Clinical trials: Clinical Pain
Post-operative Pain
Postoperative Pain in Children Aged From 3 to 5 Years Following Full Mouth Dental Rehabilitation Under General Anesthesia. A Cross-sectional Study. Rehabilitation Under General Anesthesia
the purpose of this study is monitoring Postoperative pain in Children Aged from 3 to 5 years following Full mouth Dental Rehabilitation under General Anesthesia
- Trial name
- NCT03739567
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neck Pain, Low Back Pain
Effects of Percutaneous Peripheral Nerve Stimulation on Neck and Low Back Pain
Percutaneous Peripheral Nerve Stimulation (pPNS) is a physical therapy technique, whose main objective is to treat neuro-musculo-skeletal signs and symptoms by applying a current to a peripheric nerve with a blunt dry needle.
- Trial name
- NCT06153875
- Testing
- Sensory Thresold, Burst High Frecuency, Theta-Burst Stimulation, Transcutaneous Electrical Nerve Stimulation
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Clinica Francisco Ortega Rehabilitacion Avanzada SL
Rib Fractures, Pain, Acute
Erector Spinae Plane (ESP) Versus Paravertebral Nerve (PVB) Blockade for Acute Unilateral Rib Fracture Pain
Continuous paravertebral analgesia and erector spinae plane blockade (ESP) are accepted techniques at University of Pittsburgh Medical Center (UPMC) for the management of thoracic pain following surgery and trauma.
- Conditions
- Rib Fractures, Pain, Acute, Thoracic Injuries, Neuropathic Pain
- Trial name
- NCT03540095
- Testing
- Erector Spinae Plane Block, Paravertebral Nerve Block
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh
Neck Pain
Therapeutic Exercise Through Exergames on Mobile Devices for Cervical Rehabilitation
The objective of this study is to determine whether performing cervical therapeutic exercises using a serious game through a mobile application enhances treatment adherence compared to performing the same exercises at home…
- Trial name
- RehbeCa (NCT06794528)
- Testing
- RehbeCa mobile application, Home exercise program
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universitat de les Illes Balears
Depression, Pain
Efficacy of Pain Treatment on Depression in Patients With Dementia
The purpose of this study is to determine whether pain treatment can reduce symptoms of depression in patients suffering from dementia and depression. Depression is commonly diagnosed in patients with dementia.
- Conditions
- Depression, Pain, Dementia
- Trial name
- DEP-PAIN-DEM (NCT02267057)
- Testing
- Paracetamol, Buprenorphine
- Where
- Norway
- Volunteers
- 163 people
- Sponsor
- University of Bergen
Post Operative Pain
Two Doses of Dexmedetomidine as Adjuvent to Bupivacaine in Tap Block
The aim of this study to determine the optimal dose of dexmedetomidine as an adjuvant to bupivacaine in U.S guided TAP block for preemptive analgesia In patients undergoing lower abdominal cancer surgeries.
- Trial name
- Dexmed/tap (NCT06624319)
- Testing
- Dexmedetomidine as adjuvent to bupvacaine in tap block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Acute Pain, Opioid Use
Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the ED
The KetMo study is an investigator-initiated, randomized, parallel group, double blinded trial investigating if ketamine as an adjunct to morphine improves pain treatment in the ED.
- Trial name
- KetMo (NCT05422001)
- Testing
- low dose ketamine
- Where
- Denmark
- Volunteers
- 116 people
- Sponsor
- University of Aarhus
Colon Cancer, Rectal Cancer
Trial Comparing Transversus Abdominis Plane Block Versus Epidural Anesthesia for Pain Management in Colorectal Surgery
The primary outcome for this study is the Numeric Pain Score (NPS) for elective patients undergoing elective colorectal surgery that have been randomized to transversus abdominis plane block or epidural anesthesia for the…
- Conditions
- Colon Cancer, Rectal Cancer, Colonic Diverticulosis
- Trial name
- TAP (NCT02591407)
- Testing
- TAP Block, Continuous Epidural Analgesia
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Trinity Health Michigan
Unstable Angina
Incidence, Clinical Characteristics and Outcomes of Unstable Angina in the contempoRary Area.
The study aims to evaluate clinical characteristics and prognostic of a contemporary population of patients with UA defined using T hs-cTn measurements The study includes all patients admitted in 2 French university centers with…
- Trial name
- ICAR (NCT06378333)
- Testing
- patients who underwent coronary angiography
- Where
- France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Montpellier
Musculoskeletal Pain
Altering The Transition From Acute to Chronic Pain (ATTAC-Pain)
The current way that pain is treated after trauma and injury is problematic. Most often pain after trauma is treated with opioids (ex. Percocet® or Vicodin®) or anti-inflammatories (ex. ibuprofen).
- Trial name
- ATTAC-PAIN (NCT03315533)
- Testing
- Duloxetine 30 milligrams (MG), Duloxetine 60 milligrams (MG)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Rhode Island Hospital
Neuralgia
Ketamine and fMRI for Neuropathic Pain
Neuropathic or nerve injury related pain (NP), an extremely unpleasant condition that is difficult to treat, often has a severe, persistent, and unremitting course. Conventional treatments are often ineffective in relieving NP.
- Trial name
- NCT02373449
- Testing
- RS-fMRI, Ketamine
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- University Health Network, Toronto
Anesthesia, Local
Cold Vibratory Stimuli on Pain Perception Governing Infiltration Anesthesia in in Children
Local anesthesia injections are sometimes painful, resulting in antagonistic cooperation, fear, and anxiety in children. This study aims to investigate the effectiveness of vibratory and cold stimulation before the injection to…
- Trial name
- NCT05857033
- Testing
- Buccal and direct palatal injection with the aid of Buzzy, Buccal and indirect palatal injection with the aid of Buzzy, Buccal and direct palatal injection without Buzzy
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Alexandria University
Vaso-occlusive Pain Episodes
Arginine Therapy in Sickle Cell Disease-VOC Clinical Trial
Vaso-occlusion contributes significantly to morbidity in sickle cell disease (SCD). Vaso-occlusive painful episodes (VOE) are common and debilitating, causing the majority of emergency department visits.
- Trial name
- NCT01796678
- Testing
- Arginine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Diabetic Peripheral Neuropathic Pain (DPNP)
Randomized, Double-blind, Placebo-controlled, Multicenter Phase IIb Clinical Trial of Spray YJ001 for the Treatment of Diabetic Peripheral Neuropathic Pain
The goal of this clinical trial is to learn if YJ001 Spray can treat diabetic patients with Diabetic Peripheral Neuropathic Pain(DPNP).
- Trial name
- NCT07858344
- Testing
- YJ001 spray simulator, YJ001 Spray 240 mg/day, YJ001 Spray 480 mg/day
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Zhejiang Yuejia Pharmaceuticals Co., Ltd.
Multiple Sclerosis, Neuropathic Pain
OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis
This is an early phase safety evaluation of the use of oral extended release (OER) glibenclamide, which is otherwise known as glyburide, for use as a treatment for neurologic pain in people with multiple sclerosis.
- Trial name
- NCT07221799
- Testing
- glibenclamide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Ankle (Ligaments); Instability (Old Injury), Ankle Sprain
A Study on Reducing Opioid Use After Ankle Arthroscopy
Study Title Effect of a Postoperative Multimodal Analgesic Protocol Predominantly Based on Non-Opioid Medications vs Opioid-Based Analgesia on Pain After Ankle Arthroscopy: A Noninferiority Randomized Clinical Trial Purpose This…
- Conditions
- Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect, Opioid Analgesia
- Trial name
- NCT07154433
- Testing
- Opioid Analgesic Regimen, Non-opioid analgesic regimen
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Root Canal Obturation
Pain After Root Canal Obturation With Sealer Containing or Not 1% Enoxolone
This study aims to assess the efficacy of a zinc oxide eugenol sealer containing Enoxolone, a non-steroidal anti inflammatory drug (NSAID) on the pain relief after endodontic treatment.
- Trial name
- NCT03874949
- Testing
- SEALITE Regular, SEALITE Ultra
- Where
- France
- Volunteers
- 95 people
- Sponsor
- ACTEON Group
Postoperative Pain
Comparative Evaluation of the Efficacy of Intraoral Cryotherapy Versus Intracanal Cryotherapy on Postoperative Pain
The aim of this study is to clinically compare the efficacy of intraoral cryotherapy versus intracanal cryotherapy after single visit root canal therapy in lower molars with irreversible pulpitis and symptomatic apical…
- Trial name
- NCT05041738
- Testing
- Intraoral Cryotherapy, Intracanal Cryotherapy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vertebral Body Compression Fractures
KAVIAR Study - Kyphoplasty And Vertebroplasty In the Augmentation and Restoration of Vertebral Body Compression Fractures
Patients with osteoporotic vertebral body compression fractures will be randomly assigned to treatment with balloon kyphoplasty or vertebroplasty.
- Trial name
- NCT00323609
- Testing
- Vertebroplasty, Kyphoplasty
- Where
- 26 sites in United States, Canada
- Volunteers
- 404 people
- Sponsor
- Medtronic Spine LLC
Anesthesia, Pain
Surgical Pleth Index (SPI) Versus Standard Clinical Approach Analgesia
The study is aimed at confronting a surgical pleth index based protocol for intraoperative analgesia in a desflurane based general anesthesia for thyroidectomy, versus a standard clinical approach.
- Conditions
- Anesthesia, Pain, Surgery
- Trial name
- SPIDER (NCT03218306)
- Testing
- Surgical Pleth Index, Clinical guidance
- Where
- Italy
- Volunteers
- 198 people
- Sponsor
- University of Cagliari