Trial name
- NCT00595842
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Irreversible Pulpitis
Post Operative Pain and Oral Health Related Quality of Life Following Pulpotomy VS Extraction of Permanent First Molar
The goal of this clinical trial is to compare between post operative pain and oral health related quality of life in participants receiving two treatments for first permanent mandibular molars with poor prognosis.
- Trial name
- NCT06420583
- Testing
- MTA pulpotomy, Extraction
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Clinical Syndrome
Oral Ivermectin for Chikungunya Viral Infection
Chikungunya viral infection (CVI) is a mosquito-borne infection, caused by chikungunya virus (CHIKV), an alphavirus, belonging to the family Togaviridae.
- Trial name
- NCT06259383
- Testing
- Ivermectin
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Healthy
VASER-Assisted Lipoplasty Compared With Suction-Assisted Lipoplasty
This study is being done to compare two commonly available types of body contouring, VASER-Assisted Lipoplasty (VAL) and Suction-Assisted Lipoplasty (SAL), and to decide if one procedure is preferred by patients and/or surgeons…
- Trial name
- Contra-Lateral (NCT00731354)
- Testing
- Suction-assisted Lipoplasty, VASER-assisted lipoplasty
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Sound Surgical Technologies, LLC.
Osteopetrosis
Clinical Assessment of Patients With High Bone Mass Due to Mutation in Lrp5
The aim of the study is to describe patients with a high bone mass phenotype due to a mutation in the low density lipoprotein l receptor 5 gene (LRP5) and compare them with age and sex matched controls.
- Trial name
- NCT01199094
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Metabolic Syndrome
Safety, Tolerability and Pharmacokinetic Study of MB12066 in Healthy Male Volunteers
The purpose of this study is to investigate the safety and tolerability of MB12066 after multiple dose and to investigate the pharmacokinetic characteristics of MB12066 after multiple dose.
- Trial name
- NCT02338856
- Testing
- MB12066 200mg
- Where
- South Korea
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Health Care Utilization
Economic and Clinical Outcomes of (Whole Exome) Sequencing in Tapestry
The purpose of this research is to learn more about the impact of genetic testing on healthcare costs, clinical care, and quality of life.
- Trial name
- ECOST (NCT05045222)
- Where
- 2 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy, Febrile
Comparison of a Novel Non-Invasive, Non-Touch Infrared Thermometer With Routine Thermometry in Routine Clinical Practice
Quantify the reliability and agreement of estimated core body temperature using the InstaTemp MD™ and other widely marketed reference Thermometers
- Trial name
- NCT02805322
- Testing
- ARC InstaTemp MD, Covidien Genius 2 Tympanic Thermometer, Welch Allen SureTemp Plus Sublingual Thermometer
- Where
- Ireland
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- ARC Devices
Overactive Bladder, Pharmacokinetics
A Clinical Study to Determine the Effect of YM178 on the Pharmacokinetics of Warfarin in Healthy Subjects
This study investigates whether YM178 has an effect on the pharmacokinetics of warfarin, to exclude any drug-drug interaction between YM178 and warfarin, and evaluates the safety and tolerability of warfarin alone and combined…
- Trial name
- NCT00856570
- Testing
- warfarin, YM178
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Vital Pulp Therapy
Comparative Evaluation of Three Pulpotomy Agents for Permanent Mature Molars With Irreversible Pulpitis
Statement of the problem: Accurate pulpal diagnosis is essential for decision making between vital pulp therapy and root canal treatment.
- Trial name
- NCT06232941
- Testing
- Full pulpotomy procedure
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy Elderly
Clinical Study to Investigate the Pharmacokinetics and Pharmacodynamics of Metformin in the Elderly
This study aims to investigate the pharmacokinetics/pharmacodynamics metformin IR after oral administration in healthy elderly male volunteers.
- Trial name
- ME01 (NCT02125305)
- Testing
- Metformin
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Encephalitis, Encephalitis, Viral
Venezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine
The primary objective of the study is to evaluate the safety and immunogenicity of non-adjuvanted and adjuvanted monovalent VEE VLP Vaccine in healthy adults (ages 18-50 years) when administered via intramuscular (IM) injection…
- Conditions
- Encephalitis, Encephalitis, Viral, Infectious Encephalitis, Virus Diseases
- Trial name
- VEEV (NCT03776994)
- Testing
- Vaccinations on Day 0, Day 28, and Day 140
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- SRI International
Gut Health, Body Composition
A Clinical Trial to Evaluate the Effects of Cowboy Colostrum on Gut Health, Body Composition, Hair Growth, and Skin Appearance
This study evaluates the effects of Cowboy Colostrum bovine colostrum powder on gut health, body composition, hair growth, and skin appearance in generally healthy adults aged 21-47 with concerns in these areas.
- Conditions
- Gut Health, Body Composition, Hair Growth, Skin Appearance
- Trial name
- NCT07756866
- Testing
- Cowboy Colostrum
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cowboy Colostrum
Diphtheria, Tetanus
Phase I Clinical Trial of Diphtheria-Tetanus-acellular Pertussis Component Combined Vaccine
This study is a randomized, blinded, active-controlled phase I clinical trial to evaluate the safety and preliminary immunogenicity of the Diphtheria-Tetanus-acellular Pertussis Component Combined Vaccine (DTacP) in subjects…
- Conditions
- Diphtheria, Tetanus, Pertussis
- Trial name
- NCT06184542
- Testing
- DTacP (one-dose booster), DTacP (three-dose primary vaccination), DT (one-dose booster)
- Where
- 3 sites in China
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
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