Clinical trials: Clinical High-risk
Multiple Sclerosis
Evaluation of the Clinical Contribution of Quantitative MRI in Neuro-imaging
This study aims to develop the use of a quantitative MRI (qMRI) approach in neuroimaging for MS patients. To achieve this task the main goals of this study will be: to standardize and optimize qMRI protocols (acquisition time…
- Trial name
- NormaBRAIN (NCT07245589)
- Testing
- 3T MRI, 7T MRI, Clinical examination of MS patients
- Where
- France
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Polydiastema Disorder
18-month Clinical Performance of Stand Alone and Nanohybrid Supported Injectable Composite Veneers
This is a double blinded, randomized clinical study that evaluated the performance of a high filled injectable resin composite in polydiastema .
- Trial name
- nanoinjectcomb (NCT07267143)
- Testing
- Nanohybrid Composite (G-ænial A'Chord, GC Corp., Tokyo, Japan), Highly Filled Injectable Composite (G-ænial Universal Injectable, GC Corp., Tokyo, Japan)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tolunay Aytas
Plaque, Atherosclerotic Disease
BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population
The BioImage Study is a study of the characteristics of subclinical cardiovascular disease, as measured by imaging modalities, unsupervised circulating biomarker measurements, and risk factors that predict progression to overt…
- Conditions
- Plaque, Atherosclerotic Disease, Heart Disease, Stroke
- Trial name
- NCT00738725
- Where
- 2 sites in United States
- Volunteers
- 7,687 people, healthy volunteers welcome
- Sponsor
- BG Medicine, Inc
Real Neurofeedback From DMN, Sham Neurofeedback From Motor Cortex
Neurofeedback in Clinical High Risk
The goal of this trial is to test whether fMRI based neurofeedback from default mode network (DMN) will reduce DMN hyperconnectivity in clinical high risk individuals, which will lead to reductions in clinical symptoms and…
- Trial name
- NCT06492343
- Testing
- fMRI based neurofeedback
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston VA Research Institute, Inc.
H7N9 Influenza
Influenza A (H7N9) Vaccine Delivered Intradermally by High-density Microarray Patch (HD-MAP)
Study SP-1219-007 is a multi-centre, randomised, study designed to access the safety and tolerability of two doses of monovalent Influenza A (H7N9) vaccine delivered intradermally by a microarray patch delivery system in healthy…
- Trial name
- HD-MAP (NCT06417853)
- Testing
- Unadjuvanted Influenza A (H7N9) Monovalent Vaccine Injection, Unadjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (low dose HA), Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (high dose HA)
- Where
- 4 sites in Australia
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Vaxxas Pty Ltd
Dysphagia, Swallowing Disorders
Novel Pharyngeal Metrics to Predict Dysphagia Outcomes
This multi-site trial will follow a cohort of Veterans with dysphagia for 8 weeks as they undergo clinically guided oropharyngeal exercises with oropharyngeal strengthening as the primary goal.
- Trial name
- NCT04569097
- Testing
- standard of care lingual strengthening
- Where
- 3 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
High Risk Cancer, Lung Cancer
Retrospective Clinical Trial Comparing Radiologists' Diagnosis Accuracy in Lung Cancer Screening Population With and Without the Help of an AI/ML Tech-based SaMD
This is a two arm, randomized, controlled, blinded, multi-case multi reader (MRMC), retrospective study for the evaluation of the efficacy and safety of an AI/ML technology-based CADe/x developed to detect, localize and…
- Trial name
- RELIVE (NCT06751576)
- Testing
- Median LCS
- Where
- 5 sites in United States, Spain
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Median Technologies
High-Normal Blood Pressure
Food Supplementation With Diuripres for Blood Pressure Modulation in Subjects With High-Normal Blood Pressure
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, reaching the 31% of deaths in 2012. CVDs represent also the major cause of disability in developed countries and has been estimated that their growing…
- Trial name
- CONDOR (NCT05167747)
- Testing
- Dietary Supplement
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Lung Cancer
Implementing Fragmentomics Into Real World Screening IntervenTions to Evaluate Clinical Utility Among Individuals With Elevated Risk for Lung Cancer
The purpose of this study is to determine whether availability of DNA Evaluation of Fragments for Early Interception (DELFI) Lung Cancer Screening Test, FirstLook™ to practicing physicians affects overall lung cancer screening…
- Trial name
- FIRSTLUNG (NCT06145750)
- Testing
- Ability to order FirstLook™, Continuing Medical Education for Lung Cancer
- Where
- 3 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Delfi Diagnostics Inc.
Flat Feet, High Arched Foot
Validation of Plantar Orthoses for Abnormal Plantar Arch Using a New Non-invasive Clinical Imaging System
The goal of this project is to validate a new non-invasive clinical imaging system to evaluate the efficacy of plantar orthotics and to assess the biomechanical efficiency of plantar orthotics for people with flat or high arch…
- Trial name
- NCT05163418
- Testing
- Foot orthosis for flat feet, Foot orthoses for high arches feet
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- TOPMED
Triglycerides High
Clinical Study to Evaluate the Blood Triglyceride Decreasing Effect and Safety of Korean Post-Fermented Tea Extracts
This study was conducted to investigate the effects of daily supplementation of Korean Post-Fermented Tea(Heukcha) Extracts on improvement of Blood Triglyceride Level.
- Trial name
- NCT04850352
- Testing
- Heukcha Extracts
- Where
- 3 sites in South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amorepacific Corporation
Peripheral Neuropathy Pain
PK and Food Effect of Pregabalin Study After Dosing in Healthy Male Volunteers
This study is to assess the pharmacokinetics of Pregabalin controlled release formulation after multiple dosing as compared to Pregabalin immediate release formulation and the food effect of high fat diet after single dosing in…
- Trial name
- NCT02783638
- Testing
- YHD1119, Lyrica
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Nursing Education, Simulation-Based Learning
High-Fidelity Simulation and Longitudinal Outcomes in Novice Nurses (HFS-NOVA)
This study examined whether high-fidelity simulation (HFS) training - a realistic, hands-on learning method using advanced patient mannequins - can improve both technical skills and psychological well-being in newly graduated…
- Conditions
- Nursing Education, Simulation-Based Learning, Simulation Training
- Trial name
- HFS-NOVA (NCT07604363)
- Testing
- High-Fidelity Simulation Training for Airway Management
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Diabetic Foot Ulcer (DFU)
High Purity Type I Collagen Based Skin Substitute Vs Dehydrated Human Amnion/Chorion Membrane in Treatment of DFUs
This is a randomized controlled clinical investigation in patients suffering from diabetic foot ulcers. The study intends to compare patient outcome data using Standard of Care with Type-I Collagen-based Skin Substitute and…
- Trial name
- NCT06470087
- Testing
- SOC and Type-I Collagen-based Skin Substitute, SOC and Human Amnion/Chorion Membrane
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Cardiovascular Diseases
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of Highdose CKD-385 in Healthy Volunteers(Fasting)
This study is a randomized, open-label, fasting, single dose, crossover study to investigate the pharmacokinetic profiles and safety of high-dose CKD-385 in healthy volunteers under fasting conditions.
- Trial name
- NCT04083872
- Testing
- Reference drug, Test drug
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Overweight
The Effect of a High Protein Diet on Body Weight Change During Post-partum
Nearly 20% of women do not return to their pré-gestacional body weight. The purpose of this study is to investigate the effect of diet and socio-demographics factors during gestation and postpartum period to body weight change…
- Trial name
- NCT00969488
- Testing
- High protein diet
- Where
- Brazil
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Hand, Foot and Mouth Disease
Safety and Immunogenicity of High-dose IN-B001 in Healthy Subjects
This study aims to evaluate the safety and immunogenicity of high-dose IN-B001 after administration in healthy subjects
- Trial name
- NCT04637919
- Testing
- IN-B001 EV71 A dose, IN-B001 CVA16 B dose, IN-B001 Bivalent C dose
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Endodontically Treated Molar, Marginal Fit
Assessment of Marginal and Internal Fit of High Performance Polymer PEEK Endocrown Using Two Preparation Designs
First, Participants in this study will be recruited according to inclusion criteria. Proper examination for the participants (clinically and radiographically).
- Conditions
- Endodontically Treated Molar, Marginal Fit, Internal Fit
- Trial name
- PEEK (NCT06500845)
- Testing
- Bevel marginal design endocrown for endodontically treated teeth, Butt marginal design endocrown for endodontically treated teeth
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Skin Laxity (Submental and Neck), Facial Skin Laxity
Safety and Effectiveness Evaluation of the High-intensity Focused Ultrasound Device for Lifting Lax Submental and Neck Tissue
This is a prospective, multicenter, randomized, evaluator-blinded, parallel-controlled, non-inferiority clinical study designed to evaluate the safety and effectiveness of the ULTRAFORMER MPT PLUS, a high-intensity focused…
- Conditions
- Skin Laxity (Submental and Neck), Facial Skin Laxity, Submental Tissue Laxity
- Trial name
- NCT07229430
- Testing
- ULTRAFORMER MPT PLUS, Ulthera System
- Where
- 5 sites in United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- CLASSYS Inc.
Bone Loss
Comparison Between High-speed Drilling With Irrigation and Low-speed Drilling With Irrigation
A randomized controlled clinical trial was conducted in the Oral Surgery Unit, Faculty of Medicine and Dentistry, University of Valencia.
- Trial name
- NCT05286866
- Testing
- Dental implant bed preparation
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Valencia