Clinical trials: Clinical Pain
Lumbosacral Radiculopathy
Does Magnetic Resonance Imaging (MRI) Improve Interventional Outcomes for Lumbosacral Radiculopathy?
Epidural steroid injections (ESI) are the most frequently performed procedures in pain clinics. When performing ESI, there is no consensus about how to best select candidates for this intervention, and which level(s) to inject.
- Trial name
- NCT00826124
- Testing
- Epidural steroid injection, Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Johns Hopkins University
Pain, Symptomatic Irreversible Pulpitis
Ethyl Chloride Versus 5% Lidocaine for Topical Anesthesia of Oral Mucosa
Local anesthesia in the oral cavity is a pain full experience for the patient. All means should be made to reduce the pain and anxiety of the patient for needle stick procedures.
- Trial name
- NCT05306470
- Testing
- Ethyl chloride, 5% lidocaine gel
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Migraine
Migraine Characteristics and Associated Factors
This cross-sectional study aims to evaluate the clinical characteristics of migraine and factors associated with migraine-related disability and impact in adults diagnosed with primary migraine.
- Trial name
- NCT07822386
- Testing
- Observational assessment
- Volunteers
- 100 people
- Sponsor
- Lokman Hekim University
Pain
Comparison of Self-ligating and Conventional MBT Brackets Regarding Alignment Efficiency and Pain Perception
The rate of Orthodontic tooth movement affects the efficacy and time duration of the treatment. One of the key factors, during the initial alignment phase, is the amount of the force that the arch-wire applies to the dentition.
- Trial name
- NCT06895083
- Testing
- self ligating brackets
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shoaib Rahim
Chronic Pain
Effects of Expectancy and Mindfulness Instructions on Chronic Pain
This randomized 2×2 factorial study will examine how verbal expectancy framing and mindfulness-specific practice instructions influence acute pain and brain activity in adults with chronic pain.
- Trial name
- NCT07916805
- Testing
- Mindfulness of Breath Practice (15 min)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Florida State University
Greater Trochanteric Pain Syndrome, Hip Pain Chronic
Research Study to Compare the Addition of Topaz Micro Debridement to the Standard of Care Surgery
Compare the surgical use of Topaz with the Standard Of Care in the treatment of Greater Trochanteric Pain Syndrome (a type of hip pain). The hypothesis is that there is a difference between the two treatment groups.
- Trial name
- NCT01562366
- Testing
- Topaz, Iliotibial band release and trochanteric bursectomy
- Where
- Australia
- Volunteers
- 66 people
- Sponsor
- Smith & Nephew, Inc.
Low Back Pain, Headache
Safe Harbors in Emergency Medicine, Specific Aim 3
Many patients who present to the emergency department (ED) receive a vast array of diagnostic tests, some of which might not be useful.
- Conditions
- Low Back Pain, Headache, Head Injury, Minor
- Trial name
- NCT05410366
- Testing
- Safe harbor clinical practice guideline
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Opiate Dependence, Chronic Pain
Clinical Trial of Integrated Treatment for Pain and Opioid Dependence
This study is designed to develop an effective psychotherapy for chronic pain and opioid dependence.
- Trial name
- POD (NCT00634803)
- Testing
- CBT, Buprenorphine, Educational Counseling
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Peripheral Nueropathy Pain
A Open-label, Randomized, Crossover Study to Assess PK of Pregabalin
The purpose of this trial to compare the pharmacokinetic characteristics of YHD1119(Pregabalin 300mg) and Lyrica capsule(Pregabalin 150mg). YHD1119 is controlled release formulation which is made by Yuhan Corporation.
- Trial name
- NCT02783183
- Testing
- YHD1119, Lyrica
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Neck Pain
Chiropractic and Exercise for Seniors With Neck Pain
The purpose of this randomized clinical trial is to assess the relative effectiveness of three conservative treatment approaches for seniors with chronic neck pain: 1) chiropractic manual treatment plus home exercise, 2)…
- Trial name
- NCT00269308
- Testing
- Chiropractic Manual treatment + home exercise ( procedure+behavior), Supervised rehabilitative exercise + home exercise, Home exercise
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Northwestern Health Sciences University
Postoperative Pain
Can the Different Instruments Used ın Root Canal Treatment Have an Effect on Postoperative Pain?
Root canal treatment is a treatment method in which the pulp is irreversibly infected due to caries or trauma or when the pulp loses its vitality.
- Trial name
- NCT05927025
- Testing
- Hand K-files
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Herniated Lumbar Disk
Confirmatory Clinical Study of Oxiplex
This is a prospective, multi-center, randomized, controlled, patient and evaluator-blinded clinical study to assess the safety and effectiveness for the reduction of pain and symptoms following lumbar surgery.
- Trial name
- NCT03433391
- Testing
- Oxiplex, Surgery Only
- Where
- 17 sites in United States
- Volunteers
- 135 people
- Sponsor
- FzioMed
Analgesic Drugs, Pain Relief
Ibuprofen, Paracetamol Versus Placebo on Pain During Local Anesthetic Injection (RCT)
The Effect of Ibuprofen, Paracetamol versus Placebo on Pain during Local Anesthetic Injection and Following Dental Extraction in Primary Molars: A Randomized clinical trial
- Trial name
- NCT03184649
- Testing
- Ibuprofen, paracetamol
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Pain, Trismus
Effect of CGF on Short Term Clinical Outcomes After Partially Impacted Mandibular Third Molar Surgery
The aim of this study was to evaluate the effectiveness of concentrated growth factor (CGF) on soft tissue healing and postoperative side effects following third molar surgery.
- Conditions
- Postoperative Pain, Trismus, Edema
- Trial name
- CGF (NCT03913884)
- Testing
- Concentrated growth factor, Non-Concentrated growth factor Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ege University
Coronary Artery Disease, Angina Pectoris
Investigation of a Novel Gene Expression Test (ASGES or Corus CAD) for Diagnosis of Obstructive Coronary Artery Disease
The objective of this study is to collect data on the commercial use of Corus CAD (Age/Sex/Gene Expression score - ASGES) blood test to evaluate the clinical referral patterns of Primary Care Physicians after receipt of their…
- Conditions
- Coronary Artery Disease, Angina Pectoris, Chest Pain, Cardiovascular Diseases
- Trial name
- REGISTRY-I (NCT01557855)
- Testing
- Corus CAD (ASGES)
- Where
- 7 sites in United States
- Volunteers
- 342 people
- Sponsor
- CardioDx
Rotator Cuff Related Shoulder Pain
Implementation of Shoulder School in Albania
Shoulder pain is a common musculoskeletal condition that can cause pain, movement limitations, disability, and difficulties performing daily and occupational activities.
- Trial name
- NCT07885878
- Testing
- Shoulder school, Standard Care (in control arm)
- Volunteers
- 50 people
- Sponsor
- University of Valladolid
Endometriosis-related Pain
A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034)
The purpose of this study is to evaluate the efficacy, safety, and tolerability of gefapixant (MK-7264) in premenopausal female participants with moderate to severe endometriosis-related pain.
- Trial name
- NCT03654326
- Testing
- Gefapixant, Naproxen
- Where
- 78 sites in United States, Australia and 7 more
- Volunteers
- 187 people
- Sponsor
- Merck Sharp & Dohme LLC
Subacromial Pain Syndrome
Transcranial Electrical Stimulation in Subacromial Pain Syndrome
The goal of this clinical trial is to analyze whether a physiotherapy protocol based on strengthening exercises to the shoulder girdle muscles carried on during anodal transcranial electrical stimulation (a-TES) is more effective…
- Trial name
- NCT05951933
- Testing
- Strenghtening + TES
- Where
- Spain
- Sponsor
- University of Valencia
Gluteal Tendinitis, Greater Trochanteric Pain Syndrome
Exercise and Patient Education for Patients With Lateral Hip Pain
This prospective cohort trial will investigate a progressive exercise protocol and patient education for patients with hip abductor tendon pathology.
- Conditions
- Gluteal Tendinitis, Greater Trochanteric Pain Syndrome, Hip and Thigh Injury, Rupture of Hip Abductor Tendon (Disorder)
- Trial name
- NCT06418217
- Testing
- Exercise and Patient Education
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Jeppe Lange
Back Pain
Health Effects of Mindfulness Based Stress Reduction Course in Treatment of Back Pain
Health effects of mindfulness based stress reduction course versus usual care in treatment of back pain: a randomized clinical trial Mindfulness based stress reduction (MBSR) course intervention for half of the research patients…
- Trial name
- NCT07528833
- Testing
- Mindfulness based stress reduction (MBSR) course
- Where
- 4 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Tampere University Hospital
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