Clinical trials: Clinical
Onchocerciasis, Ocular, Loiasis
Clinical Trial Evaluating the Safety and Efficacy of Levamisole in Loa Loa Microfilaremic Patients
This study aims at evaluating the safety and efficacy of levamisole in patients with loiasis infection.
- Trial name
- EOLoa (NCT04049630)
- Testing
- LEV 1 mg/kg, LEV 1,5 mg/kg, LEV 2,5 mg/kg
- Where
- Republic of the Congo
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Programme National de Lutte contre l'Onchocercose, Republic of the Congo
Prosthodontics, Implants, Dental
Effect of PEEK and Titanium Framework Reinforcement on Marginal Bone Loss Around Implants Supporting a Fixed All-on-four Prosthesis in Completely Edentulous Mandibles
A fixed all-on-four prosthesis will be constructed for the lower arch for each patient and the marginal bone loss will be evaluated at baseline, 3,6,9 and 12 months.
- Conditions
- Prosthodontics, Implants, Dental, Prosthesis, Bone Loss, Alveolar
- Trial name
- NCT07475507
- Testing
- Titanium framework reinforced all on four prosthesis, PEEK framework reinforced all on four prosthesis
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bacterial Count Reduction in Oval Canal After Rotary Instrumentation With Different Systems, Post-operative Pain After Rotary Instrumentation of Oval Canal With Different Systems
Postoperative Pain and Bacterial Reduction in Oval Canals After Instrumentation With Different Noval Rotary Files Systems
Postoperative pain after endodontic treatment can affect a patient's quality of life. It is reported that debris extrusion after the instrumentation technique can influence postoperative pain.
- Trial name
- NCT07019792
- Testing
- Protaper ultimate, Truanatomy file system, Hyflex EDM
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Monoclonal Gammopathy of Undetermined Significance (MGUS), Intestinal Flora
Characteristics and Clinical Significance of Gut Microbiota in Patients With Monoclonal Gammopathy
This is an observational case-control study, aiming to systematically analyze the gut microbiome characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS).
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Intestinal Flora, Multiple Myeloma, M-Protein
- Trial name
- NCT06690593
- Where
- China
- Volunteers
- 2,990 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Orthodontic Appliances
Micro-abrasive Blasting vs Acid Etching of Orthodontic Bracket Bases
To describe a method of acid etching the base of a bracket, and to compare the bond failures between micro-abrasive blasted (sandblasted) brackets and acid etched brackets over an eighteen month period
- Trial name
- NCT04456114
- Testing
- Acid etched brackets, Sandblasted brackets
- Where
- Pakistan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Healthy
Single Rising Doses of BI 655064 in Healthy Chinese and Japanese Male Volunteers
Safety, tolerability, pharmacokinetics and pharmacodynamics of BI 655064 after single rising doses in healthy Asian male volunteers.
- Trial name
- NCT01917916
- Testing
- BI 655064
- Where
- 2 sites in Japan, South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Molar Incisor Hypomineralization
Evaluation of Three Different Minimally Invasive Techniques for Management of Enamel Opacities in Patients With Molar Incisor Hypomineralization "Randomized Controlled Clinical Trial"
The controlled clinical trial will be done to evaluate Resin infiltration, Resin modified glass ionomer varnish and Light cured giomer varnish as minimally invasive techniques for management of enamel opacities of patients with…
- Trial name
- NCT06135272
- Testing
- Resin infiltration, Resin modified glass ionomer varnish, Light cured giomer varnish
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Implant, Bone Resorption
Influence of Abutment Shape on Peri-implant Marginal Bone Loss
A study designed as a randomized controlled trial of parallel group design will be conducted at the Dental clinic of the University of Valencia to evaluate the influence of 2.5 mm high abutments with different shapes…
- Trial name
- NCT03888339
- Testing
- Commercially available high abutments placement, Modified shape abutments
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Periodontal Diseases
Photobiomodulation and Platelets Rich in Growth Factors (PRGFs)-Assisted Flap Surgery in Treating Stage III Periodontal Defects
Stage 3 periodontitis is a condition marked by swift and severe destruction of periodontal tissues. To effectively regenerate osseous defects resulting from periodontal disease, it is crucial to leverage the intrinsic…
- Trial name
- NCT06641739
- Testing
- laser assisted SPPF, Platelet Rich Plasma
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Overweight (BMI > 25)
To Evaluate Efficacy and Safety of Proprietary Healthy Diet Combinations for Weight Management in Overweight Volunteers
This is an open-label, four-arm, randomized, controlled clinical study designed to evaluate the efficacy and safety of a structured Weight Management Program (WMP) in overweight and obese adults with a body mass index (BMI) ≥ 23…
- Trial name
- NCT07452757
- Testing
- Arm II, Arm III, Arm IV
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bioagile Therapeutics Pvt. Ltd.
Adhesion
Dentin Treatments for Restorations of Cervical Lesions Non-Carious
The surface of non-carious cervical lesions (LCNC) is a challenge to adhesive systems, it presents a dentin layer sclera hypermineralized, presence of bacteria and lack of mechanical retention, so this study aimed to evaluate the…
- Trial name
- NCT02434601
- Testing
- Treatment of Dentin Surface, Dentin Surface, Treatment
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Bacterial Infections, Virus Diseases
Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-005)
This is a study to assess the safety, tolerability, and immunogenicity of V419 (PR5I) when administered as an infant series at 2, 4, and 6 months of age followed by a toddler dose of DAPTACEL™, Prevnar 13™ and PedvaxHIB™ at 15…
- Trial name
- NCT01337167
- Testing
- V419, DAPTACEL™, PedvaxHIB™
- Volunteers
- 1,473 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Type II Diabetes Mellitus
A Clinical Trial to Evaluate the Food Effect of CKD-379
A clinical trial to evaluate the food effect of CKD-379
- Trial name
- CKD-379 (NCT06652971)
- Testing
- CKD-379
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Hepatic Impairment
A Clinical Trial of the Study Medicine (Called Fosmanogepix) in Participants With Varying Degrees of Hepatic Function.
The primary purpose of this open-label study is to characterize the plasma pharmacokinetics (PK) of manogepix (active moiety of fosmanogepix) in participants with varying degrees of hepatic function following administration of a…
- Trial name
- NCT05582187
- Testing
- Fosmanogepix
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
COVID-19
Phase I/II Clinical Trial of Recombinant Novel Coronavirus (COVID-19) Vaccine (Adenovirus Type 5 Vector) for Inhalation
This study is a randomized, double-blind, placebo-controlled I/II clinical trial, in order to evaluate the safety and immunogenicity of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) for Inhalation in adults 18…
- Trial name
- NCT04840992
- Testing
- Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) for Inhalation, Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
- Where
- China
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Arthropathy of Hip
Clinical Analysis of Suction Drainage in Cementless Hip Replacement
Randomized prospective study assessing suction drainage in total hip arthroplasty. Group without drainage, 50 hips, compared with group with suction drainage, 50 hips.
- Trial name
- NCT04333264
- Testing
- suction drainage, no suction drainage
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bartosz Paweł
Anti-biotic Resistance
A Clinical Study to Evaluate if Benzalkonium Chloride (BAK) in a Quinolone Eyedrop Reduces the Likelihood of Developing Resistant Organisms
The purpose of this study is to assess if the presence of BAK in a fluoroquinolone in the study eye affects the development of resistant bacteria on the conjunctiva based upon changes in the surface flora over the course of 2…
- Trial name
- NCT00874887
- Testing
- moxifloxacin 0.5% HCI ophthalmic solution, gatifloxacin ophthalmic solution 0.3%
- Where
- 2 sites in United States, Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Allergan
Endometriosis
HerResolve™ in Detecting the Presence of Endometriosis Among Symptomatic Women
Endometriosis (EMS) is a common gynecological disease that affects 176 million girls and women globally. EMS affects 5-10% of women and adolescents within the reproductive age range of 15-49 years, and for those facing…
- Trial name
- NCT07006987
- Testing
- A non-invasive blood-based (HerResolve)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Egg Banking
Egg-Banking and Ovo-donation
Egg-banking would considerably simplify the logistics and means by which oocytes could be donated. These banks would make it easier to immediately provide oocytes that would be compatible to the recipient, shortening or even…
- Trial name
- NCT00785993
- Testing
- Vitrification of oocytes for IVF treatment, Protocolary IVF treatment with fresh donor oocytes
- Where
- Spain
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Gingivitis
A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease
Participants will be given special instructions about taking care of their teeth during the 18 hours before they come to the dentist's office for screening/baseline, 1 week, 2 weeks and 4 weeks.
- Trial name
- NCT02065414
- Testing
- Listerine Advance Gum Defense, Mouth rinse containing Chlorhexidine, Mouth rinse containing 5% Hydroalcohol
- Where
- United Kingdom
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
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