Clinical trials: Clinical Malaria
Malaria, Malaria,Falciparum
A Phase 1 Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI
USSPZV7 is a randomized, phase 1, double-blind, placebo-controlled trial of Sanaria® PfSPZ Vaccine administered on Days 1, 8 and 29 by direct venous inoculation (DVI) to assess safety, tolerability, immunogenicity, and vaccine…
- Trial name
- NCT05604521
- Testing
- PfSPZ Vaccine, PfSPZ Challenge (7G8), Normal Saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Severe Malaria, Thrombocytopenia
Platelet-Directed Whole Blood Transfusion Strategy for Malaria
Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.
- Trial name
- PLATFORM (NCT05711485)
- Testing
- Whole blood transfusion
- Where
- 2 sites in United States, Zambia
- Volunteers
- 132 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Malaria,Falciparum
Safety and Immunogenicity of RH5.1/Matrix-M in Adults and Infants Living in Tanzania
This is an age de-escalation, dose-escalation open label randomised trial studying the safety and immunogenicity of RH5.1/Matrix-M, administered intramuscularly in healthy adults, young children and infants in Tanzania
- Trial name
- NCT04318002
- Testing
- RH5.1/Matrix-M
- Where
- Tanzania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
A Clinical Trial of the PfSPZ Vaccine Administered by Direct Venous Inoculation in Healthy Malaria-Naïve Adults: Heterologous vs. Homologous Controlled Human Malaria Infection and Reduction in Number of Doses
This is an open-label evaluation of the safety, tolerability immunogenicity and efficacy of the PfSPZ Vaccine administered by Direct Venous Inoculation (DVI) in healthy, malaria-naïve subjects.
- Trial name
- NCT02215707
- Testing
- PfSPZ Vaccine
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Malaria, Malaria,Falciparum
A Study to Assess the Safety and Effectiveness of Two Experimental Malaria Vaccines
Malaria is a major public health problem. There were around 240 million cases of malaria and 627,000 deaths worldwide in 2020. There is a great need for a safe, effective malaria vaccine and the team at University of Oxford is…
- Conditions
- Malaria, Malaria,Falciparum, Parasitic Disease, Vector Borne Diseases
- Trial name
- NCT05978037
- Testing
- RH5.1 and/or RH5.2-VLP with Matrix-M
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Automated Microscopy Evaluation Study
Since the introduction of Giemsa stain in 1904 until today, malaria microscopy has been the standard of practice for malaria diagnosis.
- Trial name
- AutoMic (NCT04558515)
- Testing
- Novel malaria diagnostics & tools
- Where
- Sudan
- Volunteers
- 190 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
HIV Infections, Malaria
Drug Interaction Study Between Antimalarial and Anti-HIV Medications
The purpose of this study is to find out whether taking certain anti-HIV medicines with certain antimalarial medicines affects the amount of the medicines in the blood.
- Trial name
- NCT00266058
- Testing
- Lopinavir/Ritonavir, Efavirenz, Artemether/lumefantrine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria, Diarrhea
Clinical Evaluation of the Use of an mHealth Intervention on Quality of Care
Under the World Health Organization's (WHO) integrated community case management (iCCM) Rapid Access Expansion Program (RAcE), World Vision Niger and Canada supported the Niger Ministry of Public Health to implement iCCM in four…
- Conditions
- Malaria, Diarrhea, Acute Respiratory Infection
- Trial name
- NCT03874143
- Testing
- mHealth Intervention for Quality of Care
- Volunteers
- 520 people
- Sponsor
- World Vision Canada
Plasmodium Vivax Infection
Vivax Malaria Human Infection Studies in Thailand
This study is a human challenge study to assess the feasibility and safety of controlled human malaria infection (via P. vivax sporozites) in healthy volunteers, and to develop a bank of P.
- Trial name
- MIST1 (NCT04083508)
- Testing
- Mosquito bites
- Where
- Thailand
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Uncomplicated Malaria
Malaria Therapeutic Efficacy Study, Rwanda
WHO recommends that Therapeutic Efficacy Studies (TES) for 1st and 2nd line antimalarial medicines should be routinely carried out and data made available for decision-making due to the threat of emergence and spread of…
- Trial name
- NCT04767217
- Testing
- artemether-lumefantrine (ALN), dihydroartemisinin-piperaquine (DHA-PPQ)
- Where
- 3 sites in Rwanda
- Volunteers
- 528 people
- Sponsor
- Jhpiego
Healthy Volunteer, HV
Improving the Efficacy of Experimental Malaria Vaccine AMA1-C1/Alhydrogel® (Registered Trademark)
This study will evaluate the safety and efficacy of the experimental malaria vaccine AMA1-C1/Alhydrogel® (Registered Trademark) and determine whether a new, additional component of the vaccine may increase its effectiveness.
- Trial name
- NCT00340574
- Testing
- AMA1-C1/Alhydrogel + CpG 7909
- Where
- 2 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria in Pregnancy, HIV Infections
Establishing Effectiveness of Daily Co-trimoxazole Prophylaxis For Prevention of Malaria in Pregnancy
Malaria is a major contributor of disease burden in Sub-Saharan Africa: 90% of global cases occur there, and pregnant women and children under 5 years are the most vulnerable.
- Trial name
- NCT01053325
- Testing
- Cotrimoxazole prophylaxis, SP IPT
- Where
- Zambia
- Volunteers
- 848 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Parasitologically Confirmed; Malarial
Artemether-Lumefantrine Clinical Effectiveness Study
In 2009, Papua New Guinea officially adopted artemether-lumefantrine (AL) as new national first-line drug for uncomplicated malaria.
- Trial name
- NCT01599000
- Testing
- Artemether-lumefantrine combination
- Where
- Papua New Guinea
- Volunteers
- 159 people
- Sponsor
- Papua New Guinea Institute of Medical Research
Malaria
A Clinical Trial to Evaluate the Safety, Efficacy and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
This was a randomized, dose-escalation Phase I/IIa study to evaluate safety, tolerability, immunogenicity and efficacy of an investigational RNA-based vaccine (BNT165e) for prevention of P.
- Trial name
- NCT06069544
- Testing
- BNT165c, BNT165d
- Where
- 5 sites in United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Malaria, Malaria Vivax
This is a Clinical Study to Assess Whether the Combination of SJ733 and Tafenoquine Will be a Safe and Rapidly Acting Anti-malarial for the Radical Cure of P. Vivax Malaria
The goal of this Phase 2b study is to examine the safety and efficacy of the combination of SJ733, an investigational agent, and tafenoquine for the radical cure of uncomplicated P.
- Conditions
- Malaria, Malaria Vivax, Radical Cure
- Trial name
- SJ733-2002 (NCT07430592)
- Testing
- CQ/TQ, SJ733 (3-day)/TQ, SJ733 (2-day ) /TQ
- Where
- Peru
- Volunteers
- 104 people
- Sponsor
- R. Kiplin Guy
Malaria, Anemia
Intermittent Treatment With Sulfadoxine-pyrimethamine for Malaria Control in Infants
The purpose of this study is to assess the effectiveness of Intermittent Preventive Treatment in Infants (IPTi) with Sulfadoxine-Pyrimethamine to reduce the numbers of malaria attacks, episodes of anemia, and the overall…
- Trial name
- NCT00206739
- Testing
- Sulfadoxine (12.5 mg)/Pyrimethamine (250 mg)
- Where
- Ghana
- Volunteers
- 1,070 people, healthy volunteers welcome
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Malaria, Filariasis
Medical Implications of Coinfection With Malaria and Filariasis Parasites
This study will examine the clinical, immunological and epidemiological effects of concurrent infections with P. falciparum and W. bancrofti or M.
- Trial name
- NCT00471666
- Where
- Mali
- Volunteers
- 1,039 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA)
The BOHEMIA program consists of a combination of studies organized around a central community prevention mass drug administration protocol and four sub-studies (i.e.; social science, entomology, health economics, and…
- Trial name
- BOHEMIA (NCT04966702)
- Testing
- Albendazole Pill, Ivermectin Pill, Ivermectin Injectable Product
- Where
- 2 sites in Kenya, Mozambique
- Volunteers
- 48,145 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Malaria
Dried Leaf Artemisia (DLA) Compared to Artemisinin Combination Therapy (ACT) vs Malaria
The overall goal is to validate efficacy and potential superiority of dried leaf Artemisia annua (DLA) vs. artemisinin combination therapy (ACT) to cure malaria and to demonstrate elimination of the transmission stage…
- Trial name
- NCT03199755
- Testing
- ACT, DLA1, DLA2
- Where
- Democratic Republic of the Congo
- Sponsor
- Worcester Polytechnic Institute
Malaria
Clinical Investigation Study to Evaluate the Consistency and Reproducibility of Two Consecutive Mosquito Feeding Assays
The proposed trial design has been developed to assess the consistency and reproducibility of two consecutive direct skin feeding assays (DSFA) at 24-hour interval.
- Trial name
- NCT04666350
- Testing
- Direct Skin Feeding Assay (DSFA), Primaquine, Artemether/Lumefantrine
- Where
- Kenya
- Volunteers
- 42 people
- Sponsor
- PATH