Clinical trials: Clinical Pain
Diabetic Peripheral Neuropathic Pain (DPNP)
Randomized, Double-blind, Placebo-controlled, Multicenter Phase IIb Clinical Trial of Spray YJ001 for the Treatment of Diabetic Peripheral Neuropathic Pain
The goal of this clinical trial is to learn if YJ001 Spray can treat diabetic patients with Diabetic Peripheral Neuropathic Pain(DPNP).
- Trial name
- NCT07858344
- Testing
- YJ001 spray simulator, YJ001 Spray 240 mg/day, YJ001 Spray 480 mg/day
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Zhejiang Yuejia Pharmaceuticals Co., Ltd.
Root Canal Obturation
Pain After Root Canal Obturation With Sealer Containing or Not 1% Enoxolone
This study aims to assess the efficacy of a zinc oxide eugenol sealer containing Enoxolone, a non-steroidal anti inflammatory drug (NSAID) on the pain relief after endodontic treatment.
- Trial name
- NCT03874949
- Testing
- SEALITE Regular, SEALITE Ultra
- Where
- France
- Volunteers
- 95 people
- Sponsor
- ACTEON Group
Vertebral Body Compression Fractures
KAVIAR Study - Kyphoplasty And Vertebroplasty In the Augmentation and Restoration of Vertebral Body Compression Fractures
Patients with osteoporotic vertebral body compression fractures will be randomly assigned to treatment with balloon kyphoplasty or vertebroplasty.
- Trial name
- NCT00323609
- Testing
- Vertebroplasty, Kyphoplasty
- Where
- 26 sites in United States, Canada
- Volunteers
- 404 people
- Sponsor
- Medtronic Spine LLC
Greater Trochanteric Pain Syndrome, Hip Pain Chronic
Research Study to Compare the Addition of Topaz Micro Debridement to the Standard of Care Surgery
Compare the surgical use of Topaz with the Standard Of Care in the treatment of Greater Trochanteric Pain Syndrome (a type of hip pain). The hypothesis is that there is a difference between the two treatment groups.
- Trial name
- NCT01562366
- Testing
- Topaz, Iliotibial band release and trochanteric bursectomy
- Where
- Australia
- Volunteers
- 66 people
- Sponsor
- Smith & Nephew, Inc.
Peripheral Nueropathy Pain
A Open-label, Randomized, Crossover Study to Assess PK of Pregabalin
The purpose of this trial to compare the pharmacokinetic characteristics of YHD1119(Pregabalin 300mg) and Lyrica capsule(Pregabalin 150mg). YHD1119 is controlled release formulation which is made by Yuhan Corporation.
- Trial name
- NCT02783183
- Testing
- YHD1119, Lyrica
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Herniated Lumbar Disk
Confirmatory Clinical Study of Oxiplex
This is a prospective, multi-center, randomized, controlled, patient and evaluator-blinded clinical study to assess the safety and effectiveness for the reduction of pain and symptoms following lumbar surgery.
- Trial name
- NCT03433391
- Testing
- Oxiplex, Surgery Only
- Where
- 17 sites in United States
- Volunteers
- 135 people
- Sponsor
- FzioMed
Coronary Artery Disease, Angina Pectoris
Investigation of a Novel Gene Expression Test (ASGES or Corus CAD) for Diagnosis of Obstructive Coronary Artery Disease
The objective of this study is to collect data on the commercial use of Corus CAD (Age/Sex/Gene Expression score - ASGES) blood test to evaluate the clinical referral patterns of Primary Care Physicians after receipt of their…
- Conditions
- Coronary Artery Disease, Angina Pectoris, Chest Pain, Cardiovascular Diseases
- Trial name
- REGISTRY-I (NCT01557855)
- Testing
- Corus CAD (ASGES)
- Where
- 7 sites in United States
- Volunteers
- 342 people
- Sponsor
- CardioDx
Endometriosis-related Pain
A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034)
The purpose of this study is to evaluate the efficacy, safety, and tolerability of gefapixant (MK-7264) in premenopausal female participants with moderate to severe endometriosis-related pain.
- Trial name
- NCT03654326
- Testing
- Gefapixant, Naproxen
- Where
- 78 sites in United States, Australia and 7 more
- Volunteers
- 187 people
- Sponsor
- Merck Sharp & Dohme LLC
Primary and Secondary Bone Tumor in the Proximal Femur Region
Clinical Evaluation of Moment Tumor Hip Replacement Products
The aim is to ensure that the patients are functionally adequately and painlessly mobilized with the proximal femoral tumor resection prosthesis used, to increase the survival of patients who underwent wide resection, and to…
- Trial name
- KRIOS (NCT05847868)
- Testing
- Moment Tumour Hip Prothesis
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Estas Tıbbi Mamülleri Medikal
Major Depressive Disorder, Fibromyalgia
Duloxetine Compassionate Use in Patients Who Have Completed a Previous Neuroscience Duloxetine Clinical Trial
The primary objective of this study is to provide duloxetine to investigators for the treatment of patients who have previously participated in neuroscience duloxetine clinical trials and for whom effective alternative therapy is…
- Conditions
- Major Depressive Disorder, Fibromyalgia, Diabetic Peripheral Neuropathic Pain, Generalized Anxiety Disorder
- Trial name
- NCT00071708
- Testing
- Duloxetine Hydrochloride
- Where
- 13 sites in Australia
- Sponsor
- Eli Lilly and Company
Diabetic Peripheral Neuropathic Pain
Evaluate the Efficacy and Safety of HL-1186 in Patients With Diabetic Peripheral Neuropathic Pain
This is a multi-center, randomized, double-blind, placebo-controlled study design evaluating the safety, efficacy, and PK parameter of HL-1186 tablet for diabetic peripheral neuropathic pain.
- Trial name
- NCT07159243
- Testing
- HL-1186
- Volunteers
- 180 people
- Sponsor
- Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.
Low Back Pain
Study of Low Level Laser Therapy to Treat Low Back Pain
The purpose of this study is to determine whether the Erchonia® ML Scanner (MLS) is effective in the treatment of acute minor episodic chronic low back pain of musculoskeletal origin.
- Trial name
- NCT01835756
- Testing
- Erchonia MLS
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Erchonia Corporation
Neuropathy, Pain
Clinical Study for Assessment of the Efficacy of Gabapentin (Carbatin and Neurontin) in Patients With Neuropathy Pain
The purpose of this study is to assess the efficacy of Gabapentin (Carbatin \& Neurontin) in patients with neuropathy pain.
- Trial name
- NCT02074267
- Testing
- Carbatin, Neurontin
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Nang Kuang Pharmaceutical Co., Ltd.
Pain
Fixed Dose Combination of COdeine + DIpyrone to Mitigate Moderate to Intense Pain Post-impacted Third Lower Molar Extraction
A clinical, multicenter, randomized, parallel-group, double-blind, double-dummy, comparative study of non-inferiority. ⚠️Study will only be conducted in research centers in Brazil (please do not send e-mail if your center is…
- Trial name
- CODI (NCT04972292)
- Testing
- FDC of codeine 30 mg/dipyrone 500 mg, Tylex
- Where
- 2 sites in Brazil
- Volunteers
- 288 people
- Sponsor
- Eurofarma Laboratorios S.A.
Pain, Cancer
Clinical Study of KW-2246 in Patients With Cancer Pain
This study is a Phase II open-label study to investigate the recommended conversion ratio (oral morphine dose to KW-2246) when switching oral morphine or oxycodone to KW-2246 in cancer patients.
- Trial name
- NCT00355628
- Testing
- KW-2246 (fentanyl citrate)
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Moderate Pain, Severe Pain
Efficacy and Safety of DIT112 in the Treatment of Moderate to Severe Pain After Dental Surgery for the Extraction of Impacted Third Molars
The purpose of this study is to evaluate the efficacy and safety of DIT112 in adolescents and adults with acute pain after dental surgery for the extraction of impacted third molars.
- Trial name
- ALIV (NCT06237231)
- Testing
- DIT112, DIPYRONE, TRAMADOL
- Volunteers
- 252 people
- Sponsor
- EMS
Osteoarthritis, Rheumatoid Arthritis
A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809
Randomized, Open-label, Oral, Single-dose, two-Sequence, four-Period, crossover study
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Back Pain, Acute Upper Respiratory Tract Infection
- Trial name
- NCT05214677
- Testing
- DW1809, DW1809-1
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Acute Pain
Efficacy and Safety of Escócia Association in the Treatment of Acute Pain
The purpose of this study is to evaluate the efficacy and safety of Escócia association in adults with acute pain.
- Trial name
- NCT04666701
- Testing
- Escócia association, Ketorolac Tromethamine, Scopolamine
- Sponsor
- EMS
Oral Pain, Oral Pungent Sensation
Efficacy of Oral HA35 for Rapid Relief of Oral Pain and Pungent Sensation
This prospective, open-label, controlled pilot study evaluates oral 10% 35 kDa hyaluronan (HA35) versus four control interventions (C60 grapeseed oil，normal saline) for relief of capsaicin/AITC-induced oral pain and pungent…
- Conditions
- Oral Pain, Oral Pungent Sensation, Capsaicin-Induced Pain, AITC-Induced Irritation
- Trial name
- NCT07630571
- Testing
- Capsaicin Oral Challenge, Allyl Isothiocyanate (AITC) Oral Challenge, 10% 35 kDa Hyaluronan (HA35) Oral Solution
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nakhia Impex LLC
Acute Pain Due to Trauma
Methoxyflurane vs Standard Analgesic Treatment for Trauma Pain in Spanish Emergency Units
Clinical trial to compare pain relief between methoxyflurane and any analgesic treatment used in usual clinical practice, in patients with trauma and associated pain, treated in Spanish emergency units.
- Trial name
- InMEDIATE (NCT03256903)
- Testing
- Methoxyflurane, Standard of care
- Where
- 14 sites in Spain
- Volunteers
- 310 people
- Sponsor
- Mundipharma Pharmaceuticals S.L.