Clinical trials: Clinical Pain
Joint Disease
PMCF Study Protocol for PROFEMUR® Gladiator Plasma Femoral Stems and PROCOTYL® L Beaded Acetabular Components
MicroPort Orthopedics (MPO) is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its total hip arthroplasty (THA) components marketed in the European Union (EU).
- Trial name
- NCT02823834
- Testing
- PROFEMUR® Gladiator Plasma Femoral Stems
- Where
- Germany
- Volunteers
- 121 people
- Sponsor
- MicroPort Orthopedics Inc.
Acute Pain, Bunionectomy
A Clinical Trial of GRT7040 in Adults With Acute Pain Following Bunionectomy
This is a Phase 2 clinical trial of GRT7040, currently being developed for the treatment of moderate-to-severe acute pain. The primary purpose of this trial is to assess efficacy and safety of GRT7040 compared with placebo in…
- Trial name
- NCT07807644
- Testing
- GRT7040, Hydrocodone bitartrate/ acetaminophen (HB/APAP)
- Volunteers
- 400 people
- Sponsor
- Grünenthal GmbH
Sacroiliac Joint Dysfunction, Sacroiliac Joint Pain
Post-Market Clinical Study Using TRAQ™ for Minimally Invasive Posterior Sacroiliac Joint Fusion
The purpose of this study is to evaluate the real-world performance, safety and efficacy of the TRAQ System.
- Trial name
- TRAQTION (NCT07547215)
- Testing
- Bone Allograft
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- PainTEQ, LLC
Herpes Zoster, Zoster-Associated Pain
Efficacy and Safety of High-Concentration 35 kDa Hyaluronan Gel for Herpes Zoster-Associated Pain
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of topical 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with herpes zoster-associated pain (ZAP).
- Conditions
- Herpes Zoster, Zoster-Associated Pain, Postherpetic Neuralgia, Neuropathic Pain
- Trial name
- HA35-HZ (NCT07569978)
- Testing
- 10% High-Concentration 35 kDa Hyaluronan (HA35) Topical Analgesic Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
Muscular Atrophy, Sprains
Study to Assess the Efficacy and Safety of Ibuprofen 50 mg/g Gel Compared to Profenid 25mg/g Gel
The aim of this study is to determine that ibuprofen 50mg/g gel is effective and safety treating patients with muscle aches, joint pains or due to sprains, bruises, tendinitis or myofascial compared to Profenid 25mg/g gel.
- Conditions
- Muscular Atrophy, Sprains, Tendonitis
- Trial name
- NCT01373697
- Testing
- Ibuprofen, Profenid
- Where
- Brazil
- Volunteers
- 144 people
- Sponsor
- Laboratório Teuto Brasileiro S/A
Postherpetic Neuralgia ( PHN )
A Clinical Trial to Evaluate the Efficacy and Safety of HL-1186 Tablet in the Treatment of Postherpetic Neuralgia
This is a multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group trial to evaluate the safety, efficacy and pharmacokinetic (PK) profile of HL-1186 Tablet in patients with postherpetic…
- Trial name
- NCT07758920
- Testing
- HL-1186, Pregabalin capsule
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.
Premenstrual Syndrome, Premenstrual Dysphoric Disorder
CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life
This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device…
- Conditions
- Premenstrual Syndrome, Premenstrual Dysphoric Disorder, Dysmenorrhea, Endometriosis
- Trial name
- CREST (NCT07679074)
- Testing
- Lutea Transcranial Direct Current Stimulation (tDCS) Device, Samphire Guided Care Program
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samphire Group, Inc.
Pain
Clinical Pilot Study in Healthy Men to Characterize the Uptake of Buprenorphine Into and Its Elimination From the Body After Topical Application of Two New Forms of a Skin Patch in Comparison to a Reference Patch
This study is intended to produce information on the pharmacokinetic characteristics (uptake into and elimination from the body) of two new patch formulations of the analgesic buprenorphine as compared to the reference patch…
- Trial name
- NCT03785613
- Testing
- Test Product T1: Buprenorphine patch (9 mg), Test Product T2: Buprenorphine patch (3.8 mg), Reference Product R: Transtec patch (20 mg)
- Where
- Switzerland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Coronary Artery Disease
Safety and Efficacy Study of PB127 Ultrasound Contrast Agent for Diagnosis of Coronary Artery Disease
The purpose of this study is to determine if the use of PB127 with cardiac ultrasound assists in the diagnosis or exclusion of coronary artery disease.
- Trial name
- POINT II (NCT00584896)
- Testing
- PB127 for Injectable Suspension
- Where
- 40 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Point Biomedical
Aging
Effectiveness and Safety of STYLAGE® M LIDOCAINE Versus STYLAGE® M in Filling Nasolabial Folds
This clinical investigation is designed to compare the STYLAGE® M Lidocaïne to STYLAGE® M in terms of correction of nasolabial folds severity and pain felt by the subject, and to assess and compare the safety and effectiveness of…
- Trial name
- MLIDOM (NCT05087732)
- Testing
- STYLAGE® M Lidocaïne, STYLAGE® M
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Acute Pharyngitis
A Clinical Trial Investigating the Short-term Relief of Symptoms of Acute Pharyngitis by Treatment With Three Different Doses of MYRAMISTIN™ Oromucosal Spray
In this multi-center, randomized, placebo-controlled, double-blind stuy in which patients with acute pharyngitis will receive Myramistin™ / Placebo, which is provided as a spray.
- Trial name
- MIRA1 (NCT04470089)
- Testing
- Myramistin
- Where
- 12 sites in Austria, Germany
- Volunteers
- 170 people
- Sponsor
- Megainpharm GmbH
Peripheral Neuropathic Pain
Clinical Trial of YHD1119 in Patients With Peripheral Neuropathic Pain
A Randomized, Double-blind, Active-Controlled, Multi-center, Phase 3 Trial to Compare the Safety and Efficacy between YHD1119 and Pregabalin in Patients with Peripheral Neuropathic Pain
- Trial name
- NCT02985216
- Testing
- YHD1119, Lyrica
- Where
- South Korea
- Volunteers
- 371 people
- Sponsor
- Yuhan Corporation
Cervical Radiculopathy, Degenerative Disc Disease
Restore CLINICAL TRIAL
This is a prospective, concurrently controlled, multi-center study to evaluate the safety and effectiveness of the Spinal Kinetics M6-C artificial cervical disc compared to anterior cervical discectomy and fusion (ACDF) for the…
- Trial name
- NCT01609374
- Testing
- M6-C Artificial Cervical Disc, Anterior plate system with corticocancellous allograft bone
- Volunteers
- 258 people
- Sponsor
- Spinal Kinetics
Chronic Prostatitis
Efficacy and Safety of Ningmitai Capsule in Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
1. Clinical trial title：Efficacy and safety of Ningmitai capsule in patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome：A prospective, randomized, positive drug-controlled, multicenter clinical study 2.
- Trial name
- NCT05890235
- Testing
- Ningmitai Capsule, Tamsulosin Hydrochloride
- Where
- China
- Volunteers
- 323 people
- Sponsor
- Xintian Pharmaceutical
Catheter Site Pain, Catheter Site Discomfort
Investigation of New Intermittent Catheter Swelling Media in Healthy Volunteers
Investigation of novel swelling media for CE marked intermittent urinary catheters. The study was a randomized, single blinded, cross-over investigation comparing a novel swelling media with a comparator swelling media in 22…
- Trial name
- NCT04633291
- Testing
- Novel swelling media, Comparator swelling media
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Coloplast A/S
Aging, Pain
RHA® Redensity With New Anesthetic Agent - Perioral Rhytids
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® Redensity with new anesthetic agent is non-inferior to RHA® Redensity with lidocaine in…
- Trial name
- NCT04069585
- Testing
- RHA® Redensity with new anesthetic agent, RHA® Redensity with lidocaine
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Tooth Extraction Site Healing
Effect of a Bioactive Mineral-Ionic Mouthrinse on Periodontal Soft Tissue Healing
This randomized, double-blinded clinical trial was designed to evaluate the effects of a bioactive mineral-ionic mouthrinse (THERAVEX® Total Oral Care Plus) on postoperative healing and patient comfort following simple tooth…
- Trial name
- Bioactive Mine (NCT07611123)
- Testing
- Normal Saline, chlorhexidine (CHX), Theravex Bioactive Solutions (Tissue Care Plus and Oral)
- Where
- Saudi Arabia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Biointelligent Technology Systems SL
Pain Management, Osteoarthritis
Efficacy and Safety of Etoricoxib+Diacerein in Osteoarthritis.
The goal of this clinical trial is to learn if fixed-dose combination etoricoxib 90 mg + diacerein 50 mg capsule works to treat knee/hip osteoarthritis-associated pain in adults. It will also learn about the safety of the drug.
- Trial name
- NCT07549386
- Testing
- Etoricoxib 90 mg + diacerein 50 mg, Meloxicam 15 mg + diacerein 50 mg
- Where
- 4 sites in Mexico
- Volunteers
- 123 people
- Sponsor
- Laboratorios Liomont
Constipation, Dyspepsia
Study of Yili "Changqing" Pro-ABB Yoghurt in the Improvement of Human Gastrointestinal Tract System
The purpose of this study is to determine whether Yili "Chang Qing" Pro-ABB yoghurt is effective in improving mild constipation and the intestinal micro-ecology environment \& alimentation.
- Conditions
- Constipation, Dyspepsia, Flatulence, Abdominal Pain
- Trial name
- NCT01682798
- Testing
- Yili "Chang Qing" Pro-ABB yoghurt (Formula 1), Yili "Chang Qing" Pro-ABB yoghurt (Formula 2)
- Where
- 2 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Inner Mongolia Yili Industrial Group Co., Ltd
Healthy, Pain
A Clinical Study of MK-4318 and Diltiazem in Healthy People (MK-4318-003)
The goal of this study is to learn what happens to MK-4318 in a person's body over time. Researchers will compare what happens to levels of MK-4318 in people's blood when it is taken with and without diltiazem.
- Trial name
- NCT06692647
- Testing
- MK-4318, Diltiazem
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC