Clinical trials: Clinical Pain
Primary Total Knee Arthroplasty
Quadriblock Versus "IPACK + Femoral Triangle Block + Obturator Nerve Block" in Total Knee Arthroplasty
Total knee arthroplasty (TKA) is one of the most common orthopedic surgical procedure and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.
- Trial name
- QuITO (NCT04499716)
- Testing
- IPACK, Femoral triangle block, Obturator nerve block
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Clinique Medipole Garonne
Postoperative Pain, Pelvic Pain
Interfascial Abdominal Wall Block for Gynecological Laparoskopy: A Randomized Clinical Trial
The purpose of this study is to evaluate the clinical efficacy of combining ultrasound-guided bilateral rectus sheath blocks (RSB) and quadratus lumborum blocks (QLB) compared to using a quadratus lumborum block alone for…
- Trial name
- NCT07705516
- Testing
- Bilateral QLB and RSB, Bilateral QLB alone
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Medical and Diagnostic Center "MEDION" LLC
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Topical Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy
The goal of this clinical trial is to learn if menthol works to relieve chronic neuropathic pain and chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07693387
- Testing
- menthol-based hand and foot gloves
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Childhood Cancer Survivor, Chronic Pain
Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial
The purpose of the study is to determine if an adapted mobile cognitive behavioral therapy (CBT) app (WebMAP Onc) is more effective than standard pain education in reducing chronic pain and improving daily functioning in…
- Trial name
- ADAPTED2 (NCT07160621)
- Testing
- Cognitive Behavioral Therapy (CBT), Education, Questionnaires
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- St. Jude Children's Research Hospital
COVID-19, Musculoskeletal Pain
Noninvasive Neuromodulation in the Management of Post-COVID Musculoskeletal Pain
Brief Summary: The post-Covid syndrome is a problem that affects a significant number of people in the world. Among the most common symptoms is pain, and although there is no specific data on neuropathic pain and Covid, due to…
- Trial name
- NCT06723821
- Testing
- Neuromodulation group
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Alcala
Postoperative Nausea and Vomiting, Postoperative Pain
Dexamethasone Improves Postoperative Symptoms After Laparoscopic Cholecystectomy
Dexamethasone has been reported to reduce postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy (LC). However, its effects on other surgical outcomes such as pain and fatigue have been unclear.
- Conditions
- Postoperative Nausea and Vomiting, Postoperative Pain, Postoperative Fatigue
- Trial name
- dxt (NCT01030614)
- Testing
- Dexamethasone
- Where
- Mexico
- Volunteers
- 210 people
- Sponsor
- Instituto Mexicano del Seguro Social
Airway Obstruction, Pain
Dental Isolation Systems Among Pediatric Patients With Different Airway Patency
This randomized clinical trial will aim to evaluate the effect of DryShield isolation (DSI) and Rubber Dam isolation (RDI) systems on arterial oxygen saturation (SpO2), heart rate (HR), blood pressure (BP), behavior, subjective…
- Conditions
- Airway Obstruction, Pain, Behavior
- Trial name
- NCT06128811
- Testing
- Rubber Dam Isolation, DryShieled isolation, fissure sealant
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Neck Pain, Cervical Spondylosis
Ultrasound-guided Cervical Medial Branch Blocks
In this study we will prospectively examine the safety and clinical effects of ultrasound-guided cervical medial branch blocks.
- Trial name
- NCT04852393
- Testing
- Block
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Montreal General Hospital
Abdominal Pain, Deglutition Disorders
Evaluating the Impact of Automated Evaluation of Gastrointestinal Symptoms (AEGIS) on Clinical Outcomes
Healthcare delivery now mandates shorter visits with higher documentation requirements, undermining the patient-provider interaction.
- Conditions
- Abdominal Pain, Deglutition Disorders, Fecal Incontinence, Nausea
- Trial name
- AEGIS (NCT02530216)
- Testing
- AEGIS (Automated Evaluation of Gastrointestinal Symptoms)
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Cedars-Sinai Medical Center
Cancer Pain
Phase I Study of sss40 Injection for Moderate-to-Severe Bone Metastatic Cancer Pain
This is a Phase Ib/IIa, multicenter, sequential clinical trial evaluating the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of SSS40 injection in patients with moderate-to-severe bone metastatic cancer…
- Trial name
- NCT07008703
- Testing
- Injection of humanized nerve growth factor (NGF) antibody
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Dentine Hypersensitivity
Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity
A study to compare the efficacy of a test dentifrice against a control dentifrice in reducing dentinal hypersensitivity over a two week treatment period.
- Trial name
- NCT01592851
- Testing
- Stannous Fluoride, Sodium Monofluorophosphate
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anesthesia, Pain
Clinical Observation of Ciprofol for Anesthesia Induction
To evaluate the effect of ciprofol anesthesia Induction on hemodynamics in elderly patients undergoing elective noncardiac surgery，a prospective, randomized, controlled trial.
- Conditions
- Anesthesia, Pain, Hemodynamic Instability
- Trial name
- NCT05706337
- Testing
- Propofol, Ciprofol
- Volunteers
- 90 people
- Sponsor
- Xiumei Song
Shoulder Pain, Shoulder Injuries
MDR - Comprehensive Reverse/Versa Dial Ti Glenosphere
The objective of this retrospective/prospective consecutives series PMCF study is to collect data confirming safety, performance and clinical benefits of the Comprehensive Versa-Dial Reverse Ti Glenosphere when used for primary…
- Conditions
- Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Arthritis
- Trial name
- NCT04003272
- Testing
- Comprehensive Reverse Versa-Dial Titanium Glenosphere
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Zimmer Biomet
Pain
Delayed Release Diclofenac Sodium Formulation vs Voltaren®
This is a single-centre, open-label, randomised, three-arm crossover study with a fourth fixed arm in a subset of subjects. Up to 36 healthy male volunteers will participate in the study.
- Trial name
- NCT02714842
- Testing
- Radiolabelled Diclofenac Tablet A, Radiolabelled Diclofenac tablet B, Radiolabelled Diclofenac tablet C
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- BDD Pharma Ltd
Osteoarthritis, Knee
Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Surgery
Preemptive analgesia is a treatment modality which starts even before the surgery, so that the central sensitization is prevented due to incisional injury at the time of surgery, so it covers the period of surgery and initial…
- Trial name
- NCT03604354
- Testing
- Tapentadol 100 MG Oral Tablet, Pregabalin 150mg
- Where
- India
- Volunteers
- 95 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Low Back Pain
Risk Stratification in Primary Care Combined With Stratified-specific Physical Therapy Care for Low Back Pain
This study aims to examine patient outcomes following risk stratification for low back pain in Family Medicine combined with either matched physical therapy (PT - i.e., stratified-specific PT) treatments or current treatment in…
- Trial name
- NCT03065894
- Testing
- Matched Physical Therapy Intervention, Current Care in Family Medicine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Vermont Medical Center
Peripheral Neuropathic Pain
Observation of the Use of QUTENZA™ in Standard Clinical Practice
This non-interventional study will evaluate the efficacy, tolerability, health related quality of life and use of health resources associated with QUTENZA treatment when QUTENZA is used in standard clinical practice.
- Trial name
- ASCEND (NCT01737294)
- Testing
- Qutenza exposure
- Where
- 50 sites in Austria, Greece and 5 more
- Volunteers
- 429 people
- Sponsor
- Astellas Pharma Europe Ltd.
Sciatica
A Registry Study of Shujinjianyao Pill Used in Clinical Real World
The purpose of this study is to get to know how Shujinjianyao Pill in hospital results in drug-induced liver injury or other adverse drug reactions from a cohort event monitoring as registration research.
- Trial name
- NCT03598153
- Testing
- Shujinjianyao Pill
- Volunteers
- 3,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Manual Therapy, Myofascial Pain Syndrome
Plantar Pressures After Pressure Release of the Flexor Digitorum Brevis Muscle Versus a Non-emission Laser.
In this study we will test the effects of pressure release on the Flexor digitorum brevis muscle on the plantar pressures variables using a pressure platform.
- Conditions
- Manual Therapy, Myofascial Pain Syndrome, Foot, Flat Foot
- Trial name
- NCT06499545
- Testing
- Pressure release, Non emision Laser
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mayuben Private Clinic
Wound, Anesthesia, Local
To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo.
The purpose of this study is to evaluate if applying a lidocaine topical solution before wounds treatment decreases the pain of the procedure in comparison with placebo solution.
- Trial name
- NCT03676556
- Testing
- Lidocaine, Saline Solution
- Where
- 2 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Hospital Universitari de Bellvitge
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