Clinical trials: Clinical High-risk
Polypharmacy
Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges R01 Trial
High-risk polypharmacy is common among older adults in the United States, is particularly dangerous for individuals with dementia or cognitive impairment, and is associated with harms such as adverse drug reactions, falls, and…
- Trial name
- HRPP (NCT05656560)
- Testing
- Clinical decision support (CDS)-Commitment nudge, Clinician education, Clinical decision support (CDS)-Justification nudge
- Where
- 2 sites in United States
- Volunteers
- 786 people
- Sponsor
- Northwestern University
Upper Tract Urothelial Carcinoma, Lymph Node Dissection
Radical Nephroureterectomy With vs Without Template Lymph Node Dissection in High-Risk Upper Tract Urothelial Carcinoma (T-LND UTUC)
The goal of this clinical trial is to learn if adding a template lymph node dissection (TLND) to the standard surgery for upper tract urothelial cancer (UTUC) can improve patient survival and prevent the cancer from recurrence.
- Trial name
- UTLUND (NCT07321210)
- Testing
- Template Lymph Node Dissection, Selective Lymph Node Resection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tianjin Medical University Second Hospital
Rheumatoid Arthritis
Assessment of Clinical Effectiveness and Safety of Adalimumab and High Dose Methotrexate in Routine Clinical Practice
This was a single-arm, multicenter, open label, prospective cohort study (post-marketing observational study) to determine the effectiveness and safety of adalimumab in combination with high-dose methotrexate (≥12 mg/week) in…
- Trial name
- NCT01736189
- Testing
- Adalimumab
- Volunteers
- 346 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Leiomyoma, Uterine, High-Intensity Focused Ultrasound Ablation
Establishment of a Decision Aid Tool for Asymptomatic Small Leiomyoma and Analysis of Influencing Factors for Clinical Decision-making Using HIFU
With the younger patients diagnosed with asymptomatic leiomyoma, delay in the reproductive age of women, the advancement of medical technology, and the rapid development of treatment methods, there are many choices between…
- Conditions
- Leiomyoma, Uterine, High-Intensity Focused Ultrasound Ablation, Patients Decision Aids
- Trial name
- NCT05500118
- Testing
- Patients Decision Aids
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenzhen Maternity & Child Healthcare Hospital
Anxiety, Depression
High-Intensity Interval Training and Mental Health in Psychiatric Inpatients: A Pilot Study
The goal of this pilot clinical trial is to investigate the feasibility of conducting a high-intensity interval training intervention among adult inpatients in a psychiatric care setting and to explore changes in mental health…
- Conditions
- Anxiety, Depression, Mental Health, Psychiatric Inpatients
- Trial name
- NCT07864324
- Testing
- High-Intensity Interval Training (1 × 4)
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- University Hospital of North Norway
Covid19
Favipiravir in High-risk COVID-19 Patients
The study aims to investigate the efficacy of favipiravir in high-risk COVID-19 patients. The study population includes symptomatic mild-to-moderate COVID-19 inpatients, within first 7 days of illness, who are 50 years old and…
- Trial name
- NCT04818320
- Testing
- Favipiravir
- Where
- Malaysia
- Volunteers
- 500 people
- Sponsor
- Penang Hospital, Malaysia
Endodontically Treated Molar
Comparison of the Clinical Performance of High Strength Hybrid Ceramic Indirect Restorations Cemented on Endodontically Treated Teeth Using Bioactive Versus Conventional Self Adhesive Resin Cements.
Cementation of indirect restoration is a determinant of the success or failure of the fabricated restoration and consequentially the entire tooth.
- Trial name
- NCT06787469
- Testing
- Resin Cement
- Volunteers
- 50 people
- Sponsor
- Cairo University
Glucose, Glucose Metabolism Disorders (Including Diabetes Mellitus)
The Effect of Kombucha on Blood Sugar Levels in Humans
As a phase 0 clinical trial, we will learn how kombucha influences glucose metabolism in humans.
- Conditions
- Glucose, Glucose Metabolism Disorders (Including Diabetes Mellitus), Blood Sugar; High
- Trial name
- NCT04051294
- Testing
- Commercial kombucha tea, Brewed kombucha tea, Control: Tea
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Malignant Solid Tumors, Moderate to High Emetogenic Chemotherapy (MEC/HEC) Drugs
Nanocrystalline Megestrol for Managing Chemotherapy-Induced Nausea and Vomiting
The goal of this clinical trial is to learn if medroxyprogesterone acetate oral suspension (Meishiya®) works to prevent nausea and vomiting caused by single-day moderate to high emetogenic chemotherapy (MEC/HEC) in the…
- Trial name
- NCT07124195
- Testing
- Medroxyprogesterone acetate oral suspension, high antiemetic regimen, moderate antiemetic regimen
- Where
- China
- Volunteers
- 126 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Myocardial Infarction
Abbott i-STAT High Sensitivity Troponin I Study
The goal of this observational multi-center study is to evaluate the clinical performance of the i-STAT hs-TnI test (i-STAT High Sensitivity Troponin I) using the investigational i-STAT hs-TnI cartridge for the proposed intended…
- Trial name
- i-STAT hs-TnI (NCT05629572)
- Testing
- i-STAT hs-TnI Cartridge Testing on i-STAT 1 and i-STAT Alinity
- Where
- 28 sites in United States
- Volunteers
- 3,697 people
- Sponsor
- Abbott Point of Care
Sleep Disorders, Circadian Rhythm, Cognitive Impairment
High-frequency tRNS for Sleep Disturbances in Neurocognitive Disorders Due to Vascular Disease
The investigators aim to 1) investigate and compare the safety, efficacy and sustainability of hf-tRNS, tACS and sham transcranial current stimulation (tCS) over left inferior parietal lobe (IPL) in mild neurocognitive disorder…
- Conditions
- Sleep Disorders, Circadian Rhythm, Cognitive Impairment, Vascular Dementia
- Trial name
- NCT06169254
- Testing
- Transcranial current stimulation (tCS)
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Breast Cancer
Study of Blood Samples From High-Risk Postmenopausal Women Who Received Treatment on Breast Cancer Prevention Clinical Trials NSABP-P-1 or NSABP-P-2
RATIONALE: Studying the genes expressed in samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00967239
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Volunteers
- 1,881 people, healthy volunteers welcome
- Sponsor
- NSABP Foundation Inc
Lactose Intolerance
Effect of a Probiotic With High Beta-galactosidase Activity on Patients With Lactose Intolerance
Lactose intolerance is a chronic disease caused by the total/partial lack of lactase production. When lactose is not properly digest, it is consumed by the microbiota.
- Trial name
- PROBIOLAC (NCT05367453)
- Testing
- Tropical juice with probiotics (B.coagulans), a Tropical juice with no probiotics, lactase tablet
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Streptococcus Mutans
Streptococcus Mutans Pathogenicity by Real-time Polymerase Chain Reaction (PCR) in High Caries Risk Patients
In patients with high caries risk, will the use of sage extract or chlorohexidine based mouthwashes have an effect on the percentage recovery of Streptococcus Mutans (SM) and its pathogenicity detected by Real-Time Polymerase…
- Trial name
- NCT04565912
- Testing
- Sage extract mouthwash, Chlorohexidine based mouthwash
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetes, Type I
Prevention of Clinical Onset of Type 1 Diabetes in High Risk First Degree Relatives
Prophylactic administration of metabolically active insulin can prevent or delay clinical onset of diabetes in a high risk group of nondiabetic siblings as defined by positivity for autoantibodies against IA-2 (IA-2-A).
- Trial name
- NCT00654121
- Testing
- Actrapid HM
- Where
- 3 sites in Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Aortic Valve Stenosis
The Multidisciplinary, Multimodality, But Minimalist Approach to Transfemoral Transcatheter Aortic Valve Replacement
The primary objective of this study is to determine the efficacy, safety and feasibility of next day discharge home in patients undergoing balloon-expandable transfemoral TAVR utilizing the Vancouver 3M Clinical Pathway in low…
- Trial name
- 3MTAVR (NCT02287662)
- Testing
- Vancouver 3M Clinical Pathway
- Where
- Canada
- Volunteers
- 411 people
- Sponsor
- BC Centre for Improved Cardiovascular Health
Localized Prostate Carcinoma, Oligometastatic Prostate Carcinoma
Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer
This clinical trial evaluates the use of an imaging scan (18F-rhPSMA-7.3 positron emission tomography [PET]/magnetic resonance imaging [MRI]) for identifying patients who are at risk of having their disease spread to the lymph…
- Conditions
- Localized Prostate Carcinoma, Oligometastatic Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8
- Trial name
- NCT06389786
- Testing
- Bilateral Pelvic Lymph Node Dissection, Biospecimen Collection, Bone Scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
ESKD, Dialysis Patients
Comparisons Of Biochemical And Clinical Outcomes Of Hemodialysis Patients Treated With Middle Cut-Off Dialyzers Versus High-Flux Hemodialysis Or Hemodiafiltration
The CONCORDIA study is a retrospective, observational study evaluating clinical and biochemical outcomes among patients receiving maintenance hemodialysis with medium cut-off (MCO) dialyzers (Theranova) compared with high-flux…
- Trial name
- CONCORDIA (NCT07561424)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Arbor Research Collaborative for Health
Hypertension
Dietary Counseling to Reduce Salt Intake in Patients With High Blood Pressure
High salt diet increases risk of development of hypertension. In hypertensive patients, low salt diet decreases blood pressure. Not surprisingly public health authorities endorse low salt diet in hypertensive patients.
- Trial name
- NCT02283697
- Testing
- Dietary Counseling, Control: Standard Care
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Ottawa Hospital Research Institute
Precancerous Condition, Stage 0 Melanoma
Lovastatin in Treating Patients At High Risk of Melanoma
The use of lovastatin may slow disease progression in patients at high risk of melanoma. It is not yet known whether lovastatin is more effective than a placebo in treating patients at high risk of melanoma.
- Conditions
- Precancerous Condition, Stage 0 Melanoma, Stage I Melanoma, Stage II Melanoma
- Trial name
- NCT00462280
- Testing
- lovastatin, biopsy, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
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