Clinical trials: Clinical High Risk for Psychosis (CHR)
Clinical High Risk for Psychosis (CHR)
Efficacy of Mindfulness in PREventing Progression to Psychosis in Individuals With an Ultra High Risk for Psychosis
The main objective is to evaluate the efficacy of a group-based mindfulness therapy programme in reducing distress associated with symptoms of UHR (Ultra High Risk) or FEP (first psychotic episode) compared with usual treatment.
- Trial name
- EM-PREPS (NCT06870305)
- Testing
- MBTP : Mindflulness based training for psychosis
- Where
- 2 sites in France
- Volunteers
- 270 people
- Sponsor
- Centre Psychothérapique de Nancy
Clinical High Risk for Psychosis (CHR)
French Validation of Schizophrenia Proneness Instrument- Child Youth
The clinical concept of a at risk mental state of developing psychosis is based on the identification of attenuated psychotic symptoms during the prodromal phase of psychoses (Schmidt et al., 2015).
- Trial name
- SPI-CY-Fr (NCT06649552)
- Testing
- Psychiatric and psychological diagnostic tests
- Where
- 3 sites in France
- Volunteers
- 52 people
- Sponsor
- Centre Psychothérapique de Nancy
Clinical High Risk for Psychosis (CHR)
A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis
The goal of this clinical trial is to learn how tests undertaken by people at high risk of developing psychosis (aged 17 to 30 years old) change when those people are given the study drug MT1988 daily for 8 weeks.
- Trial name
- NCT07226895
- Testing
- MT1988 Low Dose, MT1988 High Dose
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- Monument Therapeutics Limited
Clinical High Risk for Psychosis (CHR)
Interventions for Clinical High Risk Youth in Tunisia
Study participants will take part in one of the two types of treatments aimed at improving daily functioning as follows: either a Cognitive Training (CT) Program or an Enhanced - Treatment as Usual (E-TAU) Group.
- Trial name
- CHRTUNISIA (NCT06582901)
- Testing
- Cognitive training (CT) plus the neuropsychological educational approach to cognitive remediation (NEAR) model and an Enhanced - Treatment as Usual (E-TAU), Enhanced - Treatment as Usual
- Where
- Tunisia
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Clinical High Risk for Psychosis (CHR)
Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis
This study aims to evaluate the feasibility and effectiveness of telehealth interventions for individuals at clinical high risk for psychosis (CHR).
- Trial name
- NCT05968560
- Testing
- CBT Skills Group for CHR Youth, Individual CBT sessions, CBT Skills Group for Families
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Psychosis, Psychosocial Functioning
Optimizing Mental Health for Young People at Clinical High Risk for Psychosis (CHR)
This proposal aims to adapt an evidence-based comprehensive psychosocial and mental health support program, the Optimal Health Program (OHP), to improve functioning, reduce distress, and build resiliency in youth who are at…
- Trial name
- NCT05757128
- Testing
- Optimal Health Program
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
Prodromal Schizophrenia
Effects of NAC on Symptoms of CHR Patients
Schizophrenia is a chronic debilitating psychotic disorder. Identifying persons with "clinical high-risk" (CHR) symptoms, which are like those of schizophrenia but less severe, and providing psychiatric care to these individuals…
- Trial name
- NCT05142735
- Testing
- N-Acetylcysteine
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Centre for Addiction and Mental Health
First Episode Psychosis (FEP), At Risk Mental State (ARMS)
Reducing the Duration of Untreated Psychosis in the United States
The goal of this project is to investigate whether a systematic screening approach for individuals with first episode psychosis (FEP) can substantially reduce Duration of Untreated Psychosis (DUP).
- Trial name
- NCT03369730
- Where
- 3 sites in United States
- Volunteers
- 94 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Clinical High Risk for Psychosis (CHR), Psychotic Disorders
Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis
The goal of this study is to learn whether an accelerated form of neuromodulation therapy is safe, feasible, and well tolerated in young people at clinical high risk for psychosis (CHR-P), and whether it is associated with…
- Conditions
- Clinical High Risk for Psychosis (CHR), Psychotic Disorders, Prodromal Symptoms
- Trial name
- TMS-CHR (NCT07786714)
- Testing
- Active Intermittent Theta Burst Stimulation (BEAM-F3 Targeting)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Douglas Mental Health University Institute
Schizophrenia, Clinical High Risk for Psychosis (CHR)
Mobile Thinking Intervention: A Inital Test
This study will test the inital efficacy of a brief mobile intervention targeting biased thinking.
- Trial name
- NCT06909422
- Testing
- Mobile Intervention for Biased Thinking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Clinical High Risk for Psychosis (CHR)
Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis
This study examines the feasibility and acceptability of a digital dialectical behavior therapy (d-DBT) intervention for youth at clinical high risk (CHR) for psychosis.
- Trial name
- NCT06928935
- Testing
- d-DBT
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Clinical High Risk for Psychosis (CHR)
Experience of UHR and PEP Individuals During Mindfulness: a Qualitative Phenomenological Study
The goal of this qualitative study is to explore and describe the lived experiences of individuals at ultra-high risk (UHR) or first episode of psychosis (FEP) who have participated in a group-based mindfulness-based…
- Trial name
- EMIP (NCT07499934)
- Testing
- Qualitative interview
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Psychothérapique de Nancy
Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis
Stratification and Treatment in Early Psychosis Study - PROMOTE
The purpose of this trial is: To investigate whether cannabidiol (CBD), compared to placebo, can reduce the severity of attenuated psychotic symptoms in individuals at clinical high risk for psychosis.
- Conditions
- Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis, Clinical High Risk for Developing Psychosis
- Trial name
- STEP-PROMOTE (NCT07434973)
- Testing
- Cannabidiol (CBD)
- Where
- 19 sites in Austria, Canada and 8 more
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Prodromal Schizophrenia, Psychosis
Feasibility Trial of a Lifestyle Intervention for CHR-P
The present study will assess the feasibility and social validity of an adjunctive health promotion group for youth and clinical high risk for psychosis (CHR-P).
- Conditions
- Prodromal Schizophrenia, Psychosis, Psychological Disorder, Psychological Stress
- Trial name
- NCT05532683
- Testing
- Health Behaviors Group
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, Los Angeles
Psychosis
Mentalization Based Treatment (MBT) in Help Seeking Youths With a Clinical High-Risk Condition for Psychosis (CHR-P)
The primary objective of this study is to evaluate the efficacy of Mentalization-Based Treatment (MBT) combined with Need-Based Clinical Interventions (NBCI) compared to NBCI alone, on CHR-P diagnostic statuses and symptom…
- Trial name
- MBT-Psychosis (NCT07093671)
- Testing
- MBT + NBCI
- Where
- Switzerland
- Volunteers
- 212 people
- Sponsor
- Marco Armando
Psychosis, Prodromal Schizophrenia
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk
This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability…
- Conditions
- Psychosis, Prodromal Schizophrenia, Prodromal Symptoms
- Trial name
- SCORES (NCT05131035)
- Testing
- SCORES (Specific COgnitive Remediation with Support)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
First Episode Psychosis (FEP), Clinical High Risk for Psychosis (CHR)
Reducing the Duration of Untreated Psychosis in the United States: The Impact of Screening and Systematic Communication
The goal of this project is to investigate whether a systematic screening approach enhanced by an innovative model of communicating information about psychosis and treatment options to patients and families (ComPsych) can reduce…
- Trial name
- EaSIE (NCT05509998)
- Testing
- Screening Method (SM), Screening and Communication Method (SCM)
- Where
- United States
- Volunteers
- 912 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Clinical High Risk for Psychosis (CHR), Suicidal Ideation
Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis
Young people at clinical high risk for psychosis are more likely to experience suicide thoughts than the general population, but there are few suicide prevention programs designed specifically for them.
- Conditions
- Clinical High Risk for Psychosis (CHR), Suicidal Ideation, Psychosis, Suicidal Behavior
- Trial name
- NCT07756567
- Testing
- Suicide Prevention Intervention, Standard Care (in control arm)
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of California, San Diego
Psychosis Nos/Other
A Treatment Engagement Protocol for Psychiatrically Hospitalized Adolescents at Clinical High Risk for Psychosis
The current study explores the development and use of a family engagement intervention for psychiatrically hospitalized adolescents with emerging psychosis symptoms.
- Trial name
- NCT04314635
- Testing
- Brief family engagement intervention for CHR, Treatment as usual (TAU)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rhode Island Hospital
Clinical High-risk Syndrome of Psychosis
RTMS for CHR Based on Personalized Targets Using Magnetoencephalography
This study is an before-after study in the same subject, which enrolled 26 individuals with high-risk psychiatric syndrome (CHR). The target of subjects intervention relies on the results of magnetoencephalography localization.
- Trial name
- NCT06802952
- Testing
- rTMS
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Shanghai Mental Health Center