Clinical trials: Clinical Course
Mental Health, Child Wellbeing
Generation Victoria Cohort 2020s: A Statewide Longitudinal Cohort Study of Victorian Children and Their Parents
Generation Victoria (GenV) is a longitudinal, population-based study of Victorian children and their parents that will bring together data on a wide range of conditions ,exposures and outcomes.
- Conditions
- Mental Health, Child Wellbeing, Infant Health, Child Health
- Trial name
- GenV (NCT05394363)
- Where
- Australia
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Chronic Heart Failure, Coronary Artery Disease
The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes
It is well known fact, that prediabetes is a predictor of high cardiovascular mortality, increasing the risk of developing such adverse cardiovascular events as myocardial infarction, stroke and sudden cardiac death.
- Conditions
- Chronic Heart Failure, Coronary Artery Disease, PreDiabetes
- Trial name
- NCT04549415
- Testing
- Metformin Hydrochloride, lifestyle modification
- Where
- Kyrgyzstan
- Volunteers
- 97 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Chronic Hepatitis C
Clinical Trial to Assess Safety and Efficacy of Combination Therapy: Hydroxychloroquine, Pegylated Interferon Alpha-2a and Ribavirin in Chronic Hepatitis C Subjects Non-responders to the Standard of Care Therapy.
The study is aimed to investigate the safety, tolerability and efficacy of a fixed dose combination therapy of: Hydroxychloroquine (HCQ), Pegylated Interferon Alpha-2a (PEG-IFN alpha-2a) and Ribavirin (RBV) in Chronic Hepatitis C…
- Trial name
- NCT01272310
- Testing
- Hydroxychloroquine (HCQ), Pegylated Interferon Alpha-2a (Peg-IFN alpha-2a) and Ribavirin
- Volunteers
- 36 people
- Sponsor
- Sheba Medical Center
Students
The Effectiveness of Using Empathy Courses to Guide OT Students in Case-base Clinical Reasoning
Clinical reasoning is an important cognitive process in medical decision making. In recent years, medical education advocates holistic medicine, but systematic learning is rare in school education.Therefore, this study used an…
- Trial name
- NCT05479110
- Testing
- Empathy experience courses and case-base clinical reasoning, case studies
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Cystic Fibrosis (CF)
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
This is a longitudinal, observational epidemiological study designed to estimate the prevalence of depression, anxiety, and behavior problems in children ages 18 months through 11 years with cystic fibrosis (CF).
- Trial name
- TIDES 2 (NCT07048574)
- Where
- 13 sites in United States
- Volunteers
- 600 people
- Sponsor
- State University of New York at Buffalo
Adenocarcinoma of the Esophagus or Esophagogastric Junction
Palliative Short-course Hypofractionated Radiotherapy Followed by Chemotherapy in Adenocarcinoma of the Esophagus or Esophagogastric Junction Trial - a Phase II Clinical Trial Protocol.
In this trial, patients with histologically proven adenocarcinoma of the esophagus or esophagogastric junction noneligible for surgery or chemoradiation with curative intent will be included.
- Trial name
- PALAESTRA (NCT02241499)
- Testing
- Radiation therapy, Oxaliplatin and fluorouracil.
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Lund University Hospital
Multifocal Motor Neuropathy
A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy
This prospective longitudinal study will follow participants with Multifocal Motor Neuropathy over time and collect data on their clinical outcomes, quality of life, and use of health care resources.
- Trial name
- iMMersioN (NCT05988073)
- Where
- 114 sites in United States, Australia and 18 more
- Volunteers
- 413 people
- Sponsor
- argenx
Recurrent Malignant Glioma
Avastin / Irinotecan in Patients With Recurrent or Progressive Malignant Glioma
Malignant glioma are the most common and aggressive primary brain tumors in adults. Despite advances in multimodal treatment including surgery, radiation and chemotherapy, most patients have a dismal prognosis of 9-15 months…
- Trial name
- AVIRMA01-09 (NCT01144988)
- Testing
- Bevacizumab / Irinotecan
- Where
- 2 sites in Austria
- Volunteers
- 35 people
- Sponsor
- Medical University Innsbruck
Nasopharyngeal Carcinoma
A Multicenter Trial Comparing Multi-course Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
Locoregionally advanced nasopharyngeal carcinoma (NPC)(stage III, IV in UICC 2002 Classification) can be divided into two groups according to the risk of metastasis: high-risk metastasis group (T4 or N2-3) and low-risk metastasis…
- Trial name
- NCT00705627
- Testing
- neoadjuvant chemotherapy plus concurrent chemoradiotherapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Sun Yat-sen University
Medical Education
Analysis of the Effect of Pre-course Videos on Improving Clinical Skills in Emergency Ultrasound Training
Project Background Point-of-Care Ultrasound (POCUS) has become an important part of medical education in recent years. However, due to limited resources of ultrasound machines and clinical instructors, hands-on practice…
- Trial name
- CVC (NCT06947733)
- Testing
- pre-class videos, no pre-class videos
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
COVID-19 Infection
An Open-Label Study of Apabetalone in Covid Infection
The primary objective of the study is to evaluate the safety and effect on clinical course of oral apabetalone in hospitalized subjects with Covid-19 infection
- Trial name
- NCT04894266
- Testing
- Apabetalone, Standard of care
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Resverlogix Corp
Covid19
Impact of Colchicine and Low-dose Naltrexone on COVID-19
The purpose of this study is to explore the impact of two medications-colchicine and low-dose naltrexone (LDN)-relative to standard of care (SOC) on COVID-19 disease progression to severe/critical illness and/or intubation in…
- Trial name
- COLTREXONE (NCT04756128)
- Testing
- Colchicine 0.6 mg, Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- HealthPartners Institute
Bipolar Disorder
BIPLONG - The Bipolar Disorder in the Longitudinal Course
The BIPLONG (The Bipolar Disorder in the Longitudinal Course ) study is a longitudinal study on the course of bipolar disorders and comprises two sub-studies: On the one hand, BIPLONG examines the genetic foundation and change in…
- Trial name
- BIPLONG (NCT05064995)
- Where
- Austria
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Idiopathic Pulmonary Fibrosis
Clinical Progression of Mild to Moderate Idiopathic Pulmonary Fibrosis (IPF) Under a Therapy With Esbriet® (Pirfenidone)
The purpose of the study was to assess the clinical outcome of patients with a mild to moderate IPF after a one-year therapy with Esbriet® (Pirfenidone).
- Trial name
- NCT02622477
- Testing
- Pirfenidone
- Where
- 17 sites in Germany
- Volunteers
- 12 people
- Sponsor
- Hoffmann-La Roche
Inflammatory Myopathy, Idiopathic, Dermatomyositis
Add-on Intravenous Immunoglobulins in Early Myositis
In patients with myositis early immunomodulation by intensive treatment ("hit-early/hit-hard" principle) may induce faster reduction of disease activity and prevent chronic disability.
- Conditions
- Inflammatory Myopathy, Idiopathic, Dermatomyositis, Antisynthetase Syndrome, Immune-Mediated Necrotizing Myopathy
- Trial name
- TIMEISMUSCLE (NCT05832034)
- Testing
- Immune Globulin Intravenous (Human)
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mantle Cell Lymphoma (MCL)
Orelabrutinib Combined With Obinutuzumab and Short-Course Venetoclax in Patients With Treatment-Naïve Mantle Cell Lymphoma (MCL)
This study aims to evaluate the safety and efficacy of orelabrutinib (O) in combination with obinutuzumab (G) and short-course venetoclax (V) in patients with treatment-naïve MCL.
- Trial name
- NCT07719556
- Testing
- Orelabrutinib, Obinutuzumab, Venetoclax
- Where
- 2 sites in China
- Volunteers
- 39 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Locally Advanced Rectal Cancer
Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer
phase II clinical trial to evaluate node-sparing short-course radiation combined with total neoadjuvant CAPOX and Sintilimab for MSS locally advanced rectal cancers.
- Trial name
- CASINOs (NCT06204094)
- Testing
- node-sparing short-course radiotherapy, Sintilimab, Capecitabine
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Jinhua Central Hospital
Solid Tumor, Adult
Epidemiological Features and Clinical Course of COVID -19 Infection in Cancer Patients: The Rovid Study
The study aims to retrospectively collect epidemiological and clinical data in patients with solid tumors and SARS Covid2 infections belonging to oncology centers within the Veneto Oncology Network
- Trial name
- NCT04811781
- Where
- 3 sites in Italy
- Volunteers
- 761 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Rectal Cancer, Total Neoadjuvant Therapy
A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer
This study is a national multicenter, prospective randomized, placebo- controlled Phase III clinical trial designed to investigate the potential therapeutic benefit of immunotherapy combined with total neoadjuvant therapy (TNT)…
- Conditions
- Rectal Cancer, Total Neoadjuvant Therapy, Radiotherapy, Immunotherapy
- Trial name
- NCT07113275
- Testing
- Short-course radiotherapy, Long-course radiotherapy, Capecitabine
- Where
- China
- Volunteers
- 444 people
- Sponsor
- Tao Zhang
Educational Course
A Prospective Patient Education Program for IBD Patients
During the past few decades, key medical organizations have highlighted the importance of patient education and support. Evidence suggests that improving inflammatory bowel disease (IBD) patients' knowledge of their disease may…
- Trial name
- NCT05168345
- Testing
- Course and web information
- Where
- Israel
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center