Clinical trials: Clinical Pain
Back Pain, Intervertebral Disc Degeneration
The Role of Disc Nutrition in the Etiology and Clinical Treatment of Disc Degeneration
The purpose of this research study is to examine the effects of physical therapy on the spinal discs. Back pain is the number one cause of disability in the US, and the spine is the most common location of chronic pain in…
- Trial name
- NCT04134910
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Molar, Third, Pain
Influence of CYP2C9 Genotype on Clinical Efficacy of Tenoxicam
The goal of this study is to evaluate the different gene haplotypes for the clinical efficacy of tenoxicam after third lower molar surgery for pain, edema and trismus, adverse reactions, need of rescue medication, patient…
- Trial name
- NCT04182191
- Testing
- Tenoxicam
- Where
- Brazil
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pain, Osteo Arthritis Knee
Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee
This is a phase 2, randomized, double-blind, placebo-controlled trial of multiple doses and multiple administrations of LEVI-04 for the treatment of pain due to osteoarthritis of the knee.
- Conditions
- Pain, Osteo Arthritis Knee, Knee Osteoarthritis, Arthritis
- Trial name
- NCT05618782
- Testing
- LEVI-04
- Where
- 13 sites in Czechia, Denmark and 3 more
- Volunteers
- 518 people
- Sponsor
- Levicept
Fibromyalgia, Hyperbaric Oxygen
Hyperbaric Oxygen Compared to Pharmaceutical Therapies for Fibromyalgia Syndrome
The investigators have previously studied the efficacy of hyperbaric oxygen therapy (HBOT) as a treatment for Fibromyalgia syndrome (FMS) in a prospective, active control, crossover clinical trial.
- Trial name
- FMSRCT (NCT03325959)
- Testing
- Hyperbaric oxygen therapy (HBOT) treatment, Cymbalta / Lyrica treatment, Crossover Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 76 people
- Sponsor
- Assaf-Harofeh Medical Center
Myofascial Dysfunction
Quantifying Myofascial Dysfunction in Post-Stroke Pain
The purpose of this study is to quantify the extent of GlycosAminoGlycan/Hyaluronic Acid (GAG/HA) accumulation using T1rho (T1ρ) MRI in the paretic versus non-paretic shoulder rotator muscles, and correlate the T1ρ Magnetic…
- Trial name
- Myofascial (NCT05762679)
- Testing
- Imaging
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Johns Hopkins University
Metastatic Breast Cancer, Tumor
Anastrozole Adjuvant Trial - Study of Anastrozole Compared to NOLVADEX (Tamoxifen Citrate) for Adjuvant Treatment of Early Breast Cancer Clinical Studies), Adjunct Cytotoxic Chemotherapy and Malignant Joint Tumor
At a median follow-up of 33 months, the combination of anastrozole and NOLVADEX (tamoxifen citrate) did not demonstrate any efficacy benefit when compared to NOLVADEX (tamoxifen citrate) therapy given alone in all patients as…
- Conditions
- Metastatic Breast Cancer, Tumor, Muscle Neoplasms, Chronic Pain
- Trial name
- NASBP-B-09 (NCT06154590)
- Testing
- Method(s)1 Attribution, Method(s)2 Attribution,
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- DR. DIANE CHISESI NFS. MD. PHD.
Low Back Pain
Clinical Efficacy and Safety of Axiom Worldwide DRX9000 Axial Decompression System for Treatment of Low Back Pain
This study will document efficacy and safety of the Axiom Worldwide DRX9000™ for treatment of low back pain (LBP) in a prospective, randomized, crossover, multicenter trial utilizing a standardized clinical research multimodal…
- Trial name
- NCT00469118
- Testing
- DRX9000™
- Where
- United States
- Sponsor
- NEMA Research, Inc.
Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome
Thalidomide to Treat Oral Lesions in HIV-Infected Patients
This study will test the effectiveness of topical thalidomide in healing mouth sores in HIV infected patients. Oral (PO) thalidomide heals these sores at a dose of 200 mg per day.
- Conditions
- Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome, HIV Infection
- Trial name
- NCT00001524
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Ectopic Pregnancy
The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy
The experiment aims to explore the clinical effect of subclinical doses of ketamine on early postoperative pain sensitivity in ectopic pregnancy population.
- Trial name
- NCT06559280
- Testing
- esketamine
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Fujian Provincial Hospital
Chronic Pain
Tele-Yoga Therapy for Chronic Pain
Chronic pain is highly prevalent and associated with a large symptom burden, that is had been more concerning during Covid-19 outbreak and lockdown. Benefits of yoga in chronic pain management are very well known.
- Trial name
- NCT04457388
- Testing
- Tele-Yoga Therapy
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Aarogyam UK
Major Ankle Surgery
Saphenous Nerve Block: Single Shot Versus Continuous Infusion to Supplement a Continuous Sciatic Nerve Block After Major Ankle Surgery
The most useful method to manage pain after major ankle surgery is infusion of local analgesics with a catheter close to the sciatic nerve.
- Trial name
- NCT01445210
- Testing
- Continuous saphenous nerve block
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Osteoarthritis, Knee
A Clinical Study to Investigate the Effect on Pain Relief of a Single Dose of JNJ-39439335 in Patients With Chronic Osteoarthritis Pain of the Knee
The purpose of this single-center study is to evaluate the potential analgesic effects of a single oral dose (50 mg) of JNJ-39439335, an investigational drug being developed for the treatment of pain in patients with chronic…
- Trial name
- NCT00933582
- Volunteers
- 33 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy Volunteers Only
Effects of Substance P on Headache Induction in Healthy Individuals
Substance P is a signaling molecule that has been implicated in the pathogenesis of headache. This study aims to ascertain whether administration of substance P can induce headache in healthy adults.
- Trial name
- NCT06632080
- Testing
- Substance P
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Lumbar Disc Disease
NOCISCAN-Lumbar Spine (LS) Clinical Evaluation Study
A prospective, double blinded, multi-center study to assess the validity and clinical utility of the pre-operative NOCISCAN-LS software in the identification of painful lumbar discs, and the correlation with improved surgical…
- Trial name
- NCT04015791
- Testing
- NOCISCAN-LS Disc MR Spectroscopy
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Nocimed, LLC
Postoperative Pain, Pain, Dental
Influence of Intra Canal Medications on Postoperative Flare-up in Endodontic Re-treatment Cases
Is to evaluate the influence of the calcium hydroxide / chlorhexidine combination and calcium hydroxide alone as an intra-canal medication in postoperative flare-up in two visits endodontic retreatment cases
- Trial name
- NCT03064191
- Testing
- calcium hydroxide chlorhexidine combination, calcium hydroxide intra-canal medicament
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- rayan rabie dahab
Hawthorn Red Combined Refractory Cancer Pain
Phase Ⅰa Clinical Study of Hawthorn Red Pigment Combined With Standard Analgesic for Refractory Cancer Pain
To evaluate the safety and tolerance of Hawthorn red pigment in the treatment of cancer pain Determine the maximum tolerated dose (MTD, if any) of Hawthorn red pigment and the recommended dose for phase II clinical study (RP2D)
- Trial name
- NCT05561023
- Testing
- Hawthorn red pigment
- Volunteers
- 14 people
- Sponsor
- Fujian Cancer Hospital
Heel Spur
Comparative Effects of TherapeuticU and Shockwave Therapy on Pain and QOL in Patients With Chronic Heel Spur Pain
This research aims to compare the effectiveness of therapeutic ultrasound (TUS) and extracorporeal shockwave therapy (ESWT) in managing chronic heel spur pain and improving patients' quality of life.
- Trial name
- NCT06983457
- Testing
- Therapeutic ultrasound, Shockwave Therapy
- Where
- Pakistan
- Volunteers
- 41 people
- Sponsor
- Superior University
Rheumatic Arthritis, Chronic Pain
Effect of Home-Based Transcranial Direct Current Stimulation on Pain in Patients With Rheumatoid Arthritis With Low Inflammatory Activity
Rheumatoid arthritis (RA) is a highly complex inflammatory autoimmune disease. Several drugs have been developed in recent decades to target the immune components of inflammation.
- Trial name
- tDCS RA (NCT07162311)
- Testing
- tDCS
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Total Shoulder Arthroplasty
Exparel for Total Shoulder Arthroplasty
The primary objective of this study is to determine if Exparel leads to better pain scores at 24, 48 and 72 hours after Total Shoulder Arthroplasty (TSA) compared to a pain pump.
- Trial name
- NCT04364867
- Testing
- Exparel, Pain Pump
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Norton Healthcare
Osteochondritis Dissecans of Ankle and Joints of Foot
the Effect of Weight Bearing Status on Healing and Pain Outcomes After Surgery for Osteochondral Defects of the Ankle
The rationale for this research study is to evaluate the effect on clinical outcomes of weight bearing as tolerated after forage surgery for the treatment of osteochondral defects of the ankle, thus potentially eliminating the…
- Trial name
- NCT01405664
- Testing
- Weight-Bearing as Tolerated
- Where
- Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
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