Clinical trials: Clinical Efficacy
Jawline Contour Deficit
A Clinical Trial to Evaluate the Efficacy and Safety of LANLUMA V to Improve Jawline Contour Deficit
A Multi-center, Randomized, No-treatment Controlled, Evaluator-blinded, Superiority Clinical Trial to Evaluate the Efficacy and Safety of LANLUMA V to Improve Jawline Contour Deficit
- Trial name
- NCT06391580
- Testing
- Poly-L-lactin Acid (PLLA) Based Facial Injectable
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Sinclair Pharmaceuticals Limited
Chronic Spontaneous Uriticaria
Interleukin-2 for Refractory Chronic Spontaneous Urticaria
The goal of this clinical trial is to learn if human interleukin-2 (IL-2) works to treat moderate to severe chronic spontaneous urticaria in adults who remain symptomatic despite oral antihistamine treatment (refractory CSU).
- Trial name
- ESIT-CSU (NCT06924762)
- Testing
- Human interleukin-2 (I) intramuscular injection
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Second Xiangya Hospital of Central South University
Chronic Hepatitis C
An Efficacy and Safety Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in the Treatment of Chronic Hepatitis C Virus (HCV) Genotype (GT)1, 4, or 6 Infection in Treatment-Naïve Participants Who Are on Opiate Substitution Therapy (MK-5172-062)
This is a 2-part study. The purpose of Part A is to assess the efficacy and safety of grazoprevir (MK-5172) 100 mg in combination with elbasvir (MK-8742) 50 mg for 12 weeks in the treatment of chronic HCV GT1, GT4, or GT6…
- Trial name
- C-EDGE CO-STAR (NCT02105688)
- Testing
- Grazoprevir 100 mg/Elbasvir 50 mg FDC tablet (MK-5172A)
- Volunteers
- 301 people
- Sponsor
- Merck Sharp & Dohme LLC
Atrophy
Postmenopausal Facial Skin After Estradiol and Genistein Topical Treatment
The aim of this trial was to compare the effects of estradiol or genistein treatment on the hialuronic acid concentration on the postmenopausal facial skin.
- Trial name
- NCT01553773
- Testing
- isoflavone, Estradiol
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
D010051, Ovarian Cancer
Validation of ESGO Quality Indicators in Advanced Ovarian Cancer Surgery
This study, organized by the European Society of Gynaecological Oncology (ESGO), evaluates the clinical impact of adherence to ten ESGO-established quality indicators (QIs) in advanced ovarian cancer surgery.
- Conditions
- D010051, Ovarian Cancer, Advanced-stage Ovarian Cancer, FIGO Stages III and IV
- Trial name
- retroESGO ov1 (NCT07567573)
- Testing
- Preoperative Evaluations, Cytoreductive Surgery, Perioperative Management
- Where
- Belgium
- Volunteers
- 11,383 people
- Sponsor
- European Society of Gynaecological Oncology
Non-Small Cell Lung Cancer
Efficacy and Safety Study of Stereotactic Body Radiotherapy (SBRT) With or Without Pembrolizumab (MK-3475) in Adults With Unresected Stage I or II Non-Small Cell Lung Cancer (NSCLC) (MK-3475-867/KEYNOTE-867)
The purpose of this study is to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) plus pembrolizumab (MK-3475) in the treatment of adult participants with unresected Stage I or II (Stage IIB N0, M0)…
- Trial name
- NCT03924869
- Testing
- Stereotactic Body Radiotherapy (SBRT), Pembrolizumab
- Where
- 194 sites in United States, Argentina and 22 more
- Volunteers
- 448 people
- Sponsor
- Merck Sharp & Dohme LLC
Marijuana Dependence
Effectiveness Study of Dronabinol and BRENDA for the Treatment of Cannabis Withdrawal
This treatment study is targeted specifically for those who want to stop using marijuana. We want to find out if patients who are dependent on marijuana and want to stop using are helped by a combination of the drug dronabinol…
- Trial name
- NCT00480441
- Testing
- Dronabinol, BRENDA therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Pennsylvania
Alcohol Dependence
Genetic and Brain Mechanisms of Naltrexone's Treatment Efficacy for Alcoholism
The overarching aim of this trial is to evaluate naltrexone's efficacy in light of genetic variation and brain response to alcohol cues utilizing a neuroimaging paradigm. This trial has four specific aims.
- Trial name
- NCT00920829
- Testing
- Naltrexone 50 Mg
- Where
- 2 sites in United States
- Volunteers
- 358 people
- Sponsor
- Medical University of South Carolina
Prostatitis
Trial to Compare Alfuzosin Versus Placebo in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome
The purpose of this randomized clinical trial is to evaluate the efficacy and safety of the alpha adrenergic blocker Alfuzosin (Uroxatral) in men with relatively new onset of chronic prostatitis/chronic pelvic pain syndrome…
- Trial name
- NCT00103402
- Testing
- Alfuzosin
- Where
- 10 sites in United States, Canada
- Volunteers
- 272 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Overactive Bladder
MIrabegron With oveRACtive bLadder Symptoms in mEn
The proportion of male patients who participated in the phase III study of mirabegron was about 28% and the data on the efficacy and safety of mirabegron in Korean male OAB patients have limits.
- Trial name
- NCT02361502
- Testing
- mirabegron
- Where
- 15 sites in South Korea
- Volunteers
- 462 people
- Sponsor
- Seoul National University Hospital
Hallux Valgus
Efficacy of Splinting, Exercise and Electrotherapy on Hallux Valgus
The aim of this study was to investigate the effects of splinting, exercise and electrotherapy on the hallux valgus (HV) angle, and foot-specific health-related quality of life.
- Trial name
- NCT04393545
- Testing
- hallux valgus night splint, exercise, Electrotherapy
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
Hypercholesterolemia
A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)
This study will evaluate the efficacy and safety and tolerability of 2 dose levels of MK-0653H in Japanese participants. The primary hypotheses are that the administration of MK-0653H is safe and tolerable and that MK-0653H is…
- Trial name
- NCT02741245
- Testing
- Ezetimibe 10 mg, Rosuvastatin 2.5 mg
- Volunteers
- 321 people
- Sponsor
- Organon and Co
Diabetic Complication
YJP-14 Capsules for the Treatment of Endothelial Dysfunction in Patients With Diabetes Mellitus
The purpose of this study is to evaluate the safety and efficacy of YJP-14 capsules for the treatment of endothelial dysfunction in patients with diabetes mellitus.
- Trial name
- NCT01836172
- Testing
- YJP-14
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Han Wha Pharma Co., Ltd.
Sedation in the Upper Gastrointestinal Endoscopy
A Study of Remimazolam Tosilate for Sedation in the Upper Gastrointestinal Endoscopy
The purpose of this study is to evaluate the efficacy and safety of Remimazolam Tosilate for Injection for sedation in Upper Gastrointestinal Endoscopy
- Trial name
- NCT06169995
- Testing
- Remimazolam Tosilate
- Where
- 2 sites in China
- Volunteers
- 31 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Black Stains
A Crossover Clinical Study to Evaluate the Effect of Chitosan Mouthwash on Recurrence of Black Stains in Pediatric Patients
The goal of this clinical trial is to learn if Chitosan mouthwash works to affect the recurrence of black stains in pediatric patients.
- Trial name
- NCT06714695
- Testing
- Chitosan
- Where
- Egypt
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Malaria
In Vivo Efficacy of Artemether-lumefantrine and Amodiaquine-artesunate in Mozambican Children (MEFI_III)
This is a classical in vivo clinical trial, following World Health organization's recommendations, ran as a multisite study within Mozambique trying to assess the efficacy and safety in 4 sites of the two oral ACTS…
- Trial name
- MEFI_III (NCT04370977)
- Testing
- Coartem™ (Artemether-lumefantrine combination), Winthrop™ (Amodiaquine-artesunate combination)
- Where
- 6 sites in Mozambique
- Volunteers
- 630 people
- Sponsor
- Centro de Investigacao em Saude de Manhica
HPV16/18 Positive
Investigator-Initiated Study of BBM-C101 Injection in Subjects With HPV16/18 Infection
This is a single-arm, single-center, open-label Investigator-Initiated Trial (IIT) designed to evaluate the safety and efficacy of BBM-C101 Injection in subjects with HPV16/18 infection and histopathologically confirmed ≤ Grade 2…
- Trial name
- NCT07714577
- Testing
- BBM-C101
- Volunteers
- 200 people
- Sponsor
- Tianjin First Central Hospital
Tetanus, Diphtheria
A Study to Evaluate the Safety and Efficacy(Immunogenicity) of GC3111 in Healthy Adults
The purpose of this study is to evaluate safety and efficacy (immunogenicity) of a single dose of GC3111 versus Boostrix® vaccine among healthy adults in 19-64 years of age.
- Conditions
- Tetanus, Diphtheria, Whooping Cough
- Trial name
- NCT04238975
- Testing
- GC3111 vaccine, Boostrix® vaccine
- Where
- South Korea
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Green Cross Corporation
Enamel Hypomineralization, Dental
The Effectiveness of Biomimetic Materials in Preventing Enamel Demineralization During Fixed Orthodontic Treatment
This study will be done to evaluate the impact of Biosmalto Impact Action Mousse™ on the development and healing of WSLs in individuals receiving orthodontic treatment.
- Trial name
- NCT05940701
- Testing
- Curasept Biosmalto Mousse and toothpaste, Colgate toothpaste
- Where
- Iraq
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Multiple Sclerosis
Multiple Sclerosis Self Monitoring Study
This study is a multicenter, prospective, randomized controlled trial (RCT) to compare the effectiveness of a smartphone-based self-monitoring and self-management tool on control self-efficacy with respect to standard clinical…
- Trial name
- MSSM (NCT06125301)
- Testing
- MS Sherpa
- Where
- Netherlands
- Volunteers
- 225 people
- Sponsor
- Amsterdam UMC, location VUmc
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