Clinical trials: Clinical High-risk
Ischemic Stroke
Dysphagia Assessment in Acute Ischemic Stroke Using High-resolution Manometry
Dysphagia occurs relatively commonly in patients with acute stroke, and can lead to aspiration pneumonia and malnutrition. By using the stroke registry of our hospital, we will evaluate the feasibility and usefulness of Dysphagia…
- Trial name
- DASH (NCT01683591)
- Testing
- High-resolution impedance manometry test
- Where
- South Korea
- Volunteers
- 293 people
- Sponsor
- The Catholic University of Korea
Cervical Lesion
Clinical Trial Evaluating Secondary HPV Vaccination After Treatment of High-grade Cervical Lesions
This is a single-center, Phase II interventional study evaluating secondary HPV vaccination after treatment of high-grade cervical lesions.
- Trial name
- HPV2 (NCT06658405)
- Testing
- Human Papillomavirus 9-valent Vaccine, Recombinant
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Centre Oscar Lambret
Cataract, High Myopia
To Evaluate IOL Position, Clinical Outcome of PanOptix in High Myopic Cataract Patients
To evaluate IOL position, clinical outcome of PanOptix in high myopic cataract patients
- Trial name
- NCT05042856
- Testing
- PanOptix IOL implantation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Wenzhou Medical University
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma
Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma
This is a observational, retrospective and prospective study designed to assess the potential correlations between MYC alterations, lymphoma mutational landscape and functional immune contextures in Diffuse Large B-cell Lymphoma…
- Conditions
- Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
- Trial name
- FIL_MIMYC (NCT06588205)
- Where
- 20 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Critical Illness Myopathy, Guillain Barré Syndrome
High-Tech Rehabilitation Pathway for Acute Adult Neuromuscular Diseases - Fit4MedRob-Acute MND Project
The goal of this study is determine if a high-tech rehabilitation circuit is more effective than usual rehabilitation methods in improving functional outcome, particularly balance control, for patients with acute neuromuscolar…
- Conditions
- Critical Illness Myopathy, Guillain Barré Syndrome, Critical Illness Polyneuromyopathy (CIPNM)
- Trial name
- Fit4MR-AcMND (NCT06822231)
- Testing
- High-tech rehabilitative treatment, Rehabilitation
- Where
- 8 sites in Italy
- Volunteers
- 124 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Male Factor Infertility
Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI)
The purpose of this study is to determine if using microdots of hyaluronan (PICSI) to select sperm for ICSI will result in increased pregnancies especially with men that have a low hyaluronan binding score (HBA).
- Trial name
- NCT00741494
- Testing
- PICSI dish
- Where
- 9 sites in United States
- Volunteers
- 801 people
- Sponsor
- Biocoat
Prevention of Ebola Infection
Evaluation of the Safety and Immunogenicity of Three Consistency Lots and a High-Dose Lot of rVSV-ZEBOV-GP (V920 Ebola Vaccine) in Healthy Adults (V920-012)
The study evaluated the safety and immunogenicity of 3 consistency lots and a high-dose lot of rVSV-ZEBOV-GP (V920 Ebola Vaccine) in healthy adults.
- Trial name
- NCT02503202
- Testing
- V920 Consistency Lot A, V920 Consistency Lot B, V920 Consistency Lot C
- Volunteers
- 1,197 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Bladder Cancer
Prognostic Effect of Whether Doing PLND During RC for High-risk NMIBC
There is no consensus on the need for lymph node dissection in radical cystectomy (RC) for high-risk non-muscular invasive bladder cancer (NMIBC).
- Trial name
- PLND-Less (NCT05123625)
- Testing
- Reduce surgical procedures
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Acute Viral Bronchitis, Hypoxemic Respiratory Failure
NHF vs. COT in Hypoxemic Pandemic Viral Illness
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
- Conditions
- Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- HIVI (NCT04750408)
- Testing
- Standard oxygen, Nasal high-flow
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Jens Bräunlich
Osteoarthritis of the Knee
Efficacy of Spearmint Tea in Relieving Osteoarthritis of the Knee
The purpose of this study is to investigate the benefits of daily consumption of a high rosmarinic acid spearmint tea, developed by the University of Guelph, on measures of pain, physical function and disease activity in…
- Trial name
- NCT01380015
- Testing
- Commercially spearmint tea, High Rosmarinic Acid Spearmint Tea
- Where
- 2 sites in Canada
- Volunteers
- 49 people
- Sponsor
- University of Guelph
Type-2 Diabetes
GLP-1 and Oxyntomodulin Release in Relation to Diet in Type 2 Diabetes Patients.
The aim of this trial was to assess glycemic control and incretin release in subjects affected by type-2 diabetes, a condition in which GLP-1 release is impaired.
- Trial name
- VAS (NCT04105608)
- Testing
- High-fiber vegetarian meal, Mediterranean-like meal
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Antonio Di Mauro
Eosinophilic Asthma
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment
This study evaluates the efficacy and safety of benralizumab as an add-on therapy in uncontrolled eosinophilic asthma participants treated with medium-dose ICS-LABA compared to the conventional treatment step of escalation of…
- Trial name
- BRISOTE (NCT06750289)
- Testing
- ICS-LABA, benralizumab
- Where
- 86 sites in United States, Bulgaria and 11 more
- Volunteers
- 130 people
- Sponsor
- AstraZeneca
IgA Nephropathy, Membranous Nephropathy
IM19 CAR-T Cell Therapy for IgA Nephropathy Patients and Membranous Nephropathy Patients
IM19 CAR-T cell therapy for IgA nephropathy patients with urinary protein and renal dysfunction, as well as patients with intermediate to high-risk primary membranous nephropathy
- Trial name
- NCT06690359
- Testing
- IM19 chimeric antigen receptor T cell injection
- Volunteers
- 12 people
- Sponsor
- Beijing Immunochina Medical Science & Technology Co., Ltd.
Wounds and Injuries
Evaluation of Exufiber Ag+ and Other Gelling Fibre Dressings
Investigate impact of gelling fiber dressings on handling exudate in medium to high exuding wounds
- Trial name
- NCT03249909
- Testing
- Exufiber Ag+, Exufiber, Aquacel Ag Extra
- Where
- 8 sites in United States
- Volunteers
- 109 people
- Sponsor
- Molnlycke Health Care AB
Age-related Cataract
IOL-capsular Complex After Different Intraocular Lenses Implantation in Patients With High Myopia
The IOL-capsular complex is formed after cataract surgery and intraocular lens (IOL) implantation. Early postoperative mechanical wrapping of the anterior and posterior capsules plays a significant role in preventing IOL…
- Trial name
- NCT05255796
- Testing
- one-piece, plate-haptic
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Wenzhou Medical University
Advanced Fallopian Tube Carcinoma, Advanced Fallopian Tube High Grade Serous Adenocarcinoma
Folate Receptor Alpha Dendritic Cells (FRαDCs) or Placebo for the Treatment of Patients With Stage III or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer, FAROUT Trial
This phase II trial compares the effect of folate receptor alpha dendritic cells (FRαDCs) to placebo in treating patients with stage III or IV ovarian, fallopian tube or primary peritoneal cancer.
- Conditions
- Advanced Fallopian Tube Carcinoma, Advanced Fallopian Tube High Grade Serous Adenocarcinoma, Advanced Ovarian Carcinoma, Advanced Ovarian Carcinosarcoma
- Trial name
- NCT06639074
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- 3 sites in United States
- Volunteers
- 78 people
- Sponsor
- Mayo Clinic
Carbon Ion Radiotheray, High-grade Glioma
Clinical Study of Carbon Ion Radiotherapy for High-grade Glioma
The objective is to use the advantages of heavy ion physical dosimetry and biology to improve the tumor control rate and long-term survival rate of high-grade glioma, reduce the occurrence of brain tissue radiation damage caused…
- Conditions
- Carbon Ion Radiotheray, High-grade Glioma, Heavy Ion Radiotherapy
- Trial name
- NCT06831773
- Testing
- Carbon ion combined with photon radiotherapy
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Gansu Wuwei Tumor Hospital
Uterine Cervical Neoplasms, Cervix Intraepithelial Neoplasia
Safety and Tolerability of Cidofovir Gel Applied on Cervix Squamous Lesions
Human Papilloma Virus (HPV) infections induce cervical intraepithelial neoplasia (CIN) of cervix. To reduce incidence of invasive tumor associated with high grade CIN lesions, the standard treatment is the conisation of cervix…
- Trial name
- NCT00989443
- Testing
- Cidofovir gel
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Mithra Pharmaceuticals
Cancer
Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy
RATIONALE: Vaccines may help the body build an effective immune response to kill cytomegalovirus infections. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating patients who have…
- Trial name
- NCT00509691
- Testing
- cytomegalovirus pp65-specific cytotoxic T lymphocytes, polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Psychosis
The Clinical and Socio-demographic Characteristics of Young People Aged 12 to 25 Consulting on Ambulatory Structures in the Seine Saint-Denis
A prospective study of the clinical and socio-demographic characteristics of young people aged 12 to 25 consulting on ambulatory structures in the Seine Saint-Denis.
- Trial name
- EPS-12-25 (NCT04365621)
- Testing
- we enrolled ultra-high risk of psychosis (UHR) patient to describe
- Where
- 5 sites in France
- Volunteers
- 900 people
- Sponsor
- Januel
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