Clinical trials: Clinical Pain
Parkinson Disease
OpiCapone Effect on Motor Fluctuations and pAiN
The aim of this study is to investigate the efficacy of 50 mg opicapone when administered with the existing treatment of levodopa (L-dopa) plus a dopa decarboxylase inhibitor (DDCI), in Parkinson's disease (PD) patients with…
- Trial name
- OCEAN (NCT04986982)
- Testing
- Opicapone 50 mg
- Where
- United Kingdom
- Volunteers
- 144 people
- Sponsor
- Bial - Portela C S.A.
Appendicitis Acute, Acute Abdomen in Children
The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary Care
BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g.
- Trial name
- ISAAK (NCT06762275)
- Testing
- Diagnostic strategy
- Where
- Netherlands
- Volunteers
- 566 people
- Sponsor
- University Medical Center Groningen
Wounds and Injuries, Cancer Pain
Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds
The goal of this clinical trial is to compare in compare pain reduction in patients with malignant wounds using morphine gel or lidocaine gel.
- Conditions
- Wounds and Injuries, Cancer Pain, Cancer, Breast, Cancer Head Neck
- Trial name
- MorphineGEL (NCT05800834)
- Testing
- Morphine Sulfate, Lidocaine Hcl 2% Jelly
- Where
- Brazil
- Volunteers
- 106 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Post Operative Pain
Comparison Between Two Instrumentation Techniques on Postoperative Pain and Level of Neuropeptides
General aim: assessment of post operative pain and time of preparation with the execution of manual-less technique and conventional technique.
- Trial name
- NCT07357233
- Testing
- Manual-less, Conventional technique
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Temporomandibular Joint Dysfunction Syndrome, Chronic Pain
Restoring Masticatory Function to Treat Chronic Pain
The primary endpoint will be the average change in pain score from baseline to the three- and six-month assessments. Efficacy will be demonstrated by superior pain relief with the active treatment compared with the placebo.
- Trial name
- MAP (NCT02144233)
- Testing
- Occlusal adjustment
- Where
- 2 sites in Spain
- Volunteers
- 77 people
- Sponsor
- Urbano Santana Penin, MD, DDS, PhD
Fibromyalgia (FM), Fibromyalgia
FIBROmyalgia: Somatic Tracking and Exercise Program Study
The goal of this clinical trial is to learn if the combination of two interventions is more effective in treating fibromyalgia symptoms than one intervention alone.
- Conditions
- Fibromyalgia (FM), Fibromyalgia, Fibromyalgia Syndrome
- Trial name
- FIBROSTEPS (NCT06922747)
- Testing
- Group exercising, Somatic tracking, General activity recommendaitons
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University of Tromso
Piriformis Syndrome
Comparative Effects of Stecco-fascial Manipulation and Rolfing Structural Integration in Patients With Piriformis Syndrome
This study aims to compare the effectiveness of Stecco Fascial Manipulation and Rolfing Structural Integration in treating Piriformis syndrome, focusing on special outcomes like pain severity and functional outcomes.
- Trial name
- Piriformis (NCT07322185)
- Testing
- Experimental: GROUP A ( Stecco fascial Manipulation), Experimental: GROUP B (Rolfing Structural Integration)
- Where
- 3 sites in Pakistan
- Volunteers
- 42 people
- Sponsor
- Danyal Ahmad
Wounds, Local Anesthesia
To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo
The purpose of this study is to evaluate if applying a lidocaine topical solution before wounds treatment decreases the pain of the procedure in comparison with placebo solution.
- Trial name
- NCT02584335
- Testing
- Lidocaine solution ("A"), Saline solution ("B")
- Where
- Spain
- Volunteers
- 7 people
- Sponsor
- Hospital Universitari de Bellvitge
Non Specific Low Back Pain
Vertical Oscillatory Pressure and Sustained Natural Apophyseal Glides in ow Back Pain
Among different spinal manual therapies, which have been reported to be effective in the management of LBP are Sustained Natural Apophyseal Glide (SNAGS) and Vertical Oscillatory Pressure (VOP) .
- Trial name
- VOP&SNAG (NCT05612308)
- Testing
- Vertical Oscillatory Pressure (VOP)
- Where
- Nigeria
- Volunteers
- 25 people
- Sponsor
- Obafemi Awolowo University
Postoperative Pain
Effect of Manual Glide Path Establishment on Endodontic Postoperative Pain
All patients will be treated in a single session approach regardless of the group. All molars will be anesthetized either through infiltration in case of maxillary molars or inferior alveolar nerve block in case of mandibular…
- Trial name
- NCT05206214
- Testing
- Manual glide path, Mechanical glide path
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Other Surgical Procedures
Comparison of the Clinical Efficacy of Ketoprofen, Associated or Not With Omeprazole in Lower Third Molar Removal
The control of pain, swelling and trismus in patients undergoing oral and maxillofacial surgery is frequently performed through the administration of non-steroidal anti-inflammatory drugs (NSAIDS).
- Trial name
- NCT02730026
- Testing
- Ketoprofen, Ketoprofen and Omeprazole
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Luis Fernando Simoneti
Myofascial Trigger Points
A Clinical Observation on Neuropsychology and Electrophysiology in Headache Patinets With Myofascial Trigger Points
To study the clinical characteristics of headache patients with pericranial myofascial trigger points(MTrPs),and to explore the possible pathogenesis of MTrPs,investigators hope to find the possible electrical biomarkers for…
- Trial name
- NCT03082547
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Root Canal Infection
Evaluation of Post Operative Pain and Success Rate After Pulpotomy
The aim of this randomized controlled trial is to assess the post-operative pain as primary outcome and the success rate as secondary outcome after pulpotomy using different calcium silicate based materials in mature permanent…
- Trial name
- NCT04933955
- Testing
- vital pulp therapy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain, Postoperative
Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection.
Laparoscopic colorectal surgery (LCS) has gained wide acceptance in the treatment of various pathology from diverticular disease to colon cancer.
- Trial name
- NCT02086123
- Testing
- Epidural Analgesia, Parenteral Analgesia (Intravenous)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, Irvine
Sickle Cell Disease, Thalassemia
A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease
This clinical trial is a Phase 2 study that will evaluate the safety and clinical activity of etavopivat in patients with thalassemia or sickle cell disease and test how well etavopivat works to lower the number of red blood cell…
- Trial name
- GLADIOLUS (NCT04987489)
- Testing
- Etavopivat tablets
- Where
- 32 sites in United States, Canada and 4 more
- Volunteers
- 53 people
- Sponsor
- Forma Therapeutics, Inc.
Varicose Veins with Self-declared Knee Pain
A Clinical Study to Determine the Safety and Efficacy of Bio-Ray Knee Guard in Panelists with Varicose Vein and Knee Pain.
Prospective, Open-Label, Control-group, Proof-Of-Science, Real-life Setting Clinical Safety and Efficacy Study of a Bio-Ray Knee Guard in Panelists with varicose vein and Self-Declared Knee Pain.
- Trial name
- NCT06440889
- Testing
- Bio-Ray Knee Guard
- Where
- India
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Critical Illness
The Optimization of Procedural Pain Control in Intensive Care Unit (ICU) Patients
The purpose of this study is to determine the influence of morphine 2,5 mg or morphine 7,5 mg iv during a painful and unavoidable intervention in critically ill patients.
- Trial name
- OPCIC (NCT00558090)
- Testing
- morphine
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Chronic Non-Specific Low Back Pain
Comparison of High-Intensity Interval Training With Moderate-Intensity Continuous Training in Chronic Non-Specific Low Back Pain Patients
The goal of this clinical trial is to compare the HIIT with MICT in chronic non-specific low back pain patients. The main questions it aims to answer are: The broad aim of the study is to compare HIIT with MICT in pain reduction…
- Trial name
- NCT07645859
- Testing
- Brisk walk and jog, Normal walk
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Dow University of Health Sciences
Acupuncture, Chronic Pelvic Pain, Woman
Acupuncture for Chronic Pelvic Pain
The aim of the study is to assess the effects and safety of acupuncture for moderate to severe chronic pelvic pain in women.
- Trial name
- NCT05223517
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Rotator Cuff Tear
Clinical Research Study of the Benefits of BREG Polar Care Wave to Reduce Opioid Use by Patients Having Undergone Arthroscopic Rotator Cuff Repair Shoulder Surgery
The goal of this clinical trial is to compare effect of cold compression to standard of care in patients undergoing rotator cuff repair.
- Trial name
- CCROUT (NCT07455474)
- Testing
- Breg Polar Care Wave Cold Compression Device
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Nevada, Reno
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