Clinical trials: Clinical Pain
Stable Angina, Ischemic Heart Disease Silent
A Randomized Clinical Evaluation of the BioFreedom™ Stent
The purpose of this study is to demonstrate that a BioFreedom™ Drug Coated Stent is non-inferior to a bare metal stent at one year as measured by the composite safety endpoint of cardiovascular death, myocardial infarction and…
- Conditions
- Stable Angina, Ischemic Heart Disease Silent, ST Elevation (STEMI) and Non-ST Elevation (NSTEMI) Myocardial Infarction, In-stent Coronary Artery Restenosis
- Trial name
- Leaders Free (NCT01623180)
- Testing
- Biofreedom™ Drug Coated Stent (DCS), Gazelle™ Bare Metal Coronary Stent (BMS)
- Where
- Switzerland
- Volunteers
- 2,456 people
- Sponsor
- Biosensors Europe SA
Chronic Ischemic Heart Disease, Heart Failure
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy
Phase I-II Clinical Trial-Safety and efficacy of umbilical cord derived mesenchymal stem cells (UC-MSCs) in patients with chronic heart ischemia cohort and perspective study.
- Conditions
- Chronic Ischemic Heart Disease, Heart Failure, Angina
- Trial name
- UCMSC-Heart (NCT02439541)
- Testing
- UCMSC group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Stomatitis
Evaluation of Efficacy and Mechanisms of an Antiinflammatory Intervention for Chemotherapy Related Mucosal Injury
This study consisted of two parts: the pilot study and the main study. The purpose of the pilot study is to demonstrate the effectiveness of planned laboratory techniques to assess for TNF-alpha gene expression from unstimulated…
- Trial name
- NCT00031551
- Testing
- Etanercept
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Nursing Research (NINR)
Shoulder Pain
Development of a Clinical Prediction Rule to Identify Patients With Shoulder Pain Likely to Benefit From Cervicothoracic Manipulation
The investigators seek to develop a clinical prediction rule (CPR) to identify patients with a primary complaint of shoulder pain who are likely to benefit from manual therapy to the neck and upper back regions.
- Trial name
- NCT00835302
- Testing
- Cervicothoracic manipulation
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Knee Osteoarthritis (Mild to Moderate, Medial Compartment)
Enhancing Medial Knee Pain Rehabilitation : A Clinical Trial On The Effectiveness Of Blood Flow Restriction In Combination With Targeted Exercises For Adult With Varus Deformity
Medial knee pain is common in active adults with varus knee alignment and can limit daily and sports activities. Standard physiotherapy can reduce pain and improve function, but strength gains may be suboptimal when patients…
- Trial name
- NCT07283237
- Testing
- Targeted Exercise Program, Blood Flow Restriction (BFR) Training with Targeted Exercise Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Faceto-genic Neck Pain, Shoulder Pain Chronic
Pulsed vs Continuous Radiofrequency Neurotomy for Cervical Facet Joint Mediated Pain
Different studies have revealed different success rates and patient satisfaction after cervical facet C-RF. In a study on 32 patients, with 15 months follow up, 25% had complete pain relief (8).
- Conditions
- Faceto-genic Neck Pain, Shoulder Pain Chronic, Faceto-genic Headache
- Trial name
- NCT04124445
- Testing
- Pulsed Radiofrequency Ablation
- Where
- 2 sites in Canada
- Volunteers
- 88 people
- Sponsor
- Allevio Pain Management Clinic
Back Pain, Lower Back Pain
Naltrexone and Clonidine Combination (ATNC05) in the Treatment of Chronic Back Pain
The study includes back pain of the cervical, thoracic, and the lumbar regions.
- Conditions
- Back Pain, Lower Back Pain, Cervical Pain
- Trial name
- NCT01415895
- Testing
- Naltrexone and Clonidine Combination
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Annette C. Toledano MD
Low Back Pain (LBP)
Pilot Study: Clinical Trial of Ultrasound Guiding Pharmacopuncture Therapy for Acute Low Back Pain
This pilot randomized controlled clinical trial aims to evaluate the effectiveness and safety of ultrasound-guided deep pharmacopuncture therapy for acute low back pain (LBP) that occurs within seven days following a traffic…
- Trial name
- NCT07126951
- Testing
- Ultrasound-guided Deep Pharmacopuncture Treatment, Korean medical treatment
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jaseng Medical Foundation
Anaesthesia, Anxiety
Virtual Reality (VR) Tour to Reduce Preoperative Anxiety Before Anaesthesia
Anxiety and apprehension are common among patients prior to surgery. This anxiety can lead to additional discomfort, increased pain sensation and increased stress symptoms.
- Conditions
- Anaesthesia, Anxiety, Postoperative Pain
- Trial name
- VR OP- tour (NCT04579354)
- Testing
- virtual reality tour
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- RWTH Aachen University
Angina (Stable), INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain
Long Covid-19 INOCA is an investigator-initiated, prospective, randomized, sham-controlled, single center study. Its objective is to investigate the benefits of tailored medical therapy according to the results of the coronary…
- Conditions
- Angina (Stable), INOCA (Ischemia With Non Obstructive Coronary Artery Disease), Long COVID-19 Syndrome
- Trial name
- NCT07559994
- Testing
- Coronary functional test
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
Odontectomy (Tooth Extraction), Socket Preservation and Healing Following Simple, Non-surgical Extraction
Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.
This study evaluates the use of Concentrated Growth Factor (CGF) plugs-a third-generation healing material made from the patient's own blood-to improve recovery after simple tooth extractions.
- Conditions
- Odontectomy (Tooth Extraction), Socket Preservation and Healing Following Simple, Non-surgical Extraction, Alveolar Bone Density and Postoperative Pain Management, Periapical Radiolucency
- Trial name
- CGF (NCT07542795)
- Testing
- Concentrated Growth Factor (CGF) Plug
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Cairo University
Chronic Neck Pain
Effectiveness of an Intervention Plan Aimed at the Diaphragm in Chronic Non-specific Neck Pain
The aim of this study is to analyse the effectiveness of an intervention plan targeting the diaphragm, namely stretching technique, neuromuscular diaphragm and phrenic centre inhibition, in the treatment of chronic non-specific…
- Trial name
- NCT06377995
- Testing
- Diaphragm protocol
- Where
- Portugal
- Volunteers
- 45 people
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris
A Multi-center, Real-World Clinical Trial of caIMR on Two Specific Kinds of Patients.
The coronary angiography-derived index of microcirculatory resistance (caIMR) can be used to provide a binary assessment whether patients（with stable angina, unstable angina, suspected myocardial ischemia, or coronary artery…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris, Unstable Angina Pectoris, Myocardial Ischemia, Angina Pectoris
- Trial name
- FlashV (NCT06945094)
- Testing
- caIMR
- Volunteers
- 508 people
- Sponsor
- Ge Junbo
Mild to Moderate Acne, Stiffness of Joint, Nec, Involving Ankle and Foot in MDR24_1
A Proof of Science, Dose-Response Study to Evaluate the Safety, Efficacy of Different Dosages of Test Treatments
A proof of science clinical study with randomized, four-arm, comparative, single-blind, within the arm - Dose-Response Study to evaluate the safety and efficacy of different collagen peptide-containing test treatments in adult…
- Conditions
- Mild to Moderate Acne, Stiffness of Joint, Nec, Involving Ankle and Foot in MDR24_1, Other Specified Diseases of Hair and Hair Follicles, Brittle Nails
- Trial name
- NCT05613660
- Testing
- Veg Collagen Peptide, Bovine Collagen Peptide, Fish | Marine Collagen Peptide
- Where
- India
- Volunteers
- 264 people
- Sponsor
- NovoBliss Research Pvt Ltd
Dexmedetomidine, Esketamine, Postoperative Pain and Recovery Quality
The Clinical Study of Dexmedetomidine and Esketamine Combined Infusion Undergoing Modified Radical Mastectomy
BACKGROUND: Some studies have revealed that intravenous dexmedetomidine and esketamine alleviated postoperative pain and improve the quality of recovery after surgery.
- Trial name
- NCT05283408
- Testing
- Dexmedetomidine infusion, Co-administration dexmedetomidine and low-dose esketamine infusion, Co-administration dexmedetomidine and high-dose esketamine infusion
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital
Post-operative Pain
QSPainRelief-patientCNS : Clinical Biomarkers of Nociception, Sedation and Cognition
QSPainRelief-patientCNS is a monocentric prospective longitudinal study conducted in patients suffering from disabling post-surgical pain for which the treating physician is about to prescribe a given drug combination for the…
- Trial name
- NCT04742790
- Testing
- Scalp electroencephalography (EEG), Laser-evoked potentials (LEPs), Cognitive auditory-evoked potentials (P300)
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Université Catholique de Louvain
Patellofemoral Pain Syndrome
Comparison Study of Two Chiropractic Treatment Protocols for Knee Pain Due to Patellofemoral Pain Syndrome
The purpose of this study is to compare outcomes of combined chiropractic care in anterior knee pain patients with patellofemoral pain syndrome.
- Trial name
- NCT00401050
- Testing
- chiropractic manipulative therapy, knee exercises, Graston Instrument Soft Tissue Mobilization (GISTM)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Cleveland Chiropractic College
Coronary Disease, Heart Diseases
Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions
The objective of this study is to assess the safety and efficacy of the Freesolve resorbable magnesium scaffold (RMS) in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to the Xience…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- BIOMAG-III (NCT07258290)
- Testing
- Freesolve RMS, Xience DES
- Where
- 3 sites in United States, Latvia
- Volunteers
- 1,859 people
- Sponsor
- Teleflex
Myofascial Pain Syndrome
Evaluation of Pain Regression in Patients With Myofascial Facial Pain Using Dextrose, Local Anaesthesia and Saline.
The aim of this study is to compare the treatment effects of dextrose prolotherapy, saline, and mepivacaine for deactivating myofascial trigger points within the jaw muscles.
- Trial name
- NCT03161210
- Testing
- Dextrose Prolotherapy, Local Anaesthesia, Saline
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Low Back Pain
Resolving the Burden of Low Back Pain in Military Service Members and Veterans: A Pragmatic Clinical Trial
The RESOLVE trial will provide a pragmatic approach to evaluate whether Physical Therapy Clinical Practice Guideline adherence can reduce pain, disability and downstream healthcare utilization for low back pain within the…
- Trial name
- RESOLVE (NCT04494490)
- Testing
- Clinical Practice Guidelines and Psychologically Informed Physical Therapy training/audit/feedback
- Where
- United States
- Volunteers
- 4,039 people
- Sponsor
- Sara Gorczynski